(Q32061148)

6 July 2017

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title

The beta-secretase, BACE: a prime drug target for Alzheimer's disease (English)

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6 July 2017

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Vassar R

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6 July 2017

publication date

1 October 2001

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Journal of Molecular Neuroscience

6 July 2017

published in

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6 July 2017

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6 July 2017

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6 July 2017

page(s)

157-170

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Characterization of Alzheimer's beta -secretase protein BACE. A pepsin family member with unusual properties

6 July 2017

cites work

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12 December 2020

Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

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12 December 2020

Generation and regulation of beta-amyloid peptide variants by neurons.

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12 December 2020

Genetics of Alzheimer's disease

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12 December 2020

Purification and cloning of amyloid precursor protein beta-secretase from human brain

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12 December 2020

The BACE gene: genomic structure and candidate gene study in late-onset Alzheimer's disease.

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12 December 2020

beta-Amyloid peptide and a 3-kDa fragment are derived by distinct cellular mechanisms.

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12 December 2020

Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

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12 December 2020

Secretion of β-amyloid precursor protein cleaved at the amino terminus of the β-amyloid peptide

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12 December 2020

Amyloid beta protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus

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12 December 2020

Amino-terminal Deletions Enhance Aggregation of β-Amyloid Peptides in Vitro

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12 December 2020

Cell-type and amyloid precursor protein-type specific inhibition of A beta release by bafilomycin A1, a selective inhibitor of vacuolar ATPases

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12 December 2020

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

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12 December 2020

Evidence that production and release of amyloid beta-protein involves the endocytic pathway

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12 December 2020

Maturation and pro-peptide cleavage of beta-secretase

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12 December 2020

Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

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12 December 2020

Characterization of the glycosylation profiles of Alzheimer's beta -secretase protein Asp-2 expressed in a variety of cell lines.

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12 December 2020

The gene encoding DRAP (BACE2), a glycosylated transmembrane protein of the aspartic protease family, maps to the down critical region

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12 December 2020

Processing of beta-secretase by furin and other members of the proprotein convertase family

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12 December 2020

A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid

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12 December 2020

The vacuolar H(+)-ATPase inhibitor bafilomycin A1 differentially affects proteolytic processing of mutant and wild-type beta-amyloid precursor protein

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12 December 2020

Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor

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12 December 2020

Abeta-generating enzymes: recent advances in beta- and gamma-secretase research

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12 December 2020

Coordinated Expression of β-Amyloid Precursor Protein and the Putative β-Secretase BACE and α-Secretase ADAM10 in Mouse and Human Brain

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12 December 2020

Are presenilins intramembrane-cleaving proteases? Implications for the molecular mechanism of Alzheimer's disease

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12 December 2020

The pro domain of beta-secretase does not confer strict zymogen-like properties but does assist proper folding of the protease domain

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12 December 2020

Inhibition of amyloid beta-protein production in neural cells by the serine protease inhibitor AEBSF.

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12 December 2020

Beta-secretase processing of the beta-amyloid precursor protein in transgenic mice is efficient in neurons but inefficient in astrocytes

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12 December 2020

Maturation and endosomal targeting of beta-site amyloid precursor protein-cleaving enzyme. The Alzheimer's disease beta-secretase

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12 December 2020

Structural alterations in the peptide backbone of beta-amyloid core protein may account for its deposition and stability in Alzheimer's disease.

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12 December 2020

The role of A beta 42 in Alzheimer's disease

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12 December 2020

A furin-like convertase mediates propeptide cleavage of BACE, the Alzheimer's beta -secretase

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12 December 2020

Amyloidogenesis in Alzheimer's disease: some possible therapeutic opportunities

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12 December 2020

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

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12 December 2020

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

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12 December 2020

Modeling of substrate specificity of the Alzheimer's disease amyloid precursor protein beta-secretase.

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12 December 2020

Function and dysfunction of the presenilins

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12 December 2020

Generation of amyloid β protein from its precursor is sequence specific

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12 December 2020

Prodomain processing of Asp1 (BACE2) is autocatalytic.

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12 December 2020

Alzheimer's disease: genes, proteins, and therapy

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12 December 2020

A splice variant of beta-secretase deficient in the amyloidogenic processing of the amyloid precursor protein

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12 December 2020

A68: a major subunit of paired helical filaments and derivatized forms of normal Tau.

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12 December 2020

The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway

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12 December 2020

Mechanism of Inhibition of beta-site amyloid precursor protein-cleaving enzyme (BACE) by a statine-based peptide

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12 December 2020

Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor

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12 December 2020

Expression analysis of BACE2 in brain and peripheral tissues

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12 December 2020

ASP1 (BACE2) cleaves the amyloid precursor protein at the beta-secretase site

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12 December 2020

Amyloid beta-peptide is produced by cultured cells during normal metabolism

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12 December 2020

BACE1 is the major beta-secretase for generation of Abeta peptides by neurons

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12 December 2020

BACE2, a beta -secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein

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12 December 2020

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

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12 December 2020

Post-translational processing of beta-secretase (beta-amyloid-converting enzyme) and its ectodomain shedding. The pro- and transmembrane/cytosolic domains affect its cellular activity and amyloid-beta production

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12 December 2020

BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics

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12 December 2020

Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein

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12 December 2020

Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease

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12 December 2020

BACE2 functions as an alternative alpha-secretase in cells

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12 December 2020

Phosphorylation regulates intracellular trafficking of beta-secretase

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12 December 2020

Constitutive alpha-secretase cleavage of the beta-amyloid precursor protein in the furin-deficient LoVo cell line: involvement of the pro-hormone convertase 7 and the disintegrin metalloprotease ADAM10.

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12 December 2020

A new aspartyl protease on 21q22.3, BACE2, is highly similar to Alzheimer's amyloid precursor protein beta-secretase

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12 December 2020

Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation

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12 December 2020

Identifiers

DOI

10.1385/JMN:17:2:157

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Dimensions Publication ID

6 July 2017

1044500486

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1 reference