(Q45989111)

18 December 2017

title

The proto-oncogene product p120(cbl) links c-Src and phosphatidylinositol 3'-kinase to the integrin signaling pathway. (English)

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18 December 2017

J M Olefsky

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18 December 2017

M Ojaniemi

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18 December 2017

S S Martin

series ordinal

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18 December 2017

F Dolfi

series ordinal

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18 December 2017

K Vuori

series ordinal

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18 December 2017

language of work or name

English

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publication date

1 February 1997

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18 December 2017

Journal of Biological Chemistry

published in

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18 December 2017

volume

272

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18 December 2017

issue

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18 December 2017

page(s)

3780-3787

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18 December 2017

Integrins: versatility, modulation, and signaling in cell adhesion

cites work

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21 January 2018

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Integrins: emerging paradigms of signal transduction

21 January 2018

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Tyrosine phosphorylation of paxillin and pp125FAK accompanies cell adhesion to extracellular matrix: a role in cytoskeletal assembly

21 January 2018

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Integrin-mediated cell adhesion promotes tyrosine phosphorylation of p130Cas, a Src homology 3-containing molecule having multiple Src homology 2-binding motifs

21 January 2018

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Tyrosine phosphorylation of p130Cas and cortactin accompanies integrin-mediated cell adhesion to extracellular matrix

21 January 2018

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Introduction of p130cas signaling complex formation upon integrin-mediated cell adhesion: a role for Src family kinases

21 January 2018

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Stable association of pp60src and pp59fyn with the focal adhesion-associated protein tyrosine kinase, pp125FAK.

21 January 2018

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Identification of Tyr-397 as the primary site of tyrosine phosphorylation and pp60src association in the focal adhesion kinase, pp125FAK.

21 January 2018

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Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60src

21 January 2018

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Direct interaction of v-Src with the focal adhesion kinase mediated by the Src SH2 domain

21 January 2018

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Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: a role for Src family kinases

21 January 2018

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Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase

21 January 2018

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Analysis of the binding of the Src homology 2 domain of Csk to tyrosine-phosphorylated proteins in the suppression and mitotic activation of c-Src

21 January 2018

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pp125FAK-dependent tyrosine phosphorylation of paxillin creates a high-affinity binding site for Crk

21 January 2018

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Identification and Characterization of a High-Affinity Interaction Between v-Crk and Tyrosine-Phosphorylated Paxillin in CT10-Transformed Fibroblasts

21 January 2018

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Adhesion through the interaction of lymphocyte function-associated antigen-1 with intracellular adhesion molecule-1 induces tyrosine phosphorylation of p130cas and its association with c-CrkII.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.6.3780

Direct binding of C-terminal region of p130Cas to SH2 and SH3 domains of Src kinase

21 January 2018

1 reference

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Overexpressed Csk tyrosine kinase is localized in focal adhesions, causes reorganization of alpha v beta 5 integrin, and interferes with HeLa cell spreading

21 January 2018

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Adhesion and direct integrin engagement differentially regulate gene transcription, transcript stabilization and translation

21 January 2018

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21 January 2018

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Mitogenic properties of major extracellular proteins

21 January 2018

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The role of protein tyrosine phosphorylation in integrin-mediated gene induction in monocytes

21 January 2018

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Integrin-mediated tyrosine phosphorylation and cytokine message induction in monocytic cells. A possible signaling role for the Syk tyrosine kinase.

21 January 2018

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Integrin alpha v beta 5-dependent serine phosphorylation of paxillin in cultured human macrophages adherent to vitronectin.

21 January 2018

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Expression of a gene encoding a unique protein-tyrosine kinase within specific fetal- and adult-derived hematopoietic lineages.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.6.3780

The cbl oncogene: a novel substrate of protein tyrosine kinases

21 January 2018

1 reference

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Identification of the major tyrosine kinase substrate in signaling complexes formed after engagement of Fc gamma receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.6.3780

Association of insulin receptor substrate-1 with integrins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.6.3780

Microinjection of the SH2 domain of the 85-kilodalton subunit of phosphatidylinositol 3-kinase inhibits insulin-induced DNA synthesis and c-fos expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.6.3780

Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.6.3780

Formation of c-Cbl.phosphatidylinositol 3-kinase complexes on lymphocyte membranes by a p56lck-independent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.6.3780

Rapid T-cell receptor-mediated tyrosine phosphorylation of p120, an Fyn/Lck Src homology 3 domain-binding protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.6.3780

C3G, a guanine nucleotide-releasing protein expressed ubiquitously, binds to the Src homology 3 domains of CRK and GRB2/ASH proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.6.3780

The SH3 domain-binding T cell tyrosyl phosphoprotein p120. Demonstration of its identity with the c-cbl protooncogene product and in vivo complexes with Fyn, Grb2, and phosphatidylinositol 3-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.6.3780

p120cbl is a cytosolic adapter protein that associates with phosphoinositide 3-kinase in response to epidermal growth factor in PC12 and other cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.6.3780

Tyrosine phosphorylation of Cbl upon epidermal growth factor (EGF) stimulation and its association with EGF receptor and downstream signaling proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.6.3780

p120cbl is a major substrate of tyrosine phosphorylation upon B cell antigen receptor stimulation and interacts in vivo with Fyn and Syk tyrosine kinases, Grb2 and Shc adaptors, and the p85 subunit of phosphatidylinositol 3-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.6.3780

Interactions of Cbl with Grb2 and phosphatidylinositol 3'-kinase in activated Jurkat cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.6.3780

Oct-1 protein promotes functional transcription complex assembly on the mouse mammary tumor virus promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.6.3780

Specific association of the beta isoform of the p85 subunit of phosphatidylinositol-3 kinase with the proto-oncogene c-cbl

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.6.3780

Interactions of Cbl with two adapter proteins, Grb2 and Crk, upon T cell activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.6.3780

The product of the cbl oncogene forms stable complexes in vivo with endogenous Crk in a tyrosine phosphorylation-dependent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.6.3780

The proto-oncogene product c-Cbl becomes tyrosine phosphorylated by stimulation with GM-CSF or Epo and constitutively binds to the SH3 domain of Grb2/Ash in human hematopoietic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.6.3780

Knockouts of Src-family kinases: stiff bones, wimpy T cells, and bad memories.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.6.3780

Beta 2 integrin-dependent protein tyrosine phosphorylation and activation of the FGR protein tyrosine kinase in human neutrophils

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.6.3780

Deficiency of Src family kinases p59/61hck and p58c-fgr results in defective adhesion-dependent neutrophil functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.6.3780

SH2 domains recognize specific phosphopeptide sequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.6.3780

Phosphatidylinositol 3-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.6.3780

Stimulation through the T cell receptor induces Cbl association with Crk proteins and the guanine nucleotide exchange protein C3G

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.6.3780

21 January 2018

Identifiers

DOI

10.1074/JBC.272.6.3780

1 reference

18 December 2017

1 reference

18 December 2017