Abstract
The radio synthesis and in vivo evaluation of two α7 nAChRs radioligands [125I]CAIPE and [125I]IPPU were reported. They were obtained from their tributyltin precursors with high radio chemical yields (>90 %) and good radio chemical purities (>95 %). Biodistribution and blockade studies of [125I]CAIPE showed that the accumulation of radioactivity in the mouse brain was specific and selective.
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Acknowledgments
This work was financially supported by Natural Science Foundation of China (No. 21371026), Science and Technology Support Program (No. 2014BAA03B03), Sinificant New Drugs Development (Grant No. 2014ZX09507007).
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Wu, A., Li, X., Xue, Q. et al. Radio synthesis and in vivo evaluation of two α7 nAChRs radioligands: [125I]CAIPE and [125I]IPPU. J Radioanal Nucl Chem 307, 1345–1351 (2016). https://doi.org/10.1007/s10967-015-4235-x
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DOI: https://doi.org/10.1007/s10967-015-4235-x