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Radiological and biochemical effects (CTX-II, MMP-3, 8, and 13) of low-level laser therapy (LLLT) in chronic osteoarthritis in Al-Kharj, Saudi Arabia

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Abstract

Inflammation of synovial membrane and degeneration of articular cartilage in osteoarthritis (OA) lead to major changes in joint space width (JSW) and biochemical components such as collagen-II telopeptide (CTX-II) and matrix metallo protineases (MMP-3, 8, and 13). Low-level laser therapy (LLLT) is thought to have an analgesic effect as well as biomodulatory effect on microcirculation and cartilage regeneration in animal studies. The objective of this study was to examine the analgesic and biochemical effect of LLLT in patients with knee osteoarthritis. Subjects (n = 34) who fulfilled the selection criteria were randomly divided into active group (n = 17) and placebo group. Subjects in active group were irradiated laser with the frequency of 3 days per week for 4 weeks with the specific parameters on 8 different points on the joint at 1.5 J per point for 60 s for 8 points for a total dose of 12 J in a skin contact method. The placebo group was treated with the same probe with minimum emission of energy. Visual analog scale for pain intensity, joint space width, collagen-II telopeptide, and matrix metallo protinease-3, 8, and 13 was measured before treatment and at 4 and 8 weeks following treatment. Data are analyzed with mean values and standard deviation with p < 0.05. Baseline values of all outcome measures show insignificant difference (p > 0.05) in both groups which shows homogeneity. After 4- and 8-week treatment, active laser group shows more significant difference (p < 0.001) in all the parameters than the placebo laser group (p > 0.05). Our results show that low-level laser therapy was more efficient in reducing pain and improving cartilage thickness through biochemical changes.

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Acknowledgements

This study was supported financially by the Prince Sattam Bin Abdul Aziz University, AL-Kharj, Saudi Arabia. We are grateful for the support of the staff members of the physiotherapy department who provide us with the information necessary to perform this study and, finally, to all people who generously participated in this study.

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Authors and Affiliations

  1. Department of Physical Therapy and Health Rehabilitation, Prince Sattam Bin Abdul Aziz University, Al-Kharj, Saudi Arabia

    Gopal Nambi S, Walid Kamal & Julie George

  2. Radiology and Medical Imaging Department, Prince Sattam Bin Abdul Aziz University, Al-Kharj, Saudi Arabia

    Elbagir Manssor

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  1. Gopal Nambi S
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  2. Walid Kamal
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Correspondence to Gopal Nambi S.

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Funding source

Authors are grateful to the Deanship of scientific Research, Prince Sattam Bin Abdul Aziz University, Al-Kharj, Saudi Arabia for the financial support to carry out this project no 2015/01/4375.

Research funding program: Specialized Research Grant program (Health)

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The authors declare that they have no conflict of interest.

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S, G., Kamal, W., George, J. et al. Radiological and biochemical effects (CTX-II, MMP-3, 8, and 13) of low-level laser therapy (LLLT) in chronic osteoarthritis in Al-Kharj, Saudi Arabia. Lasers Med Sci 32, 297–303 (2017). https://doi.org/10.1007/s10103-016-2114-5

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  • DOI: https://doi.org/10.1007/s10103-016-2114-5

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