(Q28276832)

0 references

Petek Ballar

0 references

Shouqing Luo

0 references

Yuxian Shen

0 references

David C Rubinsztein

0 references

Mervyn J Monteiro

0 references

Shengyun Fang

Experimental Cell Research

0 references

language of work or name

English

0 references

publication date

1 February 2007

0 references

published in

0 references

volume

313

0 references

issue

0 references

page(s)

538-50

0 references

cites work

Protein aggregation and the ubiquitin proteasome pathway: gaining the UPPer hand on neurodegeneration

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2006.10.031

The ubiquitin proteasome system in neurodegenerative diseases: sometimes the chicken, sometimes the egg.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2006.10.031

The ubiquitin-proteasome pathway in Parkinson's disease and other neurodegenerative diseases

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2006.10.031

ER-associated degradation in protein quality control and cellular regulation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2006.10.031

Protein degradation and protection against misfolded or damaged proteins

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2006.10.031

Protein folding and misfolding

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2006.10.031

Quality control in the endoplasmic reticulum protein factory

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2006.10.031

Folding proteins in fatal ways

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2006.10.031

For whom the bell tolls: protein quality control of the endoplasmic reticulum and the ubiquitin-proteasome connection

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2006.10.031

The tumor autocrine motility factor receptor, gp78, is a ubiquitin protein ligase implicated in degradation from the endoplasmic reticulum

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2006.10.031

CHIP: a link between the chaperone and proteasome systems

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2006.10.031

Parkin's substrates and the pathways leading to neuronal damage

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2006.10.031

CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2006.10.031

A novel mammalian endoplasmic reticulum ubiquitin ligase homologous to the yeast Hrd1

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2006.10.031

Human HRD1 is an E3 ubiquitin ligase involved in degradation of proteins from the endoplasmic reticulum

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2006.10.031

Checkpoints in ER-associated degradation: excuse me, which way to the proteasome?

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2006.10.031

Membrane topology and function of Der3/Hrd1p as a ubiquitin-protein ligase (E3) involved in endoplasmic reticulum degradation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2006.10.031

A conserved ubiquitin ligase of the nuclear envelope/endoplasmic reticulum that functions in both ER-associated and Matalpha2 repressor degradation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2006.10.031

Membrane and soluble substrates of the Doa10 ubiquitin ligase are degraded by distinct pathways

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2006.10.031

TEB4 is a C4HC3 RING finger-containing ubiquitin ligase of the endoplasmic reticulum

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2006.10.031

Degradation-mediated protein quality control in the nucleus

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2006.10.031

Parkin facilitates the elimination of expanded polyglutamine proteins and leads to preservation of proteasome function.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2006.10.031

An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2006.10.031

A foldable CFTR{Delta}F508 biogenic intermediate accumulates upon inhibition of the Hsc70-CHIP E3 ubiquitin ligase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2006.10.031

Co-chaperone CHIP associates with expanded polyglutamine protein and promotes their degradation by proteasomes.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2006.10.031

U-box protein carboxyl terminus of Hsc70-interacting protein (CHIP) mediates poly-ubiquitylation preferentially on four-repeat Tau and is involved in neurodegeneration of tauopathy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2006.10.031

CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2006.10.031

CHIP-Hsc70 Complex Ubiquitinates Phosphorylated Tau and Enhances Cell Survival

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2006.10.031

Co-chaperone CHIP associates with mutant Cu/Zn-superoxide dismutase proteins linked to familial amyotrophic lateral sclerosis and promotes their degradation by proteasomes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2006.10.031

A molecular investigation of true dominance in Huntington's disease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2006.10.031

Alpha-synuclein overexpression promotes aggregation of mutant huntingtin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2006.10.031

RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2006.10.031

Cdk5 phosphorylation of huntingtin reduces its cleavage by caspases: implications for mutant huntingtin toxicity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2006.10.031

Huntingtin associates with acidic phospholipids at the plasma membrane

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2006.10.031

Glycogen synthase kinase 3beta (GSK3beta) mediates 6-hydroxydopamine-induced neuronal death

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2006.10.031

An amphipathic helix targets serum and glucocorticoid-induced kinase 1 to the endoplasmic reticulum-associated ubiquitin-conjugation machinery

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2006.10.031

Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2006.10.031

Intranuclear inclusions and neuritic aggregates in transgenic mice expressing a mutant N-terminal fragment of huntingtin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2006.10.031

Pivotal role of oligomerization in expanded polyglutamine neurodegenerative disorders.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2006.10.031

Huntingtin forms toxic NH2-terminal fragment complexes that are promoted by the age-dependent decrease in proteasome activity.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2006.10.031

Huntingtin-encoded polyglutamine expansions form amyloid-like protein aggregates in vitro and in vivo

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2006.10.031

Proteases acting on mutant huntingtin generate cleaved products that differentially build up cytoplasmic and nuclear inclusions

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2006.10.031

Proteasomal-dependent aggregate reversal and absence of cell death in a conditional mouse model of Huntington's disease.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2006.10.031

Altered proteasomal function due to the expression of polyglutamine-expanded truncated N-terminal huntingtin induces apoptosis by caspase activation through mitochondrial cytochrome c release

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2006.10.031

Huntingtin aggregation and toxicity in Huntington's disease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2006.10.031

Transcriptional abnormalities in Huntington disease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2006.10.031

Targeting expression of expanded polyglutamine proteins to the endoplasmic reticulum or mitochondria prevents their aggregation.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2006.10.031

RING finger proteins: mediators of ubiquitin ligase activity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2006.10.031

In vivo action of the HRD ubiquitin ligase complex: mechanisms of endoplasmic reticulum quality control and sterol regulation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2006.10.031

A genomic screen identifies Dsk2p and Rad23p as essential components of ER-associated degradation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2006.10.031

Fatty acids regulate pigmentation via proteasomal degradation of tyrosinase: a new aspect of ubiquitin-proteasome function

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2006.10.031

Misfolding diverts CFTR from recycling to degradation: quality control at early endosomes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2006.10.031

The activity of a human endoplasmic reticulum-associated degradation E3, gp78, requires its Cue domain, RING finger, and an E2-binding site

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2006.10.031

Human HRD1 protects against ER stress-induced apoptosis through ER-associated degradation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2006.10.031

Retro-translocation of proteins from the endoplasmic reticulum into the cytosol

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2006.10.031

Huntingtin and the molecular pathogenesis of Huntington's disease. Fourth in molecular medicine review series

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2006.10.031

Global impairment of the ubiquitin-proteasome system by nuclear or cytoplasmic protein aggregates precedes inclusion body formation.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2006.10.031

Aggresomes, inclusion bodies and protein aggregation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2006.10.031

Molecular pathways to neurodegeneration

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2006.10.031

Quality control in the secretory assembly line

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2006.10.031

The fusion oncoprotein PML-RARalpha induces endoplasmic reticulum (ER)-associated degradation of N-CoR and ER stress.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2006.10.031

Hrd1p/Der3p is a membrane-anchored ubiquitin ligase required for ER-associated degradation.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2006.10.031

Interaction of huntingtin fragments with brain membranes--clues to early dysfunction in Huntington's disease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2006.10.031

A novel N-terminal hydrophobic motif mediates constitutive degradation of serum- and glucocorticoid-induced kinase-1 by the ubiquitin-proteasome pathway

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2006.10.031

Huntingtin expression stimulates endosomal-lysosomal activity, endosome tubulation, and autophagy.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2006.10.031

Huntingtin bodies sequester vesicle-associated proteins by a polyproline-dependent interaction.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2006.10.031

siRNA-mediated inhibition of endogenous Huntington disease gene expression induces an aberrant configuration of the ER network in vitro

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2006.10.031