(Q14872812)

English

Ataxia telangiectasia mutated

mammalian protein found in Mus musculus

serine-protein kinase ATM
A-T mutated homolog
ataxia telangiectasia gene mutated in human beings
ataxia telangiectasia mutated homolog
Atm

In more languages

default for all languages

No label defined

No description defined

Statements

1 reference

25 May 2022

UniProt protein ID

1 reference

19 January 2017

UniProt protein ID

serine/threonine-protein kinase ATM

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q62388

Protein kinase-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q62388

Armadillo-type fold

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q62388

Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q62388

Phosphatidylinositol 3-/4-kinase, catalytic domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

PIK-related kinase, FAT family

1 reference

based on heuristic

inferred from protein domain or family

PIK-related kinase family

1 reference

based on heuristic

inferred from protein domain or family

FATC domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Telomere-length maintenance and DNA damage repair, protein family

1 reference

based on heuristic

inferred from protein domain or family

Phosphatidylinositol 3/4-kinase, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

transferase activity

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

nucleotide binding

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

protein kinase activity

determination method or standard

3 references

8 April 2019

NIMA-related protein kinase 1 is involved early in the ionizing radiation-induced DNA damage response

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

8 April 2019

DNA damage-induced activation of p53 by the checkpoint kinase Chk2

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

8 April 2019

Functional interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrest

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

protein N-terminus binding

determination method or standard

1-phosphatidylinositol-3-kinase activity

determination method or standard

protein serine/threonine kinase activity

determination method or standard

5 references

24 April 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62388&geneProductId=UniProtKB:Q62388

determination method or standard

24 April 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62388&geneProductId=UniProtKB:Q62388

determination method or standard

24 April 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62388&geneProductId=UniProtKB:Q62388

determination method or standard

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62388&geneProductId=UniProtKB:Q62388

determination method or standard

24 April 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62388&geneProductId=UniProtKB:Q62388

determination method or standard

protein binding

determination method or standard

1 reference

8 April 2019

The haploinsufficient tumor suppressor p18 upregulates p53 via interactions with ATM/ATR

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

kinase activity

determination method or standard

protein serine/threonine kinase activity

determination method or standard

6 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

DNA-dependent protein kinase activity

determination method or standard

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

protein-containing complex binding

determination method or standard

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

protein dimerization activity

determination method or standard

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

determination method or standard

1 reference

8 April 2019

Serine-threonine kinases and transcription factors active in signal transduction are detected at high levels of phosphorylation during mitosis in preimplantation embryos and trophoblast stem cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

cytoplasmic vesicle

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

determination method or standard

4 references

24 April 2018

NIMA-related protein kinase 1 is involved early in the ionizing radiation-induced DNA damage response

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62388&geneProductId=UniProtKB:Q62388

determination method or standard

24 April 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62388&geneProductId=UniProtKB:Q62388

determination method or standard

24 April 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62388&geneProductId=UniProtKB:Q62388

determination method or standard

24 April 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62388&geneProductId=UniProtKB:Q62388

determination method or standard

determination method or standard

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

determination method or standard

5 references

8 April 2019

NIMA-related protein kinase 1 is involved early in the ionizing radiation-induced DNA damage response

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

determination method or standard

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

determination method or standard

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

DNA repair complex

determination method or standard

1 reference

14 February 2019

The histone demethylase LSD1/KDM1A promotes the DNA damage response

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

biological process

determination method or standard

1 reference

8 April 2019

p53-Independent apoptosis disrupts early organogenesis in embryos lacking both ataxia-telangiectasia mutated and Prkdc

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

response to ionizing radiation

determination method or standard

6 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

8 April 2019

Analysis of the relationships between ATM and the Rad54 paralogs involved in homologous recombination repair

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

8 April 2019

Atm and Bax cooperate in ionizing radiation-induced apoptosis in the central nervous system

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

neuron apoptotic process

determination method or standard

1 reference

8 April 2019

Genetic interactions between ATM and the nonhomologous end-joining factors in genomic stability and development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

female gamete generation

determination method or standard

1 reference

8 April 2019

Distinct DNA-damage-dependent and -independent responses drive the loss of oocytes in recombination-defective mouse mutants

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

determination of adult lifespan

determination method or standard

1 reference

8 April 2019

Analysis of the relationships between ATM and the Rad54 paralogs involved in homologous recombination repair

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

phosphorylation

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

replicative senescence

determination method or standard

meiotic telomere clustering

determination method or standard

1 reference

8 April 2019

Mutations that affect meiosis in male mice influence the dynamics of the mid-preleptotene and bouquet stages

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

positive regulation of telomere maintenance via telomerase

determination method or standard

1 reference

8 April 2019

ATM Kinase Is Required for Telomere Elongation in Mouse and Human Cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

mitotic spindle assembly checkpoint signaling

determination method or standard

oocyte development

determination method or standard

1 reference

8 April 2019

Caspase-2 deficiency prevents programmed germ cell death resulting from cytokine insufficiency but not meiotic defects caused by loss of ataxia telangiectasia-mutated (Atm) gene function

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

cellular response to DNA damage stimulus

determination method or standard

5 references

24 April 2018

Defective neurogenesis resulting from DNA ligase IV deficiency requires Atm

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62388&geneProductId=UniProtKB:Q62388

determination method or standard

24 April 2018

PARP1-dependent recruitment of KDM4D histone demethylase to DNA damage sites promotes double-strand break repair

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62388&geneProductId=UniProtKB:Q62388

determination method or standard

24 April 2018

Analysis of the relationships between ATM and the Rad54 paralogs involved in homologous recombination repair

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62388&geneProductId=UniProtKB:Q62388

determination method or standard

24 April 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62388&geneProductId=UniProtKB:Q62388

determination method or standard

24 April 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62388&geneProductId=UniProtKB:Q62388

determination method or standard

lipoprotein catabolic process

determination method or standard

1 reference

8 April 2019

Heterozygous mutation of ataxia-telangiectasia mutated gene aggravates hypercholesterolemia in apoE-deficient mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

protein phosphorylation

determination method or standard

3 references

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

8 April 2019

Functional interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrest

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

heart development

determination method or standard

1 reference

8 April 2019

p53-Independent apoptosis disrupts early organogenesis in embryos lacking both ataxia-telangiectasia mutated and Prkdc

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

brain development

determination method or standard

1 reference

8 April 2019

p53-Independent apoptosis disrupts early organogenesis in embryos lacking both ataxia-telangiectasia mutated and Prkdc

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

double-strand break repair via homologous recombination

determination method or standard

1 reference

8 April 2019

Analysis of the relationships between ATM and the Rad54 paralogs involved in homologous recombination repair

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

intrinsic apoptotic signaling pathway in response to DNA damage

determination method or standard

3 references

24 April 2018

Selective utilization of nonhomologous end-joining and homologous recombination DNA repair pathways during nervous system development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62388&geneProductId=UniProtKB:Q62388

determination method or standard

24 April 2018

Defective neurogenesis resulting from DNA ligase IV deficiency requires Atm

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62388&geneProductId=UniProtKB:Q62388

determination method or standard

24 April 2018

BRCA2 is required for neurogenesis and suppression of medulloblastoma

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62388&geneProductId=UniProtKB:Q62388

determination method or standard

V(D)J recombination

determination method or standard

1 reference

8 April 2019

Functional intersection of ATM and DNA-dependent protein kinase catalytic subunit in coding end joining during V(D)J recombination

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

pre-B cell allelic exclusion

determination method or standard

1 reference

8 April 2019

RAG-1 and ATM coordinate monoallelic recombination and nuclear positioning of immunoglobulin loci

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

histone mRNA catabolic process

determination method or standard

apoptotic process

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

regulation of autophagy

determination method or standard

3 references

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

8 April 2019

Reactive nitrogen species regulate autophagy through ATM-AMPK-TSC2-mediated suppression of mTORC1

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

phosphatidylinositol-3-phosphate biosynthetic process

determination method or standard

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

negative regulation of TORC1 signaling

determination method or standard

3 references

24 April 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62388&geneProductId=UniProtKB:Q62388

determination method or standard

24 April 2018

Reactive nitrogen species regulate autophagy through ATM-AMPK-TSC2-mediated suppression of mTORC1

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62388&geneProductId=UniProtKB:Q62388

determination method or standard

24 April 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62388&geneProductId=UniProtKB:Q62388

determination method or standard

ovarian follicle development

determination method or standard

1 reference

8 April 2019

Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

immune system process

determination method or standard

1 reference

8 April 2019

Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

immunoglobulin production

determination method or standard

1 reference

8 April 2019

Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

DNA damage induced protein phosphorylation

determination method or standard

male meiotic nuclear division

determination method or standard

1 reference

8 April 2019

Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

female meiotic nuclear division

determination method or standard

1 reference

8 April 2019

Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

female gonad development

determination method or standard

1 reference

8 April 2019

Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

post-embryonic development

determination method or standard

1 reference

8 April 2019

Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

multicellular organism growth

determination method or standard

1 reference

8 April 2019

Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

protein autophosphorylation

determination method or standard

thymus development

determination method or standard

1 reference

8 April 2019

Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

chromosome organization involved in meiotic cell cycle

determination method or standard

1 reference

8 April 2019

Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

telomere maintenance

determination method or standard

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62388&geneProductId=UniProtKB:Q62388

determination method or standard

determination method or standard

4 references

8 April 2019

The mouse genomic instability mutation chaos1 is an allele of Polq that exhibits genetic interaction with Atm

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

8 April 2019

Accumulation of DNA damage and reduced levels of nicotine adenine dinucleotide in the brains of Atm-deficient mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

8 April 2019

Functional interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrest

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

positive regulation of neuron apoptotic process

determination method or standard

4 references

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

8 April 2019

Selective utilization of nonhomologous end-joining and homologous recombination DNA repair pathways during nervous system development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

8 April 2019

Atm and Bax cooperate in ionizing radiation-induced apoptosis in the central nervous system

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

DNA damage checkpoint signaling

determination method or standard

3 references

8 April 2019

DNA damage-induced G2/M checkpoint in SV40 large T antigen-immortalized embryonic fibroblast cells requires SHP-2 tyrosine phosphatase

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

response to hypoxia

determination method or standard

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

cellular response to DNA damage stimulus

determination method or standard

6 references

8 April 2019

Defective neurogenesis resulting from DNA ligase IV deficiency requires Atm

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

8 April 2019

PARP1-dependent recruitment of KDM4D histone demethylase to DNA damage sites promotes double-strand break repair

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

8 April 2019

Analysis of the relationships between ATM and the Rad54 paralogs involved in homologous recombination repair

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

intrinsic apoptotic signaling pathway in response to DNA damage

determination method or standard

4 references

8 April 2019

Defective neurogenesis resulting from DNA ligase IV deficiency requires Atm

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

8 April 2019

Selective utilization of nonhomologous end-joining and homologous recombination DNA repair pathways during nervous system development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

8 April 2019

BRCA2 is required for neurogenesis and suppression of medulloblastoma

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

positive regulation of gene expression

determination method or standard

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

peptidyl-serine phosphorylation

determination method or standard

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

positive regulation of cell migration

determination method or standard

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

negative regulation of B cell proliferation

determination method or standard

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

regulation of telomere maintenance via telomerase

determination method or standard

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

peptidyl-serine autophosphorylation

determination method or standard

1 reference

14 February 2019

PARP1-dependent recruitment of KDM4D histone demethylase to DNA damage sites promotes double-strand break repair

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

positive regulation of apoptotic process

determination method or standard

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

positive regulation of DNA damage response, signal transduction by p53 class mediator

determination method or standard

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

positive regulation of neuron apoptotic process

determination method or standard

3 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

14 February 2019

Atm and Bax cooperate in ionizing radiation-induced apoptosis in the central nervous system

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

14 February 2019

Selective utilization of nonhomologous end-joining and homologous recombination DNA repair pathways during nervous system development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

positive regulation of cell adhesion

determination method or standard

1 reference

8 April 2019

The ZFHX3 (ATBF1) transcription factor induces PDGFRB, which activates ATM in the cytoplasm to protect cerebellar neurons from oxidative stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

positive regulation of transcription by RNA polymerase II

determination method or standard

1 reference

8 April 2019

The ZFHX3 (ATBF1) transcription factor induces PDGFRB, which activates ATM in the cytoplasm to protect cerebellar neurons from oxidative stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

regulation of cell cycle

determination method or standard

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

cellular response to retinoic acid

determination method or standard

1 reference

8 April 2019

The ZFHX3 (ATBF1) transcription factor induces PDGFRB, which activates ATM in the cytoplasm to protect cerebellar neurons from oxidative stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

cellular response to gamma radiation

determination method or standard

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

cellular response to X-ray

determination method or standard

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

cellular response to nitrosative stress

determination method or standard

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

establishment of RNA localization to telomere

determination method or standard

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

positive regulation of neuron death

determination method or standard

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

positive regulation of DNA catabolic process

determination method or standard

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

regulation of microglial cell activation

determination method or standard

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

negative regulation of TORC1 signaling

determination method or standard

3 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

14 February 2019

Reactive nitrogen species regulate autophagy through ATM-AMPK-TSC2-mediated suppression of mTORC1

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

negative regulation of telomere capping

determination method or standard

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

positive regulation of telomere maintenance via telomere lengthening

determination method or standard

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

positive regulation of telomerase catalytic core complex assembly

determination method or standard

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

regulation of cellular response to gamma radiation

determination method or standard

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

positive regulation of response to DNA damage stimulus

determination method or standard

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

negative regulation of TORC1 signaling

determination method or standard

4 references

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

8 April 2019

Reactive nitrogen species regulate autophagy through ATM-AMPK-TSC2-mediated suppression of mTORC1

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388

determination method or standard

PIK-related kinase, FAT

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q62388

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q62388

PIK-related kinase

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q62388

Phosphatidylinositol 3-/4-kinase, catalytic domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q62388

Phosphatidylinositol 3/4-kinase, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q62388

Telomere-length maintenance and DNA damage repair

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q62388

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000113388

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000113388

ENSMUSP00000115394

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000115394

ENSMUSP00000118199

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000118199

ENSMUSP00000156344

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000156344

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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