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The hallmarks of aging

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The hallmarks of aging (English)

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Carlos López Otín

1

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Linda Partridge

3

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5

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Guido Kroemer

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Manuel Serrano

4

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Maria A Blasco

2

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language of work or name

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publication date

6 June 2013

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153

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6

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1194-217

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Deletion of the mitochondrial superoxide dismutase sod-2 extends lifespan in Caenorhabditis elegans

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Delayed and accelerated aging share common longevity assurance mechanisms

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DNA Damage, Aging, and Cancer

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The Hallmarks of Cancer

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Hallmarks of Cancer: The Next Generation

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Detectable clonal mosaicism and its relationship to aging and cancer

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Premature ageing in mice expressing defective mitochondrial DNA polymerase

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SIRT2 regulates NF-κB dependent gene expression through deacetylation of p65 Lys310

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Prelamin A acts to accelerate smooth muscle cell senescence and is a novel biomarker of human vascular aging

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SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span

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A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy

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TINF2 mutations result in very short telomeres: analysis of a large cohort of patients with dyskeratosis congenita and related bone marrow failure syndromes

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Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

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A biomarker that identifies senescent human cells in culture and in aging skin in vivo

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SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging

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Age-related gene-specific changes of A-to-I mRNA editing in the human brain

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The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms

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Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study

2 references

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Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity

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Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice

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The ageing systemic milieu negatively regulates neurogenesis and cognitive function.

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The aged microenvironment contributes to the age-related functional defects of CD4 T cells in mice

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Next-generation sequencing in aging research: emerging applications, problems, pitfalls and possible solutions

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Evaluation of resveratrol, green tea extract, curcumin, oxaloacetic acid, and medium-chain triglyceride oil on life span of genetically heterogeneous mice

2 references

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Genome sequencing reveals insights into physiology and longevity of the naked mole rat

2 references

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mTOR is a key modulator of ageing and age-related disease

2 references

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Role of AMPK-mTOR-Ulk1/2 in the regulation of autophagy: cross talk, shortcuts, and feedbacks

2 references

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Genome-environment interactions that modulate aging: powerful targets for drug discovery

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Telomerase gene therapy in adult and old mice delays aging and increases longevity without increasing cancer

2 references

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SRT1720 improves survival and healthspan of obese mice

2 references

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Short-term calorie restriction enhances skeletal muscle stem cell function

2 references

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The telomere syndromes

2 references

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mTOR signaling in growth control and disease

2 references

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Progerin and telomere dysfunction collaborate to trigger cellular senescence in normal human fibroblasts

2 references

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Polycomb Repressive Complex 2 and Trithorax modulate Drosophila longevity and stress resistance

2 references

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Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

2 references

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Lamin A-dependent misregulation of adult stem cells associated with accelerated ageing

2 references

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Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span

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Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function

2 references

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TINF2, a component of the shelterin telomere protection complex, is mutated in dyskeratosis congenita

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

20 March 2017

Caloric restriction delays disease onset and mortality in rhesus monkeys

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

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Motif module map reveals enforcement of aging by continual NF-kappaB activity

2 references

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Lamin A-dependent nuclear defects in human aging

2 references

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Sirtuin 1 and sirtuin 3: physiological modulators of metabolism

2 references

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Sirtuins as regulators of metabolism and healthspan

2 references

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Axis of ageing: telomeres, p53 and mitochondria

2 references

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2 references

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Histone methylation makes its mark on longevity

2 references

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Heterochromatin formation promotes longevity and represses ribosomal RNA synthesis

2 references

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Resveratrol improves health and survival of mice on a high-calorie diet

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A C. elegans mutant that lives twice as long as wild type

2 references

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Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans

2 references

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Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging

2 references

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Recurrent de novo point mutations in lamin A cause Hutchinson–Gilford progeria syndrome

2 references

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2 references

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Detectable clonal mosaicism from birth to old age and its relationship to cancer

2 references

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20 March 2017

The sirtuin SIRT6 regulates lifespan in male mice

2 references

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Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

2 references

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2 references

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20 March 2017

The role of telomeres and telomerase in stem cell aging

2 references

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20 March 2017

Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

20 March 2017

Genomic instability in laminopathy-based premature aging

2 references

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2 references

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A method for the isolation of longevity mutants in the nematode Caenorhabditis elegans and initial results

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2 references

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Metformin induces a dietary restriction-like state and the oxidative stress response to extend C. elegans Healthspan via AMPK, LKB1, and SKN-1

2 references

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20 March 2017

Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age

2 references

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Genomic instability and aging-like phenotype in the absence of mammalian SIRT6

2 references

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mRNA decay factor AUF1 maintains normal aging, telomere maintenance, and suppression of senescence by activation of telomerase transcription

2 references

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20 March 2017

Hsp72 preserves muscle function and slows progression of severe muscular dystrophy

2 references

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20 March 2017

Longevity in mice is promoted by probiotic-induced suppression of colonic senescence dependent on upregulation of gut bacterial polyamine production

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

20 March 2017

The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

20 March 2017

Ageing-related chromatin defects through loss of the NURD complex

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

20 March 2017

Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

20 March 2017

Ink4a/Arf expression is a biomarker of aging

2 references

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20 March 2017

Meta-analysis of age-related gene expression profiles identifies common signatures of aging.

1 reference

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7 April 2017

Molecular chaperones in protein folding and proteostasis

1 reference

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7 April 2017

The genetics of ageing

1 reference

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7 April 2017

Mitochondrial membrane permeabilization in cell death

1 reference

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7 April 2017

A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine

1 reference

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7 April 2017

The serial cultivation of human diploid cell strains

1 reference

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7 April 2017

Autophagy and aging

1 reference

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7 April 2017

Enhancement of proteasome activity by a small-molecule inhibitor of USP14

1 reference

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7 April 2017

Induction of autophagy by spermidine promotes longevity

1 reference

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7 April 2017

Ribosomal protein S6 kinase 1 signaling regulates mammalian life span

1 reference

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7 April 2017

Biological and chemical approaches to diseases of proteostasis deficiency

1 reference

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7 April 2017

How shelterin protects mammalian telomeres

1 reference

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7 April 2017

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1 reference

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7 April 2017

Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

7 April 2017

Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

7 April 2017

Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

7 April 2017

Rejuvenation of aged progenitor cells by exposure to a young systemic environment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

7 April 2017

Physiological roles of mitochondrial reactive oxygen species

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

7 April 2017

Gut microbiota composition correlates with diet and health in the elderly

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

7 April 2017

The cell-non-autonomous nature of electron transport chain-mediated longevity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

7 April 2017

Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

7 April 2017

Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

7 April 2017

Understanding the odd science of aging

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

7 April 2017

Regulation of Aging and Age-Related Disease by DAF-16 and Heat-Shock Factor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

7 April 2017

Hypothalamic programming of systemic ageing involving IKK-β, NF-κB and GnRH

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

Long-term p110α PI3K inactivation exerts a beneficial effect on metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

ω-6 Polyunsaturated fatty acids extend life span through the activation of autophagy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

Genetics of longevity in model organisms: debates and paradigm shifts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

Negative regulation of inflammation by SIRT1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

The aged niche disrupts muscle stem cell quiescence.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

An immunosurveillance mechanism controls cancer cell ploidy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

Nuclear lamina defects cause ATM-dependent NF-κB activation and link accelerated aging to a systemic inflammatory response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

Minimizing the damage: repair pathways keep mitochondrial DNA intact

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

Chromosome-specific accumulation of aneuploidy in the aging mouse brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

Reprogramming aging and progeria.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

Review: a meta-analysis of GWAS and age-associated diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

The let-7-Imp axis regulates ageing of the Drosophila testis stem-cell niche

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

Global heterochromatin loss: a unifying theory of aging?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

Epigenetic variation during the adult lifespan: cross-sectional and longitudinal data on monozygotic twin pairs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

The critical role of metabolic pathways in aging

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

Heterochronic parabiosis for the study of the effects of aging on stem cells and their niches

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

Rapamycin slows aging in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

Cdc42 activity regulates hematopoietic stem cell aging and rejuvenation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

SIRT3, a pivotal actor in mitochondrial functions: metabolism, cell death and aging.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

Lamin B1 loss is a senescence-associated biomarker.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

The C. elegans microRNA mir-71 acts in neurons to promote germline-mediated longevity through regulation of DAF-16/FOXO

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

Immune surveillance of senescent cells--biological significance in cancer- and non-cancer pathologies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

Genes against aging

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

Inflammaging: disturbed interplay between autophagy and inflammasomes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

Pten positively regulates brown adipose function, energy expenditure, and longevity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

The role of DNA damage and repair in aging through the prism of Koch-like criteria.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

The microRNA miR-34 modulates ageing and neurodegeneration in Drosophila

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

A senescent cell bystander effect: senescence-induced senescence

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

Age-related somatic structural changes in the nuclear genome of human blood cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

Whole genome sequences of a male and female supercentenarian, ages greater than 114 years

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

MicroRNAs and their roles in aging.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

HSF-1 regulators DDL-1/2 link insulin-like signaling to heat-shock responses and modulation of longevity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

Aging, rejuvenation, and epigenetic reprogramming: resetting the aging clock

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

The DNA damage response and cancer therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

Muscle-derived stem/progenitor cell dysfunction limits healthspan and lifespan in a murine progeria model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

Small-molecule proteostasis regulators for protein conformational diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

The role of nuclear lamin B1 in cell proliferation and senescence.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

Sirtuins, aging, and metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

SirT1 regulates adipose tissue inflammation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

Micromanaging aging with miRNAs: new messages from the nuclear envelope

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

Modulation of longevity and tissue homeostasis by the Drosophila PGC-1 homolog.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

The biology of aging: 1985-2010 and beyond

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

Hormesis, cellular stress response and vitagenes as critical determinants in aging and longevity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

Direct mutation analysis by high-throughput sequencing: from germline to low-abundant, somatic variants

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

Transgenerational epigenetic inheritance of longevity in Caenorhabditis elegans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

A mouse model of accelerated liver aging caused by a defect in DNA repair

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

Nuclear lamins and laminopathies.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

Regulation of Caenorhabditis elegans lifespan by sir-2.1 transgenes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

Elevated proteasome capacity extends replicative lifespan in Saccharomyces cerevisiae

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

Taking a "good" look at free radicals in the aging process

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

Dietary restriction and aging: a unifying perspective

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

The causes and consequences of polyploidy in normal development and cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

Histone H4 lysine 16 hypoacetylation is associated with defective DNA repair and premature senescence in Zmpste24-deficient mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

Mitochondrial aging is accelerated by anti-retroviral therapy through the clonal expansion of mtDNA mutations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

EGF signalling activates the ubiquitin proteasome system to modulate C. elegans lifespan

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

Human aging is characterized by focused changes in gene expression and deregulation of alternative splicing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

Mitochondrial DNA mutations in disease and aging

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

Targeted gene correction of laminopathy-associated LMNA mutations in patient-specific iPSCs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

Emerging models and paradigms for stem cell ageing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

Ultra-deep sequencing of mouse mitochondrial DNA: mutational patterns and their origins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

Amyloid-binding compounds maintain protein homeostasis during ageing and extend lifespan

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

dFOXO-independent effects of reduced insulin-like signaling in Drosophila

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

Epigenetic regulation of aging stem cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

The telomerase activator TA-65 elongates short telomeres and increases health span of adult/old mice without increasing cancer incidence

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

If started early in life, metformin treatment increases life span and postpones tumors in female SHR mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

Endurance exercise rescues progeroid aging and induces systemic mitochondrial rejuvenation in mtDNA mutator mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

Lifespan extension induced by AMPK and calcineurin is mediated by CRTC-1 and CREB

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

Four faces of cellular senescence.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

Regulation of PGC-1α, a nodal regulator of mitochondrial biogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

Mitochondria removal by autophagy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

Disruption of telomerase trafficking by TCAB1 mutation causes dyskeratosis congenita

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

Sirt3-mediated deacetylation of evolutionarily conserved lysine 122 regulates MnSOD activity in response to stress.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

Effect of daily aspirin on long-term risk of death due to cancer: analysis of individual patient data from randomised trials

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

HIV infection, inflammation, immunosenescence, and aging

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

The essence of senescence

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

Roles of SIRT1 in the Acute and Restorative Phases following Induction of Inflammation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

The Aging Stress Response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

Oncogene-induced senescence: the bright and dark side of the response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

Insulin-like growth factor 1 treatment extends longevity in a mouse model of human premature aging by restoring somatotroph axis function.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

Identification of MOAG-4/SERF as a regulator of age-related proteotoxicity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

Caloric restriction or catalase inactivation extends yeast chronological lifespan by inducing H2O2 and superoxide dismutase activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

Aging of the innate immune system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

Progeria syndromes and ageing: what is the connection?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

Metabolic networks of longevity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

Role of shelterin in cancer and aging

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

Members of the H3K4 trimethylation complex regulate lifespan in a germline-dependent manner in C. elegans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

Use of cells expressing gamma subunit variants to identify diverse mechanisms of AMPK activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

Altered histone acetylation is associated with age-dependent memory impairment in mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

Mitochondrial uncoupling and lifespan.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

Increased uncoupling protein (UCP) activity in Drosophila insulin-producing neurons attenuates insulin signaling and extends lifespan

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

Protein homeostasis and aging: The importance of exquisite quality control

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

Widespread and tissue specific age-related DNA methylation changes in mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogaster

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

Macrophage death and defective inflammation resolution in atherosclerosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

Short telomeres are sufficient to cause the degenerative defects associated with aging

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

mTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

Mice deficient in both Mn superoxide dismutase and glutathione peroxidase-1 have increased oxidative damage and a greater incidence of pathology but no reduction in longevity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

mTOR mediates Wnt-induced epidermal stem cell exhaustion and aging.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

Tissue regenerative delays and synthetic lethality in adult mice after combined deletion of Atr and Trp53.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

Novel roles for A-type lamins in telomere biology and the DNA damage response pathway.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

Mouse models to decipher the PI3K signaling network in human cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

The shock of aging: molecular chaperones and the heat shock response in longevity and aging--a mini-review

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

Endocrine regulation of heat shock protein mRNA levels in long-lived dwarf mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

Anti-aging activity of the Ink4/Arf locus.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

Stress-inducible regulation of heat shock factor 1 by the deacetylase SIRT1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

The overexpression of major antioxidant enzymes does not extend the lifespan of mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

Against the oxidative damage theory of aging: superoxide dismutases protect against oxidative stress but have little or no effect on life span in Caenorhabditis elegans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

Telomerase reverse transcriptase delays aging in cancer-resistant mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

DNA damage and ageing: new-age ideas for an age-old problem

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

Aging: ROS or TOR.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

Puzzles, promises and a cure for ageing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

Nordihydroguaiaretic acid and aspirin increase lifespan of genetically heterogeneous male mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

Combined treatment with statins and aminobisphosphonates extends longevity in a mouse model of human premature aging.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

CHIP deficiency decreases longevity, with accelerated aging phenotypes accompanied by altered protein quality control

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

Nuclear lamins: major factors in the structural organization and function of the nucleus and chromatin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

Nuclear envelope defects cause stem cell dysfunction in premature-aging mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

Stems cells and the pathways to aging and cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

Telomere length, stem cells and aging

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

How stem cells age and why this makes us grow old.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

The role of nuclear architecture in genomic instability and ageing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

Endocrine regulation of ageing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

Cellular senescence in cancer and aging

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

Epigenetics and aging: the targets and the marks

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

Fracture healing in the elderly patient.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

Telomeres and telomerase: the path from maize, Tetrahymena and yeast to human cancer and aging

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

A farnesyltransferase inhibitor improves disease phenotypes in mice with a Hutchinson-Gilford progeria syndrome mutation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

Increased cell-to-cell variation in gene expression in ageing mouse heart

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

Mutant nuclear lamin A leads to progressive alterations of epigenetic control in premature aging

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

Kidney disease as a risk factor for development of cardiovascular disease: a statement from the American Heart Association Councils on Kidney in Cardiovascular Disease, High Blood Pressure Research, Clinical Cardiology, and Epidemiology and Preventi

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

Lamin a truncation in Hutchinson-Gilford progeria.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

Senescence, aging, and malignant transformation mediated by p53 in mice lacking the Brca1 full-length isoform

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

Cell-by-cell scanning of whole mitochondrial genomes in aged human heart reveals a significant fraction of myocytes with clonally expanded deletions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

Telomeres, telomerase, and aging: origin of the theory

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

29 September 2017

SIRT3 reverses aging-associated degeneration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

2 June 2018

Age-associated inflammation inhibits epidermal stem cell function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

2 June 2018

Rapamycin ameliorates age-dependent obesity associated with increased mTOR signaling in hypothalamic POMC neurons

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

2 June 2018

NF-κB inhibition delays DNA damage-induced senescence and aging in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

2 June 2018

Meta-analysis of gene expression in the mouse liver reveals biomarkers associated with inflammation increased early during aging

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

2 June 2018

Systemic elevation of PTEN induces a tumor-suppressive metabolic state

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

2 June 2018

SIRT6 protects against pathological damage caused by diet-induced obesity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

2 June 2018

Random point mutations with major effects on protein-coding genes are the driving force behind premature aging in mtDNA mutator mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

2 June 2018

Telomere length behaves as biomarker of somatic redundancy rather than biological age.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

27 November 2018

RPN-6 determines C. elegans longevity under proteotoxic stress conditions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

27 November 2018

Rapamycin-induced glucose intolerance: hunger or starvation diabetes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

27 November 2018

Senescence surveillance of pre-malignant hepatocytes limits liver cancer development.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

27 November 2018

Splicing-Directed Therapy in a New Mouse Model of Human Accelerated Aging

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

27 November 2018

Néstor-Guillermo progeria syndrome: A novel premature aging condition with early onset and chronic development caused by BANF1 mutations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

27 November 2018

Gut microbiota as a candidate for lifespan extension: an ecological/evolutionary perspective targeted on living organisms as metaorganisms.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

27 November 2018

Histone demethylase UTX-1 regulates C. elegans life span by targeting the insulin/IGF-1 signaling pathway.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

27 November 2018

Alternate-day fasting reverses the age-associated hypertrophy phenotype in rat heart by influencing the ERK and PI3K signaling pathways.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

27 November 2018

Nuclear envelope alterations generate an aging-like epigenetic pattern in mice deficient in Zmpste24 metalloprotease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

27 November 2018

Mitochondrial longevity pathways.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

27 November 2018

FoxO1 is involved in the antineoplastic effect of calorie restriction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

27 November 2018

Polyamine-rich food decreases age-associated pathology and mortality in aged mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

27 November 2018

p53 deletion impairs clearance of chromosomal-instable stem cells in aging telomere-dysfunctional mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

27 November 2018

Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

27 November 2018

Mild mitochondrial uncoupling in mice affects energy metabolism, redox balance and longevity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

27 November 2018

A systematic look at an old problem

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

27 November 2018

Respiratory uncoupling in skeletal muscle delays death and diminishes age-related disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

27 November 2018

Delayed ageing through damage protection by the Arf/p53 pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

27 November 2018

Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

27 November 2018

p16INK4A is a robust in vivo biomarker of cellular aging in human skin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

27 November 2018

DNA methyltransferases control telomere length and telomere recombination in mammalian cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

27 November 2018

p21 loss compromises the relative quiescence of forebrain stem cell proliferation leading to exhaustion of their proliferation capacity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

27 November 2018

Overexpression of the small mitochondrial Hsp22 extends Drosophila life span and increases resistance to oxidative stress

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836174

27 November 2018

Effects of aging and methionine restriction applied at old age on ROS generation and oxidative damage in rat liver mitochondria

1 reference

https://pubmed.ncbi.nlm.nih.gov/23746838

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/23746838

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Decreased Proteasomal Activity Causes Age-Related Phenotypes and Promotes the Development of Metabolic Abnormalities

1 reference

https://pubmed.ncbi.nlm.nih.gov/23746838

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lifespan extension in C. elegans by a molecular chaperone dependent upon insulin-like signals

1 reference

https://pubmed.ncbi.nlm.nih.gov/23746838

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNA damage response and cellular senescence in tissues of aging mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/23746838

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitochondrial DNA mutations as an important contributor to ageing and degenerative diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/23746838

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hematopoietic stem cell quiescence maintained by p21cip1/waf1

1 reference

https://pubmed.ncbi.nlm.nih.gov/23746838

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

THE FREE RADICAL THEORY OF AGING: EFFECT OF AGE ON SERUM COPPER LEVELS

1 reference

https://pubmed.ncbi.nlm.nih.gov/23746838

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Somatic Progenitor Cell Vulnerability to Mitochondrial DNA Mutagenesis Underlies Progeroid Phenotypes in Polg Mutator Mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/23746838

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNA deletions and clonal mutations drive premature aging in mitochondrial mutator mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/23746838

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.CELL.2013.05.039

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PMC publication ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PubMed publication ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

ResearchGate publication ID

0 references

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