(Q26825154)

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Signaling effectors underlying pathologic growth and remodeling of the heart

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Europe PubMed Central

Signaling effectors underlying pathologic growth and remodeling of the heart (English)

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author name string

Jop H. van Berlo

1

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Marjorie Maillet

2

1 reference

Jeffery D. Molkentin

3

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language of work or name

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publication date

January 2013

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Journal of Clinical Investigation

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123

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1

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37-45

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Phase 2 trial of oral vorinostat (suberoylanilide hydroxamic acid, SAHA) for refractory cutaneous T-cell lymphoma (CTCL)

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Protein kinase cascades in the regulation of cardiac hypertrophy

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Cardiac hypertrophy and histone deacetylase-dependent transcriptional repression mediated by the atypical homeodomain protein Hop

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The deltaC isoform of CaMKII is activated in cardiac hypertrophy and induces dilated cardiomyopathy and heart failure

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Identification of a functionally critical protein kinase C phosphorylation residue of cardiac troponin T

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A calcineurin-dependent transcriptional pathway for cardiac hypertrophy

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CaMKII in myocardial hypertrophy and heart failure

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TRPC channels as effectors of cardiac hypertrophy

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Ryanodine receptor phosphorylation by calcium/calmodulin-dependent protein kinase II promotes life-threatening ventricular arrhythmias in mice with heart failure

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TRPC channels are necessary mediators of pathologic cardiac hypertrophy

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28 September 2017

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28 September 2017

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28 September 2017

Phosphodiesterase inhibition in heart failure

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28 September 2017

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28 September 2017

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28 September 2017

TRPC6 fulfills a calcineurin signaling circuit during pathologic cardiac remodeling

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28 September 2017

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28 September 2017

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28 September 2017

Calcineurin-dependent cardiomyopathy is activated by TRPC in the adult mouse heart

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28 September 2017

Intermittent pressure overload triggers hypertrophy-independent cardiac dysfunction and vascular rarefaction

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28 September 2017

Suppression of class I and II histone deacetylases blunts pressure-overload cardiac hypertrophy

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28 September 2017

Targeting calcineurin and associated pathways in cardiac hypertrophy and failure

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3533272

28 September 2017

p38alpha mitogen-activated protein kinase plays a critical role in cardiomyocyte survival but not in cardiac hypertrophic growth in response to pressure overload.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3533272

28 September 2017

Cardiac-specific disruption of the c-raf-1 gene induces cardiac dysfunction and apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3533272

28 September 2017

Calcium-calcineurin signaling in the regulation of cardiac hypertrophy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3533272

28 September 2017

Cross-regulation between the renin-angiotensin system and inflammatory mediators in cardiac hypertrophy and failure

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3533272

28 September 2017

Manipulating cardiac contractility in heart failure: data from mice and men.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3533272

28 September 2017

Targeted deletion of apoptosis signal-regulating kinase 1 attenuates left ventricular remodeling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3533272

28 September 2017

Pharmacological modulation of cardiovascular remodeling: a guide to heart failure therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3533272

28 September 2017

What is the role of beta-adrenergic signaling in heart failure?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3533272

28 September 2017

2003 World Health Organization (WHO)/International Society of Hypertension (ISH) statement on management of hypertension

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3533272

28 September 2017

c-Jun N-terminal kinases (JNK) antagonize cardiac growth through cross-talk with calcineurin-NFAT signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3533272

28 September 2017

Independent beta-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3533272

28 September 2017

Comparison of carvedilol and metoprolol on clinical outcomes in patients with chronic heart failure in the Carvedilol Or Metoprolol European Trial (COMET): randomised controlled trial

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3533272

28 September 2017

Targeted inhibition of p38 MAPK promotes hypertrophic cardiomyopathy through upregulation of calcineurin-NFAT signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3533272

28 September 2017

MEKK1 is essential for cardiac hypertrophy and dysfunction induced by Gq.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3533272

28 September 2017

In vivo ventricular gene delivery of a beta-adrenergic receptor kinase inhibitor to the failing heart reverses cardiac dysfunction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3533272

28 September 2017

The dual-specificity phosphatase MKP-1 limits the cardiac hypertrophic response in vitro and in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3533272

28 September 2017

The MEK1-ERK1/2 signaling pathway promotes compensated cardiac hypertrophy in transgenic mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3533272

28 September 2017

Differentiation stage-specific inhibition of the Raf-MEK-ERK pathway by Akt.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3533272

28 September 2017

Receptor-specific in vivo desensitization by the G protein-coupled receptor kinase-5 in transgenic mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3533272

28 September 2017

Direct Demonstration of Impaired Functionality of a Purified Desensitized β-Adrenergic Receptor in a Reconstituted System

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3533272

28 September 2017

Left ventricular function in experimental aorto-caval fistula with circulatory congestion and fluid retention

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3533272

28 September 2017

Effect of propranolol in myocardial infarction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3533272

28 September 2017

Wall stress and patterns of hypertrophy in the human left ventricle

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3533272

28 September 2017

Myocardial beta-adrenergic receptor signaling in vivo: insights from transgenic mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3533272

28 September 2017

C/EBPβ controls exercise-induced cardiac growth and protects against pathological cardiac remodeling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3533272

31 May 2018

The State of the Cardiac Muscle in Hypertrophy and Atrophy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3533272

31 May 2018

The cardiac-specific nuclear delta(B) isoform of Ca2+/calmodulin-dependent protein kinase II induces hypertrophy and dilated cardiomyopathy associated with increased protein phosphatase 2A activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3533272

31 May 2018

Action of the calcium channel blocker lacidipine on cardiac hypertrophy and endothelin-1 gene expression in stroke-prone hypertensive rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3533272

31 May 2018

The effect of carvedilol on morbidity and mortality in patients with chronic heart failure. U.S. Carvedilol Heart Failure Study Group

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3533272

31 May 2018

Wall stress in the normal and hypertrophied human left ventricle.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3533272

31 May 2018

Risk of ventricular arrhythmias in left ventricular hypertrophy: the Framingham Heart Study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3533272

31 May 2018

Effect of ruboxistaurin (RBX) On visual acuity decline over a 6-year period with cessation and reinstitution of therapy: results of an open-label extension of the Protein Kinase C Diabetic Retinopathy Study 2 (PKC-DRS2).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3533272

28 November 2018

Role for CaMKII inhibition in rheumatoid arthritis: effects on HIF-1-induced VEGF production by rheumatoid synovial fibroblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3533272

28 November 2018

Cardiac-specific deletion of mkk4 reveals its role in pathological hypertrophic remodeling but not in physiological cardiac growth.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3533272

28 November 2018

A new G(q)-initiated MAPK signaling pathway in the heart.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3533272

28 November 2018

Effect of ruboxistaurin on the visual acuity decline associated with long-standing diabetic macular edema

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3533272

28 November 2018

Long-term inhibition of Rho-kinase ameliorates diastolic heart failure in hypertensive rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3533272

28 November 2018

PKCbeta modulates ischemia-reperfusion injury in the heart

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3533272

28 November 2018

Left ventricular mass predicts heart failure not related to previous myocardial infarction: the Cardiovascular Health Study.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3533272

28 November 2018

Inhibition of p38 mitogen-activated protein kinase attenuates left ventricular dysfunction by mediating pro-inflammatory cardiac cytokine levels in a mouse model of diabetes mellitus.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3533272

28 November 2018

Inhibition of histone deacetylation blocks cardiac hypertrophy induced by angiotensin II infusion and aortic banding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3533272

28 November 2018

Opposing effect of p38 MAP kinase and JNK inhibitors on the development of heart failure in the cardiomyopathic hamster

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3533272

28 November 2018

Chronic inhibition of cyclic GMP phosphodiesterase 5A prevents and reverses cardiac hypertrophy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3533272

28 November 2018

MEK1-ERK2 signaling pathway protects myocardium from ischemic injury in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3533272

28 November 2018

Akt signaling mediates postnatal heart growth in response to insulin and nutritional status

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3533272

28 November 2018

Confirmation of a heart failure epidemic: findings from the Resource Utilization Among Congestive Heart Failure (REACH) study.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3533272

28 November 2018

Effects of growth hormone and IGF-I on cardiac hypertrophy and gene expression in mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3533272

28 November 2018

HDAC inhibitors and cardiac safety

1 reference

https://pubmed.ncbi.nlm.nih.gov/23281408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sensitivity of CaM kinase II to the frequency of Ca2+ oscillations

1 reference

https://pubmed.ncbi.nlm.nih.gov/23281408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Augmented protein kinase C-alpha-induced myofilament protein phosphorylation contributes to myofilament dysfunction in experimental congestive heart failure

1 reference

https://pubmed.ncbi.nlm.nih.gov/23281408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of protein kinase C-beta by ruboxistaurin preserves cardiac function and reduces extracellular matrix production in diabetic cardiomyopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/23281408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ca(2+)-related signaling and protein phosphorylation abnormalities play central roles in a new experimental model of electrical storm

1 reference

https://pubmed.ncbi.nlm.nih.gov/23281408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of histone deacetylase on ventricular remodeling in infarcted rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/23281408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calmodulin kinase II inhibition protects against structural heart disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/23281408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TAK1 is activated in the myocardium after pressure overload and is sufficient to provoke heart failure in transgenic mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23281408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of p38 mitogen-activated protein kinase protects the heart against cardiac remodeling in mice with heart failure resulting from myocardial infarction

1 reference

https://pubmed.ncbi.nlm.nih.gov/23281408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased left ventricular mass is a risk factor for the development of a depressed left ventricular ejection fraction within five years: the Cardiovascular Health Study

1 reference

https://pubmed.ncbi.nlm.nih.gov/23281408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The insulin-like growth factor 1 receptor induces physiological heart growth via the phosphoinositide 3-kinase(p110alpha) pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/23281408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential Activation of Signal Transduction Pathways in Human Hearts With Hypertrophy Versus Advanced Heart Failure

1 reference

https://pubmed.ncbi.nlm.nih.gov/23281408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cardiotoxicity of histone deacetylase inhibitor depsipeptide in patients with metastatic neuroendocrine tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/23281408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quantifying the heart failure epidemic: prevalence, incidence rate, lifetime risk and prognosis of heart failure The Rotterdam Study

1 reference

https://pubmed.ncbi.nlm.nih.gov/23281408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prevention of Cardiac Hypertrophy in Mice by Calcineurin Inhibition

1 reference

https://pubmed.ncbi.nlm.nih.gov/23281408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chronic Inhibition of cGMP Phosphodiesterase 5A Improves Diabetic Cardiomyopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/23281408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calcium channel blockers in heart failure

1 reference

https://pubmed.ncbi.nlm.nih.gov/23281408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of protein kinase C reduces left ventricular fibrosis and dysfunction following myocardial infarction

1 reference

https://pubmed.ncbi.nlm.nih.gov/23281408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of myocardial catecholamines in cardiac contractility

1 reference

https://pubmed.ncbi.nlm.nih.gov/23281408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cardiac-specific disruption of the c-raf-1 gene induces cardiac dysfunction and apoptosis

1 reference

https://api.crossref.org/works/10.1172%2FJCI62839

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1172/JCI62839

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PMC publication ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PubMed publication ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

ResearchGate publication ID

0 references

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