Papers by Sebastian Palmqvist
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Alzheimer's Research & Therapy, 2014
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International Psychogeriatrics, 2014
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Alzheimer's & Dementia, 2014
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JAMA neurology, 2014
Before adding cerebrospinal fluid (CSF) biomarkers to the diagnostic workup of Alzheimer disease,... more Before adding cerebrospinal fluid (CSF) biomarkers to the diagnostic workup of Alzheimer disease, it needs to be determined whether CSF biomarkers analyzed in routine clinical practice can reliably predict cortical β-amyloid (Aβ) deposition. To study whether CSF biomarkers, analyzed consecutively in routine clinical practice during 2 years, can predict cortical Aβ deposition and to establish a threshold for Aβ42 abnormality. This cross-sectional study (The Swedish BioFINDER [Biomarkers For Identifying Neurodegenerative Disorders Early and Reliably] Study) was conducted at 3 memory clinics. It involved consecutively referred, nondemented patients with mild cognitive symptoms (original cohort, n = 118; validation cohort, n = 38). Amyloid positron emission tomography imaging with 18F-flutemetamol. Analyses of CSF Aβ42, total tau, and phosphorylated tau using an enzyme-linked immunosorbent assay (INNOTEST) in clinical samples. The agreement between Aβ classification with CSF Aβ42 and 18...
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JAMA psychiatry, 2014
Several studies suggest that the apolipoprotein E (APOE) ε4 allele modulates cerebrospinal fluid ... more Several studies suggest that the apolipoprotein E (APOE) ε4 allele modulates cerebrospinal fluid (CSF) levels of β-amyloid 42 (Aβ42). Whether this effect is secondary to the association of the APOE ε4 allele with cortical Aβ deposition or whether APOE ε4 directly influences CSF levels of Aβ42 independently of Aβ pathology remains unknown. To evaluate whether the APOE genotype affects the diagnostic accuracy of CSF biomarkers for Alzheimer disease (AD), in particular Aβ42 levels, and whether the association of APOE ε4 with CSF biomarkers depends on cortical Aβ status. We collected data from 4 different centers in Sweden, Finland, and Germany. Cohort A consisted of 1345 individuals aged 23 to 99 years with baseline CSF samples, including 309 with AD, 287 with prodromal AD, 399 with stable mild cognitive impairment, 99 with dementias other than AD, and 251 controls. Cohort B included 105 nondemented younger individuals (aged 20-34 years) with CSF samples available. Cohort C included 11...
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Dementia and Geriatric Cognitive Disorders Extra, 2013
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PLoS ONE, 2012
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International Journal of Geriatric Psychiatry, 2009
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Current Alzheimer Research, 2012
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Alzheimer's & Dementia, 2010
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Alzheimer's & Dementia, 2008
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Papers by Sebastian Palmqvist