(Q28269333)

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Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases

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Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases (English)

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neurodegeneration

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oxidative stress

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M Flint Beal

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Michael T Lin

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19 October 2006

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443

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Cell death: critical control points

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7 January 2021

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Mitochondrial DNA deletions in human brain: regional variability and increase with advanced age

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7 January 2021

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Strikingly higher frequency in centenarians and twins of mtDNA mutation causing remodeling of replication origin in leukocytes

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7 January 2021

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Point mutations of the mtDNA control region in normal and neurodegenerative human brains

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Low mutational burden of individual acquired mitochondrial DNA mutations in brain

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High aggregate burden of somatic mtDNA point mutations in aging and Alzheimer's disease brain

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Human brain contains high levels of heteroplasmy in the noncoding regions of mitochondrial DNA.

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High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease

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Mitochondrial DNA deletions are abundant and cause functional impairment in aged human substantia nigra neurons

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Mitochondrial DNA and ageing

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Mitochondrial metabolism of reactive oxygen species.

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7 January 2021

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High-quality life extension by the enzyme peptide methionine sulfoxide reductase

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7 January 2021

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Extension of murine life span by overexpression of catalase targeted to mitochondria

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7 January 2021

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Gene regulation and DNA damage in the ageing human brain

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7 January 2021

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Oxidative damage is the earliest event in Alzheimer disease

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7 January 2021

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Increased lipid peroxidation precedes amyloid plaque formation in an animal model of Alzheimer amyloidosis.

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7 January 2021

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Gene expression profiles of transcripts in amyloid precursor protein transgenic mice: up-regulation of mitochondrial metabolism and apoptotic genes is an early cellular change in Alzheimer's disease.

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7 January 2021

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Selective increase in cellular A beta 42 is related to apoptosis but not necrosis.

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7 January 2021

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Altered metabolism of the amyloid beta precursor protein is associated with mitochondrial dysfunction in Down's syndrome

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7 January 2021

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Increased plaque burden in brains of APP mutant MnSOD heterozygous knockout mice.

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7 January 2021

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Energy inhibition elevates beta-secretase levels and activity and is potentially amyloidogenic in APP transgenic mice: possible early events in Alzheimer's disease pathogenesis.

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7 January 2021

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Beta-site APP cleaving enzyme up-regulation induced by 4-hydroxynonenal is mediated by stress-activated protein kinases pathways.

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7 January 2021

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Induction of hyperphosphorylated tau in primary rat cortical neuron cultures mediated by oxidative stress and glycogen synthase kinase-3.

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7 January 2021

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Oxidative modification and down-regulation of Pin1 in Alzheimer's disease hippocampus: A redox proteomics analysis

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7 January 2021

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The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-beta production

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7 January 2021

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Role of the prolyl isomerase Pin1 in protecting against age-dependent neurodegeneration.

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7 January 2021

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Cybrids in Alzheimer's disease: a cellular model of the disease?

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7 January 2021

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Does the mitochondrial genome play a role in the etiology of Alzheimer's disease?

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7 January 2021

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Alzheimer's brains harbor somatic mtDNA control-region mutations that suppress mitochondrial transcription and replication

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7 January 2021

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Mitochondrial targeting and a novel transmembrane arrest of Alzheimer's amyloid precursor protein impairs mitochondrial function in neuronal cells

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7 January 2021

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ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease

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7 January 2021

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Copper-dependent inhibition of human cytochrome c oxidase by a dimeric conformer of amyloid-beta1-42.

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https://api.crossref.org/works/10.1038%2FNATURE05292

7 January 2021

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Mitochondria are a direct site of A beta accumulation in Alzheimer's disease neurons: implications for free radical generation and oxidative damage in disease progression

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7 January 2021

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Beta-amyloid inhibits integrated mitochondrial respiration and key enzyme activities

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7 January 2021

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Reduced Activities of Thiamine-Dependent Enzymes in the Brains and Peripheral Tissues of Patients With Alzheimer's Disease

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7 January 2021

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Cytochrome oxidase deficiency in Alzheimer's disease

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7 January 2021

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Alzheimer's disease-associated amyloid beta interacts with the human serine protease HtrA2/Omi

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7 January 2021

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Nicastrin, presenilin, APH-1, and PEN-2 form active gamma-secretase complexes in mitochondria

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7 January 2021

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Chronic systemic pesticide exposure reproduces features of Parkinson's disease

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7 January 2021

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Parkinson-like syndrome induced by continuous MPTP infusion: convergent roles of the ubiquitin-proteasome system and alpha-synuclein

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7 January 2021

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Mechanism of toxicity in rotenone models of Parkinson's disease

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7 January 2021

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Mitochondrial complex I deficiency in Parkinson's disease

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7 January 2021

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Familial multisystem degeneration with parkinsonism associated with the 11778 mitochondrial DNA mutation

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7 January 2021

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Parkinsonism, premature menopause, and mitochondrial DNA polymerase gamma mutations: clinical and molecular genetic study.

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7 January 2021

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Sequence analysis of the entire mitochondrial genome in Parkinson's disease

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7 January 2021

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Somatic mitochondrial DNA mutations in cortex and substantia nigra in aging and Parkinson's disease

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7 January 2021

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Mitochondrial DNA haplogroup cluster UKJT reduces the risk of PD.

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7 January 2021

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A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine

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7 January 2021

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Enhanced substantia nigra mitochondrial pathology in human alpha-synuclein transgenic mice after treatment with MPTP.

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https://api.crossref.org/works/10.1038%2FNATURE05292

7 January 2021

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Parkinson's disease alpha-synuclein transgenic mice develop neuronal mitochondrial degeneration and cell death.

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7 January 2021

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Mice lacking alpha-synuclein are resistant to mitochondrial toxins

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7 January 2021

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Drosophila parkin mutants have decreased mass and cell size and increased sensitivity to oxygen radical stress

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7 January 2021

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Mitochondrial dysfunction and oxidative damage in parkin-deficient mice

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7 January 2021

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Mitochondrial complex I and IV activities in leukocytes from patients with parkin mutations.

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7 January 2021

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Parkin prevents mitochondrial swelling and cytochrome c release in mitochondria-dependent cell death.

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7 January 2021

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Parkin enhances mitochondrial biogenesis in proliferating cells

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7 January 2021

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S-nitrosylation of parkin regulates ubiquitination and compromises parkin's protective function

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7 January 2021

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Increased glutathione S-transferase activity rescues dopaminergic neuron loss in a Drosophila model of Parkinson's disease

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7 January 2021

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Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism

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7 January 2021

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DJ-1 is present in a large molecular complex in human brain tissue and interacts with alpha-synuclein

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7 January 2021

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Association of DJ-1 and parkin mediated by pathogenic DJ-1 mutations and oxidative stress

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7 January 2021

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Association of PINK1 and DJ-1 confers digenic inheritance of early-onset Parkinson's disease

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7 January 2021

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The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization

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7 January 2021

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Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and phosphatidylinositol 3-kinase/Akt signaling

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7 January 2021

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DJ-1, a novel regulator of the tumor suppressor PTEN.

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Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress.

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7 January 2021

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Mutational analysis of DJ-1 in Drosophila implicates functional inactivation by oxidative damage and aging

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7 January 2021

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Hereditary early-onset Parkinson's disease caused by mutations in PINK1

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Mitochondrial import and enzymatic activity of PINK1 mutants associated to recessive parkinsonism

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7 January 2021

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Wild-type PINK1 prevents basal and induced neuronal apoptosis, a protective effect abrogated by Parkinson disease-related mutations

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7 January 2021

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Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin

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7 January 2021

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Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity

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7 January 2021

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Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease

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7 January 2021

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Neuroprotective role of the Reaper-related serine protease HtrA2/Omi revealed by targeted deletion in mice

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7 January 2021

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Mutated human SOD1 causes dysfunction of oxidative phosphorylation in mitochondria of transgenic mice.

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Neural mitochondrial Ca2+ capacity impairment precedes the onset of motor symptoms in G93A Cu/Zn-superoxide dismutase mutant mice

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7 January 2021

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Massive mitochondrial degeneration in motor neurons triggers the onset of amyotrophic lateral sclerosis in mice expressing a mutant SOD1

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CuZn superoxide dismutase (SOD1) accumulates in vacuolated mitochondria in transgenic mice expressing amyotrophic lateral sclerosis-linked SOD1 mutations

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ALS-associated mutant SOD1G93A causes mitochondrial vacuolation by expansion of the intermembrane space and by involvement of SOD1 aggregation and peroxisomes

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7 January 2021

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Mutant superoxide dismutase 1 forms aggregates in the brain mitochondrial matrix of amyotrophic lateral sclerosis mice.

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7 January 2021

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Toxicity of familial ALS-linked SOD1 mutants from selective recruitment to spinal mitochondria.

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7 January 2021

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Mitochondrial localization of mutant superoxide dismutase 1 triggers caspase-dependent cell death in a cellular model of familial amyotrophic lateral sclerosis

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https://api.crossref.org/works/10.1038%2FNATURE05292

7 January 2021

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Amyotrophic lateral sclerosis: a proposed mechanism

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7 January 2021

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Amyotrophic lateral sclerosis-associated SOD1 mutant proteins bind and aggregate with Bcl-2 in spinal cord mitochondria

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https://api.crossref.org/works/10.1038%2FNATURE05292

7 January 2021

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Evidence for impairment of energy metabolism in vivo in Huntington's disease using localized 1H NMR spectroscopy

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https://api.crossref.org/works/10.1038%2FNATURE05292

7 January 2021

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Mitochondrial defect in Huntington's disease caudate nucleus

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7 January 2021

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Mitochondrial respiration and ATP production are significantly impaired in striatal cells expressing mutant huntingtin

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7 January 2021

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Chronic mitochondrial energy impairment produces selective striatal degeneration and abnormal choreiform movements in primates

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7 January 2021

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Involvement of mitochondrial complex II defects in neuronal death produced by N-terminus fragment of mutated huntingtin

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7 January 2021

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Early mitochondrial calcium defects in Huntington's disease are a direct effect of polyglutamines.

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Mutant huntingtin directly increases susceptibility of mitochondria to the calcium-induced permeability transition and cytochrome c release

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Transcriptional abnormalities in Huntington disease

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PUMA induces the rapid apoptosis of colorectal cancer cells

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Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis

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7 January 2021

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p53 mediates cellular dysfunction and behavioral abnormalities in Huntington's disease

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7 January 2021

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Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice

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7 January 2021

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Progressive loss of striatal neurons causes motor dysfunction in MND2 mutant mice and is not prevented by Bcl-2.

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7 January 2021

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