Karolinska Institutet
Department of Clinical Neuroscience
Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders affecting women of fertile age. The aim was to study whether PCOS has an effect on sexual functioning. Women meeting the Rotterdam criteria for PCOS (n=49),... more
In this study, we evaluated the in vivo characteristics of a new monoamine oxidase type B (MAO-B) radioligand, [18F]fluorodeprenyl, by positron emission tomography (PET) in two cynomolgus monkeys. The brain uptake of [18F]fluorodeprenyl... more
(S)-5-bromo-N-[(1-cyclopropylmethyl-2-pyrrolidinyl)methyl]-2,3-dimethoxybenzamide (4) has pico-molar in vitro binding affinity to D(2) receptor (K(i) (D(2))=0.003 nM) with lower affinity to D(3) receptor (K(i) (D(3))=0.22 nM). In this... more
The objective of this study was to synthesize and evaluate a novel fluorine-18 labeled deuterium substituted analogue of rasagiline (9, [(18)F]fluororasagiline-D2) as a potential PET radioligand for studies of monoamine oxidase B (MAO-B).... more
Imaging the 18-kDa translocator protein (TSPO) is considered a potential tool for in vivo evaluation of microglial activation and neuroinflammation in the early stages of... more
The aim in this project was to synthesize and to study fluorine-18 labeled analogues of l-deprenyl which bind selectively to the enzyme monoamine oxidase B (MAO-B). Three fluorinated l-deprenyl analogues have been generated in multistep... more
Page 1. CHAPTER 26 SYNTHESIS OF [carbonyl-11C]WAY-100635 JAN D. ANDERSSON AND SANGRAM NAG ... ACKNOWLEDGMENTS We thank Drs. Ryuji Nakao, Anna Sumic, Arsalan Amir, and Guennadi Jogolev for their valuable support. ...
- by Sangram Nag