(Q33974271)

30 July 2017

title

Mechanism of toxicity in rotenone models of Parkinson's disease (English)

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30 July 2017

Mechanism of Toxicity in Rotenone Models of Parkinson's Disease (English)

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J. Timothy Greenamyre

object named as

J Timothy Greenamyre

J. Timothy Greenamyre

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30 July 2017

Jason R Richardson

Jason R. Richardson

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30 July 2017

Todd B Sherer

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30 July 2017

Ranjita Betarbet

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30 July 2017

Claudia M Testa

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30 July 2017

Byoung Boo Seo

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30 July 2017

Jin Ho Kim

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30 July 2017

Gary W Miller

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30 July 2017

Takao Yagi

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30 July 2017

Akemi Matsuno-Yagi

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30 July 2017

Todd B. Sherer

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Claudia M. Testa

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Gary W. Miller

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language of work or name

English

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publication date

1 November 2003

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30 July 2017

26 November 2003

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published in

Journal of Neuroscience

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30 July 2017

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30 July 2017

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30 July 2017

page(s)

10756-10764

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Mitochondrial involvement in Parkinson's disease, Huntington's disease, hereditary spastic paraplegia and Friedreich's ataxia

30 July 2017

cites work

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12 December 2020

Novel free radical spin traps protect against malonate and MPTP neurotoxicity.

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12 December 2020

Titrating the effects of mitochondrial complex I impairment in the cell physiology

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Enhanced vulnerability to oxidative stress by alpha-synuclein mutations and C-terminal truncation

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6-Hydroxydopamine toxicity towards human SH-SY5Y dopaminergic neuroblastoma cells: independent of mitochondrial energy metabolism

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12 December 2020

Glutathione depletion in PC12 results in selective inhibition of mitochondrial complex I activity. Implications for Parkinson's disease.

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12 December 2020

alpha-synuclein promotes mitochondrial deficit and oxidative stress

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12 December 2020

Use of the NADH-quinone oxidoreductase (NDI1) gene of Saccharomyces cerevisiae as a possible cure for complex I defects in human cells

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12 December 2020

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12 December 2020

Sensitization of neuronal cells to oxidative stress with mutated human alpha-synuclein

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12 December 2020

Chronic systemic pesticide exposure reproduces features of Parkinson's disease

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12 December 2020

Neuroprotective effect of vitamin E on the early model of Parkinson's disease in rat: behavioral and histochemical evidence.

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12 December 2020

Lack of complex I activity in human cells carrying a mutation in MtDNA-encoded ND4 subunit is corrected by the Saccharomyces cerevisiae NADH-quinone oxidoreductase (NDI1) gene

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12 December 2020

Formation and removal of alpha-synuclein aggregates in cells exposed to mitochondrial inhibitors

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12 December 2020

Environment, mitochondria, and Parkinson's disease

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12 December 2020

Environmental risk factors and Parkinson's disease: selective degeneration of nigral dopaminergic neurons caused by the herbicide paraquat

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12 December 2020

An in vitro model of Parkinson's disease: linking mitochondrial impairment to altered alpha-synuclein metabolism and oxidative damage.

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12 December 2020

Complex I-mediated reactive oxygen species generation: modulation by cytochrome c and NAD(P)+ oxidation-reduction state.

1 reference

12 December 2020

A single-subunit NADH-quinone oxidoreductase renders resistance to mammalian nerve cells against complex I inhibition

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12 December 2020

Effects of coenzyme Q10 in early Parkinson disease: evidence of slowing of the functional decline

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12 December 2020

Rotenone destroys dopaminergic neurons and induces parkinsonian symptoms in rats

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12 December 2020

Subcutaneous rotenone exposure causes highly selective dopaminergic degeneration and alpha-synuclein aggregation.

1 reference

12 December 2020

The role of oxidative stress in paraquat-induced neurotoxicity in rats: protection by non peptidyl superoxide dismutase mimetic

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12 December 2020

Oxidative dimer formation is the critical rate-limiting step for Parkinson's disease alpha-synuclein fibrillogenesis

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12 December 2020

Vitamin E prevents oxidation of antiapoptotic proteins in neuronal cells

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12 December 2020

Chronic systemic complex I inhibition induces a hypokinetic multisystem degeneration in rats

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12 December 2020

Nicotine protects rat brain mitochondria against experimental injuries.

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12 December 2020

A simple method for organotypic cultures of nervous tissue

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12 December 2020

Deficiencies in complex I subunits of the respiratory chain in Parkinson's disease

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12 December 2020

Abnormalities of the electron transport chain in idiopathic Parkinson's disease

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12 December 2020

Mitochondrial complex I deficiency in Parkinson's disease

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12 December 2020

Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenyl-pyridine, a metabolite of the neurotoxin, 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine

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12 December 2020

Basal lipid peroxidation in substantia nigra is increased in Parkinson's disease

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12 December 2020

Exposure of striatal [corrected] synaptosomes to L-dopa increases levels of oxidized glutathione.

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12 December 2020

Coupling of dopamine oxidation (monoamine oxidase activity) to glutathione oxidation via the generation of hydrogen peroxide in rat brain homogenates

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12 December 2020

Low platelet mitochondrial complex I and complex II/III activity in early untreated Parkinson's disease

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12 December 2020

Mitochondrial respiratory chain activity in skeletal muscle from patients with Parkinson's disease

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12 December 2020

Effects of tocopherol and deprenyl on the progression of disability in early Parkinson's disease

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12 December 2020

Immunohistochemical detection of 4-hydroxynonenal protein adducts in Parkinson disease

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12 December 2020

Reactive dopamine metabolites and neurotoxicity: implications for Parkinson's disease

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12 December 2020

Alpha-synuclein in Lewy bodies

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12 December 2020

A generalised increase in protein carbonyls in the brain in Parkinson's but not incidental Lewy body disease.

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12 December 2020

Increased protein oxidation in human substantia nigra pars compacta in comparison with basal ganglia and prefrontal cortex measured with an improved dinitrophenylhydrazine assay.

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12 December 2020

Elevated reactive oxygen species and antioxidant enzyme activities in animal and cellular models of Parkinson's disease

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12 December 2020

Alterations in the distribution of glutathione in the substantia nigra in Parkinson's disease

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12 December 2020

The risk of Parkinson's disease with exposure to pesticides, farming, well water, and rural living

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12 December 2020

Oxidative mechanisms in nigral cell death in Parkinson's disease.

1 reference

12 December 2020

Parkinson's disease, pesticides, and glutathione transferase polymorphisms

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12 December 2020

Interaction of alpha-phenyl-N-tert-butyl nitrone and alternative electron acceptors with complex I indicates a substrate reduction site upstream from the rotenone binding site.

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12 December 2020

10.1523/JNEUROSCI.23-34-10756.2003

Identifiers

DOI

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PMC publication ID

6740985

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1 reference