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Keynote review: phosphodiesterase-4 as a therapeutic target

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Europe PubMed Central

Keynote review: phosphodiesterase-4 as a therapeutic target (English)

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Miles D. Houslay

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Miles D Houslay

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author name string

Peter Schafer

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Kam Y J Zhang

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publication date

15 November 2005

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Drug Discovery Today

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10

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22

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1503-19

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Cyclic nucleotide research -- still expanding after half a century

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7 January 2021

based on heuristic

inferred from DOI database lookup

Localized effects of cAMP mediated by distinct routes of protein kinase A.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903622-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Cyclic nucleotide phosphodiesterase activity, expression, and targeting in cells of the cardiovascular system

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903622-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Cyclic AMP-specific PDE4 phosphodiesterases as critical components of cyclic AMP signaling.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903622-6

7 January 2021

based on heuristic

inferred from DOI database lookup

PDE4 cAMP phosphodiesterases: modular enzymes that orchestrate signalling cross-talk, desensitization and compartmentalization

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903622-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Compartmentalisation of phosphodiesterases and protein kinase A: opposites attract

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903622-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Arrestin times for compartmentalised cAMP signalling and phosphodiesterase-4 enzymes

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903622-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Fluorescence resonance energy transfer-based analysis of cAMP dynamics in live neonatal rat cardiac myocytes reveals distinct functions of compartmentalized phosphodiesterases

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903622-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Cyclic nucleotide phosphodiesterases and their role in immunomodulatory responses: advances in the development of specific phosphodiesterase inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903622-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Nonredundant function of phosphodiesterases 4D and 4B in neutrophil recruitment to the site of inflammation

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903622-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Induction of the cyclic nucleotide phosphodiesterase PDE4B is essential for LPS-activated TNF-alpha responses

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903622-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Impaired growth and fertility of cAMP-specific phosphodiesterase PDE4D-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903622-6

7 January 2021

based on heuristic

inferred from DOI database lookup

PDE4D plays a critical role in the control of airway smooth muscle contraction

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903622-6

7 January 2021

based on heuristic

inferred from DOI database lookup

In resting COS1 cells a dominant negative approach shows that specific, anchored PDE4 cAMP phosphodiesterase isoforms gate the activation, by basal cyclic AMP production, of AKAP-tethered protein kinase A type II located in the centrosomal region

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903622-6

7 January 2021

based on heuristic

inferred from DOI database lookup

PDE4 inhibition: a novel approach for the treatment of inflammatory bowel disease

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903622-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Anti-Inflammatory Potential of the Selective Phosphodiesterase 4 InhibitorN-(3,5-Dichloro-pyrid-4-yl)-[1-(4-fluorobenzyl)-5-hydroxy-indole-3-yl]-glyoxylic Acid Amide (AWD 12-281), in Human Cell Preparations

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903622-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Phosphodiesterase 4-selective inhibition: novel therapy for the inflammation of COPD.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903622-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Antidepressant effects of inhibitors of cAMP phosphodiesterase (PDE4).

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903622-6

7 January 2021

based on heuristic

inferred from DOI database lookup

The potential of PDE4 inhibitors in respiratory disease

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903622-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Engineered deletion of the unique N-terminal domain of the cyclic AMP-specific phosphodiesterase RD1 prevents plasma membrane association and the attainment of enhanced thermostability without altering its sensitivity to inhibition by rolipram

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903622-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Cyclic AMP-dependent transcriptional up-regulation of phosphodiesterase 4D5 in human airway smooth muscle cells. Identification and characterization of a novel PDE4D5 promoter

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903622-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Identification and characterization of PDE4A11, a novel, widely expressed long isoform encoded by the human PDE4A cAMP phosphodiesterase gene

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903622-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Expression of phosphodiesterase 4D (PDE4D) is regulated by both the cyclic AMP-dependent protein kinase and mitogen-activated protein kinase signaling pathways. A potential mechanism allowing for the coordinated regulation of PDE4D activity and expr

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903622-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Long PDE4 cAMP specific phosphodiesterases are activated by protein kinase A-mediated phosphorylation of a single serine residue in Upstream Conserved Region 1 (UCR1)

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903622-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Phosphorylation and activation of a cAMP-specific phosphodiesterase by the cAMP-dependent protein kinase. Involvement of serine 54 in the enzyme activation

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903622-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Short term feedback regulation of cAMP in FRTL-5 thyroid cells. Role of PDE4D3 phosphodiesterase activation.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903622-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Sub-family selective actions in the ability of Erk2 MAP kinase to phosphorylate and regulate the activity of PDE4 cyclic AMP-specific phosphodiesterases

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903622-6

7 January 2021

based on heuristic

inferred from DOI database lookup

The MAP kinase ERK2 inhibits the cyclic AMP-specific phosphodiesterase HSPDE4D3 by phosphorylating it at Ser579.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903622-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Remodelling of the PDE4 cAMP phosphodiesterase isoform profile upon monocyte-macrophage differentiation of human U937 cells.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903622-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Inhibition of the phosphodiesterase 4 (PDE4) enzyme reverses memory deficits produced by infusion of the MEK inhibitor U0126 into the CA1 subregion of the rat hippocampus

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903622-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Attenuation of the activity of the cAMP-specific phosphodiesterase PDE4A5 by interaction with the immunophilin XAP2

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903622-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Myomegalin is a novel protein of the golgi/centrosome that interacts with a cyclic nucleotide phosphodiesterase

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903622-6

7 January 2021

based on heuristic

inferred from DOI database lookup

UCR1 and UCR2 domains unique to the cAMP-specific phosphodiesterase family form a discrete module via electrostatic interactions.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903622-6

7 January 2021

based on heuristic

inferred from DOI database lookup

The oligomerization state determines regulatory properties and inhibitor sensitivity of type 4 cAMP-specific phosphodiesterases

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903622-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Proposal for pharmacologically distinct conformers of PDE4 cyclic AMP phosphodiesterases

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903622-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Conformational difference between PDE4 apoenzyme and holoenzyme

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903622-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Dissecting the cofactor-dependent and independent bindings of PDE4 inhibitors.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903622-6

7 January 2021

based on heuristic

inferred from DOI database lookup

The human cyclic AMP-specific phosphodiesterase PDE-46 (HSPDE4A4B) expressed in transfected COS7 cells occurs as both particulate and cytosolic species that exhibit distinct kinetics of inhibition by the antidepressant rolipram

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903622-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Action of rolipram on specific PDE4 cAMP phosphodiesterase isoforms and on the phosphorylation of cAMP-response-element-binding protein (CREB) and p38 mitogen-activated protein (MAP) kinase in U937 monocytic cells

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903622-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Association with the SRC family tyrosyl kinase LYN triggers a conformational change in the catalytic region of human cAMP-specific phosphodiesterase HSPDE4A4B. Consequences for rolipram inhibition

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903622-6

7 January 2021

based on heuristic

inferred from DOI database lookup

cAMP-specific phosphodiesterase HSPDE4D3 mutants which mimic activation and changes in rolipram inhibition triggered by protein kinase A phosphorylation of Ser-54: generation of a molecular model.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903622-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Human recombinant phosphodiesterase 4B2B binds (R)-rolipram at a single site with two affinities

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903622-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Identification of a surface on the beta-propeller protein RACK1 that interacts with the cAMP-specific phosphodiesterase PDE4D5

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903622-6

7 January 2021

based on heuristic

inferred from DOI database lookup

The RACK1 signaling scaffold protein selectively interacts with the cAMP-specific phosphodiesterase PDE4D5 isoform

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903622-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Crystal structure of phosphodiesterase 4D and inhibitor complex(1)

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903622-6

7 January 2021

based on heuristic

inferred from DOI database lookup

A family of phosphodiesterase inhibitors discovered by cocrystallography and scaffold-based drug design

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903622-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Structural basis for the activity of drugs that inhibit phosphodiesterases

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903622-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Crystal structures of the catalytic domain of phosphodiesterase 4B complexed with AMP, 8-Br-AMP, and rolipram.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903622-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Dynamic activation of cystic fibrosis transmembrane conductance regulator by type 3 and type 4D phosphodiesterase inhibitors.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903622-6

7 January 2021

based on heuristic

inferred from DOI database lookup

TAPAS-1, a novel microdomain within the unique N-terminal region of the PDE4A1 cAMP-specific phosphodiesterase that allows rapid, Ca2+-triggered membrane association with selectivity for interaction with phosphatidic acid

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903622-6

7 January 2021

based on heuristic

inferred from DOI database lookup

beta-Arrestin-mediated PDE4 cAMP phosphodiesterase recruitment regulates beta-adrenoceptor switching from Gs to Gi

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903622-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Targeting of cyclic AMP degradation to beta 2-adrenergic receptors by beta-arrestins

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903622-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Phosphodiesterase 4D and protein kinase a type II constitute a signaling unit in the centrosomal area

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903622-6

7 January 2021

based on heuristic

inferred from DOI database lookup

mAKAP assembles a protein kinase A/PDE4 phosphodiesterase cAMP signaling module

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903622-6

7 January 2021

based on heuristic

inferred from DOI database lookup

In addition to the SH3 binding region, multiple regions within the N-terminal noncatalytic portion of the cAMP-specific phosphodiesterase, PDE4A5, contribute to its intracellular targeting

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903622-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Phosphodiesterase 4D is required for beta2 adrenoceptor subtype-specific signaling in cardiac myocytes

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903622-6

7 January 2021

based on heuristic

inferred from DOI database lookup

The unique amino-terminal region of the PDE4D5 cAMP phosphodiesterase isoform confers preferential interaction with beta-arrestins

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903622-6

7 January 2021

based on heuristic

inferred from DOI database lookup

TCR- and CD28-mediated recruitment of phosphodiesterase 4 to lipid rafts potentiates TCR signaling

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903622-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Occupancy of the catalytic site of the PDE4A4 cyclic AMP phosphodiesterase by rolipram triggers the dynamic redistribution of this specific isoform in living cells through a cyclic AMP independent process

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903622-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Atomic structure of PDE4: insights into phosphodiesterase mechanism and specificity

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903622-6

7 January 2021

based on heuristic

inferred from DOI database lookup

A glutamine switch mechanism for nucleotide selectivity by phosphodiesterases

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903622-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Three-dimensional structures of PDE4D in complex with roliprams and implication on inhibitor selectivity

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903622-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Phosphodiesterase-4 inhibitors for asthma and chronic obstructive pulmonary disease

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903622-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Crystal structures of phosphodiesterases 4 and 5 in complex with inhibitor 3-isobutyl-1-methylxanthine suggest a conformation determinant of inhibitor selectivity

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903622-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Anti-inflammatory activities of cAMP-elevating agents: enhancement of IL-10 synthesis and concurrent suppression of TNF production.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903622-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Elevated cyclic AMP inhibits NF-kappaB-mediated transcription in human monocytic cells and endothelial cells.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903622-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Inhibition of the NF-kappaB transcriptional activity by protein kinase A.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903622-6

7 January 2021

based on heuristic

inferred from DOI database lookup

cAMP-induced Interleukin-10 promoter activation depends on CCAAT/enhancer-binding protein expression and monocytic differentiation

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903622-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Cyclic adenosine monophosphate-responsive elements are involved in the transcriptional activation of the human IL-10 gene in monocytic cells

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903622-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Calcitonin gene-related peptide inhibits lipopolysaccharide-induced interleukin-12 release from mouse peritoneal macrophages, mediated by the cAMP pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903622-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Type 4 phosphodiesterase inhibitors have clinical and in vitro anti-inflammatory effects in atopic dermatitis

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903622-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Phosphodiesterase 4 inhibition decreases MUC5AC expression induced by epidermal growth factor in human airway epithelial cells.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903622-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Role of CFTR in airway disease

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903622-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Phosphodiesterase 4D forms a cAMP diffusion barrier at the apical membrane of the airway epithelium.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903622-6

7 January 2021

based on heuristic

inferred from DOI database lookup

A macromolecular complex of beta 2 adrenergic receptor, CFTR, and ezrin/radixin/moesin-binding phosphoprotein 50 is regulated by PKA

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903622-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Protein kinase A associates with cystic fibrosis transmembrane conductance regulator via an interaction with ezrin

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903622-6

7 January 2021

based on heuristic

inferred from DOI database lookup

E3KARP mediates the association of ezrin and protein kinase A with the cystic fibrosis transmembrane conductance regulator in airway cells

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903622-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Inhibition of PDE4 phosphodiesterase activity induces growth suppression, apoptosis, glucocorticoid sensitivity, p53, and p21(WAF1/CIP1) proteins in human acute lymphoblastic leukemia cells

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903622-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Induction of apoptosis by an inhibitor of cAMP-specific PDE in malignant murine carcinoma cells overexpressing PDE activity in comparison to their nonmalignant counterparts

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903622-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Modulation of VEGF-induced endothelial cell cycle protein expression through cyclic AMP hydrolysis by PDE2 and PDE4

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903622-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Modulation of cell adhesion molecule expression and function on human lung microvascular endothelial cells by inhibition of phosphodiesterases 3 and 4.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903622-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Vascular endothelial cell cyclic nucleotide phosphodiesterases and regulated cell migration: implications in angiogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903622-6

7 January 2021

based on heuristic

inferred from DOI database lookup

PDE4-regulated cAMP degradation controls the assembly of integrin-dependent actin adhesion structures and REF52 cell migration

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903622-6

7 January 2021

based on heuristic

inferred from DOI database lookup

The phosphodiesterase PDE4B limits cAMP-associated PI3K/AKT-dependent apoptosis in diffuse large B-cell lymphoma

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903622-6

7 January 2021

based on heuristic

inferred from DOI database lookup

The novel long PDE4A10 cyclic AMP phosphodiesterase shows a pattern of expression within brain that is distinct from the long PDE4A5 and short PDE4A1 isoforms

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903622-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Brain distribution of four rat homologues of the Drosophila dunce cAMP phosphodiesterase.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903622-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Results of a phase II study of the antidepressant effect of rolipram

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903622-6

7 January 2021

based on heuristic

inferred from DOI database lookup

The phosphodiesterase inhibitor rolipram delivered after a spinal cord lesion promotes axonal regeneration and functional recovery

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903622-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Rolipram, a type IV-specific phosphodiesterase inhibitor, facilitates the establishment of long-lasting long-term potentiation and improves memory

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903622-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Inhibitors of Type IV Phosphodiesterases Reduce the Toxicity of MPTP in Substantia Nigra NeuronsIn Vivo

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903622-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Absence of muscarinic cholinergic airway responses in mice deficient in the cyclic nucleotide phosphodiesterase PDE4D

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903622-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Phosphodiesterase 4B2 is the predominant phosphodiesterase species and undergoes differential regulation of gene expression in human monocytes and neutrophils

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903622-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Specific role of phosphodiesterase 4B in lipopolysaccharide-induced signaling in mouse macrophages

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903622-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Differential expression of PDE4 cAMP phosphodiesterase isoforms in inflammatory cells of smokers with COPD, smokers without COPD, and nonsmokers

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903622-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Vascular smooth muscle cell phenotype-dependent phosphodiesterase 4D short form expression: role of differential histone acetylation on cAMP-regulated function

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903622-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Roflumilast, an oral, once-daily phosphodiesterase 4 inhibitor, attenuates allergen-induced asthmatic reactions

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903622-6

7 January 2021

based on heuristic

inferred from DOI database lookup

The unique N-terminal domain of the cAMP phosphodiesterase PDE4D4 allows for interaction with specific SH3 domains

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903622-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Delineation of RAID1, the RACK1 interaction domain located within the unique N-terminal region of the cAMP-specific phosphodiesterase, PDE4D5.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903622-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Deletion of phosphodiesterase 4D in mice shortens alpha(2)-adrenoceptor-mediated anesthesia, a behavioral correlate of emesis

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903622-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1016/S1359-6446(05)03622-6

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PubMed publication ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

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