[go: up one dir, main page]

Skip to main content

Urinary Tract Infections in the Elderly

  • Chapter
  • First Online:
Clinical Nephrogeriatrics

Abstract

Urinary tract infections (UTIs) are traditionally the most common type of infection in the elderly. The most important risk factor is the presence of coexisting chronic illnesses, foreign bodies (stone, catheter, prosthetic devices), polypharmacy, abnormalities of the renal tract (e.g., tumors, surgery, fistulae) and in renal function, and reduced self-hygiene. Escherichia coli (E. coli) is the most commonly identified organism, and the clinical spectrum ranges from asymptomatic bacteriuria, symptomatic uncomplicated or complicated UTI (benign cystitis to pyelonephritis), recurrent UTIs, to sepsis associated with UTI requiring hospitalization. The prevalence of UTI in older adults is expected to grow, necessitating diagnostic, therapeutic, and preventive amelioration in order to improve the well-being of older adults.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Subscribe and save

Springer+ Basic
$34.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or eBook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 79.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 99.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Similar content being viewed by others

References

  1. Wagenlehner F, Wullt B, Ballarini S, Zingg D, Naber KG. Social and economic burden of recurrent urinary tract infections and quality of life: a patient web-based study (GESPRIT). Expert Rev Pharmacoecon Outcomes Res. 2018;18(1):107–17. https://doi.org/10.1080/14737167.2017.1359543.

    Article  PubMed  Google Scholar 

  2. Tal S, Guller V, Levi S, Bardenstein R, Berger D, Gurevich I, Gurevich A. Profile and prognosis of febrile elderly patients with bacteremic urinary tract infection. J Inf Secur. 2005;50(4):296–305. PMID:15998090

    Google Scholar 

  3. Koch AM, Eriksen HM, Elstrøm P, Aavitsland P, Harthug S. Severe consequences of healthcare-associated infections among residents of nursing homes: a cohort study. J Hosp Infect. 2009;71(3):269–74. https://doi.org/10.1016/j.jhin.2008.10.032. PMID:19147254

    Article  CAS  PubMed  Google Scholar 

  4. Garibaldi RA, Brodine S, Matsumiya S. Infections among patients in nursing homes: policies, prevalence, problems. N Engl J Med. 1981;305(13):731–5. PMID:7266615

    Article  CAS  Google Scholar 

  5. Nicolle LE, SHEA Long-Term-Care-Committee. Urinary tract infections in long-term-care facilities. Infect Control Hosp Epidemiol. 2001;22(3):167–75. PMID:11310697

    Article  CAS  Google Scholar 

  6. Matthews SJ, Lancaster JW. Urinary tract infections in the elderly population. Am J Geriatr Pharmacother. 2011;9(5):286309. https://doi.org/10.1016/j.amjopharm.2011.07.002. PMID:21840265

    Article  Google Scholar 

  7. Jackson SL, Boyko EJ, Scholes D, Abraham L, Gupta K, Fihn SD. Predictors of urinary tract infection after menopause: a prospective study. Am J Med. 2004;117(12):903–11. PMID:15629728

    Article  Google Scholar 

  8. Caljouw MA, den Elzen WP, Cools HJ, Gussekloo J. Predictive factors of urinary tract infections among the oldest old in the general population. A population-based prospective follow-up study. BMC Med. 2011;9:57. https://doi.org/10.1186/1741-7015-9-57. PMID:21575195

    Article  PubMed  PubMed Central  Google Scholar 

  9. Griebling TL. Urologic diseases in america project: trends in resource use for urinary tract infections in men. J Urol. 2005;173(4):1288–94. PMID:15758784

    Article  Google Scholar 

  10. Rosello A, Pouwels KB, Domenech DE Cellès M, van Kleef E, Hayward AC, Hopkins S, Robotham JV, Smieszek T, Opatowski L, Deeny SR. Seasonality of urinary tract infections in the United Kingdom in different age groups: longitudinal analysis of The Health Improvement Network (THIN). Epidemiol Infect. 2018;146(1):37–45. https://doi.org/10.1017/S095026881700259X.

    Article  CAS  PubMed  Google Scholar 

  11. Durso SC. Oxford American handbook of geriatric medicine. Oxford University Press. 2010; p. 654–62.

    Google Scholar 

  12. High KP. Infection in the elderly. In: Halter JB, Ouslander JG, Tinetti ME, Studenski S, High KP, Ashana S, editors. Hazzard’s geriatric medicine and gerontology. 6th ed. New York: McGraw-Hill; 2009. p. 333–67.

    Google Scholar 

  13. Nicolle LE. Urinary tract infection in geriatric and institutionalized patients. Curr Opin Urol. 2002;12(1):51–5. PMID:11753134

    Article  Google Scholar 

  14. Nicolle LE. Urinary tract infection in long-term-care facility residents. Clin Infect Dis. 2000;31(3):757–61. PMID:11017826

    Article  CAS  Google Scholar 

  15. Escobar C, Bhatia S, Wajnberg A. Urinary tract infection. In: Hayashi J, Leff B, editors. Geriatric home-based medical care. Switzerland: Springer International Publishing; 2016. p. 174–81.

    Google Scholar 

  16. Rogers MA, Fries BE, Kaufman SR, Mody L, McMahon LF Jr, Saint S. Mobility and other predictors of hospitalization for urinary tract infection: a retrospective cohort study. BMC Geriatr. 2008;8:31. https://doi.org/10.1186/1471-2318-8-31. PMID:19032784

    Article  PubMed  PubMed Central  Google Scholar 

  17. Juthani-Mehta M, Quagliarello VJ. Infectious diseases in the nursing home setting: challenges and opportunities for clinical investigation. Clin Infect Dis. 2010;51(8):931–6. https://doi.org/10.1086/656411. PMID:20822459

    Article  PubMed  PubMed Central  Google Scholar 

  18. Nicolle LE. Urinary tract pathogens in complicated infection and in elderly individuals. J Infect Dis. 2001;183(Suppl 1):S5–8. PMID:11171003

    Article  Google Scholar 

  19. Girard R, Gaujard S, Pergay V, Pornon P, Martin-Gaujard G, Bourguignon L, UTIC Group. Risk factors for urinary tract infections in geriatric hospitals. J Hosp Infect. 2017;97(1):74–8. https://doi.org/10.1016/j.jhin.2017.05.007.

    Article  CAS  PubMed  Google Scholar 

  20. Moore EE, Hawes SE, Scholes D, Boyko EJ, Hughes JP, Fihn SD. Sexual intercourse and risk of symptomatic urinary tract infection in post-menopausal women. J Gen Intern Med. 2008;23(5):595–9. https://doi.org/10.1007/s11606-008-0535-y. PMID:18266044

    Article  PubMed  PubMed Central  Google Scholar 

  21. Zaffanello M, Malerba G, Cataldi L, Antoniazzi F, Franchini M, Monti E, Fanos V. Genetic risk for recurrent urinary tract infections in humans: a systematic review. J Biomed Biotechnol. 2010;2010:321082. https://doi.org/10.1155/2010/321082. PMID:20379347

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  22. Renko M, Tapanainen P, Tossavainen P, Pokka T, Uhari M. Meta-analysis of the significance of asymptomatic bacteriuria in diabetes. Diabetes Care. 2011;34(1):230–5. https://doi.org/10.2337/dc10-0421. PMID:20937688

    Article  PubMed  Google Scholar 

  23. Nicolle LE, Bradley S, Colgan R, Rice JC, Schaeffer A, Hooton TM, Infectious Diseases Society of America, American Society of Nephrology, American Geriatric Society. Infectious Diseases Society of America guidelines for the diagnosis and treatment of asymptomatic bacteriuria in adults. Clin Infect Dis. 2005;40(5):643–54. PMID:15714408

    Article  Google Scholar 

  24. Nicolle LE. Urinary tract infections in the elderly. Clin Geriatr Med. 2009;25(3):423–36. https://doi.org/10.1016/j.cger.2009.04.005. PMID:19765490

    Article  CAS  PubMed  Google Scholar 

  25. Allan WR, Kumar A. Prophylactic mezlocillin for transurethral prostatectomy. Br J Urol. 1985;57(1):46–9.

    Article  CAS  Google Scholar 

  26. Thölking G, Schuette-Nuetgen K, Vogl T, Dobrindt U, Kahl BC, Brand M, et al. Male kidney allograft recipients at risk for urinary tract infection? PLoS One. 2017;12(11):e0188262. https://doi.org/10.1371/journal.pone.0188262.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  27. Katsarolis I, Poulakou G, Athanasia S, Kourea-Kremastinou J, Lambri N, Karaiskos E, Collaborative Study Group on Antibiotic Resistance in Community-acquired Urinary Tract Infections, et al. Acute uncomplicated cystitis: from surveillance data to a rationale for empirical treatment. Int J Antimicrob Agents. 2010;35(1):62–7. https://doi.org/10.1016/j.ijantimicag. PMID:19906513

    Article  CAS  PubMed  Google Scholar 

  28. Czaja CA, Scholes D, Hooton TM, Stamm WE. Population-based epidemiologic analysis of acute pyelonephritis. Clin Infect Dis. 2007;45(3):273–80. PMID:17599303

    Article  Google Scholar 

  29. Chen Y, Nitzan O, Saliba W, Chazan B, Colodner R, Raz R. Are blood cultures necessary in the management of women with complicated pyelonephritis? J Infect. 2006;53(4):235–40. PMID:16434102

    Article  Google Scholar 

  30. van Nieuwkoop C, van’t Wout JW, Spelt IC, Becker M, Kuijper EJ, Blom JW, Assendelft WJ, van Dissel JT. Prospective cohort study of acute pyelonephritis in adults: safety of triage towards home based oral antimicrobial treatment. J Inf Secur. 2010;60(2):114–21. https://doi.org/10.1016/j.jinf.2009.11.008.

    Article  Google Scholar 

  31. Kofteridis DP, Papadimitraki E, Mantadakis E, Maraki S, Papadakis JA, Tzifa G, Samonis G. Effect of diabetes mellitus on the clinical and microbiological features of hospitalized elderly patients with acute pyelonephritis. J Am Geriatr Soc. 2009;57(11):2125–8. https://doi.org/10.1111/j.1532-5415.2009.02550.x. PMID: 20121956

    Article  PubMed  Google Scholar 

  32. Marques LP, Flores JT, Barros Junior Ode O, Rodrigues GB, Mourão Cde M, Moreira RM. Epidemiological and clinical aspects of urinary tract infection in community-dwelling elderly women. Braz J Infect Dis. 2012;16(5):436–41. https://doi.org/10.1016/j.bjid.2012.06.025.

    Article  PubMed  Google Scholar 

  33. Nicolle LE. Resistant pathogens in urinary tract infections. J Am Geriatr Soc. 2002;50(7 Suppl):S230–5. PMID:12121518

    Article  Google Scholar 

  34. Nicolle LE. Asymptomatic bacteriuria in the elderly. Infect Dis Clin N Am. 1997;11(3):647–62.

    Article  CAS  Google Scholar 

  35. Artero A, Esparcia A, Alberola J, Madrazo M, Nogueira JM, Eiros JM. Prospective cohort study of risk factors for extended-spectrum ß-lactamase-producing Escherichia coli urinary tract infections in elderly patients admitted to hospital. Int J Clin Pract. 2017;71(9). doi: https://doi.org/10.1111/ijcp.13001.

    Article  Google Scholar 

  36. Gorelik Y, Paul M, Geffen Y, Khamaisi M. Urinary tract infections due to Nontyphoidal salmonella. Am J Med Sci. 2017;353(6):529–32. https://doi.org/10.1016/j.amjms.2017.03.010.

    Article  PubMed  Google Scholar 

  37. Fagan M, Lindbæk M, Grude N, Reiso H, Romøren M, Skaare D, et al. Antibiotic resistance patterns of bacteria causing urinary tract infections in the elderly living in nursing homes versus the elderly living at home: an observational study. BMC Geriatr. 2015;15:98. https://doi.org/10.1186/s12877-015-0097-x. PMID:26238248

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  38. Delcaru C, Podgoreanu P, Alexandru I,Popescu N, Măruţescu L, Bleotu C, et al. Antibiotic resistance and virulence phenotypes of recent bacterial strains isolated from urinary tract infections in elderly patients with prostatic disease. Pathogens. 2017;6(2):22. pii: E22. https://doi.org/10.3390/pathogens6020022.

    Article  Google Scholar 

  39. Tenke P, Kovacs B, Jäckel M, Nagy E. The role of biofilm infection in urology. World J Urol. 2006;24(1):13–20. PMID:16402262

    Article  CAS  Google Scholar 

  40. Kunin CM. Blockage of urinary catheters: role of microorganisms and constituents of the urine on formation of encrustations. J Clin Epidemiol. 1989;42(9):835–42. PMID:2778465

    Article  CAS  Google Scholar 

  41. Tambyah PA, Maki DG. Catheter-associated urinary tract infection is rarely symptomatic: a prospective study of 1,497 catheterized patients. Arch Intern Med. 2000;160(5):678–82. PMID: 10724054

    CAS  PubMed  Google Scholar 

  42. Tambyah PA, Halvorson KT, Maki DG. A prospective study of pathogenesis of catheter-associated urinary tract infections. Mayo Clin Proc. 1999;74(2):131–6. PMID: 10069349

    Article  CAS  Google Scholar 

  43. Matsukawa M, Kunishima Y, Takahashi S, Takeyama K, Tsukamoto T. Bacterial colonization on intraluminal surface of urethral catheter. Urology. 2005;65(3):440–4. PMID:15780351

    Article  Google Scholar 

  44. Tenke P, Köves B, Johansen TE. An update on prevention and treatment of catheter-associated urinary tract infections. Curr Opin Infect Dis. 2014;27(1):102–7. https://doi.org/10.1097/QCO.0000000000000031. PMID: 24345923

    Article  PubMed  Google Scholar 

  45. Mody L, Juthani-Mehta M. Urinary tract infections in older women: a clinical review. JAMA. 2014;311(8):844–54. https://doi.org/10.1001/jama.2014.303.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  46. Monane M, Gurwitz JH, Lipsitz LA, Glynn RJ, Choodnovskiy I, Avorn J. Epidemiologic and diagnostic aspects of bacteriuria: a longitudinal study in older women. J Am Geriatr Soc. 1995;43(6):618–22. PMID:7775718

    Article  CAS  Google Scholar 

  47. Zhanel GG, Nicolle LE, Harding GK. Prevalence of asymptomatic bacteriuria and associated host factors in women with diabetes mellitus. The Manitoba Diabetic Urinary Infection Study Group. Clin Infect Dis. 1995;21(2):316–22. PMID:8562738

    Article  CAS  Google Scholar 

  48. Köves B, Cai T, Veeratterapillay R, Pickard R, Seisen T, Lam TB, et al. Benefits and harms of treatment of asymptomatic bacteriuria: a systematic review and meta-analysis by the European Association of Urology urological infection guidelines panel. Eur Urol. 2017;72(6):865–8. https://doi.org/10.1016/j.eururo.2017.07.014.

    Article  PubMed  Google Scholar 

  49. Loeb M, Bentley DW, Bradley S, Crossley K, Garibaldi R, Gantz N, et al. Development of minimum criteria for the initiation of antibiotics in residents of long-term-care facilities: results of a consensus conference. Infect Control Hosp Epidemiol. 2001;22(2):120–4.

    Article  CAS  Google Scholar 

  50. Stone ND, Ashraf MS, Calder J, Crnich CJ, Crossley K, Drinka PJ, Society for Healthcare Epidemiology Long-Term Care Special Interest Group, et al. Surveillance definitions of infections in long-term care facilities: revisiting the McGeer criteria. Infect Control Hosp Epidemiol. 2012;33(10):965–77. https://doi.org/10.1086/667743. PMID:22961014

    Article  PubMed  PubMed Central  Google Scholar 

  51. Rowe TA, Juthani-Mehta M. Diagnosis and management of urinary tract infection in older adults. Infect Dis Clin N Am. 2014;28(1):75–89. https://doi.org/10.1016/j.idc.2013.10.004. PMID: 24484576

    Article  Google Scholar 

  52. Lipsky BA. Urinary tract infections in men. Epidemiology, pathophysiology, diagnosis, and treatment. Ann Intern Med. 1989;110(2):138–50. PMID: 2462391

    Article  CAS  Google Scholar 

  53. Beveridge LA, Davey PG, Phillips G, McMurdo ME. Optimal management of urinary tract infections in older people. Clin Interv Aging. 2011;6:173–80. https://doi.org/10.2147/CIA.S13423.

    Article  PubMed  PubMed Central  Google Scholar 

  54. Hooton TM, Bradley SF, Cardenas DD, Colgan R, Geerlings SE, Rice JC, Infectious Diseases Society of America, et al. Diagnosis, prevention, and treatment of catheter-associated urinary tract infection in adults: 2009 International Clinical Practice Guidelines from the Infectious Diseases Society of America. Clin Infect Dis. 2010;50(5):625–63. PMID:20175247

    Article  Google Scholar 

  55. Ryan S, Gillespie E, Stuart RL. Urinary tract infection surveillance in residential aged care. Am J Infect Control. 2018;46(1):67–72. https://doi.org/10.1016/j.ajic.2017.07.002.

    Article  PubMed  Google Scholar 

  56. Eriksson I, Gustafson Y, Fagerström L, Olofsson B. Do urinary tract infections affect morale among very old women? Health Qual Life Outcomes. 2010;8:73. https://doi.org/10.1186/1477-7525-8-73. PMID: 20650004

    Article  PubMed  PubMed Central  Google Scholar 

  57. Litman HJ, Steers WD, Wei JT, Kupelian V, Link CL, McKinlay JB, Boston Area Community Health Survey Investigators. Relationship of lifestyle and clinical factors to lower urinary tract symptoms: results from Boston Area Community Health survey. Urology. 2007;70(5):916–21. PMID:17919693. https://doi.org/10.1016/j.urology.2007.06.1117.

    Article  PubMed  PubMed Central  Google Scholar 

  58. McGeer A, Campbell B, Emori TG, Hierholzer WJ, Jackson MM, Nicolle LE, et al. Definitions of infection for surveillance in long-term care facilities. Am J Infect Control. 1991;19(1):1–7. PMID:1902352

    Article  CAS  Google Scholar 

  59. Wilson ML, Gaido L. Laboratory diagnosis of urinary tract infections in adult patients. Clin Infect Dis. 2004;38(8):1150–8. PMID: 15095222

    Article  Google Scholar 

  60. Rahn DD, Boreham MK, Allen KE, Nihira MA, Schaffer JI. Predicting bacteriuria in urogynecology patients. Am J Obstet Gynecol. 2005;192(5):1376–8.

    Article  Google Scholar 

  61. Shimoni Z, Glick J, Hermush V, Froom P. Sensitivity of the dipstick in detecting bacteremic urinary tract infections in elderly hospitalized patients. PLoS One. 2017;12(10):e0187381. https://doi.org/10.1371/journal.pone.0187381.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  62. Holm A, Cordoba G, Møller Sørensen T, Rem Jessen L, Frimodt-Møller N, Siersma V. Effect of point-of-care susceptibility testing in general practice on appropriate prescription of antibiotics for patients with uncomplicated urinary tract infection: a diagnostic randomised controlled trial. BMJ Open. 2017;7(10):e018028. https://doi.org/10.1136/bmjopen-2017-018028.

    Article  PubMed  PubMed Central  Google Scholar 

  63. Juthani-Mehta M, Tinetti M, Perrelli E, Towle V, Quagliarello V. Role of dipstick testing in the evaluation of urinary tract infection in nursing home residents. Infect Control Hosp Epidemiol. 2007;28(7):889–91. PMID:17564998

    Article  Google Scholar 

  64. Sundvall PD, Gunnarsson RK. Evaluation of dipstick analysis among elderly residents to detect bacteriuria: a cross-sectional study in 32 nursing homes. BMC Geriatr. 2009;9:32. https://doi.org/10.1186/1471-2318-9-32. PMID:19635163

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  65. Christiaens TC, De Meyere M, Verschraegen G, Peersman W, Heytens S, De Maeseneer JM. Randomised controlled trial of nitrofurantoin versus placebo in the treatment of uncomplicated urinary tract infection in adult women. Br J Gen Pract. 2002;52(482):729–34. PMID:12236276

    CAS  PubMed  PubMed Central  Google Scholar 

  66. Ferry SA, Holm SE, Stenlund H, Lundholm R, Monsen TJ. Clinical and bacteriological outcome of different doses and duration of pivmecillinam compared with placebo therapy of uncomplicated lower urinary tract infection in women: the LUTIW project. Scand J Prim Health Care. 2007;25(1):49–57. PMID:17354160. https://doi.org/10.1080/02813430601183074.

    Article  PubMed  PubMed Central  Google Scholar 

  67. Delirium HJ. In: Cooper N, Forrest K, Mulley G, editors. ABC of geriatric medicine. Oxford: Blackwell Publishing Ltd; 2009. p. 11–5.

    Google Scholar 

  68. Detweiler K, Mayers D, Fletcher SG. Bacteruria and urinary tract infections in the elderly. Urol Clin N Am. 2015;42(4):561–8. https://doi.org/10.1016/j.ucl.2015.07.002.

    Article  Google Scholar 

  69. Scottish Intercollegiate Guidelines Network [SIGN]. Management of suspected bacterial urinary tract infection in adults: a national clinical guideline. SIGN; 2006. Available at: www.sign.ac.uk.

  70. HPA. Diagnosis of UTI. Quick reference guide for primary care; 2009. Available at: http://www.hpa.or.uk/web/HPAwebfile/HPAweb(C/1194947330877

  71. High KP, Bradley SF, Gravenstein S, Mehr DR, Quagliarello VJ, Richards C, Infectious Diseases Society of America, et al. Clinical practice guideline for the evaluation of fever and infection in older adult residents of long-term care facilities: 2008 update by the Infectious Diseases Society of America. J Am Geriatr Soc. 2009;57(3):375–94. https://doi.org/10.1111/j.1532-5415.2009.02175.x. PMID:19278394

    Article  PubMed  Google Scholar 

  72. Baillargeon J, Holmes HM, Lin YL, Raji MA, Sharma G, Kuo YF. Concurrent use of warfarin and antibiotics and the risk of bleeding in older adults. Am J Med. 2012;125(2):183–9. https://doi.org/10.1016/j.amjmed.2011.08.014. PMID:22269622

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  73. Ahmed A, Stephens JC, Kaus CA, Fay WP. Impact of preemptive warfarin dose reduction on anticoagulation after initiation of trimethoprim-sulfamethoxazole or levofloxacin. J Thromb Thrombolysis. 2008;26(1):44–8. PMID:17985084

    Article  CAS  Google Scholar 

  74. Vicariotto F. Effectiveness of an association of a cranberry dry extract, D-mannose, and the two microorganisms Lactobacillus plantarum LP01 and Lactobacillus paracasei LPC09 in women affected by cystitis: a pilot study. J Clin Gastroenterol. 2014;48(Suppl 1):S96–101. https://doi.org/10.1097/MCG.0000000000000224.

    Article  CAS  PubMed  Google Scholar 

  75. McMurdo ME, Argo I, Phillips G, Daly F, Davey P. Cranberry or trimethoprim for the prevention of recurrent urinary tract infections? A randomized controlled trial in older women. J Antimicrob Chemother. 2009;63(2):389–95. https://doi.org/10.1093/jac/dkn489. PMID:19042940

    Article  CAS  PubMed  Google Scholar 

  76. Jepson RG, Williams G, Craig JC. Cranberries for preventing urinary tract infections. Cochrane Database Syst Rev. 2012;10:CD001321. https://doi.org/10.1002/14651858.CD001321.pub5. PMID:23076891

    Article  PubMed  Google Scholar 

  77. Gupta K, Chou MY, Howell A, Wobbe C, Grady R, Stapleton AE. Cranberry products inhibit adherence of p-fimbriated Escherichia coli to primary cultured bladder and vaginal epithelial cells. J Urol. 2007;177(6):2357–60. PMID:17509358

    Article  CAS  Google Scholar 

  78. Howell AB, Vorsa N, Der Marderosian A, Foo LY. Inhibition of the adherence of P-fimbriated Escherichia coli to uroepithelial-cell surfaces by proanthocyanidin extracts from cranberries. N Engl J Med. 1998;339(15):1085–6.

    Article  CAS  Google Scholar 

  79. Committee on Safety of Medicines and the Medicines and Healthcare products Regulatory Agency. Interactions between warfarin and cranberry juice: new advice. MHRA/CSM current problems in pharmacovigilance. 2004;30:10. Available at: http://www.mhra.gov.uk/Howweregulate/Medicines/Herbalmedicines/HerbalSafetyNews/Currentsafetyissues/con1004343

  80. Mydock-McGrane LK, Cusumano ZT, Janetka JW. Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease. Expert Opin Ther Pat. 2016;26(2):175–97. https://doi.org/10.1517/13543776.2016.1131266.

    Article  CAS  PubMed  Google Scholar 

  81. Altarac S, Papeš D. Use of D-mannose in prophylaxis of recurrent urinary tract infections (UTIs) in women. BJU Int. 2014;113(1):9–10. https://doi.org/10.1111/bju.12492.

    Article  PubMed  Google Scholar 

  82. Kranjčec B, Papeš D, Altarac S. D-mannose powder for prophylaxis of recurrent urinary tract infections in women: a randomized clinical trial. World J Urol. 2014;32(1):79–84. https://doi.org/10.1007/s00345-013-1091-6.

    Article  CAS  PubMed  Google Scholar 

  83. Lee BB, Simpson JM, Craig JC, Bhuta T. Methenamine hippurate for preventing urinary tract infections. Cochrane Database Syst Rev. 2007;(4):CD003265. Review. Update in: Cochrane Database Syst Rev. 2012;10:CD003265.PMID:17943785.

    Google Scholar 

  84. Kasanen A, Junnila SY, Kaarsalo E, Hajba A, Sundquist H. Secondary prevention of recurrent urinary tract infections. Comparison of the effect of placebo, methenamine hippurate, nitrofurantoin and trimethoprim alone. Scand J Infect Dis. 1982;14(4):293–6.

    Article  CAS  Google Scholar 

  85. Cronberg S, Welin CO, Henriksson L, Hellsten S, Persson KM, Stenberg P. Prevention of recurrent acute cystitis by methenamine hippurate: double blind controlled crossover long term study. Br Med J (Clin Res Ed). 1987;294(6586):1507–8. PMID:3111615

    Article  CAS  Google Scholar 

  86. Eriksen B. A randomized, open, parallel-group study on the preventive effect of an estradiol-releasing vaginal ring (Estring) on recurrent urinary tract infections in postmenopausal women. Am J Obstet Gynecol. 1999;180(5):1072–9. PMID:10329858

    Article  CAS  Google Scholar 

  87. Perrotta C, Aznar M, Mejia R, Albert X, Ng CW. Oestrogens for preventing recurrent urinary tract infection in postmenopausal women. Cochrane Database Syst Rev. 2008;2:CD005131. https://doi.org/10.1002/14651858.CD005131.pub2. PMID:18425910

  88. Morton SC, Shekelle PG, Adams JL, Bennett C, Dobkin BH, Montgomerie J, Vickrey BG. Antimicrobial prophylaxis for urinary tract infection in persons with spinal cord dysfunction. Arch Phys Med Rehabil. 2002;83(1):129–38. PMID:11782843

    Article  Google Scholar 

  89. Rutschmann OT, Zwahlen A. Use of norfloxacin for prevention of symptomatic urinary tract infection in chronically catheterized patients. Eur J Clin Microbiol Infect Dis. 1995;14(5):441–4.

    Article  CAS  Google Scholar 

  90. Mohler JL, Cowen DL, Flanigan RC. Suppression and treatment of urinary tract infection in patients with an intermittently catheterized neurogenic bladder. J Urol. 1987;138(2):336–40. PMID:3496470

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Eirini Grapsa .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2019 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Pipili, C., Grapsa, E. (2019). Urinary Tract Infections in the Elderly. In: Musso, C., Jauregui, J., Macías-Núñez, J., Covic, A. (eds) Clinical Nephrogeriatrics. Springer, Cham. https://doi.org/10.1007/978-3-030-18711-8_6

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-18711-8_6

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-18710-1

  • Online ISBN: 978-3-030-18711-8

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics