Abstract
Transient Receptor Potential (TRP) channels are activated by stimuli as diverse as heat, cold, noxious chemicals, mechanical forces, hormones, neurotransmitters, spices, and voltage. Besides their presumably similar general architecture, probably the only common factor regulating them is phosphoinositides. The regulation of TRP channels by phosphoinositides is complex. There are a large number of TRP channels where phosphatidylinositol 4,5 bisphosphate [PI(4,5)P2 or PIP2] acts as a positive cofactor, similarly to many other ion channels. In several cases, however, PI(4,5)P2 inhibits TRP channel activity, sometimes even concurrently with the activating effect. This chapter will provide a comprehensive overview of the literature on regulation of TRP channels by membrane phosphoinositides.
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Abbreviations
- AASt:
-
Arachydonyl-stearyl
- AKAP:
-
A-kinase anchoring protein
- DAG:
-
Diacylglycerol
- DGS-NTA:
-
1,2-dioleoyl-sn-glycero-3-[(N-(5-amino-1-carboxypentyl)iminodiacetic acid)succinyl]
- DRG:
-
Dorsal root ganglion
- ER:
-
Endoplasmic reticulum
- GPCR:
-
G Protein Coupled Receptor
- IP3 :
-
Inositol-1,4,5-trisphopshate
- Kir:
-
K+ inwardly rectifying
- PI:
-
Phosphatidylinositol
- PI(4)P:
-
Phosphatidylinositol 4-phosphate
- PI(4,5)P2 :
-
Phosphatidylinositol 4,5-bisphosphate
- PI4K:
-
Phosphatidylinositol 4-kinase
- PIP5K:
-
Phosphatidylinositol 4-phosphate 5-kinase
- PI3K:
-
Phosphoinositide 3-kinase
- PLC:
-
Phospholipase C
- PG:
-
Phosphatidyl glycerol
- PKC:
-
Protein Kinase C
- PH:
-
Pleckstrin-homology
- Pirt:
-
Phosphoinositide interacting regulator of TRP
- PM:
-
Plasma membrane
- TG:
-
Trigeminal ganglion
- TPC:
-
Two-pore channel
- TRP:
-
Transient Receptor Potential
- TRPA:
-
TRP Ankyrin
- TRPC:
-
TRP Classical
- TRPL:
-
TRP-like
- TRPM:
-
TRP Melastatin
- TRPML:
-
TRP Mucolipin
- TRPP:
-
TRP Polycystin
- TRPV:
-
TRP Vanilloid
- VSP:
-
Voltage sensitive phosphatase
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Rohacs, T. (2014). Phosphoinositide Regulation of TRP Channels. In: Nilius, B., Flockerzi, V. (eds) Mammalian Transient Receptor Potential (TRP) Cation Channels. Handbook of Experimental Pharmacology, vol 223. Springer, Cham. https://doi.org/10.1007/978-3-319-05161-1_18
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