(Q24518494)

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Protein kinase cascades in the regulation of cardiac hypertrophy

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Europe PubMed Central

Protein kinase cascades in the regulation of cardiac hypertrophy (English)

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author name string

Gerald W Dorn

1

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Thomas Force

2

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publication date

March 2005

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Journal of Clinical Investigation

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115

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3

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527-37

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mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4E

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Protein Kinase Cα Negatively Regulates Systolic and Diastolic Function in Pathological Hypertrophy

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24 March 2017

Restoration of contractile function in isolated cardiomyocytes from failing human hearts by gene transfer of SERCA2a

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24 March 2017

PKC-alpha regulates cardiac contractility and propensity toward heart failure

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24 March 2017

Stabilization of beta-catenin by a Wnt-independent mechanism regulates cardiomyocyte growth

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24 March 2017

Increased proliferation of B cells and auto-immunity in mice lacking protein kinase Cdelta

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24 March 2017

PKC alpha regulates the hypertrophic growth of cardiomyocytes through extracellular signal-regulated kinase1/2 (ERK1/2)

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24 March 2017

Activated glycogen synthase-3 beta suppresses cardiac hypertrophy in vivo

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24 March 2017

The genetic basis for cardiomyopathy: from mutation identification to mechanistic paradigms

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24 March 2017

PKCepsilon activation induces dichotomous cardiac phenotypes and modulates PKCepsilon-RACK interactions and RACK expression

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24 March 2017

Transgenic overexpression of constitutively active protein kinase C epsilon causes concentric cardiac hypertrophy

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24 March 2017

Cardiotrophic effects of protein kinase C epsilon: analysis by in vivo modulation of PKCepsilon translocation

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Loss of a gp130 cardiac muscle cell survival pathway is a critical event in the onset of heart failure during biomechanical stress

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Embryonic cardiomyocyte hypoplasia and craniofacial defects in G alpha q/G alpha 11-mutant mice

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Immunodeficiency in protein kinase cbeta-deficient mice

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24 March 2017

Molecular characterization of angiotensin II--induced hypertrophy of cardiac myocytes and hyperplasia of cardiac fibroblasts. Critical role of the AT1 receptor subtype

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Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E

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7 April 2017

Toward transcriptional therapies for the failing heart: chemical screens to modulate genes

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27 September 2017

Cardiovascular effects of growth hormone treatment: potential risks and benefits

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27 September 2017

Role of Ca2+/calmodulin-dependent protein kinase II in cardiac hypertrophy and heart failure

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27 September 2017

Calcineurin-NFAT signaling regulates the cardiac hypertrophic response in coordination with the MAPKs

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27 September 2017

Ras, PI3-kinase and mTOR signaling in cardiac hypertrophy

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27 September 2017

The role of phosphoinositide-3 kinase and PTEN in cardiovascular physiology and disease

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27 September 2017

GATA transcription factors in the developing and adult heart

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27 September 2017

Genetic manipulation of myocardial beta-adrenergic receptor activation and desensitization

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27 September 2017

Deletion of ribosomal S6 kinases does not attenuate pathological, physiological, or insulin-like growth factor 1 receptor-phosphoinositide 3-kinase-induced cardiac hypertrophy

1 reference

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27 September 2017

Advances in protein kinase B signalling: AKTion on multiple fronts

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27 September 2017

Stress-activated MAP kinases in cardiac remodeling and heart failure; new insights from transgenic studies

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27 September 2017

Redefining the roles of p38 and JNK signaling in cardiac hypertrophy: dichotomy between cultured myocytes and animal models

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27 September 2017

Protein kinase C isoform-selective signals that lead to cardiac hypertrophy and the progression of heart failure

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27 September 2017

Phosphoinositide 3-kinase(p110α) plays a critical role for the induction of physiological, but not pathological, cardiac hypertrophy

1 reference

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27 September 2017

Deficiency of PDK1 in cardiac muscle results in heart failure and increased sensitivity to hypoxia

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27 September 2017

Dynamic regulation of MEK/Erks and Akt/GSK-3beta in human end-stage heart failure after left ventricular mechanical support: myocardial mechanotransduction-sensitivity as a possible molecular mechanism

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27 September 2017

Heart failure therapy at a crossroad: are there limits to the neurohormonal model?

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27 September 2017

Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways

1 reference

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27 September 2017

Akt induces enhanced myocardial contractility and cell size in vivo in transgenic mice

1 reference

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27 September 2017

Gene therapy for cardiac cachexia?

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27 September 2017

Akt/protein kinase B promotes organ growth in transgenic mice

1 reference

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27 September 2017

MEKK1 is essential for cardiac hypertrophy and dysfunction induced by Gq.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1052008

27 September 2017

p38 Mitogen-activated protein kinase mediates a negative inotropic effect in cardiac myocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1052008

27 September 2017

Fas receptor signaling inhibits glycogen synthase kinase 3 beta and induces cardiac hypertrophy following pressure overload

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1052008

27 September 2017

Intracellular transport mechanisms of signal transducers

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27 September 2017

Seven-transmembrane-spanning receptors and heart function

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27 September 2017

Molecular biology of protein kinase C signaling in cardiac myocytes

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27 September 2017

Opposing cardioprotective actions and parallel hypertrophic effects of delta PKC and epsilon PKC.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1052008

27 September 2017

The Genetic Basis for Cardiomyopathy

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27 September 2017

Cytoplasmic signaling pathways that regulate cardiac hypertrophy

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27 September 2017

Glycogen synthase kinase-3beta is a negative regulator of cardiomyocyte hypertrophy

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1052008

27 September 2017

Protein kinase C isozymes and the regulation of diverse cell responses

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27 September 2017

The conserved phosphoinositide 3-kinase pathway determines heart size in mice

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27 September 2017

beta-adrenergic receptor blockade in chronic heart failure

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27 September 2017

Alterations in protein kinase A and protein kinase C levels in heart failure due to genetic cardiomyopathy

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27 September 2017

Proliferative defect and embryonic lethality in mice homozygous for a deletion in the p110alpha subunit of phosphoinositide 3-kinase

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27 September 2017

Enhanced Galphaq signaling: a common pathway mediates cardiac hypertrophy and apoptotic heart failure

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27 September 2017

Expression of protein kinase C beta in the heart causes hypertrophy in adult mice and sudden death in neonates.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1052008

27 September 2017

Targeted overexpression of protein kinase C beta2 isoform in myocardium causes cardiomyopathy

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1052008

27 September 2017

Transgenic Gαq overexpression induces cardiac contractile failure in mice

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1052008

27 September 2017

Insulin-like growth factor-1 enhances ventricular hypertrophy and function during the onset of experimental cardiac failure

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1052008

27 September 2017

Physiologic cardiac hypertrophy corrects contractile protein abnormalities associated with pathologic hypertrophy in rats

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1052008

27 September 2017

Studies and perspectives of protein kinase C.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1052008

27 September 2017

Identification of intracellular receptor proteins for activated protein kinase C

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1052008

27 September 2017

Wall stress and patterns of hypertrophy in the human left ventricle

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1052008

27 September 2017

Preservation of base-line hemodynamic function and loss of inducible cardioprotection in adult mice lacking protein kinase C epsilon

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1052008

30 May 2018

Ischemic protection and myofibrillar cardiomyopathy: dose-dependent effects of in vivo deltaPKC inhibition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1052008

30 May 2018

A novel nociceptor signaling pathway revealed in protein kinase C epsilon mutant mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1052008

30 May 2018

Mechanisms of impaired beta-adrenergic receptor signaling in G(alphaq)-mediated cardiac hypertrophy and ventricular dysfunction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1052008

30 May 2018

Norepinephrine-stimulated hypertrophy of cultured rat myocardial cells is an alpha 1 adrenergic response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1052008

30 May 2018

Endothelin induction of inositol phospholipid hydrolysis, sarcomere assembly, and cardiac gene expression in ventricular myocytes. A paracrine mechanism for myocardial cell hypertrophy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1052008

30 May 2018

PI3Kγ Modulates the Cardiac Response to Chronic Pressure Overload by Distinct Kinase-Dependent and -Independent Effects

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1052008

29 November 2018

Ischemic preconditioning exaggerates cardiac damage in PKC-delta null mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1052008

29 November 2018

Protein kinase Cbeta isoform inhibitors: a new treatment for diabetic cardiovascular diseases

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1052008

29 November 2018

Inhibition of mTOR signaling with rapamycin regresses established cardiac hypertrophy induced by pressure overload

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1052008

29 November 2018

Glycogen synthase kinase-3beta regulates growth, calcium homeostasis, and diastolic function in the heart

1 reference

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29 November 2018

Phosphorylation of eukaryotic translation initiation factor 2Bepsilon by glycogen synthase kinase-3beta regulates beta-adrenergic cardiac myocyte hypertrophy.

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29 November 2018

Activity of the Akt/GSK-3beta pathway in the failing human heart before and after left ventricular assist device support.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1052008

29 November 2018

Inhibition of delta-protein kinase C protects against reperfusion injury of the ischemic heart in vivo

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29 November 2018

Mechanical unloading of the failing human heart fails to activate the protein kinase B/Akt/glycogen synthase kinase-3beta survival pathway.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1052008

29 November 2018

Myocyte apoptosis: programming ventricular remodeling.

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29 November 2018

Reengineering inducible cardiac-specific transgenesis with an attenuated myosin heavy chain promoter

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29 November 2018

Activation of signal transducer and activator of transcription (STAT) pathways in failing human hearts.

1 reference

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29 November 2018

Mitochondrial death protein Nix is induced in cardiac hypertrophy and triggers apoptotic cardiomyopathy

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29 November 2018

Phenotypic spectrum caused by transgenic overexpression of activated Akt in the heart

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29 November 2018

Genetic alterations that inhibit in vivo pressure-overload hypertrophy prevent cardiac dysfunction despite increased wall stress.

1 reference

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29 November 2018

Still stressed out but doing fine: normalization of wall stress is superfluous to maintaining cardiac function in chronic pressure overload.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1052008

29 November 2018

Inducible activation of c-Myc in adult myocardium in vivo provokes cardiac myocyte hypertrophy and reactivation of DNA synthesis

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29 November 2018

Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice

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29 November 2018

Akt activation preserves cardiac function and prevents injury after transient cardiac ischemia in vivo

1 reference

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29 November 2018

PKC-beta is not necessary for cardiac hypertrophy

1 reference

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29 November 2018

Roles of growth hormone and insulin-like growth factor 1 in mouse postnatal growth.

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29 November 2018

Calcineurin and human heart failure

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29 November 2018

Defective platelet activation in G alpha(q)-deficient mice.

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29 November 2018

Gq- and ras-dependent pathways mediate hypertrophy of neonatal rat ventricular myocytes following alpha 1-adrenergic stimulation.

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29 November 2018

Increased protein kinase C and isozyme redistribution in pressure-overload cardiac hypertrophy in the rat

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12 December 2020

based on heuristic

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Activation of c-Jun N-terminal kinases and p38-mitogen-activated protein kinases in human heart failure secondary to ischaemic heart disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/15765134

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Absence of pressure overload induced myocardial hypertrophy after conditional inactivation of Gαq/Gα11 in cardiomyocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/15765134

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential regulation of mitogen-activated protein kinases in the failing human heart in response to mechanical unloading

1 reference

https://pubmed.ncbi.nlm.nih.gov/15765134

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reciprocal modulation of mitogen-activated protein kinases and mitogen-activated protein kinase phosphatase 1 and 2 in failing human myocardium

1 reference

https://pubmed.ncbi.nlm.nih.gov/15765134

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased expression of protein kinase C isoforms in heart failure due to myocardial infarction

1 reference

https://pubmed.ncbi.nlm.nih.gov/15765134

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential Activation of Signal Transduction Pathways in Human Hearts With Hypertrophy Versus Advanced Heart Failure

1 reference

https://pubmed.ncbi.nlm.nih.gov/15765134

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The tumor suppressor gene PTEN can regulate cardiac hypertrophy and survival

1 reference

https://pubmed.ncbi.nlm.nih.gov/15765134

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeting the receptor-Gq interface to inhibit in vivo pressure overload myocardial hypertrophy

1 reference

https://pubmed.ncbi.nlm.nih.gov/15765134

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Decompensation of pressure-overload hypertrophy in G alpha q-overexpressing mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/15765134

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased protein kinase C activity and expression of Ca2+-sensitive isoforms in the failing human heart

1 reference

https://pubmed.ncbi.nlm.nih.gov/15765134

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Akt-glycogen synthase kinase 3beta pathway regulates transcription of atrial natriuretic factor induced by beta-adrenergic receptor stimulation in cardiac myocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/15765134

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein kinase C and myocardial biology and function

1 reference

https://pubmed.ncbi.nlm.nih.gov/15765134

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cardiac hypertrophy is not a required compensatory response to short-term pressure overload

1 reference

https://pubmed.ncbi.nlm.nih.gov/15765134

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Epsilon protein kinase C in pathological myocardial hypertrophy. Analysis by combined transgenic expression of translocation modifiers and Galphaq

1 reference

https://pubmed.ncbi.nlm.nih.gov/15765134

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A Preliminary Study of Growth Hormone in the Treatment of Dilated Cardiomyopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/15765134

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Can neuroscience be integrated into the DSM-V?

1 reference

https://api.crossref.org/works/10.1172%2FJCI24178

7 January 2021

based on heuristic

inferred from DOI database lookup

Cardiotrophic Effects of Protein Kinase C : Analysis by In Vivo Modulation of PKC Translocation

1 reference

https://api.crossref.org/works/10.1172%2FJCI24178

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1172/JCI24178

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PMC publication ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PubMed publication ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

ResearchGate publication ID

0 references

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