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Radiotherapy for pediatric low-grade glioma
IntroductionRadiotherapy is a highly effective treatment for pediatric low-grade glioma, serving as the standard for evaluating progression-free and...
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Molecular markers for pediatric low-grade glioma
Over the past decade, our understanding of the molecular drivers of pediatric low-grade glioma (PLGG) has expanded dramatically. These tumors are...
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Predicting histological grade in pediatric glioma using multiparametric radiomics and conventional MRI features
Prediction of glioma is crucial to provide a precise treatment plan to optimize the prognosis of children with glioma. However, studies on the...
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Pediatric glioma histone H3.3 K27M/G34R mutations drive abnormalities in PML nuclear bodies
BackgroundPoint mutations in histone variant H3.3 (H3.3K27M, H3.3G34R) and the H3.3-specific ATRX/DAXX chaperone complex are frequent events in...
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Oncohistones and disrupted development in pediatric-type diffuse high-grade glioma
Recurrent, clonal somatic mutations in histone H3 are molecular hallmarks that distinguish the genetic mechanisms underlying pediatric and adult...
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How modern treatments have modified the role of surgery in pediatric low-grade glioma
Low-grade gliomas are the most common brain tumor of childhood, and complete resection offers a high likelihood of cure. However, in many instances,...
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Long-term quality of survival after pediatric low-grade glioma
BackgroundLow-grade glioma is the most common brain tumor in children with different modes of treatment and a high overall survival. Low-grade glioma...
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Pediatric diffuse intrinsic pontine glioma radiotherapy response prediction: MRI morphology and T2 intensity-based quantitative analyses
ObjectivesAn easy-to-implement MRI model for predicting partial response (PR) postradiotherapy for diffuse intrinsic pontine glioma (DIPG) is...
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Intramedullary pediatric low-grade glioma of the spine
PurposePediatric intramedullary spinal cord low-grade gliomas (pLGGs) are rare diagnoses among central nervous system (CNS) tumors in the pediatric...
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Second-look surgery in postoperative pediatric low-grade glioma
ObjectiveTo review the literature on second-look surgery in pediatric low-grade gliomas (LGG) with a view to presenting both sides of the picture of...
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Comprehensive profiling of stem-like features in pediatric glioma cell cultures and their relation to the subventricular zone
Pediatric high-grade gliomas (pHGG) are brain tumors occurring in children and adolescents associated with a dismal prognosis despite existing...
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Evaluation of chemotherapy-induced nausea and vomiting in pediatric patients with high-grade glioma treated with lomustine—a case series
PurposeAlthough lomustine has been used as a chemotherapeutic agent for decades, no recommendation on appropriate chemotherapy-induced nausea and...
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Awake craniotomy in pediatric low-grade glioma: barriers and future directions
IntroductionThe goal of surgical management in pediatric low-grade gliomas (pLGGs) is gross total resection (GTR), as it is considered curative with...
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Role of sodium fluorescein in pediatric low-grade glioma surgery: an update
PurposeComplete surgical resection is still the mainstay in the treatment of central nervous system low-grade tumors, eventually resulting curative....
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Salvage boron neutron capture therapy for pediatric patients with recurrent diffuse midline glioma
PurposePediatric diffuse malignant glioma located in the brainstem was officially named “diffuse midline glioma” (DMG) by the World Health...
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Letter to the Editor: “The relationship between imaging features, therapeutic response, and overall survival in pediatric diffuse intrinsic pontine glioma”
This letter to the editor discusses the findings of Yu et al. (2024), which highlight the prognostic significance of volumetric assessments over...
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The relationship between imaging features, therapeutic response, and overall survival in pediatric diffuse intrinsic pontine glioma
We aimed to evaluate the relationship between imaging features, therapeutic responses (comparative cross-product and volumetric measurements), and...
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The type II RAF inhibitor tovorafenib in relapsed/refractory pediatric low-grade glioma: the phase 2 FIREFLY-1 trial
BRAF genomic alterations are the most common oncogenic drivers in pediatric low-grade glioma (pLGG). Arm 1 ( n = 77) of the ongoing phase 2 FIREFLY-1...
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Pediatric-type diffuse low-grade glioma with T2-FLAIR mismatch sign: a case report and literature review
IntroductionPediatric-type diffuse low-grade gliomas are a new entity that was introduced in the fifth edition of the World Health Organization...
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Surgical treatment of pediatric low-grade glioma in developing countries
Pediatric low-grade gliomas constitute the most common brain tumors worldwide, though with some peculiarities in the presentation and surgical care...