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Karen Hambly
  • School of Sport and Exercise Sciences
    University of Kent
    Medway Building
    Chatham Maritime
    Kent ME4 4AG
    UK
  • +44 (0) 1634 888805
Cartilage rehabilitation presents many challenges for clinicians, therapists and patients. The core principles underpinning cartilage rehabilitation are those at the foundation of all musculoskeletal rehabilitation encompassing anatomy,... more
Cartilage rehabilitation presents many challenges for clinicians, therapists and patients. The core principles underpinning cartilage rehabilitation are those at the foundation of all musculoskeletal rehabilitation encompassing anatomy, biomechanics, assessment, therapeutic exercise, treatment modalities and outcome evaluation. 1 To effectively apply these principles to cartilage rehabilitation a working knowledge and understanding of the response of articular cartilage to injury and surgery is essential. Historically, cartilage rehabilitation guidelines have been time criterion based and as the durability and resilience of repair tissue was not fully established they inclined to be conservative. 2 The focus on the rehabilitation tended to be heavily weighted towards the protection of the repair tissue, often, it could be argued at the expense of other aspects critical to function and optimal long-term recovery. In the last decade there has been a drive for a change of culture and a...
ABSTRACT BACKGROUND: Ultrasound imaging (USI) has been shown to be a valid method to investigate the morphology of the thoracolumbar fascia (TLF) [1]. A USI-based study has demonstrated that the TLF of subjects with chronic lower back... more
ABSTRACT BACKGROUND: Ultrasound imaging (USI) has been shown to be a valid method to investigate the morphology of the thoracolumbar fascia (TLF) [1]. A USI-based study has demonstrated that the TLF of subjects with chronic lower back pain (LBP) is on average 25% thicker and more disorganised compared to a control group [1]. The aim of this study is to explore inter-observer agreement between a range of clinicians on (dis)organisation of TLF in ultrasound images. There are currently no validated methods for the evaluation of USI of TLF. METHODS: Design: an exploratory analysis using a fully crossed design of inter-observer agreement. This study was approved by the University of Kent's School of Sport and Exercise Sciences Research and Ethics Committee (Prop. 163 – 2013). Participants: Thirty observers consisting of 21 (70%) Medical Doctors, 7 (23%) physiotherapists and 2 (6%) radiologists, with a combined total average of 13 years of clinical experience (± SD 9.4). 57% had no experience in USI, 36% had experience ranging from monthly to daily evaluations of USI, no observers had experience in evaluating USI of TLF. Protocol: A subset of thirty ultrasound scans of TLF were randomly selected from a data set of 308 scans of subjects with and without LBP (from a larger study conducted by the first author). All scans were anonymised and displayed on a desktop computer, or projected on a screen. All observers viewed and rated each of the 30 scans independently on a Likert-type scale from 1(very disorganised) to 10 (very organised). Inter-observer agreement was assessed using a two-way mixed, consistency, average measures intra-class correlation (ICC), the Cronbach's Alpha, to assess consistency among observers. The Krippendorff's Alpha (Kalpha) [2] reliability estimate was used to assess agreement. RESULTS: The resulting ICC was in the excellent range, ICC = 0.98, indicating that observers had a high degree of consistency, suggesting that (dis)organisation was rated similarly across observers. Observers without USI experience scored an ICC = 0.96, observers with USI experience scored an ICC = 0.95, again both in the excellent range. In this small cohort, experience in USI does not appear to impact on consistency. The Krippendorff's ordinal alpha α was .621, indicating a modest degree of agreement.
Articular cartilage injury is observed with increasing frequency in both elite and amateur athletes and results from the significant acute and chronic joint stress associated with impact sports. Left untreated, articular cartilage defects... more
Articular cartilage injury is observed with increasing frequency in both elite and amateur athletes and results from the significant acute and chronic joint stress associated with impact sports. Left untreated, articular cartilage defects can lead to chronic joint degeneration and athletic and functional disability. Treatment of articular cartilage defects in the athletic population presents a therapeutic challenge due to the high mechanical demands of athletic activity. Several articular cartilage repair techniques have been shown to successfully restore articular cartilage surfaces and allow athletes to return to high-impact sports. Postoperative rehabilitation is a critical component of the treatment process for athletic articular cartilage injury and should take into consideration the biology of the cartilage repair technique, cartilage defect characteristics, and each athlete's sport-specific demands to optimize functional outcome. Systematic, stepwise rehabilitation with criteria-based progression is recommended for an individualized rehabilitation of each athlete not only to achieve initial return to sport at the preinjury level but also to continue sports participation and reduce risk for reinjury or joint degeneration under the high mechanical demands of athletic activity.
Research Interests:
Autologous chondrocyte implantation (ACI) is a tissue-engineered surgical technique initially developed for articular cartilage repair of isolated chondral lesions of the knee. Third-generation techniques (ACI3) are now available that... more
Autologous chondrocyte implantation (ACI) is a tissue-engineered surgical technique initially developed for articular cartilage repair of isolated chondral lesions of the knee. Third-generation techniques (ACI3) are now available that deliver autologous cultured chondrocytes into the defect using cell scaffolds. The successful outcomes of these techniques have some dependency on presurgical and postsurgical patient rehabilitation. To determine if the standard of reporting for rehabilitation has improved in ACI3 studies; previous reviews in this field recommended describing the detail of this rehabilitation and patient compliance as integral elements. A computerized search was performed in March 2013. Criteria for inclusion were any studies that evaluated or described the process of ACI3 in the knee and subsequent rehabilitation. The modified Coleman Methodology Score (CMS) was used to rate the standard of reporting of rehabilitation and surgical procedures; review articles were also...
Background: The use of the Internet for seekers of health-related information provides convenience and accessibility to diverse sources (of variable quality) for many medical conditions. There is a suggestion that patients may find... more
Background: The use of the Internet for seekers of health-related information provides convenience and accessibility to diverse sources (of variable quality) for many medical conditions. There is a suggestion that patients may find empowerment by engaging with Internet health care strategies and communities. The profile of consumers of online health information on knee pain has not been explored.
Objective: Our objective was to identify the characteristics and motivations of online health information-seekers accessing the online health community, KNEEguru (KG). The study was designed to obtain the respondents’ sociodemographic profile, together with their main reasons and motivations for joining such a community, their health information-seeking behavior, the extent of their knee problems, and their general Internet usage.
Methods: We undertook an online questionnaire survey, offered to users of the KG website from June to July 2012. A mix of open and closed questions was used to facilitate inductive enquiry. Quantitative responses were analyzed using univariate analysis; qualitative thematic analysis of the open responses was completed and a conceptual model was developed.
Results: One-hundred and fifty-two respondents took part (11.56% response rate, 152/1315), with a mean age of 40.1 years. Of this cohort, 61.2% were female, 68.4% were in domestic partnerships, 57.2% were employed, 75.0% had higher education qualifications, and 80.3% were of white/Caucasian ethnicity. Females were associated with joining KG in order to get emotional support from other users (OR 2.11, 95% CI 1.04 - 4.27, P=.04). Respondents’ self-perception of health was associated with reported quality of life (OR 10.86, 95% CI 3.85 - 30.43, P<.001). Facebook users were associated with joining KG to share experiences (OR 2.34, 95% CI 1.04 - 5.56, P=.03). Post-surgery respondents were associated with joining KG to compare symptoms with other users (OR 7.31, 95% CI 2.06 - 39.82, P<.001). Three key themes were induced: condition, emotion and support. Respondents expressed distress and frustration at uncertainty of prognosis around various knee conditions, with some users preferring to initially observe rather than engage. Conversely, a strong desire to inform and support other community members was stated with reciprocation of ideas and experiences. KG was conceptualized as a filter that takes an individual’s condition and emotional response to that condition as basis for support; this filter facilitated validation as the outcome of engagement.
Conclusions: This study, in line with wider literature, suggests that users of an online knee-specific community are typically female, middle-aged, white/Caucasian, married, employed, and have attained a level of higher education. These users demonstrate a pragmatic approach to health care information with altruistic motivations and a desire to share experiences as a means of validation. This finding emphasizes a means of promoting efficient and appropriate online health care, and demonstrates the benefits of the Internet as a viable complement to clinical engagement.
Research Interests:
Unloading knee braces often are used aftertibiofemoral articular cartilage repair. However, theexperimental basis for their use in patients with normaltibiofemoral alignment such as those undergoing cartilagerepair is lacking.
Using a criteria-based approach, clinical symptoms are used to individually guide the progress of the athlete through rehabilitation. Pain and particularly joint effusion following the rehabilitation exercise should be avoided as they can... more
Using a criteria-based approach, clinical symptoms are used to individually guide the progress of the athlete through rehabilitation. Pain and particularly joint effusion following the rehabilitation exercise should be avoided as they can lead to quadriceps inhibition with its negative effect on neuromuscular joint control, joint biomechanics and resultant increase in joint reaction force in the area of the cartilage repair.
Background: Novel smartphone applications are potential alternatives to the long arm goniometer (LAG) but have not undergone evaluation. Purpose: To establish the level of agreement between a novel smartphone application and a LAG for the... more
Background: Novel smartphone applications are potential alternatives to the long arm goniometer (LAG) but have not undergone evaluation. Purpose: To establish the level of agreement between a novel smartphone application and a LAG for the assessment of knee flexion by an inexperienced tester. Methods: Ninety-six healthy participants (mean age 31 years±11) were recruited.
Background: Participation in football can put both male and female players at an increased risk for knee osteoarthritis. There is a higher prevalence of focal chondral defects in the knee of athletes compared to non-athletes. The... more
Background:
Participation in football can put both male and female players at an increased risk for knee osteoarthritis. There is a higher prevalence of focal chondral defects in the knee of athletes compared to non-athletes. The management of chondral defects in the football player is complex and multifactorial.

Objective:
The aim of this paper is to provide an overview of the current strategies for rehabilitation after articular cartilage repair of the knee in the football player. 

Design:
A review of current literature and the scientific evidence for rehabilitation after articular cartilage repair of the knee.

Conclusions:
Articular cartilage repair has been shown to allow return to sport but rehabilitation timescales are lengthy. Successful rehabilitation for a return to football after articular cartilage repair of the knee requires the player to be able to accept the load of the sport. This necessitates a multidisciplinary approach to rehabilitation especially in the transition from therapy to performance care. It should be recognised that not all players will return to football after articular cartilage repair. The evidence base for rehabilitative practice after articular cartilage repair is increasing but remains sparse in areas.

Key words:
Rehabilitation; articular cartilage repair; knee
Background: Articular cartilage repair (ACR) procedures aim to alleviate pain and restore function for individuals with chondral defects. Rehabilitation is lengthy, and there are limited data on return to sports and exercise activities... more
Background: Articular cartilage repair (ACR) procedures aim to alleviate pain and restore function for individuals with chondral defects. Rehabilitation is lengthy, and there are limited data on return to sports and exercise activities after ACR in non-elite-athlete populations. The Internet is a growing source of health-related information for patients, and it has resulted in the emergence of online health communities.

Purpose: To establish a postoperative activity profile of users of an online health community who have undergone ACR of the knee and to compare this profile with those from the same community who have undergone initial anterior cruciate ligament reconstruction (ACLR).

Study Design: Cross-sectional.

Methods: Tegner Activity Scale ratings were collected via a self-reported online questionnaire from 201 participants of an online health community who had undergone tibiofemoral and/or patellofemoral ACR (n = 75) or ACLR (n = 126).

Results: A higher Tegner activity level was significantly correlated to time from surgery for ACR (P < 0.005) and ACLR (P < 0.01). At a minimum of 24 months’ follow-up, the ACR group had a median postoperative Tegner score of 3, compared with 6 for the ACLR group. Tegner score was significantly negatively correlated with age at time of surgery for ACLR (P < 0.05) but not for ACR. Men demonstrated significantly higher Tegner activity levels than did women for both ACLR and ACR (P < 0.05).

Conclusions: Activity levels after ACR in this population increased with postoperative time but remained lower than expected when compared with current published clinical and normative data.

Clinical Relevance: Engagement with an online health community may influence expectations regarding return to sports and exercise activities. Reporting of activity-level data within clinical studies should be differentiated on the basis of sex. Further research is needed to elucidate factors that determine return to sports and exercise activities after ACR.
PURPOSE: The Tegner Activity Scale (TAS) was developed in 1984 and has been widely used in studies on knee populations. The primary objective of this study was to undertake a systematic review on the use of the TAS for articular cartilage... more
PURPOSE: The Tegner Activity Scale (TAS) was developed in 1984 and has been widely used in studies on knee populations. The primary objective of this study was to undertake a systematic review on the use of the TAS for articular cartilage repair (ACR) of the knee.

METHODS: A systematic review was conducted using electronic databases (MEDLINE, CINAHL, SPORTDiscus™, NHS Evidence, ISI Web of Knowledge, AMED, BNI, PEDro and The Cochrane Collaboration of Systematic Reviews) and reference lists from extracted articles. Studies were selected that were published between 1984 and 2009 in which the TAS was reported for patients who had undergone ACR of the knee.

RESULTS: The search strategy identified 442 citations of which 34 articles met the inclusion criteria. There was a large degree of study heterogeneity especially regarding data reporting a wide variation in the number of participants (range 5-137), participant age (range 12-76 years), follow-up time (range 3-120 months) and male-to-female participant ratio. Where pre- to postoperative TAS change was analysed, 88% of studies demonstrated a significant improvement in postoperative TAS scores.

CONCLUSIONS: In general, TAS data were inconsistently reported and methodological detail was often lacking. Caution is advised in the interpretation of TAS scores following ACR of the knee where there are large ranges in postoperative follow-up times, mixed gender cohorts and wide ranges in participant ages. TAS data should be presented and analysed fully and ideally in a standardised fashion to facilitate the comparison of outcomes between studies.
Autologous chondrocyte implantation is an advanced, cell-based orthobiological technology used for the treatment of chondral defects of the knee. It has been in clinical use since 1987 and has been performed on 12 000 patients... more
Autologous chondrocyte implantation is an advanced, cell-based orthobiological technology used for the treatment of chondral defects of the knee. It has been in clinical use since 1987 and has been performed on 12 000 patients internationally; but despite having been in clinical use for more than 15 years, the evidence base for rehabilitation after autologous chondrocyte implanta- tion is notably deficient. The authors review current clinical practice and present an overview of the principles behind autologous chondrocyte implantation rehabilitation practices. They examine the main rehabilitation components and discuss their practical applications within the overall treatment program, with the aim of facilitating the formulation of appropriate, individualized patient rehabilitation protocols for autologous chondrocyte implantation.
Background: The relevance of knee-specific subjective measures of outcome to patients has not been evaluated for cartilage repair procedures. Purpose: The aim of this study was to identify which instrument out of the Knee injury... more
Background: The relevance of knee-specific subjective measures of outcome to patients has not been evaluated for cartilage repair procedures.
Purpose: The aim of this study was to identify which instrument out of the Knee injury Osteoarthritis Outcome Score and the International Knee Documentation Committee Subjective Knee Form measures symptoms and disabilities most important to postoperative articular cartilage repair patients.
Study Design: Cross-sectional study; Level of evidence, 3.
Methods: Data were collected from 58 participants of an Internet knee forum via a self-reported online questionnaire consisting of demographic and surgical data, the Tegner activity scale, and 49 consolidated items from the Knee injury Osteoarthritis Outcome Score and the International Knee Documentation Committee Subjective Knee Form. Item importance, frequency, and frequency-importance product were calculated.
Results: Overall, the International Knee Documentation Committee Subjective Knee Form was the highest scoring instrument in all categories. However, 2 of the Knee injury Osteoarthritis Outcome Score subscales (“function in sport and recreation” and “knee-related quality of life”) scored higher on mean importance and frequency-importance product than the overall International Knee Documentation Committee Subjective Knee Form score.
Conclusion: The International Knee Documentation Committee Subjective Knee Form provided the best overall measure of symp- toms and disabilities that are most important to this population of postoperative articular cartilage repair patients. This brings into question the validity of using the Knee injury Osteoarthritis Outcome Score in shorter-term—less than 10 years—studies. Issues related to sports activity appear to be highly valued and very pertinent to evaluation of outcomes for this patient group.
Background: Knee-specific patient-reported outcome measures are frequently used after anterior cruciate ligament reconstruction but little is known about whether they measure outcomes important to patients. Purpose: The aim of this study... more
Background: Knee-specific patient-reported outcome measures are frequently used after anterior cruciate ligament reconstruction but little is known about whether they measure outcomes important to patients.
Purpose: The aim of this study was to identify which instrument, the Knee injury and Osteoarthritis Outcome Score (KOOS) or the International Knee Documentation Committee Subjective Knee Form (IKDC), captures symptoms and disabilities most important to patients who have undergone initial anterior cruciate ligament reconstruction.
Study Design: Cross-sectional study; Level of evidence, 3.
Methods: Data were collected from 126 participants of an Internet knee forum. A self-reported online questionnaire was developed consisting of demographic and surgical data, the Tegner Activity Scale, and 49 consolidated items from the KOOS and the IKDC. Item importance, frequency, and frequency-importance product were calculated.
Results: Seventy-eight percent of the items from the IKDC were experienced by more than half of the patients, compared with 57% from the KOOS. Items extracted from the Function in Sports/Recreation and Quality of Life KOOS subscales were highly important to this group of patients. For patients 12 months or more after anterior cruciate ligament reconstruction, 94% of the IKDC items had a frequency-importance product of 1 or less compared with 86% of the KOOS items.
Conclusion: Overall, the IKDC items outperformed the KOOS items on all of the 5 criteria with the exception of the frequency- importance product for patients who were 12 months after anterior cruciate ligament reconstruction. The KOOS Function in Sports/Recreation and Knee-Related Quality of Life subscales outperformed the IKDC for the total cohort as well as for male and female subgroups. However, differences in individual items were not always evident from either total scale or subscale ratings. Studies should use patient-reported outcomes that reflect patients’ most important concerns and further prospective longitudinal research is required in this area.
Keywords: Knee injury and Osteoarthritis Outcome Score (KOOS); International Knee Documentation Committee Subjective Knee Form (IKDC); outcome measures; anterior cruciate ligament (ACL) reconstruction; knee ligament; patient-reported outcome
Background: Articular cartilage injury in the athlete’s knee presents a difficult clinical challenge. Despite the importance of return- ing injured athletes to sports, information is limited on whether full sports participation can be... more
Background: Articular cartilage injury in the athlete’s knee presents a difficult clinical challenge. Despite the importance of return- ing injured athletes to sports, information is limited on whether full sports participation can be successfully achieved after articular cartilage repair in the knee.
Hypothesis: Systematic analysis of athletic participation after articular cartilage repair will demonstrate the efficacy of joint sur- face restoration in high-demand patients and help to optimize outcomes in athletes with articular cartilage injury of the knee.
Study Design: Systematic review.
Methods: A comprehensive literature review of original studies was performed to provide information about athletic participation after articular cartilage repair. The athlete’s ability to perform sports postoperatively was assessed by activity outcome scores, rate of return to sport, timing of the return, level of postoperative sports participation, and the continuation of athletic activity over time.
Results: Twenty studies describing 1363 patients were included in the review, with an average follow-up of 42 months. Return to sports was possible in 73% overall, with highest return rates after osteochondral autograft transplantation. Time to return to sports varied between 7 and 18 months, depending on the cartilage repair technique. Initial return to sports at the preinjury level was possible in 68% and did not significantly vary between surgical techniques. Continued sports participation at the preinjury level was possible in 65%, with the best durability after autologous chondrocyte transplantation. Several factors affected the abil- ity to return to sport: athlete’s age, preoperative duration of symptoms, level of play, lesion size, and repair tissue morphology.
Conclusion: Articular cartilage repair in the athletic population allows for a high rate of return to sports, often at the preinjury level. Return to sports participation is influenced by several independent factors. The findings provide pertinent information that is help- ful for the clinical decision-making process and for the management of the athlete’s postoperative expectations.
Keywords: sport; athletics; cartilage; articular; injury; repair; resurfacing; chondroplasty; knee
*Karen Hambly, PT, MCSP, Centre for Sports Studies, University of Kent, Chatham, Kent ME4 4AG, United Kingdom (e-mail: k.hambly{at}kent.ac.uk). ... Background: Knee-specific patient-reported outcome measures are frequently used after... more
*Karen Hambly, PT, MCSP, Centre for Sports Studies, University of Kent, Chatham, Kent ME4 4AG, United Kingdom (e-mail: k.hambly{at}kent.ac.uk). ... Background: Knee-specific patient-reported outcome measures are frequently used after anterior cruciate ligament ...
Hambly, Karen and Van Assche, Dieter and Wondrasch, Barbara and Bobic, Vladimir and Marlovits, Stefan (2006) Current status and prospects for rehabilitation following cell-based cartilage repair. In: Basic science and clinical repair of... more
Hambly, Karen and Van Assche, Dieter and Wondrasch, Barbara and Bobic, Vladimir and Marlovits, Stefan (2006) Current status and prospects for rehabilitation following cell-based cartilage repair. In: Basic science and clinical repair of articular cartilage defects: Current status ...
... Divisions: Faculties &amp;gt; Social Sciences &amp;gt; School of Sports Studies. ID Code: 26285. Deposited by: Karen Hambly. Deposited on: 21 Jan 2011 17:05. Last Modified: 21 Jan 2011 17:05. Repository staff only: item control page.... more
... Divisions: Faculties &amp;gt; Social Sciences &amp;gt; School of Sports Studies. ID Code: 26285. Deposited by: Karen Hambly. Deposited on: 21 Jan 2011 17:05. Last Modified: 21 Jan 2011 17:05. Repository staff only: item control page. ...
... Divisions: Faculties &amp;amp;gt; Social Sciences &amp;amp;gt; School of Sports Studies. ID Code: 26284. Deposited by: Karen Hambly. Deposited on: 21 Jan 2011 17:02. Last Modified: 21 Jan 2011 17:02. Repository staff only: item... more
... Divisions: Faculties &amp;amp;gt; Social Sciences &amp;amp;gt; School of Sports Studies. ID Code: 26284. Deposited by: Karen Hambly. Deposited on: 21 Jan 2011 17:02. Last Modified: 21 Jan 2011 17:02. Repository staff only: item control page. ...
Cartilage Surgery: An Operative Manual by Mats Brittberg, MD and Wayne Gersoff, MD is your guide to applying the most recent advances in cartilage repair, and performing cutting-edge surgical procedures. An internationally diverse... more
Cartilage Surgery: An Operative Manual by Mats Brittberg, MD and Wayne Gersoff, MD is your guide to applying the most recent advances in cartilage repair, and performing cutting-edge surgical procedures. An internationally diverse collection of authors offers a global perspective on timely topics such as cartilage biologics. Clinical pearls, operative video clips, and detailed, full-color intraoperative photographs offer step-by-step guidance on essential techniques. You can access the full content and videos online at expertconsult. ...
Osteoarthritis (OA) is not an inevitable consequence of human aging but age-associated sarcopenia is. Loss of strength in healthy men and women begins around the fourth decade initially proceeding at a rate of loss of around 1% per year... more
Osteoarthritis (OA) is not an inevitable consequence of human aging but age-associated sarcopenia is. Loss of strength in healthy men and women begins around the fourth decade initially proceeding at a rate of loss of around 1% per year before accelerating from the seventh decade ...
... Divisions: Faculties &amp;gt; Social Sciences &amp;gt; School of Sports Studies. ID Code: 26287. Deposited by: Karen Hambly. Deposited on: 21 Jan 2011 17:09. Last Modified: 21 Jan 2011 17:09. Repository staff only: item control page.... more
... Divisions: Faculties &amp;gt; Social Sciences &amp;gt; School of Sports Studies. ID Code: 26287. Deposited by: Karen Hambly. Deposited on: 21 Jan 2011 17:09. Last Modified: 21 Jan 2011 17:09. Repository staff only: item control page. ...