(Q28277251)

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The Cbl interactome and its functions

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Europe PubMed Central

The Cbl interactome and its functions (English)

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Ivan Dikic

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Mirko H H Schmidt

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Mirko H H Schmidt

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December 2005

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Nature Reviews Molecular Cell Biology

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6

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12

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907-18

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Cell signaling by receptor tyrosine kinases

1 reference

https://api.crossref.org/works/10.1038%2FNRM1762

21 January 2018

Untangling the ErbB signalling network

1 reference

https://api.crossref.org/works/10.1038%2FNRM1762

21 January 2018

Signaling networks: the origins of cellular multitasking

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https://api.crossref.org/works/10.1038%2FNRM1762

21 January 2018

Compartmentalization of growth factor receptor signalling

1 reference

https://api.crossref.org/works/10.1038%2FNRM1762

21 January 2018

Cbl: many adaptations to regulate protein tyrosine kinases

1 reference

https://api.crossref.org/works/10.1038%2FNRM1762

21 January 2018

v-cbl, an oncogene from a dual-recombinant murine retrovirus that induces early B-lineage lymphomas

1 reference

https://api.crossref.org/works/10.1038%2FNRM1762

21 January 2018

cbl-3: a new mammalian cbl family protein

1 reference

https://api.crossref.org/works/10.1038%2FNRM1762

21 January 2018

Molecular cloning and characterization of a novel cbl-family gene, cbl-c

1 reference

https://api.crossref.org/works/10.1038%2FNRM1762

21 January 2018

Cbl-3-deficient mice exhibit normal epithelial development

1 reference

https://api.crossref.org/works/10.1038%2FNRM1762

21 January 2018

Themes and variations on ubiquitylation

1 reference

https://api.crossref.org/works/10.1038%2FNRM1762

21 January 2018

Protein regulation by monoubiquitin

1 reference

https://api.crossref.org/works/10.1038%2FNRM1762

21 January 2018

When ubiquitin meets ubiquitin receptors: a signalling connection

1 reference

https://api.crossref.org/works/10.1038%2FNRM1762

21 January 2018

Cbl signaling networks in the regulation of cell function

1 reference

https://api.crossref.org/works/10.1038%2FNRM1762

21 January 2018

Tyrosine phosphorylation of the c-cbl proto-oncogene protein product and association with epidermal growth factor (EGF) receptor upon EGF stimulation

1 reference

https://api.crossref.org/works/10.1038%2FNRM1762

21 January 2018

Coupling of the Proto-oncogene Product c-Cbl to the Epidermal Growth Factor Receptor

1 reference

https://api.crossref.org/works/10.1038%2FNRM1762

21 January 2018

LET-23-mediated signal transduction during Caenorhabditis elegans development

1 reference

https://api.crossref.org/works/10.1038%2FNRM1762

21 January 2018

Similarity of sli-1 , a Regulator of Vulval Development in C. elegans , to the Mammalian Proto-Oncogene c- cbl

1 reference

https://api.crossref.org/works/10.1038%2FNRM1762

21 January 2018

The cbl oncogene: a novel substrate of protein tyrosine kinases

1 reference

https://api.crossref.org/works/10.1038%2FNRM1762

21 January 2018

Ligand-induced, receptor-mediated dimerization and activation of EGF receptor

1 reference

https://api.crossref.org/works/10.1038%2FNRM1762

21 January 2018

Grb2 regulates internalization of EGF receptors through clathrin-coated pits

1 reference

https://api.crossref.org/works/10.1038%2FNRM1762

21 January 2018

Tyrosine phosphorylation of Cbl upon epidermal growth factor (EGF) stimulation and its association with EGF receptor and downstream signaling proteins

1 reference

https://api.crossref.org/works/10.1038%2FNRM1762

21 January 2018

Direct interaction of Cbl with pTyr 1045 of the EGF receptor (EGFR) is required to sort the EGFR to lysosomes for degradation

1 reference

https://api.crossref.org/works/10.1038%2FNRM1762

21 January 2018

The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase

1 reference

https://api.crossref.org/works/10.1038%2FNRM1762

21 January 2018

Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1

1 reference

https://api.crossref.org/works/10.1038%2FNRM1762

21 January 2018

Negative receptor signalling

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https://api.crossref.org/works/10.1038%2FNRM1762

21 January 2018

CIN85/CMS family of adaptor molecules

1 reference

https://api.crossref.org/works/10.1038%2FNRM1762

21 January 2018

The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met

1 reference

https://api.crossref.org/works/10.1038%2FNRM1762

21 January 2018

Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors

1 reference

https://api.crossref.org/works/10.1038%2FNRM1762

21 January 2018

A Cortactin-CD2-associated protein (CD2AP) complex provides a novel link between epidermal growth factor receptor endocytosis and the actin cytoskeleton

1 reference

https://api.crossref.org/works/10.1038%2FNRM1762

21 January 2018

Receptor endocytosis via ubiquitin-dependent and -independent pathways

1 reference

https://api.crossref.org/works/10.1038%2FNRM1762

21 January 2018

Clathrin-independent endocytosis of ubiquitinated cargos

1 reference

https://api.crossref.org/works/10.1038%2FNRM1762

21 January 2018

Cbl-mediated Ubiquitinylation Is Required for Lysosomal Sorting of Epidermal Growth Factor Receptor but Is Dispensable for Endocytosis

1 reference

https://api.crossref.org/works/10.1038%2FNRM1762

21 January 2018

The role of phosphoinositides in membrane transport

1 reference

https://api.crossref.org/works/10.1038%2FNRM1762

21 January 2018

Negative regulation of PI 3-kinase by Ruk, a novel adaptor protein

1 reference

https://api.crossref.org/works/10.1038%2FNRM1762

21 January 2018

Phosphatidylinositol 4,5-bisphosphate functions as a second messenger that regulates cytoskeleton-plasma membrane adhesion

1 reference

https://api.crossref.org/works/10.1038%2FNRM1762

21 January 2018

CIN85 associates with multiple effectors controlling intracellular trafficking of epidermal growth factor receptors

1 reference

https://api.crossref.org/works/10.1038%2FNRM1762

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM1762

21 January 2018

Rab proteins as membrane organizers

1 reference

https://api.crossref.org/works/10.1038%2FNRM1762

21 January 2018

Interaction of the c-cbl proto-oncogene product with the Tyk-2 protein tyrosine kinase

1 reference

https://api.crossref.org/works/10.1038%2FNRM1762

21 January 2018

WW domain HECT E3s target Cbl RING finger E3s for proteasomal degradation

1 reference

https://api.crossref.org/works/10.1038%2FNRM1762

21 January 2018

Src promotes destruction of c-Cbl: implications for oncogenic synergy between Src and growth factor receptors

1 reference

https://api.crossref.org/works/10.1038%2FNRM1762

21 January 2018

Src-catalyzed phosphorylation of c-Cbl leads to the interdependent ubiquitination of both proteins

1 reference

https://api.crossref.org/works/10.1038%2FNRM1762

21 January 2018

Epidermal growth factor receptor signaling intensity determines intracellular protein interactions, ubiquitination, and internalization

1 reference

https://api.crossref.org/works/10.1038%2FNRM1762

21 January 2018

Modulation of signalling by Sprouty: a developing story

1 reference

https://api.crossref.org/works/10.1038%2FNRM1762

21 January 2018

Sprouty2 acts at the Cbl/CIN85 interface to inhibit epidermal growth factor receptor downregulation

1 reference

https://api.crossref.org/works/10.1038%2FNRM1762

21 January 2018

Activated Cdc42 Sequesters c-Cbl and Prevents EGF Receptor Degradation

1 reference

https://api.crossref.org/works/10.1038%2FNRM1762

21 January 2018

Suppressors of T-cell receptor signaling Sts-1 and Sts-2 bind to Cbl and inhibit endocytosis of receptor tyrosine kinases

1 reference

https://api.crossref.org/works/10.1038%2FNRM1762

21 January 2018

Regulation of ZAP-70 activation and TCR signaling by two related proteins, Sts-1 and Sts-2

1 reference

https://api.crossref.org/works/10.1038%2FNRM1762

21 January 2018

Src phosphorylation of Alix/AIP1 modulates its interaction with binding partners and antagonizes its activities

1 reference

https://api.crossref.org/works/10.1038%2FNRM1762

21 January 2018

Alix/AIP1 antagonizes epidermal growth factor receptor downregulation by the Cbl-SETA/CIN85 complex.

1 reference

https://api.crossref.org/works/10.1038%2FNRM1762

21 January 2018

AIP1/ALIX Is a Binding Partner for HIV-1 p6 and EIAV p9 Functioning in Virus Budding

1 reference

https://api.crossref.org/works/10.1038%2FNRM1762

21 January 2018

The immunological synapse balances T cell receptor signaling and degradation

1 reference

https://api.crossref.org/works/10.1038%2FNRM1762

21 January 2018

Scaffolding of antigen receptors for immunogenic versus tolerogenic signaling.

1 reference

https://api.crossref.org/works/10.1038%2FNRM1762

21 January 2018

Adaptor proteins in lymphocyte activation.

1 reference

https://api.crossref.org/works/10.1038%2FNRM1762

21 January 2018

SLAP, a dimeric adapter protein, plays a functional role in T cell receptor signaling

1 reference

https://api.crossref.org/works/10.1038%2FNRM1762

21 January 2018

Characterization of the CIN85 adaptor protein and identification of components involved in CIN85 complexes

1 reference

https://api.crossref.org/works/10.1038%2FNRM1762

21 January 2018

Phosphotyrosine binding domain-dependent upregulation of the platelet-derived growth factor receptor alpha signaling cascade by transforming mutants of Cbl: implications for Cbl's function and oncogenicity

1 reference

https://api.crossref.org/works/10.1038%2FNRM1762

21 January 2018

Distinct tyrosine phosphorylation sites in ZAP-70 mediate activation and negative regulation of antigen receptor function

1 reference

https://api.crossref.org/works/10.1038%2FNRM1762

21 January 2018

The non-receptor tyrosine kinase Syk is a target of Cbl-mediated ubiquitylation upon B-cell receptor stimulation.

1 reference

https://api.crossref.org/works/10.1038%2FNRM1762

21 January 2018

Cbl-b negatively regulates B cell antigen receptor signaling in mature B cells through ubiquitination of the tyrosine kinase Syk.

1 reference

https://api.crossref.org/works/10.1038%2FNRM1762

21 January 2018

Cbl promotes ubiquitination of the T cell receptor zeta through an adaptor function of Zap-70.

1 reference

https://api.crossref.org/works/10.1038%2FNRM1762

21 January 2018

Cbl-b, a RING-type E3 ubiquitin ligase, targets phosphatidylinositol 3-kinase for ubiquitination in T cells.

1 reference

https://api.crossref.org/works/10.1038%2FNRM1762

21 January 2018

c-Cbl and Cbl-b regulate T cell responsiveness by promoting ligand-induced TCR down-modulation

1 reference

https://api.crossref.org/works/10.1038%2FNRM1762

21 January 2018

Tissue hyperplasia and enhanced T-cell signalling via ZAP-70 in c-Cbl-deficient mice

1 reference

https://api.crossref.org/works/10.1038%2FNRM1762

21 January 2018

Altered thymic positive selection and intracellular signals in Cbl-deficient mice

1 reference

https://api.crossref.org/works/10.1038%2FNRM1762

21 January 2018

Cbl-b regulates the CD28 dependence of T-cell activation.

1 reference

https://api.crossref.org/works/10.1038%2FNRM1762

21 January 2018

A mouse with a loss-of-function mutation in the c-Cbl TKB domain shows perturbed thymocyte signaling without enhancing the activity of the ZAP-70 tyrosine kinase

1 reference

https://api.crossref.org/works/10.1038%2FNRM1762

21 January 2018

Cbl-b is a negative regulator of receptor clustering and raft aggregation in T cells

1 reference

https://api.crossref.org/works/10.1038%2FNRM1762

21 January 2018

Molecular controls of antigen receptor clustering and autoimmunity

1 reference

https://api.crossref.org/works/10.1038%2FNRM1762

21 January 2018

70Z/3 Cbl induces PLCγ1 activation in T lymphocytes via an alternate Lat- and Slp-76-independent signaling mechanism

1 reference

https://api.crossref.org/works/10.1038%2FNRM1762

21 January 2018

Cbl suppresses B cell receptor-mediated phospholipase C (PLC)-gamma2 activation by regulating B cell linker protein-PLC-gamma2 binding

1 reference

https://api.crossref.org/works/10.1038%2FNRM1762

21 January 2018

Cbl-b positively regulates Btk-mediated activation of phospholipase C-gamma2 in B cells

1 reference

https://api.crossref.org/works/10.1038%2FNRM1762

21 January 2018

E3 ubiquitin ligases as T cell anergy factors.

1 reference

https://api.crossref.org/works/10.1038%2FNRM1762

21 January 2018

Essential role of the E3 ubiquitin ligase Cbl-b in T cell anergy induction.

1 reference

https://api.crossref.org/works/10.1038%2FNRM1762

21 January 2018

Serine phosphorylation of Cbl induced by phorbol ester enhances its association with 14-3-3 proteins in T cells via a novel serine-rich 14-3-3-binding motif

1 reference

https://api.crossref.org/works/10.1038%2FNRM1762

21 January 2018

Nuclear lipid signalling

1 reference

https://api.crossref.org/works/10.1038%2FNRM1762

21 January 2018

Cbl-b interacts with ubiquitinated proteins; differential functions of the UBA domains of c-Cbl and Cbl-b

1 reference

https://api.crossref.org/works/10.1038%2FNRM1762

21 January 2018

The multi-adaptor proto-oncoprotein Cbl is a key regulator of Rac and actin assembly

1 reference

https://api.crossref.org/works/10.1038%2FNRM1762

21 January 2018

Phosphorylation- and activation-independent association of the tyrosine kinase Syk and the tyrosine kinase substrates Cbl and Vav with tubulin in B-cells

1 reference

https://api.crossref.org/works/10.1038%2FNRM1762

21 January 2018

Rapid microtubule-dependent induction of neurite-like extensions in NIH 3T3 fibroblasts by inhibition of ROCK and Cbl

1 reference

https://api.crossref.org/works/10.1038%2FNRM1762

21 January 2018

The biogenesis of multivesicular endosomes

1 reference

https://api.crossref.org/works/10.1038%2FNRM1762

21 January 2018

The proto-oncogene product p120(cbl) links c-Src and phosphatidylinositol 3'-kinase to the integrin signaling pathway.

1 reference

https://api.crossref.org/works/10.1038%2FNRM1762

21 January 2018

Regulation of beta 1-integrin-mediated cell adhesion by the Cbl adaptor protein

1 reference

https://api.crossref.org/works/10.1038%2FNRM1762

21 January 2018

A beta 1 integrin signaling pathway involving Src-family kinases, Cbl and PI-3 kinase is required for macrophage spreading and migration

1 reference

https://api.crossref.org/works/10.1038%2FNRM1762

21 January 2018

c-Cbl is downstream of c-Src in a signalling pathway necessary for bone resorption.

1 reference

https://api.crossref.org/works/10.1038%2FNRM1762

21 January 2018

Coordinated regulation of the tyrosine phosphorylation of Cbl by Fyn and Syk tyrosine kinases

1 reference

https://api.crossref.org/works/10.1038%2FNRM1762

21 January 2018

Fyn, Yes, and Syk phosphorylation sites in c-Cbl map to the same tyrosine residues that become phosphorylated in activated T cells

1 reference

https://api.crossref.org/works/10.1038%2FNRM1762

21 January 2018

Physical and functional association of the cbl protooncogen product with an src-family protein tyrosine kinase, p53/56lyn, in the B cell antigen receptor-mediated signaling

1 reference

https://api.crossref.org/works/10.1038%2FNRM1762

21 January 2018

Cbl-mediated ubiquitinylation and negative regulation of Vav.

1 reference

https://api.crossref.org/works/10.1038%2FNRM1762

21 January 2018

APS facilitates c-Cbl tyrosine phosphorylation and GLUT4 translocation in response to insulin in 3T3-L1 adipocytes

1 reference

https://api.crossref.org/works/10.1038%2FNRM1762

21 January 2018

Requirements for pYXXM motifs in Cbl for binding to the p85 subunit of phosphatidylinositol 3-kinase and Crk, and activation of atypical protein kinase C and glucose transport during insulin action in 3T3/L1 adipocytes

1 reference

https://api.crossref.org/works/10.1038%2FNRM1762

21 January 2018

Cbl PYXXM motifs activate the P85 subunit of phosphatidylinositol 3-kinase, Crk, atypical protein kinase C, and glucose transport during thiazolidinedione action in 3T3/L1 and human adipocytes

1 reference

https://api.crossref.org/works/10.1038%2FNRM1762

21 January 2018

A role for CAP, a novel, multifunctional Src homology 3 domain-containing protein in formation of actin stress fibers and focal adhesions

1 reference

https://api.crossref.org/works/10.1038%2FNRM1762

21 January 2018

Cbl-ArgBP2 complex mediates ubiquitination and degradation of c-Abl

1 reference

https://api.crossref.org/works/10.1038%2FNRM1762

21 January 2018

SETA/CIN85/Ruk and its binding partner AIP1 associate with diverse cytoskeletal elements, including FAKs, and modulate cell adhesion

1 reference

https://api.crossref.org/works/10.1038%2FNRM1762

21 January 2018

The adapter type protein CMS/CD2AP binds to the proto-oncogenic protein c-Cbl through a tyrosine phosphorylation-regulated Src homology 3 domain interaction

1 reference

https://api.crossref.org/works/10.1038%2FNRM1762

21 January 2018

Recruitment of Pyk2 and Cbl to lipid rafts mediates signals important for actin reorganization in growing neurites

1 reference

https://api.crossref.org/works/10.1038%2FNRM1762

21 January 2018

Complexes of focal adhesion kinase (FAK) and Crk-associated substrate (p130(Cas)) are elevated in cytoskeleton-associated fractions following adhesion and Src transformation. Requirements for Src kinase activity and FAK proline-rich motifs

1 reference

https://api.crossref.org/works/10.1038%2FNRM1762

21 January 2018

Cbl associates with Pyk2 and Src to regulate Src kinase activity, alpha(v)beta(3) integrin-mediated signaling, cell adhesion, and osteoclast motility

1 reference

https://api.crossref.org/works/10.1038%2FNRM1762

21 January 2018

Newest findings on the oldest oncogene; how activated src does it

1 reference

https://api.crossref.org/works/10.1038%2FNRM1762

21 January 2018

Activation of R-Ras by Ras-guanine nucleotide-releasing factor

1 reference

https://api.crossref.org/works/10.1038%2FNRM1762

21 January 2018

Insulin-stimulated GLUT4 translocation requires the CAP-dependent activation of TC10

1 reference

https://api.crossref.org/works/10.1038%2FNRM1762

21 January 2018

Insulin-stimulated GLUT4 translocation in adipocytes is dependent upon cortical actin remodeling

1 reference

https://api.crossref.org/works/10.1038%2FNRM1762

21 January 2018

Mechanisms underlying ubiquitination

1 reference

https://api.crossref.org/works/10.1038%2FNRM1762

21 January 2018

Tal, a Tsg101-specific E3 ubiquitin ligase, regulates receptor endocytosis and retrovirus budding

1 reference

https://api.crossref.org/works/10.1038%2FNRM1762

21 January 2018

The GRID: the General Repository for Interaction Datasets

1 reference

https://api.crossref.org/works/10.1038%2FNRM1762

21 January 2018

Osprey: a network visualization system

1 reference

https://api.crossref.org/works/10.1038%2FNRM1762

21 January 2018

Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b

1 reference

https://api.crossref.org/works/10.1038%2FNRM1762

21 January 2018

Proteolysis: from the lysosome to ubiquitin and the proteasome

1 reference

https://api.crossref.org/works/10.1038%2FNRM1762

31 March 2020

Tyrosine phosphorylation and translocation of the c-cbl protein after activation of tyrosine kinase signaling pathways

1 reference

https://api.crossref.org/works/10.1038%2FNRM1762

31 March 2020

20 years of Ins(1,4,5)P3, and 40 years before

1 reference

https://api.crossref.org/works/10.1038%2FNRM1762

31 March 2020

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