(Q21120422)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P35408

GPCR, rhodopsin-like, 7TM, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

prostaglandin receptor activity

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35408

signal transducer activity

IEA

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35408&geneProductId=UniProtKB:P35408

1 reference

9 May 2019

A novel prostaglandin E receptor 4-associated protein participates in antiinflammatory signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35408

prostaglandin E receptor activity

IPI

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35408

9 May 2019

Cloning, functional expression, and characterization of the human prostaglandin E2 receptor EP2 subtype

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35408

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35408

integral component of membrane

cell component

3 references

9 May 2019

Cloning, functional expression, and characterization of the human prostaglandin E2 receptor EP2 subtype

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35408

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35408

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35408

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35408

2 references

intracellular anatomical structure

1 reference

10 September 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35408&geneProductId=UniProtKB:P35408

negative regulation of integrin activation

1 reference

9 May 2019

Interaction of eosinophils with endothelial cells is modulated by prostaglandin EP4 receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35408

adenylate cyclase-modulating G protein-coupled receptor signaling pathway

IDA

1 reference

9 May 2019

Cloning, functional expression, and characterization of the human prostaglandin E2 receptor EP2 subtype

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35408

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35408

IDA

ERK1 and ERK2 cascade

1 reference

9 May 2019

response to mechanical stimulus

ISS

1 reference

9 May 2019

Sost down-regulation by mechanical strain in human osteoblastic cells involves PGE2 signaling via EP4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35408

negative regulation of eosinophil extravasation

IEP

1 reference

9 May 2019

Interaction of eosinophils with endothelial cells is modulated by prostaglandin EP4 receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35408

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35408

response to lipopolysaccharide

ISS

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35408

1 reference

9 May 2019

Gene expression of the human prostaglandin E receptor EP4 subtype: differential regulation in monocytoid and lymphoid lineage cells by phorbol ester

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35408

regulation of ossification

IEP

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35408

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35408

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35408

cellular response to prostaglandin E stimulus

IEA

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35408

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

inflammatory response

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35408

adenylate cyclase-activating G protein-coupled receptor signaling pathway

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35408

positive regulation of cytosolic calcium ion concentration

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35408

negative regulation of inflammatory response

3 references

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35408

9 May 2019

A novel prostaglandin E receptor 4-associated protein participates in antiinflammatory signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35408

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35408

physically interacts with

1 reference

5820

17 August 2016

1 reference

1881

17 August 2016

1 reference

1882

17 August 2016

2 references

1883

English

17 August 2016

1916

17 August 2016

1 reference

1884

17 August 2016

1 reference

1915

17 August 2016

1 reference

1888

English

object of statement has role

17 August 2016

grapiprant

antagonist

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL3039498

rivenprost

object of statement has role

agonist

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL303960

has part(s)

GPCR, rhodopsin-like, 7TM

1 reference

InterPro Release 71.0