Abstract
Electrical ephaptic interactions between axons have the effect of modulating their conduction velocities and adjusting the frequency via synchronisation of action potentials. These interactions have been studied for unmyelinated axons, but have been generally disregarded for myelinated axons. However, the existence of this type of interactions in myelinated axons is expected to play a role in the transmission of signals along nerves. In this work, we run a simulation of propagation of action potentials using models of three parallel myelinated axons which interact with each other via the extracellular electrical field, and show how modifications in the conduction velocity and synchronisation occur.
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Raspopovic Stanisa, Capogrosso Marco, Micera Silvestro. A computational model for the stimulation of rat sciatic nerve using a transverse intrafascicular multichannel electrode Ieee Transactions On Neural Systems And Rehabilitation Engineering. 2011;19:333–344. (2011)
Schiefer Matthew A, Tyler Dustin J, Triolo Ronald J. Probabilistic modeling of selective stimulation of the human sciatic nerve with a flat interface nerve electrode Journal of computational neuroscience. 2012;33:179–190.
Katz Bernhard, Schmitt Otto H. Electric interaction between two adjacent nerve fibres The Journal of physiology. 1940;97:471.
Binczak S, Eilbeck JC, Scott Alwyn C. Ephaptic coupling of myelinated nerve fibers Physica D: Nonlinear Phenomena. 2001;148:159–174.
Reutskiy S, Rossoni Enrico, Tirozzi Brunello. Conduction in bundles of demyelinated nerve fibers: computer simulation Biological cybernetics. 2003;89:439–448.
Scott Alwyn C, Luzader Stephen D. Coupled solitary waves in neurophysics Physica Scripta. 1979;20:395.
Capllonch-Juan M, Kölbl F, Sepulveda F. Optimisation of the spatial discretisation of myelinated axon models 2016.
Brill MH, Waxman SG, Moore JW, Joyner RW. Conduction velocity and spike configuration in myelinated fibres: computed dependence on internode distance. Journal of Neurology, Neurosurgery & Psychiatry. 1977;40:769–774.
Hodgkin Alan L, Huxley Andrew F. A quantitative description of membrane current and its application to conduction and excitation in nerve The Journal of physiology. 1952;117:500.
Pettersen Klas H, Lindén Henrik, Dale Anders M, Einevoll Gaute T. Extracellular spikes and CSD Handbook of Neural Activity Measurement 2012;1:92–135.
Hines Michael L, Carnevale Nicholas T. The NEURON simulation environment Neural computation 1997;9:1179–1209.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2018 Springer Nature Singapore Pte Ltd.
About this paper
Cite this paper
Capllonch-Juan, M., Sepulveda, F. (2018). Conduction velocity effects due to ephaptic interactions between myelinated axons. In: Eskola, H., Väisänen, O., Viik, J., Hyttinen, J. (eds) EMBEC & NBC 2017. EMBEC NBC 2017 2017. IFMBE Proceedings, vol 65. Springer, Singapore. https://doi.org/10.1007/978-981-10-5122-7_165
Download citation
DOI: https://doi.org/10.1007/978-981-10-5122-7_165
Published:
Publisher Name: Springer, Singapore
Print ISBN: 978-981-10-5121-0
Online ISBN: 978-981-10-5122-7
eBook Packages: EngineeringEngineering (R0)