(Q14914569)

Leucine-rich repeat domain superfamily

1 reference

Immunoglobulin-like fold

1 reference

PLAT/LH2 domain superfamily

1 reference

C-type lectin-like/link domain superfamily

1 reference

polycystic kidney disease type 1 protein

1 reference

C-type lectin fold

1 reference

REJ domain, protein family

1 reference

Leucine-rich repeat N-terminal domain, protein family

1 reference

GPS motif domain, protein family

1 reference

Carbohydrate-binding WSC domain, protein family

1 reference

PKD/REJ-like domain, protein family

1 reference

C-type lectin-like domain, protein family

1 reference

PKD domain, protein family

1 reference

PKD/Chitinase domain, protein family

1 reference

PLAT/LH2 domain, protein family

1 reference

Cysteine-rich flanking region, C-terminal domain, protein family

1 reference

Polycystin cation channel, PKD1/PKD2, protein family

1 reference

Leucine-rich repeat, typical subtype, protein family

1 reference

polycystin-1 family

1 reference

Leucine-rich repeat, protein family

1 reference

1 reference

25 May 2022

1 reference

25 May 2022

calcium channel activity

TAS

protein binding

5 references

8 April 2019

Ciliary membrane proteins traffic through the Golgi via a Rabep1/GGA1/Arl3-dependent mechanism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08852

8 April 2019

Ubiquitin-dependent intramembrane rhomboid protease promotes ERAD of membrane proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08852

8 April 2019

PKD1 induces p21(waf1) and regulation of the cell cycle via direct activation of the JAK-STAT signaling pathway in a process requiring PKD2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08852

8 April 2019

Identification, characterization, and localization of a novel kidney polycystin-1-polycystin-2 complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08852

8 April 2019

Structural model of the TRPP2/PKD1 C-terminal coiled-coil complex produced by a combined computational and experimental approach.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08852

carbohydrate binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08852

1 reference

8 April 2019

calcium channel activity

PKD1 induces p21(waf1) and regulation of the cell cycle via direct activation of the JAK-STAT signaling pathway in a process requiring PKD2

3 references

7 November 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O08852&geneProductId=UniProtKB:O08852

TAS

7 November 2018

Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=O08852&geneProductId=UniProtKB:O08852

7 November 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O08852&geneProductId=UniProtKB:O08852

Wnt-activated receptor activity

1 reference

7 November 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O08852&geneProductId=UniProtKB:O08852

calcium channel activity

PKD1 induces p21(waf1) and regulation of the cell cycle via direct activation of the JAK-STAT signaling pathway in a process requiring PKD2

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08852

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08852

8 April 2019

Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08852

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08852

cell component

cytoplasm

1 reference

8 April 2019

Polycystin-1 and polycystin-2 regulate the cell cycle through the helix-loop-helix inhibitor Id2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08852

cell projection

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08852

1 reference

8 April 2019

cilium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08852

5 references

14 February 2019

14 February 2019

Ciliary membrane proteins traffic through the Golgi via a Rabep1/GGA1/Arl3-dependent mechanism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08852

14 February 2019

Bardet-Biedl syndrome proteins 1 and 3 regulate the ciliary trafficking of polycystic kidney disease 1 protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08852

14 February 2019

Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08852

14 February 2019

Endothelial cilia are fluid shear sensors that regulate calcium signaling and nitric oxide production through polycystin-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08852

cell surface

1 reference

8 April 2019

Bardet-Biedl syndrome proteins 1 and 3 regulate the ciliary trafficking of polycystic kidney disease 1 protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08852

nucleus

1 reference

8 April 2019

Mechanical stimuli induce cleavage and nuclear translocation of the polycystin-1 C terminus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08852

polycystin complex

plasma membrane

motile cilium

1 reference

8 April 2019

Localization of transient receptor potential ion channels in primary and motile cilia of the female murine reproductive organs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08852

membrane

endoplasmic reticulum

1 reference

7 November 2018

Ciliary membrane proteins traffic through the Golgi via a Rabep1/GGA1/Arl3-dependent mechanism

http://www.ebi.ac.uk/QuickGO/annotations?protein=O08852&geneProductId=UniProtKB:O08852

Golgi apparatus

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08852

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08852

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08852

8 April 2019

Ciliary membrane proteins traffic through the Golgi via a Rabep1/GGA1/Arl3-dependent mechanism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08852

calcium channel complex

1 reference

7 November 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O08852&geneProductId=UniProtKB:O08852

integral component of plasma membrane

ISS

cation channel complex

Tubby family proteins are adapters for ciliary trafficking of integral membrane proteins

7 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08852

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08852

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08852

8 April 2019

Ciliary membrane proteins traffic through the Golgi via a Rabep1/GGA1/Arl3-dependent mechanism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08852

8 April 2019

Bardet-Biedl syndrome proteins 1 and 3 regulate the ciliary trafficking of polycystic kidney disease 1 protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08852

8 April 2019

Endothelial cilia are fluid shear sensors that regulate calcium signaling and nitric oxide production through polycystin-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08852

8 April 2019

Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08852

regulation of proteasomal protein catabolic process

biological process

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08852

8 April 2019

Polycystin-1 regulates the stability and ubiquitination of transcription factor Jade-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08852

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08852

renal system development

1 reference

1 January 2018

A genetic interaction network of five genes for human polycystic kidney and liver diseases defines polycystin-1 as the central determinant of cyst formation

http://www.ebi.ac.uk/QuickGO/annotations?protein=O08852&geneProductId=UniProtKB:O08852

mesonephric tubule development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08852

receptor signaling pathway via JAK-STAT

1 reference

8 April 2019

PKD1 induces p21(waf1) and regulation of the cell cycle via direct activation of the JAK-STAT signaling pathway in a process requiring PKD2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08852

metanephric distal tubule morphogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08852

regulation of mitotic spindle organization

1 reference

8 April 2019

A genetic interaction network of five genes for human polycystic kidney and liver diseases defines polycystin-1 as the central determinant of cyst formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08852

kidney development

Systems biology approach to identify transcriptome reprogramming and candidate microRNA targets during the progression of polycystic kidney disease

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08852

8 April 2019

Pkd1 and Pkd2 are required for normal placental development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08852

8 April 2019

A genetic interaction network of five genes for human polycystic kidney and liver diseases defines polycystin-1 as the central determinant of cyst formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08852

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08852

8 April 2019

mesonephric duct development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08852

cytoplasmic sequestering of transcription factor

1 reference

8 April 2019

Polycystin-1 and polycystin-2 regulate the cell cycle through the helix-loop-helix inhibitor Id2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08852

placenta blood vessel development

1 reference

8 April 2019

Pkd1 and Pkd2 are required for normal placental development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08852

embryonic placenta development

1 reference

8 April 2019

Pkd1 and Pkd2 are required for normal placental development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08852

response to fluid shear stress

1 reference

8 April 2019

Endothelial cilia are fluid shear sensors that regulate calcium signaling and nitric oxide production through polycystin-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08852

genitalia development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08852

metanephric ascending thin limb development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08852

metanephric proximal tubule development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08852

heart development

Global genetic analysis in mice unveils central role for cilia in congenital heart disease

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08852

8 April 2019

Cardiovascular, skeletal, and renal defects in mice with a targeted disruption of the Pkd1 gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08852

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08852

cartilage development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08852

regulation of cell adhesion

1 reference

8 April 2019

Pkd1 regulates lymphatic vascular morphogenesis during development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08852

blood vessel development

1 reference

8 April 2019

Polycystin 1 is required for the structural integrity of blood vessels

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08852

nitrogen compound metabolic process

1 reference

8 April 2019

A genetic interaction network of five genes for human polycystic kidney and liver diseases defines polycystin-1 as the central determinant of cyst formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08852

calcium ion transmembrane transport

1 reference

8 April 2019

Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08852

peptidyl-serine phosphorylation

1 reference

8 April 2019

Polycystin-dependent fluid flow sensing targets histone deacetylase 5 to prevent the development of renal cysts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08852

lymph vessel morphogenesis

1 reference

8 April 2019

Pkd1 regulates lymphatic vascular morphogenesis during development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08852

protein export from nucleus

1 reference

8 April 2019

Polycystin-dependent fluid flow sensing targets histone deacetylase 5 to prevent the development of renal cysts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08852

neural tube development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08852

establishment of cell polarity

1 reference

8 April 2019

Pkd1 regulates lymphatic vascular morphogenesis during development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08852

spinal cord development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08852

metanephric collecting duct development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08852

liver development

1 reference

8 April 2019

A genetic interaction network of five genes for human polycystic kidney and liver diseases defines polycystin-1 as the central determinant of cyst formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08852

positive regulation of protein binding

1 reference

8 April 2019

Polycystin-1 and polycystin-2 regulate the cell cycle through the helix-loop-helix inhibitor Id2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08852

digestive tract development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08852

lung epithelium development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08852

branching morphogenesis of an epithelial tube

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08852

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08852

8 April 2019

Bardet-Biedl syndrome proteins 1 and 3 regulate the ciliary trafficking of polycystic kidney disease 1 protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08852

cartilage condensation

1 reference

8 April 2019

Cardiovascular, skeletal, and renal defects in mice with a targeted disruption of the Pkd1 gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08852

calcium ion transport

1 reference

8 April 2019

Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08852

skin development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08852

cell-cell adhesion

1 reference

8 April 2019

Polycystin 1 is required for the structural integrity of blood vessels

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08852

Wnt signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08852

1 reference

8 April 2019

positive regulation of cyclin-dependent protein serine/threonine kinase activity

1 reference

7 November 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O08852&geneProductId=UniProtKB:O08852

cell-cell signaling by wnt

1 reference

7 November 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O08852&geneProductId=UniProtKB:O08852

regulation of G1/S transition of mitotic cell cycle

1 reference

7 November 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O08852&geneProductId=UniProtKB:O08852

protein heterotetramerization

C-type lectin-like domain

1 reference

Leucine-rich repeat

1 reference

cysteine-rich flanking region, C-terminal

1 reference

PKD/chitinase domain

1 reference

polycystin cation channel, PKD1/PKD2

1 reference

polycystin-1 cation channel domain

1 reference

leucine-rich repeat, typical subtype

1 reference

GPS motif

1 reference

PLAT/LH2 domain

1 reference

carbohydrate-binding WSC

1 reference

PKD/REJ-like domain

1 reference

leucine-rich repeat N-terminal domain

1 reference

PKD domain

1 reference

REJ domain

1 reference