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Molecular mechanisms governing antifungal drug resistance
Fungal pathogens are a severe public health problem. The leading causative agents of systemic fungal infections include species from the Candida , Cryptococcus...
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Exploring the Potential of Farnesol as a Novel Antifungal Drug and Related Challenges
Purpose of ReviewFarnesol (FOH) is a quorum-sensing molecule with potential as an antifungal drug. Given the growing concern about fungal drug...
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Systemic Antifungal Agents
Systemic antifungal drugs used to treat serious fungal disease fall chiefly into three drug classes—azoles, echinocandins, and polyenes. A fourth...
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Drug Target Elucidation Through Isolation and Analysis of Drug-Resistant Mutants in Cryptococcus neoformans
Drug target identification is an essential component to antifungal drug development. Many methods, including large chemical library screening,...
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New Antifungal Drugs: Discovery and Therapeutic Potential
There has been an increase in invasive fungal infections, which are a universal problem due to the longer average lifespan, the number of...
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Synthesis, structure-activity relationship and evaluation of antifungal activity of tryptanthrin derivatives against drug-resistant Candida albicans
With the increasing of Candida albicans infections year by year, and the widespread use of azole drugs, especially fluconazole has led to the...
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Isolation of antimicrobial ellagic acid from endophytic fungi and their target-specific drug design through computational docking
In recent decades, there has been a dramatic increase in fundamental microbial disease pervasiveness. The evolution of multi-drug resistant organisms...
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New Systemic Antifungal: Isavuconazole
Invasive fungal infections have been increasing with the increased use of immunosuppressive drugs for the treatment of cancer, organ, stem cell and...
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Hydroxychloroquine an Antimalarial Drug, Exhibits Potent Antifungal Efficacy Against Candida albicans Through Multitargeting
Candida albicans is the primary etiological agent associated with candidiasis in humans. Unrestricted growth of C. albicans can progress to systemic...
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Heterologous Expression of Candida Antifungal Target Genes in the Model Organism Saccharomyces cerevisiae
Understanding how a gene variant may influence antifungal resistance, or other phenotypic characteristics, is an important step in determining or...
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Exploiting response surface D-optimal design study for preparation and optimization of spanlastics loaded with miconazole nitrate as a model antifungal drug for topical application
PurposeSkin fungal infections are widely spreading worldwide and are considered a main cause of skin, mucous membranes, and systemic diseases. In an...
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Oxidative effects of the human antifungal drug clotrimazole on the eucaryotic model organism Saccharomyces cerevisiae
Clotrimazole is a type of antifungal medication developed from azole compounds. It exhibits several biological actions linked to oxidative stress....
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Advanced Vesicular Systems for Antifungal Drug Delivery
Fungal infections are considered one of the most serious conditions as their occurrence has increased lately. Fungi like Candida , Fusarium , and Aspergillus...
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A dual-targeting antifungal is effective against multidrug-resistant human fungal pathogens
Drug-resistant fungal infections pose a significant threat to human health. Dual-targeting compounds, which have multiple targets on a single...
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Antifungal Stewardship Interventions in Patients with Hematologic Malignancies
Purpose of ReviewAntifungal stewardship has been recognized as a significant component of any antimicrobial stewardship program. In this article, we...
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Evaluation of the efficacy of heat shock protein inhibitors and antifungal drug combinations against Candida spp.
Candida species are one of the predominant causes of fungal infections and show drug-resistant infections in immune-compromised individuals....
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Epidemiological trends, antifungal drug susceptibility and SQLE point mutations in etiologic species of human dermatophytosis in Al-Diwaneyah, Iraq
Dermatophytes show a wide geographic distribution and are the main causative agents of skin fungal infections in many regions of the world. Recently,...
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Nanoparticles assisted intra and transdermic delivery of antifungal ointment: an updated review
This review paper highlights the trans-dermic delivery of nanoparticles (NPs) based antifungal ointments with the help of nanotechnology. It also...
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Drug to genome to drug: a computational large-scale chemogenomics screening for novel drug candidates against sporotrichosis
Sporotrichosis is recognized as the predominant subcutaneous mycosis in South America, attributed to pathogenic species within the Sporothrix genus....
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Target identification of small molecules: an overview of the current applications in drug discovery
Target identification is an essential part of the drug discovery and development process, and its efficacy plays a crucial role in the success of any...
