(Q31145317)

29 June 2017

title

A family of phosphodiesterase inhibitors discovered by cocrystallography and scaffold-based drug design (English)

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29 June 2017

Joseph Schlessinger

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29 June 2017

Sung-Hou Kim

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29 June 2017

Gideon Bollag

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29 June 2017

Chao Zhang

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29 June 2017

Sam Gillette

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29 June 2017

Kam Y J Zhang

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29 June 2017

Prabha N Ibrahim

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29 June 2017

Dean R Artis

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29 June 2017

Graeme L Card

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29 June 2017

Landy Blasdel

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29 June 2017

Bruce P England

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29 June 2017

Yoshihisa Suzuki

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29 June 2017

Daniel Fong

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29 June 2017

Michael V Milburn

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29 June 2017

publication date

30 January 2005

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29 June 2017

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29 June 2017

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29 June 2017

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29 June 2017

page(s)

201-207

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Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

29 June 2017

cites work

1 reference

Fragment-Based Drug Discovery

21 January 2018

1 reference

Fragment-based lead discovery

21 January 2018

1 reference

Discovering high-affinity ligands for proteins: SAR by NMR

21 January 2018

1 reference

Discovering novel ligands for macromolecules using X-ray crystallographic screening

21 January 2018

1 reference

Tethering: fragment-based drug discovery

21 January 2018

1 reference

Phosphodiesterase 5 inhibitors: current status and potential applications

21 January 2018

1 reference

Immunosuppressive and anti-inflammatory effects of cyclic AMP phosphodiesterase (PDE) type 4 inhibitors

21 January 2018

1 reference

Cyclic nucleotide phosphodiesterases and their role in endocrine cell signaling.

21 January 2018

1 reference

Cyclic nucleotide research -- still expanding after half a century

21 January 2018

1 reference

Phosphodiesterases and cyclic nucleotide signaling in endocrine cells

21 January 2018

1 reference

Cyclic AMP-specific PDE4 phosphodiesterases as critical components of cyclic AMP signaling.

21 January 2018

1 reference

PDE4 cAMP phosphodiesterases: modular enzymes that orchestrate signalling cross-talk, desensitization and compartmentalization

21 January 2018

1 reference

Induction of the cyclic nucleotide phosphodiesterase PDE4B is essential for LPS-activated TNF-alpha responses

21 January 2018

1 reference

Structural basis for the activity of drugs that inhibit phosphodiesterases

21 January 2018

1 reference

A glutamine switch mechanism for nucleotide selectivity by phosphodiesterases

21 January 2018

1 reference

A Second Generation Force Field for the Simulation of Proteins, Nucleic Acids, and Organic Molecules

21 January 2018

1 reference

From The Cover: Automated protein crystal structure determination using ELVES

21 January 2018

1 reference

Atomic structure of PDE4: insights into phosphodiesterase mechanism and specificity

21 January 2018

1 reference

Three-dimensional structures of PDE4D in complex with roliprams and implication on inhibitor selectivity

21 January 2018

1 reference

Improved methods for building protein models in electron density maps and the location of errors in these models

21 January 2018

1 reference

Adaptation in cyclic AMP signalling processes: A central role for cyclic AMP phosphodiesterases

21 January 2018

1 reference

Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms

21 January 2018

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Phosphodiesterase 4 conformers: preparation of recombinant enzymes and assay for inhibitors

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NBT1059

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Dimensions Publication ID

29 June 2017

1052543566

0 references

1 reference