Theory and Discussion time fellas -
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(1.) I think the Emerine Golems will assist in the killing of the zombie menace in Mythshore. I believe this is a possible route. I think we will befriend Father Golem, telling him about impending danger towards him because of his 'heart'. He will send you on quests or something, you gain his trust, then he helps by clearing out Mythshore because they cannot get spectral fever, and possibly occupying the town. Sending his sons to learn more about life, outside of protecting him, them getting more individuality. Emerine boyfriend when? Literally created to be your boyfriend by Father. Father might also control all the underground tunnels and even war with the rats because they carry spectral fever. Then a possible mass vaccination of ratkin to be cured.
(2.) I do not think the zombies were created by Nameless or the Witch, I think that there is a third threat out there. It's possible that the Witch made the Shapeshifters who in turn created the spectral fever issue but after seeing the real Lionel and the underground crypt with those sigils, I am willing to bet that there is a third big bad. Probably of the necromancer or lich variety. I was actually thinking Ruben is somehow involved due to wanting to preserve and extend his life.
(3.) I'm pretty sure the Witch created the Werewolves and will eventually turn them against the player, due to the nightmare MC had of being attacked by Logan as a werewolf. Meaning Bernard, Logan, Caleb, the Alpha and Beta will be your enemies. Logan did mention that he would like for you to experiment on him as patient 0 to find a true cure for Lycanthrope, I think the player will find a semi cure and 'recover' the werewolves in the forest giving them back their sentience like Caleb did and making a tribe of werewolf people in the forest.
(4.) Hayden will leave Bareshade for the swamps. He will become a swamp king. I don't know if the Nameless created that swamp monster tree or the Witch, or if it has been there long before the curse of lust, but Hayden got attacked by it and survived. He will somehow play a part is dealing with the swamp tree. I think he will either good ending rule the swamp trees, or bad ending get absorbed by the swamp tree like those werewolves.
(5.) Hissh is Roushks or Grushks son. It would be more interesting if he was actually Roushks son, but either is a possibility. Hissh claims to be someone born from the blessing of Lust, and that it is a good thing because it births more lizards, makes lizards stronger, among other things. Yet this curse has only been around for half a year at best due to Orthra's dialogue which gives a narrow time frame of events. If Hissh was born he would have grown to adulthood in an rapid amount of time. Another thought that crossed my mind while writing this, in the curse of lust bad ending, the MC is turned into a lizard woman and lays eggs for the tribe. Perhaps he is someone transformed by the corrupted water into a Lizard man and was originally a human or some other race.
(6.) I believe Sabal is not native to the island. Tao talks about the three races that live on the island. Ursadin, Hogsvine, and Alurines. You would think in all this conflict the fourth tribe would be involved in some way or at least known and spoken of. The reason I think this is because 'Jester' speaks of a lion. I think that the Lion tribe that Sabal originates is actually from the wasteland with the other Orcs, probably in the forest that is now closed off by the Stormclaw tribe. As Groth said Orcs are not the only race who live in the wastelands. We have Harpies, Ogres, Orcs and what else? Where could Jester have seen a lion? Not past the icy mountain, not in the jungle of a remote island, most likely in the wilderness or the plains of death. They have giant bears up there seen in the armor of some of the Orcs, why not Lions?
(7.) The temples, one in the Lizard tribe, one in the ratkin junkyard, one in Lakeshard, a crypt under the ground near Bareshade, I am so curious to learn about more of the history. Tao will surely make discoveries. I personally think that the crypt has to do with the necromancer Lionel I mentioned before, but all these destroyed temples could be an apocalypses scenario, where there was a civilization but it was destroyed by something. Maybe a society dedicated to the Nameless which was destroyed or something? I don't know its pretty interesting.
(8.) I think Bareshade will be destroyed. Perhaps Nameless and Witch working together or just the perfect storm of bad events. Right now Bareshade seems so amazing, but I think it will fall. Logan, Bernard, Caleb, werewolves, into the forest. Hayden taken by the swamp. Blake, Harold, Rose all move to northcrest because of the danger. The bandits will abandon their camp and take over Bareshade; (the bandits being outlaws in northcrest being unable to go there). Your home base in the forest is destroyed. All the problems at once, the Lizards are invaded by their lustful counterparts, the werewolves are attacked by the swamp, the Orcs war among each other, Northcrest shapeshifting noble problem while Zombies and Murcads attack Northcrest. Okay maybe thats too much, but it would be crazy to see occur. I do think Bareshade will be attacked and vacant at some point though. Perhaps by a dragon.
(9.) Rose will become an actual magic using witch. I don't have any evidence, I just think she will become capable of magic at some point.
(10.) Tank is a creation of the Witch. It is possible that he is just some odd half breed, because when Orcs fuck human women Orcs are born not humans. So maybe she was splicing creatures to make a monster of some kind and Tank was her failure.
(11.) The frozen mountain top with the Yeti was destroyed because it had a Gem that the Nameless and Witch want.
I would like to hear some of the theories some of you might have cooked up. Please share with me! :D <3