Abstract
The advent of chemotherapy brought dramatic improvements to the care of patients stricken with malignant bone tumors. Early experimentation with cytotoxic medications identified a number of agents with activity in both Ewing’s sarcoma and osteosarcoma. Survival rates in patients treated with these new agents improved five- to six-fold over the course of less than a decade. Therapies identified during the early years of chemotherapy continue to form the backbone upon which most modern regimens are built. Efforts to further improve outcomes have proved difficult. Modest, incremental gains have come only through experimentation involving large populations of patients made possible through the emergence of international cooperative groups. Advances in supportive care have facilitated the gradual intensification of treatment regimens both in terms of dose intensity and interval compression. Patients with refractory or metastatic disease continue to fare poorly. New approaches to the treatment of these patients are desperately needed.
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Roberts, R.D., Wedekind, M.F., Setty, B.A. (2015). Chemotherapy Regimens for Patients with Newly Diagnosed Malignant Bone Tumors. In: Cripe, T., Yeager, N. (eds) Malignant Pediatric Bone Tumors - Treatment & Management. Pediatric Oncology. Springer, Cham. https://doi.org/10.1007/978-3-319-18099-1_6
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