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Prenatal MRI diagnosis of fetal cerebral tuberous sclerosis

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Abstract

Tuberous sclerosis (TS) is an autosomal dominant phakomatosis. A high percentage of spontaneous mutations leads to the diagnosis of new cases in normal families. This diagnosis is suspected at antenatal ultrasound on the discovery of multiple cardiac tumors. Antenatal cerebral ultrasound shows a normal appearance in affected fetuses. Eight fetuses with multiple cardiac tumors were studied with antenatal MRI with, in five cases, an abnormal appearance showing hyperintense subependymal and cortical nodules on TI-weighted images. Among the three remaining patients MRI was non-contributive in one due to movement artefact, one had abnormal postnatal MRI consistent with TS and one had a normal postnatal and clinical examination. We conclude that MRI is a valuable tool in making the diagnosis of TS in fetuses with multiple cardiac tumors.

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References

  1. Christophe C, Bartholome J, Blum D, et al (1989) Neonatal tuberous sclerosis: US, CT and MRI diagnosis of brain and cardiac lesions. Pediatr Radiol 6:446

    Google Scholar 

  2. Pont MS, Elster AD (1992) Lesions of skin and brain: modern imaging of the neurocutaneous syndromes. AJR 158:1193

    PubMed  Google Scholar 

  3. Seindenwurn DJ, Barkovich AJ (1992) Understanding tuberous sclerosis. Radiology 183:23

    PubMed  Google Scholar 

  4. Mirlesse V, Wener H, Jacquemard F, Perotez C, Daffos F, Sonigo P, Brunelle F (1992) Magnetic resonance imaging in antenatal diagnosis of tuberous sclerosis. Lancet 340:1163

    Google Scholar 

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Authors and Affiliations

  1. Department of Pediatric Imaging, Hôpital des Enfants-Malades, 149 rue de Sèvres, Paris, France

    P. Sonigo, A. Elmaleh & E. Brunelle

  2. Pediatric Cardiology Department, Institut de Puériculture, 26 boulevard Brune, Paris, France

    L. Fermont

  3. Fetal Pathology Department, Hôpital des Enfants-Malades, 149 rue de Sèvres, Paris, France

    A. -L. Delezoíde

  4. Fetal Medicine Unit, Institut de Puériculture, 26 boulevard Brune, Paris, France

    V. Mirlesse

Authors
  1. P. Sonigo
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  2. A. Elmaleh
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  3. E. Brunelle
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  4. L. Fermont
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  5. A. -L. Delezoíde
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  6. V. Mirlesse
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Sonigo, P., Elmaleh, A., Brunelle, E. et al. Prenatal MRI diagnosis of fetal cerebral tuberous sclerosis. Pediatr Radiol 26, 1–4 (1996). https://doi.org/10.1007/BF01403693

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  • DOI: https://doi.org/10.1007/BF01403693

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