Abstract
As resistance to conventional antibiotics among bacteria continues to increase, researchers are increasingly focusing on alternative strategies for preventing and treating bacterial infections, one of which is microbiota modulation. The objective of this review is to analyze the scientific literature on the immunomodulatory effects of probiotics in bacterial infections. This is an integrative review of the literature based on systematic steps, with searches performed in the databases Medline, PubMed, Scopus, Embase, and ScienceDirect. The most prevalent bacterial genera used to evaluate infectious processes were Salmonella, Escherichia, Klebsiella, and Streptococcus. Lactobacillus was the most commonly used probiotic genus, with Lactobacillus delbrueckii subsp. bulgaricus is the most frequently used species. In most studies, prophylactic treatment with concentrations of probiotics equal to or greater than 8 log CFU/mL was chosen. However, there was considerable heterogeneity in terms of effective treatment duration, indicating that the results cannot be generalized across all studies. This review found that probiotics interact with the immune system through different mechanisms and have a positive effect on preventing different types of bacterial infections.
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This research was financially supported by Technical Cooperation Agreement to Support the Development of the Brazilian Semi-Arid Region - FAPEMA/CAPES - ACT-05691/21, ACT 01784-21 and to Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brazil (CAPES) - Finance Code 001.
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All authors contributed to the study conception and design. The authors confirm contribution to the paper as follows: TGD: Theme idea, bibliographic survey and article writing; LSR: Table and figure construction, complete review of the manuscript; JRF: Substantial contributions to the conception or design of the work; ALF: Review and correction of the content discussed in the introduction; AGNF: Review and methodology correction, as well as assistance in the implementation of tools to assist in search of bibliographic; MSN: Review and critical analysis of the discussion; RPD: Review and elaboration of the guiding question; ASR: Critical analysis of results and correction of figures and tables; RNMG: Critical analysis of writing and coherence of the text; VMN: categorization of studies that emphasized the immunomodulatory potential of probiotics; MCGM: Critical review for intellectual content and final approval of the version to be published.
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Dias, T.G., Rodrigues, L.d.S., Farias, J.R. et al. Immunomodulatory Activity of Probiotics in Models of Bacterial Infections. Probiotics & Antimicro. Prot. 16, 862–874 (2024). https://doi.org/10.1007/s12602-023-10090-6
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DOI: https://doi.org/10.1007/s12602-023-10090-6