ABSTRACT Our objective was to investigate the antioxidant effect of an aqueous extract of organic... more ABSTRACT Our objective was to investigate the antioxidant effect of an aqueous extract of organic grapevine leaves (Vitis labrusca L.) on the livers of diabetic rats and to evaluate the resulting changes in metabolic and biochemical parameters. Diabetic rats received daily intragastric doses of 50, 100 or 200 mg/kg of the grapevine extract for 30 days. Grapevine leaf extract showed a dose-dependent antioxidant effect on the livers of diabetic rats, evidenced by decreases in TBARS and in carbonyl levels and increases in sulfhydryl levels. Moreover, the extract (200 mg/kg) prevented weight loss and reduced LDL cholesterol (50 mg/kg), urea (50 mg/kg), and AST (50 and 100 mg/kg) levels in diabetic rats at the indicated doses. Thus, we suggest that chronic treatment with an extract of grapevine leaves may represent an adjuvant therapy for the treatment and/or prevention of diabetic complications because its antioxidant, hepatoprotective and possible hypolipidemic effects showed here.
ABSTRACT Our objective was to investigate the antioxidant effect of an aqueous extract of organic... more ABSTRACT Our objective was to investigate the antioxidant effect of an aqueous extract of organic grapevine leaves (Vitis labrusca L.) on the livers of diabetic rats and to evaluate the resulting changes in metabolic and biochemical parameters. Diabetic rats received daily intragastric doses of 50, 100 or 200 mg/kg of the grapevine extract for 30 days. Grapevine leaf extract showed a dose-dependent antioxidant effect on the livers of diabetic rats, evidenced by decreases in TBARS and in carbonyl levels and increases in sulfhydryl levels. Moreover, the extract (200 mg/kg) prevented weight loss and reduced LDL cholesterol (50 mg/kg), urea (50 mg/kg), and AST (50 and 100 mg/kg) levels in diabetic rats at the indicated doses. Thus, we suggest that chronic treatment with an extract of grapevine leaves may represent an adjuvant therapy for the treatment and/or prevention of diabetic complications because its antioxidant, hepatoprotective and possible hypolipidemic effects showed here.
Uploads
Papers