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Research Interests: Endocrinology, Biology, Oxidative Stress, Medicine, Internal Medicine, and 15 morePlacenta, Preeclampsia, Blood Pressure, Female, Animals, Glutathione Peroxidase, Perfusion, Clinical Sciences, Electrolytes, G protein, Malondialdehyde, Intrauterine Growth Restriction, Arterial pressure, Complete Blood Count, and Paediatrics and reproductive medicine
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Background Acute rheumatic fever (ARF) is a nonsuppurative complications of Group A β-hemolytic streptococcal (GABHS) infection due to a delayed immune response. Sydenham's chorea (SC) is an important neurological manifestation of... more
Background Acute rheumatic fever (ARF) is a nonsuppurative complications of Group A β-hemolytic streptococcal (GABHS) infection due to a delayed immune response. Sydenham's chorea (SC) is an important neurological manifestation of ARF, and heart involvement is seen in a large proportion of patients with SC. The immune system has a crucial role in initiating and spreading inflammation, which causes tissue damage in ARF. Aim The purpose of this study was to investigate urine neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for kidney injury in children with rheumatic chorea accompanying valvular involvement. Materials and Methods Twenty-eight consecutive children with SC accompanying evidence of valvular involvement, and 30 nonrheumatic, age- and sex-matched healthy children were included in the study. Cardiac evaluations were performed, and urinary NGAL, micro-total protein and creatinine levels were measured in all participants. Results Age, gender, weight, and height were similar in the patients and controls. Twenty-three patients had isolated mitral regurgitation, and five patients had mitral and aortic regurgitation. While there was no statistically significant difference between the urine creatinine and micro-total protein levels in patients and controls, the patient group demonstrated a significantly higher mean urine NGAL level (18.01 ± 7.9 vs. 3.22 ± 1.4, p = 0.002) and mean urine NGAL/creatinine ratio (2.80 ± 1.9 vs. 0.33 ± 0.1, p = 0.008). However, there were no correlations between severity of chorea and urinary NGAL or urinary NGAL/creatinine ratio, there were significant positive correlations between severity of valvular regurgitation and urinary NGAL (r = 0.751, p < 0.001) and urinary NGAL/creatinine ratio (r = 0.694, p < 0.001). Conclusion The present study revealed that urinary NGAL level and urinary NGAL/creatinine ratio were higher in patients with SC accompanying valvular involvement. The results obtained from this study suggest that ARF may cause subclinical renal injury in patients with intense and prolonged cellular immune response leading to chorea and carditis.
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Familial Mediterranean fever (FMF) is an autoinflammatory disease caused by variations in the MEFV gene, which encodes the pyrin protein, a member of the inflammasomes. Despite the complex pathogenesis of FMF, epigenetic changes also play... more
Familial Mediterranean fever (FMF) is an autoinflammatory disease caused by variations in the MEFV gene, which encodes the pyrin protein, a member of the inflammasomes. Despite the complex pathogenesis of FMF, epigenetic changes also play roles in the disease progression. In our previous study, we observed a relationship between NLRP13, which is one of the members of the inflammasome complex and has a pyrin domain in its structure, and the MEFV gene using the STRING database. In this study, we examined NLRP13 expression and methylation status in 40 patients with FMF attack and 20 healthy individuals. We then investigated the global DNA methylation status of patients with FMF in the attack period and control groups. We further examined the relationship between the clinical manifestation and global methylation as well as NLRP13 gene expression of patients with FMF and healthy individuals. As a result, we showed that hypomethylation in patients with FMF leads to different clinical outc...
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Background: The aim of this study is to evaluate the effect of 50 g oral glucose tolerance test (OGTT) on oxidative stress and interleukin-8 (IL-8) parameters in prediabetic pregnant women. Materials and Methods: Fasting and 1 hour blood... more
Background: The aim of this study is to evaluate the effect of 50 g oral glucose tolerance test (OGTT) on oxidative stress and interleukin-8 (IL-8) parameters in prediabetic pregnant women. Materials and Methods: Fasting and 1 hour blood samples were collected from 79 pregnant women who were administered 50 gr OGTT. Patients with a 1 hour blood glucose level of 140–200 mg/dl were considered as the prediabetic group. Thereafter, routine biochemical parameters and the levels of superoxide dismutase (SOD), glutathione peroxidase (GPx), malondialdehyde (MDA) and interleukin-8 (IL-8) parameters were measured from the serum samples taken during fasting and at 1 hour. Results: The serum GPx and SOD levels of the prediabetic group were remarkably lower than that of the control group (p<0.05). Whereas the serum IL-8 levels of the prediabetic group were significantly higher than that of the control group (p<0.05). When the fasting and 1 hour levels of the parameters were compared during...
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Objectives: The aim of this study was to investigate the role of serum niacin and dopamine (DA) levels and their clinical importance in fibromyalgia syndrome (FMS) patients. Patients and methods: Between April 2018 and October 2018, a... more
Objectives: The aim of this study was to investigate the role of serum niacin and dopamine (DA) levels and their clinical importance in fibromyalgia syndrome (FMS) patients. Patients and methods: Between April 2018 and October 2018, a total of 53 female patients (mean age: 38.3±5.5 years; range, 21 to 45 years) with a clinical diagnosis of FMS and 35 healthy female controls (mean age: 36.7±5.2 years; range, 25 to 44 years) were included in this cross-sectional study. The Visual Analog Scale (VAS), Beck Depression Inventory (BDI), and Fibromyalgia Impact Questionnaire (FIQ) were applied to the patients. Serum levels of niacin and DA were measured by high-performance liquid chromatography (HPLC) and enzyme-linked immunosorbent assay (ELISA) methods, respectively. Results: Niacin and DA levels of the patient group were significantly lower than those of control group (p=0.003 and p=0.02, respectively). A very strong positive correlation was found between niacin and DA levels (r=0.96 p&l...
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The complement system participates in the defense of the body against viral infections through various mechanisms. In the present study conducted on children having Crimean-Congo Hemorrhagic Fever (CCHF), the aim was to evaluate whether... more
The complement system participates in the defense of the body against viral infections through various mechanisms. In the present study conducted on children having Crimean-Congo Hemorrhagic Fever (CCHF), the aim was to evaluate whether the complement system had a role in the pathogenesis of the disease. Forty-one patients diagnosed with CCHF and 32 healthy controls were included in the study. Serum complement component 3 (C3), 4 (C4) and complement product Bb (Bb) levels were measured in both groups. Compared to the control group, serum C3 levels were lower and Bb levels were higher in CCHF patients (p < 0.01). Moreover, in the patient group, C3 levels were positively correlated with WBC and PLT counts, and Bb levels were positively correlated with AST, ALT and LDH activities. In the patient group, serum Bb levels were negatively correlated with WBC and PLT counts. The results of the present study suggest that increased activity of the alternative pathway of the complement syste...
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Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne viral disease, causing severe viral hemorrhagic fever outbreaks. This study aimed at determining the serum vitamin D levels and investigated the association between Crimean-Congo... more
Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne viral disease, causing severe viral hemorrhagic fever outbreaks. This study aimed at determining the serum vitamin D levels and investigated the association between Crimean-Congo hemorrhagic fever (CCHF) and serum vitamin D levels in children with CCHF. A total of 45 children aged between 5 and 15 yr, viz. 15 healthy control (HC) and 30 pediatric patients diagnosed with CCHF with real-time polymerase chain reaction (PCR) (patient group) were selected for the study. Analysis of the blood serum samples taken from the said individuals revealed that vitamin D, parathyroid hormone and calcium levels of the patients and the control groups were statistically different. It was found that the serum vitamin D levels of the pediatric patients with CCHF were lower when compared to those of the controls, and that a low vitamin D level could negatively affect the reaction of the body to infections in children having CCHF.
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The aim of this study was to determine the levels of plasma pregnancy-associated plasma protein-A (PAPP-A) and C-reactive protein (CRP) in pre-eclampsia and their association with the mean arterial blood pressure (MAP). Sixty-seven women... more
The aim of this study was to determine the levels of plasma pregnancy-associated plasma protein-A (PAPP-A) and C-reactive protein (CRP) in pre-eclampsia and their association with the mean arterial blood pressure (MAP). Sixty-seven women with pre-eclampsia symptoms were matched with 56 normal pregnant controls for gestational age, maternal age and parity. Both of the groups were third trimester. PAPP-A and CRP were measured in serum using chemiluminescence assay and nephelometry, respectively. Maternal serum levels of PAPP-A and CRP were increased in women with pre-eclampsia compared to controls. There were significant correlations between MAP and CRP (r = 0.372, P = 0.002) and MAP and PAPP-A parameters (r = 0.301, P = 0.013) in pregnancies complicated with pre-eclampsia. PAPP-A had no correlation with CRP in patients with pre-eclampsia and in normotensive pregnant women. We found higher levels of PAPP-A and CRP and the presence of a good correlation between CRP and MAP in pre-eclampsia.
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The major renal involvement in Familial Mediterranean Fever (FMF) is the occurrence of amyloidosis that primarily affects the kidneys manifested by proteinuria and ending in death from renal failure. This study aims to investigate whether... more
The major renal involvement in Familial Mediterranean Fever (FMF) is the occurrence of amyloidosis that primarily affects the kidneys manifested by proteinuria and ending in death from renal failure. This study aims to investigate whether serum cystatin (cys-C) levels could be used as an early marker of renal involvement in FMF patients. Forty-six patients with FMF during the attack period (AP), and 41 patients with FMF during attack-free periods (AFP), and 11 patients with FMF associated amyloidosis, and 38 healthy controls were enrolled in the study. We determined cys-C levels in the serum of FMF patients and healthy controls. Serum cys-C levels were significantly increased in patients with FMF and secondary amyloidosis, and serum cys-C is a more accurate and efficient marker for detecting renal involvement than estimated glomerular filtration rate (e-GFR) in patients with FMF. We propose a cutoff level of the serum cys-C of 876.5 pg/mL for screening renal involvement in patients ...
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Abstract Aim. Cystic fibrosis occurs as a consequence of mutations in the gene regulation of transmembrane message and shows autosomal recessive inheritance. The disease is more frequent among white people; Clinical findings and symptoms... more
Abstract Aim. Cystic fibrosis occurs as a consequence of mutations in the gene regulation of transmembrane message and shows autosomal recessive inheritance. The disease is more frequent among white people; Clinical findings and symptoms in cystic fibrosis can be very different due to the age of patients, type of mutation and complications. In our country, the most common complaints of cystic fibrosis patients in application to hospital are problems in respiratory tract and growth retardation. In this study, we aimed to findhe frequency of cystic fibrosis in children who applied to our clinic with growth retardation and/or recurrent pulmonary infections. Method. This prospective study was conducted between September 2009 and September 2010 in 218 children who applied to our clinic with symptoms of malnutrition and/or recurrent pulmonary infections and had not been diagnosed as cystic fibrosis before. These patients underwent sweat test and their clinical chracteristics were noted. The diagnosis of cystic fibrosis was made by using positive sweat test , appropriate clinical findings and by exclusion of other diseases that also cause recurrent pulmonary infections or malnutrition. Results. The mean age of children was 54.40 ± 48.70 months. Of all children, 100 (45.9%) were male and 118 (54.1%) were female. Positive sweat test was found in 9 (4.2%) children. The frequency of cystic fibrosis was found to be 7.8% in children with recurrent pulmonary infections and 10.5% in children with weight percentile values <3 p. and 9.3% in children with height percentile values <3 p. Conclusion. Sweat test is clinically important for the early diagnosis of cystic fibrosis and in prevention of complications related to this disease in children with growth retardation or recurrent pulmonary infections. Keywords: Cystic fibrosis, sweat test, pulmonary infection, growth retardation Ozet Amac. Kistik fibrozis, transmembran ileti regulasyonu genindeki mutasyon sonucu olusur ve otozomal resesif kalitim gosteren bir hastaliktir. Beyaz irkta daha sik gorulur. Hastaligin klinik bulgulari hastanin yasi, mutasyonun tipi ve komplikasyonlarina bagli olarak cok buyuk degisiklikler gostermektedir. Ulkemizde de en sik basvuru nedeni solunum yolu problemleri ve buyume gelisme geriligidir. Bu calisma ile rekurren akciger enfeksiyonu veya gelisme geriligi sikâyetleri ile klinigimize basvuran hastalarda kistik fibrozis sikliginin arastirilmasi amaclanmistir. Yontem. Bu prospektif calismada; Eylul 2009 ve Eylul 2010 tarihleri arasinda tekrarlayan akciger enfeksiyonu ve gelisme geriligi sikâyetleri ile klinigimize basvuran ve daha once tani almamis 218 hastada ter testi yapilarak, kistik fibrozis sikligi arastirilmis ve hastalarin klinik ozellikleri incelenmistir. Vakalarda kistik fibrozis tanisi; kistik fibrozis klinigi ile uyumlu bulgulara sahip olma, diger hastaliklarin dislanmasi ve ter testi pozitifligi esaslarina gore kondu. Bulgular. Vakalarin yaslari ortalama 54,40±48,70 ay idi. Vakalarin 100 (%45,9)’u kiz, 118 (%54,1)’i erkek idi. Ter testi sonucu cocuklarin 9 (%4,2)’unda pozitif bulundu. Tekrarlayan akciger enfeksiyonu olan cocuklarda kistik fibrozis sikligi %7,8 , agirlik ve boy persantilleri < 3 persantil olan cocuklarda ise kistik fibrozis sikligi sirasiyla %10,5 ve %9,3’du. Sonuc. Gelisme geriligi ve tekrarlayan akciger enfeksiyonu olan cocuklarda kistik fibrozis tanisinin erken konulmasi ve gec komplikasyonlarinin onlenmesi icin ter testi klinik olarak onemlidir. Anahtar sozcukler: Kistik fibrozis, ter testi, akciger enfeksiyonu, gelisme geriligi
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BACKGROUND Elderly people are considered to be in the risk group for vitamin D deficiency. The aim of the present study was to determine the effect of nursing interventions and sunlight exposure to reach optimum 25-hydroxyvitamin D... more
BACKGROUND Elderly people are considered to be in the risk group for vitamin D deficiency. The aim of the present study was to determine the effect of nursing interventions and sunlight exposure to reach optimum 25-hydroxyvitamin D [25(OH)D] levels by individuals living in nursing homes. METHODOLOGY Randomized controlled experimental study was carried out in June-August 2018 period in the nursing home. The question form, standardized mini mental test, Fitzpatrick skin typing questionnaire and Katz Index of activities of daily living were applied. Individuals in the intervention group (n=20) was exposed to sunlight five days a week for four weeks in July with an average duration of 21 ± 5 minutes (min 15 - max 30 minutes). For the participants in the control group (n=20), sunbathing was not offered. 25(OH)D, calcium, parathormone, phosphorus, alkaline phosphatase and albumin levels of all individuals were measured at the beginning and end of the study. RESULTS At the end of the study, the 25(OH)D was significantly higher in the intervention group than in the control group (8.06 ng/ml and 0.96 ng/ml, respectively; p = 0.008). It was observed that in the intervention group, sunlight exposure increased the 25(OH)D regardless of gender and age. Increases were observed in intervention groups for calcium and albumin levels. At the beginning of the study, 25(OH)D was sufficient only in five elderly people in the intervention group, while at the end, 11 elderly people had sufficient levels of 25(OH)D. CONCLUSION At the end of the study, it was concluded that sunlight exposure was a sufficient source to increase 25(OH)D in most elderly people living in the nursing home. Organizing sunbathing sessions as an independent nursing intervention is recommended for the elderly people living in nursing homes in order to prevent vitamin D deficiency and related consequences.
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Giris: FMF hastaliginin patogenezinde sitokinler, seroz membranlarin iltihaplanmasinda onemli rol oynarlar. Bu calismanin amaci, serum IL–1β, IL-18 ve kaspaz-1 serum duzeylerinin atak ve remisyon donemde CRP, ESR, fibrinojen ve immun... more
Giris: FMF hastaliginin patogenezinde sitokinler, seroz membranlarin iltihaplanmasinda onemli rol oynarlar. Bu calismanin amaci, serum IL–1β, IL-18 ve kaspaz-1 serum duzeylerinin atak ve remisyon donemde CRP, ESR, fibrinojen ve immun yanit ile iliskisini arastirmaktir. Gerec ve Yontem: Tel-Hashomer kriterlerine gore FMF tanisi almis 60 hasta atak ve remisyon donemi olarak iki gruba ayrildi. 60 FMF hastasinin ve 30 kontrol grubu bireyin serum sitokin duzeyleri ELISA yontemi ile incelendi ve akut faz reaktanlari ile immun yanit arasindaki iliski arastirildi. Bulgular: Pro-inflamatuar sitokinler olan IL-1β (p = 0.001), IL-18 (p = 0.043) ve kaspaz-1 (p = 0.043) serum konsantrasyonlarinda FMF atak donemi hastalarinda kontrole kiyasla belirgin bir artis gozlemlendi. Ayrica, IL-1β seviyeleri, FMF atak hastalarinda notrofiller, ESR ve CRP ile pozitif korelasyon gosterdi ve hastalik siddeti ile IL-1β arasinda bir iliski saptandi. Remisyon donemi hastalarda ise. serum IL-1β (p = 0.075) ve IL-...
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In this study, a load scheduling optimization in terms of demand response (DR) is performed to reduce total electricity bills of residential households without exceeding the maximum peak power limit set by the entity. A mixed integer... more
In this study, a load scheduling optimization in terms of demand response (DR) is performed to reduce total electricity bills of residential households without exceeding the maximum peak power limit set by the entity. A mixed integer linear programming (MILP) based model is applied to schedule shiftable loads to off-peak hours under time-of-use (TOU) rate. It is also aimed to manage electric vehicle loads to overcome problems that could be possibly arise from high penetration of the electric vehicles to the grid in a near future. Results showed that, the proposed method allows end-users to reduce their total electricity cost by managing their shiftable loads while significantly contributing to the reduction in peak-to-average ratio (PAR) of the household's load demand.
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Background: Insulin resistance (IR) is one of the most important etiological risk factors in the development of diabetes. How- ever, there is no clear data regarding the prevalence of IR in the country. Objective: This study evaluates the... more
Background: Insulin resistance (IR) is one of the most important etiological risk factors in the development of diabetes. How- ever, there is no clear data regarding the prevalence of IR in the country. Objective: This study evaluates the prevalence of IR and identifies the optimal threshold values for the HOMA indexes in Turkey. Methods: This cross-sectional, population-based survey includes 2013 participants aged 20–84 years. The values of the anthro- pometric measurements and laboratory analysis were recorded. The 90th percentile in the non-obese and non-diabetic population was accepted as cut-off values for IR. Results: The optimal threshold values for IR were 2.46 in HOMA1-IR and 1.40 in HOMA2-IR. Using the HOMA2-IR method, the overall prevalence of IR was 33.2%. The IR prevalence was higher in women (35.6%) compared to men (30.1%) [p=0.008]. There was a higher IR prevalence in men living in urban areas (p=0.001), not in women. The multivariate logistic regression analysis show...
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ABSTRACT Angiogenesis is a very essential process in tumor biology. Vascular endothelial growth factor (VEGF), angiopoietin and its receptor (TIE-2) are very important mediators for angiogenesis. In this trial, we aimed to analyze the... more
ABSTRACT Angiogenesis is a very essential process in tumor biology. Vascular endothelial growth factor (VEGF), angiopoietin and its receptor (TIE-2) are very important mediators for angiogenesis. In this trial, we aimed to analyze the role of these mediators on chemotherapy response and survival. Forty four cancer patients and 22 healthy controls were included in the study. Baseline serum samples were obtained from all participants and post-chemotherapy serum samples were obtained from the cancer patients. Serum vascular endothelial growth factor and TIE-2 levels were measured with quantitative enzyme-linked immunosorbent assay techniques. The baseline serum vascular endothelial growth factor level was 187.5 and 120.2 pg/ml in cancer patients and the control group (p = 0.006). The baseline serum TIE-2 level was 615.9 and 242.5 pg/ml in the patients and control group (p &amp;lt; 0.001). There was a significant difference between patients&amp;#39; baseline and post-chemotherapy VEGF levels (111.9 pg/ml; p &amp;lt; 0.001) and patients&amp;#39; baseline and post-chemotherapy TIE-2 levels (344.5 pg/ml; p &amp;lt; 0.001). The overall survival rate was better in patients who had lower baseline VEGF and TIE-2 levels and whose TIE-2 level had decreased with chemotherapy. Higher baseline TIE-2 and VEGF levels are related and worsen survival. Decreasing levels of TIE-2, but not VEGF, which, with chemotherapy, may be predictive for survival.
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The aim of the current study was to investigate the protective effect of naringin on bleomycin-induced pulmonary fibrosis in rats. Twenty-four Wistar rats randomly divided into four groups (control, bleomycin alone, bleomycin + naringin... more
The aim of the current study was to investigate the protective effect of naringin on bleomycin-induced pulmonary fibrosis in rats. Twenty-four Wistar rats randomly divided into four groups (control, bleomycin alone, bleomycin + naringin 40, and bleomycin + naringin 80) were used. Rats were administered a single dose of bleomycin (5 mg/kg; via the tracheal cannula) alone or followed by either naringin 40 mg/kg (orally) or naringin 80 mg/kg (orally) or water (1 mL, orally) for 14 days. Rats and lung tissue were weighed to determine the lung index. TNF-αand IL-1βlevels, hydroxyproline content, and malondialdehyde (MDA) levels were assayed. Glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) activities were determined. Tissue sections were stained with hematoxylin-eosin, Masson’s trichrome, and 0.1% toluidine blue. TNF-α, IL-1β, and MDA levels and hydroxyproline content significantly increased (p<0.01) and GPx and SOD activities significantly decreased in bleomycin group (...
Research Interests: Oxidative Stress, Mast Cells, Medicine, Antioxidants, Pulmonary fibrosis, and 15 moreAnimals, Male, Glutathione Peroxidase, Superoxide Dismutase, Lipid peroxidation, Pulmonary Medicine, Tumor necrosis factor-alpha, Body Weight, Wistar Rats, Bleomycin, Hydroxyproline, Malondialdehyde, Naringin, Random Allocation, and flavanones
Oxidative stress is a complicated process, which was defined as an increase in prooxidants and decrease in antioxidants caused by various mechanisms, including inflammation and surgical trauma. The association between acute appendicitis... more
Oxidative stress is a complicated process, which was defined as an increase in prooxidants and decrease in antioxidants caused by various mechanisms, including inflammation and surgical trauma. The association between acute appendicitis and oxidative stress has been showed in previous studies. However, comparison of oxidative stress in laparoscopic or open appendectomy (OA) has not been established. Patients who were diagnosed as acute appendicitis between October 2012 and January 2013 were randomized to open (OA, n = 50) and laparoscopic appendectomy (LA, n = 50). Blood samples for oxidative stress markers (total oxidant status [TOS] and total antioxidant status [TAS]), C-reactive protein (CRP) and white blood cells (WBC&amp;amp;amp;amp;#39;s) were collected just before the surgery and 24 h after surgery. There were no differences in preoperative values of WBC and CRP between LA and OA groups (P = 0.523 and 0.424), however, in postoperative 24(th) h, CRP was reduced in LA group (P = 0.031). There were no differences in preoperative levels of TOS, TAS, and oxidative stress index (OSI) between LA and OA groups. In the postoperative 24(th) h, TOS and OSI were found to be significantly higher in OA group when compared to LA group (P = 0.017 and 0.002) whereas no difference was detected in TAS level in the postoperative 24(th) h (P = 0.172). This double-blind, randomized clinical trial provides evidence that LA for uncomplicated appendicitis is associated with significantly lower oxidative stress compared with OA. Some of the advantages of LA may be attributed to the significant reduction of oxidative stress in these patients.
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Familial Mediterranean Fever (FMF) is an autosomal recessive disease characterized by short lived, febrile serosae inflammatory attacks. FMF has various effects in multiple systems and organs. In the present study, our aim was to evaluate... more
Familial Mediterranean Fever (FMF) is an autosomal recessive disease characterized by short lived, febrile serosae inflammatory attacks. FMF has various effects in multiple systems and organs. In the present study, our aim was to evaluate adrenal steroidogenesis in female FMF patients. There were 71 women in the study including 41 women with FMF and 30 women as healthy control group (HC group). Of 41 FMF patients, twenty were evaluated in attack period (AP-FMF group) whereas 21 of them were evaluated in attack-free period (AFP-FMF group). In all subjects; serum free testosterone, 17-OHP levels as hormones, IL-1 beta, TNF-alpha, IL-6, IL-18 as proinflammatory cytokines, CRP, fibrinogen, white blood cell (WBC) counts, and erythrocyte sedimentation rate (ESR) as acute phase reactants were measured in samples of venous blood taken in the morning before breakfast. Serum 17-OHP levels in AP-FMF group and AFP-FMF group were higher than in HC group (p < 0.001). A positive correlation was...
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Angiopoietin-related growth factor (AGF) is associated with angiogenesis but it can also affect glucose and energy metabolism. The aim of the study was to determine AGF levels in gestational diabetes mellitus (GDM). The study included 44... more
Angiopoietin-related growth factor (AGF) is associated with angiogenesis but it can also affect glucose and energy metabolism. The aim of the study was to determine AGF levels in gestational diabetes mellitus (GDM). The study included 44 patients with GDM (GDM group) and 33 non-diabetic, healthy women in the third trimester of pregnancy (control group). We analyzed serum levels of AGF and other biochemical and anthropometric markers in all subjects. The study revealed that serum AGF levels were significantly higher in patients with GDM (113.30 +/- 69.92 ng/ml) than in controls (52.30 +/- 35.59 ng/ml), (p-value<0.001). Fasting glucose (117.59 vs. 82.18), homeostasis model of assessment - insulin resistance (HOMA-IR), (2.91 vs. 1.75) diastolic (74.20 vs. 70.00) and mean (89.09 vs. 84.84) blood pressure were found to be significantly higher in the GDM group when compared to the control group (p-value<0.05). There was a significant positive association between AGF and HOMA-IR in t...
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Clinical, Radiological, and Laboratory Assessment of a Family Affected by Primary Atrophic Rhinitis Background: Atrophic rhinitis may be primary (ozena) or secondary (e.g. to radiation therapy or surgery). It manifests as widening of the... more
Clinical, Radiological, and Laboratory Assessment of a Family Affected by Primary Atrophic Rhinitis Background: Atrophic rhinitis may be primary (ozena) or secondary (e.g. to radiation therapy or surgery). It manifests as widening of the nasal cavity due to atrophy of the nasal mucosa, which is covered with foul-smelling crusts. Its etiology is not clear. Objectives: To present a large family with atrophic rhinitis showing a possible dominant trait. Material and Methods: We report the results of clinical, genetic, and immunologic examinations performed on five subjects, who were members of the same family.
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Angiopoietin-related growth factor (AGF) was recently introduced as a novel liver-derived protein that antagonizes obesity and insulin resistance. In the current study, we investigated circulating AGF levels in relation to renal function... more
Angiopoietin-related growth factor (AGF) was recently introduced as a novel liver-derived protein that antagonizes obesity and insulin resistance. In the current study, we investigated circulating AGF levels in relation to renal function and type 2 diabetes mellitus (T2DM). Angiopoietin-related growth factor was determined by enzyme-linked immunosorbent assay in subjects with a glomerular filtration rate greater than 50 mL/min (n = 60, 30 diabetic and 30 nondiabetic) and in patients on chronic hemodialysis (CD; n = 60, 32 diabetic and 28 nondiabetic). Furthermore, AGF was correlated to clinical and biochemical measures of renal function, glucose and lipid metabolism, as well as inflammation. Median serum AGF levels were significantly lower in CD patients (125.9 +/- 96.3 microg/L) as compared with subjects with a glomerular filtration rate greater than 50 mL/min (164.0 +/- 95.4 microg/L) (P &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; .05). Furthermore, AGF serum levels were significantly increased in diabetic patients (161.7 +/- 114.2 microg/L) as compared with nondiabetic subjects (123.0 +/- 88.2 microg/L) (P &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; .01). Moreover, CD negatively and T2DM positively predicted AGF concentrations in multiple regression analysis. In addition, fasting serum glucose was independently and positively correlated with circulating AGF in all patients and controls. Our results suggest that renal dysfunction is negatively and T2DM is positively associated with AGF serum levels. Further studies are needed to better elucidate the physiologic significance of circulating AGF in human disease.
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There is no study about hypertensive response to exercise (HRE), which is a marker of unborn hypertension (HT), and red cell distribution width (RDW) association, in diabetic normotensive patients. So, we aimed to investigate any... more
There is no study about hypertensive response to exercise (HRE), which is a marker of unborn hypertension (HT), and red cell distribution width (RDW) association, in diabetic normotensive patients. So, we aimed to investigate any correlation among RDW and HRE in normotensive type 2 diabetic patients. Consecutive type 2 diabetic patients without history of HT and with normal blood pressure (BP) on ambulatory BP monitoring were included to the study. We divided the patients into two groups depending on their peak systolic BP on exercise; HRE (Group 1) or normal response to exercise (Group 2). Data of 75 diabetic patients (51.9 ± 9.7) were analyzed (31 male (48%)). Their mean RDW was 13.11 ± 0.46. Patients with HRE were significantly older than patients without HRE. Smoking was more frequent in Group 2. Gender distribution and body mass index were similar between the groups. Else hemoglobin, hematocrit, red blood cell count and RDW values were not significantly different. Office systolic BP and diastolic BP, daytime and 24-h systolic BP were significantly higher in Group 1 but heart rate was similar between the groups. This study revealed that RDW do not differ between diabetic normotensive patients with HRE or not.
Research Interests: Cardiology, Medicine, Humans, Internal Medicine, Hypertension, and 15 moreDiabetes mellitus, Blood Pressure, Female, Male, Exercise, Body Mass Index, Clinical Sciences, Adult, Exercise Test, Hematocrit, Logistic Models, Ambulatory Blood Pressure, Case Control Studies, Diastole, and Erythrocyte indices
Received January 27, 2014; Accepted February 11, 2014; Epub March 15, 2014; Published March 30, 2014 Abstract: Cytokine networks play a key role in the pathogenesis of the disease in Crimean-Congo Hemorrhagic Fever (CCHF) patients.... more
Received January 27, 2014; Accepted February 11, 2014; Epub March 15, 2014; Published March 30, 2014 Abstract: Cytokine networks play a key role in the pathogenesis of the disease in Crimean-Congo Hemorrhagic Fever (CCHF) patients. Therefore, our aim was to study the effects of cytokine levels on the pathogenesis and severity of the disease in children with CCHF. Fifty-two patients diagnosed with CCHF and 34 healthy controls (HC) were included in the study. The patients with CCHF were divided into two groups (severe and non-severe). The levels of the Interleukin-10 (IL-10), IL-12, IL-6, Endothelin-1 (ET-1) and tumor necrosis factor-α (TNF-α) were measured in all groups. IL-12 levels did not show any difference between the CCHF and HC groups and among the severe, non-severe and HC groups. IL-10 and ET-1 levels were significantly higher in the severe group when compared to the non-severe group and the HC group. Moreover, IL-10 and ET-1 levels were significantly higher in the non-sever...
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Severe burn induces biochemical mediators such as reactive oxygen species that leads to lipid peroxidation which may have a key role in formation of acute lung injury (ALI). Sildenafil is a selective and potent inhibitor of cyclic... more
Severe burn induces biochemical mediators such as reactive oxygen species that leads to lipid peroxidation which may have a key role in formation of acute lung injury (ALI). Sildenafil is a selective and potent inhibitor of cyclic guanosine monophosphate specific phosphodiesterase-5. Sildenafil preserves alveolar growth, angiogenesis, reduces inflammation and airway reactivity. The purpose of the present study was to evaluate the effects of different dosages of sildenafil in ALI due to severe scald burn in rats. Twenty-four rats were subjected to 30% total body surface area severe scald injury and were randomly divided into three equal groups as follow: control, 10 and 20mg/kg sildenafil groups. Levels of malondialdehyde (MDA), activities of glutathione peroxidase (Gpx), catalase (Cat), total oxidative stress (TOS), and total antioxidative capacity (TAC) were measured in both tissues and serums. Oxidative stress index (OSI) was calculated. A semi-quantitative scoring system was used for the evaluation of histopatological findings. Sildenafil increased Gpx, Cat, TAC and decreased MDA, TOS and OSI. Sildenafil decreased inflammation scores in lungs. Our results reveal that sildenafil is protective against scald burn related ALI by decreasing oxidative stress and inflammation and the dosage of 10mg/kg could be apparently better than 20mg/kg.
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Bu calismada akut akciger hasari durumlarinda bir cok dokuda ve pulmoner dokuda duzeyleri 100 kat artan HIF-1a’nin serum duzeylerinin Covid-19 hastalarinda hastaligin siddeti ve prognozunu takipte etkili bir parametre olarak kullanilip... more
Bu calismada akut akciger hasari durumlarinda bir cok dokuda ve pulmoner dokuda duzeyleri 100 kat artan HIF-1a’nin serum duzeylerinin Covid-19 hastalarinda hastaligin siddeti ve prognozunu takipte etkili bir parametre olarak kullanilip kullanilamayacagi sorularina yanit aramak amaclanmistir. Calismaya Covid-19 klinik sikayetleri ile basvuran 40 hasta ve 20 saglikli kontrol bireyi dahil edildi. Hasta grubundan 20 hastanin PCR testi ile Covid-19 tanisi dogrulandi. Diger 20 hasta ise Covid-19 supheli grup olarak kabul edildi. Hasta gruplarinin basvuru klinik ve laboratuvar verileri kaydedildi. Covid-19 grubu hastalarin basvuru gunu ve basvuru sonrasi 1. Hafta kan orneklerinden laboratuvar testleri ve serum HIF-1α duzeyleri olculdu. Covig-19 grubu hastalik siddetine gore dort alt gruba ayrilip her grubun HIF-1α degerleri birbirleri ile karsilastirildi. Bu calismada covid-19 dogrulanmis hasta grubunda serum HIF-1α degerlerinin saglikli kontrol grup serum HIF-1α degerlerinden daha yuksek ...
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Aim: In order to evaluate the performance of the clinical laboratories, a quality measurement method, The Six-Sigma Methodology, is used. We aimed to evaluate the analytical performance of our clinical laboratory by using the internal and... more
Aim: In order to evaluate the performance of the clinical laboratories, a quality measurement method, The Six-Sigma Methodology, is used. We aimed to evaluate the analytical performance of our clinical laboratory by using the internal and external quality control data of 28 analytes, and by calculating their process sigma values. Methods: Sigma values of 28 analytes of our laboratory were determined from coefficient of variation (CV %) and bias for 3 subsequent months from December 2018 to January 2019. If the sigma values are >6, between 3 and 6, and 6 sigma value for both IQC1 and IQC2 levels for three consecutive months, respectively. Conclusions: In terms of Six-Sigma Metrics; our results were generally found as world-class or good. An appropriate quality control scheduling should be carried out for each test by using Six-Sigma Methodology in all clinical chemistry laboratories.
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Aim. Cystic fibrosis occurs as a consequence of mutations in the gene regulation of transmembrane message and shows autosomal recessive inheritance. The disease is more frequent among white people; Clinical findings and symptoms in cystic... more
Aim. Cystic fibrosis occurs as a consequence of mutations in the gene regulation of transmembrane message and shows autosomal recessive inheritance. The disease is more frequent among white people; Clinical findings and symptoms in cystic fibrosis can be very different due to the age of patients, type of mutation and complications. In our country, the most common complaints of cystic fibrosis patients in application to hospital are problems in respiratory tract and growth retardation. In this study, we aimed to findhe frequency of cystic fibrosis in children who applied to our clinic with growth retardation and/or recurrent pulmonary infections. Method. This prospective study was conducted between September 2009 and September 2010 in 218 children who applied to our clinic with symptoms of malnutrition and/or recurrent pulmonary infections and had not been diagnosed as cystic fibrosis before. These patients underwent sweat test and their clinical chracteristics were noted. The diagno...
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Purpose The debate on the metabolic effects of high fructose corn syrup (HFCS) continues. The deterioration of endoplasmic reticulum (ER) homeostasis is called ER stress. Glucose-regulated protein-78 (GRP-78) and X-box binding protein-1... more
Purpose The debate on the metabolic effects of high fructose corn syrup (HFCS) continues. The deterioration of endoplasmic reticulum (ER) homeostasis is called ER stress. Glucose-regulated protein-78 (GRP-78) and X-box binding protein-1 (XBP-1) are key markers of ER stress and the therapeutic targets of diseases. Sterol regulatory element binding protein-1c (SREBP-1c) is the most important transcription factor that regulates the expression of enzymes for fatty acid synthesis. The purpose of this paper is to research the effects of L-carnitine and trans-chalcone on ER stress and oxidative stress parameters, and to explore the therapeutic potential of L-carnitine and trans-chalcone molecules. Design/methodology/approach Forty male wistar albino rats randomly selected were divided into five groups. All groups are fed with standard chow (ad libitum). While Group I was fed with drinking water, Group II, III, IV and V were fed with water containing 15% HFCS. L-carnitine was given to Group...
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Etiopathogenesis of ankylosing spondylitis (AS), a major subtype of a group of chronic inflammatory diseases known as spondyloarthropathies, is not clearly understood yet. In this study, we aimed to investigate the interleukin 23... more
Etiopathogenesis of ankylosing spondylitis (AS), a major subtype of a group of chronic inflammatory diseases known as spondyloarthropathies, is not clearly understood yet. In this study, we aimed to investigate the interleukin 23 (IL-23)/interleukin-17 (IL-17) pathway, which is a new cytokine pathway in inflammatory diseases. We evaluated serum IL-17 and IL-23 levels after 1-year follow-up in AS patients using only nonsteroidal anti inflammatory drugs (at need or continue). Forty-four AS patients and 40 healthy controls were included in the study. Clinical evaluations of disease activity were performed. Serum tumor necrosis factor-α (TNF-α), IL-6, IL-17, and IL-23 levels were evaluated. IL-17 and IL-23 levels of the patient group at baseline and 12 months were lower than the control group. There was no significant difference between the baseline and 12th month evaluations of the patient group. TNF-α levels were similar in all groups (in the baseline and 12th month of the patient group and in the control group). Although our results are in contrast to the literature findings, the IL-23/IL-17 pathway is a newly discovered pathway, and there may still be unknowns. New studies involving larger patient groups are needed for the factors affecting serum IL-23/IL-17 levels in patients with AS. We also think that it will be useful to make more comprehensive and long-term studies about which patients will respond well to IL-23/IL-17 blockade.
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Crimean-Congo hemorrhagic fever (CCHF) is known to be associated with cardiac damage. Brain type natriuretic peptide (BNP) is secreted from stressed myocardium. This study investigated that BNP levels in CCHF and its association with... more
Crimean-Congo hemorrhagic fever (CCHF) is known to be associated with cardiac damage. Brain type natriuretic peptide (BNP) is secreted from stressed myocardium. This study investigated that BNP levels in CCHF and its association with clinical course of disease. Consecutive CCHF diagnosis confirmed patients were enrolled to the study. Results of patients were compared with age-sex-matched healthy volunteers. Blood samples for BNP levels were collected from the patients during emergency room applications. Mortality, hospitalization duration and other disease severity predictors (thrombocyte count, hemoglobin, white blood cell count, alanine aminotransferase, aspartate aminotransferase, prothrombin time, lactate dehydrogenase, international normalized ratio, activated partial thromboplastin time) were recorded. These parameters' correlations with BNP levels were analyzed. Forty-three CCHF patients and 28 control subjects recruited to the study. Groups were similar for age and gende...
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CCHF causes endothelial activation and dysfunction by affecting the endothelium directly or indirectly. In maintaining the vascular integrity, vascular endothelial growth factor (VEGF-A) and its receptor (VEGFR1) and angiopoietin-2... more
CCHF causes endothelial activation and dysfunction by affecting the endothelium directly or indirectly. In maintaining the vascular integrity, vascular endothelial growth factor (VEGF-A) and its receptor (VEGFR1) and angiopoietin-2 (Ang-2) and its receptor (Tie-2) are very important mediators. For this reason, we aimed at studying the association of Ang-2 and VEGF and their receptors Tie-2 and VEGFR1 with CCHF infection. Thirty one CCHF patients and 31 healthy controls (HC) were included in the study. CCHF patients were classified into two groups in terms of disease severity (severe and non-severe). VEGF-A, VEGFR1, Ang-2 and Tie-2 levels were measured in all groups. Serum levels of Tie-2, Ang-2, VEGF-A and VEGFR1 were significantly increased in CCHF patients compared with the HC. Furthermore, serum Tie-2, Ang-2, VEGF and VEGFR1 levels were found to be significantly higher in the severe group than in the non-severe and HC groups (p<0.05, p<0.001, respectively). Also, Tie-2, Ang...
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Cytokine networks play a key role in the pathogenesis of the disease in Crimean-Congo Hemorrhagic Fever (CCHF) patients. Therefore, our aim was to study the effects of cytokine levels on the pathogenesis and severity of the disease in... more
Cytokine networks play a key role in the pathogenesis of the disease in Crimean-Congo Hemorrhagic Fever (CCHF) patients. Therefore, our aim was to study the effects of cytokine levels on the pathogenesis and severity of the disease in children with CCHF. Fifty-two patients diagnosed with CCHF and 34 healthy controls (HC) were included in the study. The patients with CCHF were divided into two groups (severe and non-severe). The levels of the Interleukin-10 (IL-10), IL-12, IL-6, Endothelin-1 (ET-1) and tumor necrosis factor-α (TNF-α) were measured in all groups. IL-12 levels did not show any difference between the CCHF and HC groups and among the severe, non-severe and HC groups. IL-10 and ET-1 levels were significantly higher in the severe group when compared to the non-severe group and the HC group. Moreover, IL-10 and ET-1 levels were significantly higher in the non-severe group when compared to the HC group. In terms of IL-6 and TNF-α levels, there was no difference between the s...