(Q34627241)

3 August 2017

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title

Retro-translocation of proteins from the endoplasmic reticulum into the cytosol (English)

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retrograde protein transport, ER to cytosol

3 August 2017

main subject

endoplasmic reticulum

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Gene Ontology release 2020-05-02

Tom A Rapoport

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author name string

Billy Tsai

series ordinal

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3 August 2017

Yihong Ye

series ordinal

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3 August 2017

publication date

1 April 2002

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Nature Reviews Molecular Cell Biology

3 August 2017

published in

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3 August 2017

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3 August 2017

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3 August 2017

page(s)

246-255

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Protein translocation: tunnel vision

3 August 2017

cites work

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Tripartite management of unfolded proteins in the endoplasmic reticulum

31 March 2020

1 reference

Functional and genomic analyses reveal an essential coordination between the unfolded protein response and ER-associated degradation

31 March 2020

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Degradation of proteins from the ER of S. cerevisiae requires an intact unfolded protein response pathway

31 March 2020

1 reference

A regulatory link between ER-associated protein degradation and the unfolded-protein response

31 March 2020

1 reference

A pathway for targeting soluble misfolded proteins to the yeast vacuole

31 March 2020

1 reference

Protein degradation in the endoplasmic reticulum

31 March 2020

1 reference

ER quality control: the cytoplasmic connection

31 March 2020

1 reference

Assembly of ER-associated protein degradation in vitro: dependence on cytosol, calnexin, and ATP.

31 March 2020

1 reference

ER protein quality control and proteasome-mediated protein degradation

31 March 2020

1 reference

An Address on a Characteristic Organism of Cancer

31 March 2020

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Aggresomes and Russell bodies. Symptoms of cellular indigestion?

31 March 2020

1 reference

Regulation of protein secretion through controlled aggregation in the endoplasmic reticulum

31 March 2020

1 reference

Role of ATP and disulphide bonds during protein folding in the endoplasmic reticulum

31 March 2020

1 reference

Distinct retrieval and retention mechanisms are required for the quality control of endoplasmic reticulum protein folding

31 March 2020

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Degradation of endoplasmic reticulum (ER) quality control substrates requires transport between the ER and Golgi

31 March 2020

1 reference

A novel quality control compartment derived from the endoplasmic reticulum

31 March 2020

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The human cytomegalovirus US11 gene product dislocates MHC class I heavy chains from the endoplasmic reticulum to the cytosol

31 March 2020

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Sec61-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction

31 March 2020

1 reference

MHC class I ubiquitination by a viral PHD/LAP finger protein.

31 March 2020

1 reference

Entry of ricin and Shiga toxin into cells: molecular mechanisms and medical perspectives

31 March 2020

1 reference

Toxin entry: retrograde transport through the secretory pathway

31 March 2020

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Membrane traffic and the cellular uptake of cholera toxin

31 March 2020

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Cholera toxin is exported from microsomes by the Sec61p complex

31 March 2020

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ER quality control: towards an understanding at the molecular level

31 March 2020

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N-Glycosylation affects endoplasmic reticulum degradation of a mutated derivative of carboxypeptidase yscY in yeast

31 March 2020

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Degradation of misfolded endoplasmic reticulum glycoproteins in Saccharomyces cerevisiae is determined by a specific oligosaccharide structure

31 March 2020

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Oligosaccharide modification in the early secretory pathway directs the selection of a misfolded glycoprotein for degradation by the proteasome

31 March 2020

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A novel ER alpha-mannosidase-like protein accelerates ER-associated degradation

31 March 2020

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Mnl1p, an alpha -mannosidase-like protein in yeast Saccharomyces cerevisiae, is required for endoplasmic reticulum-associated degradation of glycoproteins

31 March 2020

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Htm1p, a mannosidase-like protein, is involved in glycoprotein degradation in yeast

31 March 2020

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Endoplasmic reticulum (ER)-associated degradation of misfolded N-linked glycoproteins is suppressed upon inhibition of ER mannosidase I.

31 March 2020

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Pivotal role of calnexin and mannose trimming in regulating the endoplasmic reticulum-associated degradation of major histocompatibility complex class I heavy chain.

31 March 2020

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Export of a cysteine-free misfolded secretory protein from the endoplasmic reticulum for degradation requires interaction with protein disulfide isomerase

31 March 2020

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Reduction of interchain disulfide bonds precedes the dislocation of Ig-mu chains from the endoplasmic reticulum to the cytosol for proteasomal degradation

31 March 2020

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Dislocation of type I membrane proteins from the ER to the cytosol is sensitive to changes in redox potential

31 March 2020

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Eps1, a novel PDI-related protein involved in ER quality control in yeast

31 March 2020

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Protein Disulfide Isomerase Acts as a Redox-Dependent Chaperone to Unfold Cholera Toxin

31 March 2020

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Molecular chaperones involved in protein degradation in the endoplasmic reticulum: quantitative interaction of the heat shock cognate protein BiP with partially folded immunoglobulin light chains that are degraded in the endoplasmic reticulum

31 March 2020

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Mutant analysis links the translocon and BiP to retrograde protein transport for ER degradation

31 March 2020

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The requirement for molecular chaperones during endoplasmic reticulum-associated protein degradation demonstrates that protein export and import are mechanistically distinct

31 March 2020

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BiP acts as a molecular ratchet during posttranslational transport of prepro-alpha factor across the ER membrane

31 March 2020

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Dissociation from BiP and retrotranslocation of unassembled immunoglobulin light chains are tightly coupled to proteasome activity

31 March 2020

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J proteins catalytically activate Hsp70 molecules to trap a wide range of peptide sequences

31 March 2020

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The protein translocation channel mediates glycopeptide export across the endoplasmic reticulum membrane

31 March 2020

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Sec61p mediates export of a misfolded secretory protein from the endoplasmic reticulum to the cytosol for degradation

31 March 2020

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Molecular chaperones in the yeast endoplasmic reticulum maintain the solubility of proteins for retrotranslocation and degradation

31 March 2020

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Calnexin and other factors that alter translocation affect the rapid binding of ubiquitin to apoB in the Sec61 complex

31 March 2020

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Antigen presentation subverted: Structure of the human cytomegalovirus protein US2 bound to the class I molecule HLA-A2

31 March 2020

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The mechanism underlying cystic fibrosis transmembrane conductance regulator transport from the endoplasmic reticulum to the proteasome includes Sec61beta and a cytosolic, deglycosylated intermediary

31 March 2020

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Ubiquitination is required for the retro-translocation of a short-lived luminal endoplasmic reticulum glycoprotein to the cytosol for degradation by the proteasome

31 March 2020

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Newly synthesized human delta opioid receptors retained in the endoplasmic reticulum are retrotranslocated to the cytosol, deglycosylated, ubiquitinated, and degraded by the proteasome.

31 March 2020

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Dependence of ricin toxicity on translocation of the toxin A-chain from the endoplasmic reticulum to the cytosol

31 March 2020

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Ricin A chain utilises the endoplasmic reticulum-associated protein degradation pathway to enter the cytosol of yeast

31 March 2020

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The engagement of Sec61p in the ER dislocation process

31 March 2020

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Sec61p-independent degradation of the tail-anchored ER membrane protein Ubc6p

31 March 2020

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Dislocation of membrane proteins in FtsH-mediated proteolysis

31 March 2020

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Membrane protein degradation by AAA proteases in mitochondria: extraction of substrates from either membrane surface

31 March 2020

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The aqueous pore through the translocon has a diameter of 40-60 A during cotranslational protein translocation at the ER membrane

31 March 2020

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The Structure of Ribosome-Channel Complexes Engaged in Protein Translocation

31 March 2020

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Architecture of the protein-conducting channel associated with the translating 80S ribosome

31 March 2020

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Apoprotein B100 has a prolonged interaction with the translocon during which its lipidation and translocation change from dependence on the microsomal triglyceride transfer protein to independence.

31 March 2020

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Re-entering the translocon from the lumenal side of the endoplasmic reticulum. Studies on mutated carboxypeptidase yscY species

31 March 2020

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The Sec61p complex mediates the integration of a membrane protein by allowing lipid partitioning of the transmembrane domain

31 March 2020

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ER degradation of a misfolded luminal protein by the cytosolic ubiquitin-proteasome pathway

31 March 2020

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Degradation of subunits of the Sec61p complex, an integral component of the ER membrane, by the ubiquitin-proteasome pathway.

31 March 2020

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Degradation of CFTR by the ubiquitin-proteasome pathway

31 March 2020

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The role of multiubiquitination in dislocation and degradation of the alpha subunit of the T cell antigen receptor

31 March 2020

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Polyubiquitination is required for US11-dependent movement of MHC class I heavy chain from endoplasmic reticulum into cytosol

31 March 2020

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The pathway of US11-dependent degradation of MHC class I heavy chains involves a ubiquitin-conjugated intermediate

31 March 2020

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The AAA ATPase Cdc48/p97 and its partners transport proteins from the ER into the cytosol

31 March 2020

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Role of Cue1p in ubiquitination and degradation at the ER surface

31 March 2020

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A protein translocation defect linked to ubiquitin conjugation at the endoplasmic reticulum

31 March 2020

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Ubiquitin-mediated regulation of 3-hydroxy-3-methylglutaryl-CoA reductase

31 March 2020

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Endoplasmic reticulum degradation of a mutated ATP-binding cassette transporter Pdr5 proceeds in a concerted action of Sec61 and the proteasome.

31 March 2020

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Degradation of unassembled Vph1p reveals novel aspects of the yeast ER quality control system

31 March 2020

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Role of 26S proteasome and HRD genes in the degradation of 3-hydroxy-3-methylglutaryl-CoA reductase, an integral endoplasmic reticulum membrane protein

31 March 2020

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Der3p/Hrd1p is required for endoplasmic reticulum-associated degradation of misfolded lumenal and integral membrane proteins

31 March 2020

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Hrd1p/Der3p is a membrane-anchored ubiquitin ligase required for ER-associated degradation.

31 March 2020

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Membrane topology and function of Der3/Hrd1p as a ubiquitin-protein ligase (E3) involved in endoplasmic reticulum degradation

31 March 2020

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Endoplasmic reticulum degradation requires lumen to cytosol signaling. Transmembrane control of Hrd1p by Hrd3p.

31 March 2020

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The tumor autocrine motility factor receptor, gp78, is a ubiquitin protein ligase implicated in degradation from the endoplasmic reticulum

31 March 2020

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A conserved ubiquitin ligase of the nuclear envelope/endoplasmic reticulum that functions in both ER-associated and Matalpha2 repressor degradation

31 March 2020

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A novel site for ubiquitination: the N-terminal residue, and not internal lysines of MyoD, is essential for conjugation and degradation of the protein.

31 March 2020

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Protein dislocation from the ER requires polyubiquitination and the AAA-ATPase Cdc48.

31 March 2020

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The Ins and Outs of Protein Translocation

31 March 2020

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Role of the proteasome in membrane extraction of a short-lived ER-transmembrane protein

31 March 2020

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The alpha chain of the T cell antigen receptor is degraded in the cytosol

31 March 2020

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Novel aspects of degradation of T cell receptor subunits from the endoplasmic reticulum (ER) in T cells: importance of oligosaccharide processing, ubiquitination, and proteasome-dependent removal from ER membranes

31 March 2020

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Intracellular targeting of the proteasome

31 March 2020

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HRD4/NPL4 is required for the proteasomal processing of ubiquitinated ER proteins

31 March 2020

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AAA-ATPase p97/Cdc48p, a cytosolic chaperone required for endoplasmic reticulum-associated protein degradation

31 March 2020

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Role of the ubiquitin-selective CDC48(UFD1/NPL4 )chaperone (segregase) in ERAD of OLE1 and other substrates

31 March 2020

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Structure of the AAA ATPase p97

31 March 2020

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The AAA team: related ATPases with diverse functions

31 March 2020

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p47 is a cofactor for p97-mediated membrane fusion

31 March 2020

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The conserved npl4 protein complex mediates proteasome-dependent membrane-bound transcription factor activation

31 March 2020

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Mobilization of processed, membrane-tethered SPT23 transcription factor by CDC48(UFD1/NPL4), a ubiquitin-selective chaperone

31 March 2020

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A complex of mammalian ufd1 and npl4 links the AAA-ATPase, p97, to ubiquitin and nuclear transport pathways

31 March 2020

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Crystal structure of T7 gene 4 ring helicase indicates a mechanism for sequential hydrolysis of nucleotides

31 March 2020

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Structure and mechanism of ATP-dependent proteases

31 March 2020

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AAA proteases: cellular machines for degrading membrane proteins

31 March 2020

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Valosin-containing protein is a multi-ubiquitin chain-targeting factor required in ubiquitin-proteasome degradation

31 March 2020

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Ero1p: a novel and ubiquitous protein with an essential role in oxidative protein folding in the endoplasmic reticulum

31 March 2020

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The ERO1 gene of yeast is required for oxidation of protein dithiols in the endoplasmic reticulum

31 March 2020

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Targeting of the yeast plasma membrane [H+]ATPase: a novel gene AST1 prevents mislocalization of mutant ATPase to the vacuole

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

CD4 glycoprotein degradation induced by human immunodeficiency virus type 1 Vpu protein requires the function of proteasomes and the ubiquitin-conjugating pathway

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRM780

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Dimensions Publication ID

3 August 2017

1033450592

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