A novel method to assess protein behavior in extreme environments on the proteome scale shows that proteins with more voids can be more resistant to deformation under high pressure.

Spontaneous rotations of epithelial spheres reveals chiral tissue patterning mechanisms, showing the interplay between geometry, topology, and collective dynamics.

Interactions between drug-resistant mutants and their evolutionary ancestors in the absence of treatment can significantly impact treatment efficacy. This explains pre-existing drug resistance in non-small cell lung cancer, providing new insights for treatment strategies.

In this study, the authors describe the phase diagram of an ecological system with demographic noise, heterogeneous interactions, and migration, showing how mutualism can spontaneously emerge.

In this study, RNA-mediated allosteric protein regulation is proposed as a key mechanism driving viral capsid formation, revealing how single mutations can disrupt viral assembly and identifying new targets for antiviral treatments.

In this work, authors introduce a dynamic vertex model incorporating strain-induced tension remodeling and mechanical memory dissipation to explain topological transitions commonly observed in epithelial tissues.

Drawing from the physics of self-propelled particles, the authors introduce a macroscopic model to describe their experiments on ants’ cooperative transport. They connected this to previous coupled-carrier models, bridging the gap from micro to macro scales.

This study unveils a molecular model for DNA replication control in cells at different growth conditions. It tackles the long-standing challenge of how bacteria manage DNA initiation with constant protein concentrations, achieving very precise control of their size.

In this study, the authors utilize optogenetic tools to achieve precise in vivo manipulation of actomyosin, allowing them to investigate the effects of its activation and deactivation on tissue behavior during early development in Drosophila.

This study employs the thermodynamic uncertainty relation to explore the connection between energy dissipation and mesoscopic fluctuations in sperm beating, elucidating the role of the coupling among molecular motors that actuate the flagellar movement.