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Viral Infections and Diabetes

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Diabetes

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 771))

Abstract

Type 1 diabetes mellitus (T1DM) is a multi-factorial autoimmune disease determined by the interaction of genetic, environmental and immunologic factors. One of the environmental risk factors identified by a series of independent studies is represented by viral infection, with strong evidence showing that viruses can indeed infect pancreatic β cells with consequent effects ranging from functional damage to cell death.

In this chapter we review the data obtained both in man and in experimental animal models in support of the potential participation of viral infections to Type 1 diabetes pathogenesis, with a particular emphasis on virus-triggered islet inflammation, β-cell dysfunction and autoimmunity.

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Authors and Affiliations

  1. Department of Internal Medicine, Endocrine and Metabolic Sciences and Biochemistry, University of Siena, Siena, Italy

    Letizia Galleri, Guido Sebastiani, Fabio Arturo Grieco, Isabella Spagnuolo & Francesco Dotta

  2. Fondazione Umberto Di Mario ONLUS, Siena, Italy

    Letizia Galleri, Guido Sebastiani, Francesco Vendrame, Fabio Arturo Grieco, Isabella Spagnuolo & Francesco Dotta

  3. Diabetes Research Institute, University of Miami, Miami, Florida, USA

    Francesco Vendrame

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  1. Letizia Galleri
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  2. Guido Sebastiani
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  3. Francesco Vendrame
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  4. Fabio Arturo Grieco
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  5. Isabella Spagnuolo
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  6. Francesco Dotta
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Correspondence to Francesco Dotta .

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Editors and Affiliations

  1. School of Science and Technology, Nottingham Trent University, Nottingham, UK

    Shamim I. Ahmad BSc, MSc, PhD

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Galleri, L., Sebastiani, G., Vendrame, F., Grieco, F.A., Spagnuolo, I., Dotta, F. (2013). Viral Infections and Diabetes. In: Ahmad, S.I. (eds) Diabetes. Advances in Experimental Medicine and Biology, vol 771. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-5441-0_20

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