The aim of the present study was to analyze the clo nal relations and virulence profile of clinic... more The aim of the present study was to analyze the clo nal relations and virulence profile of clinically r elevant MRSA strains collected during one year from pat ients admitted to clinical wards with high risk for nosocomial infections in a university hospital. One hundred and twenty two MRSA strains isolated from patients admitted to surgical and intensive care units during 2010 we re analyzed. Molecular characterization was perform ed using PFGE (pulsed-field gel electrophoresis), determinin g spa polymorphism and SCCmec type. The presence of genes encoding for virulence factors was assessed. We have identified 25 distinct pulsotypes clusterin g into 4 major clonal groups. Group A comprised 82% of MRSA strains (n=100), corresponding to spa type t030. Th ese strains harboured SCCmec type III and were positive for enterotoxin A genes. Fifteen percent of the st rains (n=18) belonged to group B representing spa types t 127, t015 and t321, carrying SCCmec type IV and gen es encoding for ...
This is a report of a successfully operated case of a solid liver metastasis developed following ... more This is a report of a successfully operated case of a solid liver metastasis developed following radical total laryngeal extirpation. The biological characteristic of the laryngeal cancer is also discussed from the surgical point of view. We underline the importance of a detailed, regular control of patients with malignancies and encourage of active surgical treatment of solid metachronous liver metastases.
The aim of this study was to compare in an open, controlled and prospective trial the efficacy of... more The aim of this study was to compare in an open, controlled and prospective trial the efficacy of one-week regimen using either lansoprazole (2 x 30 mg) + 2 x 500 mg metronidazole + 2 x 250 mg clarithromycin (group I, 60 cases) or ranitidine bismuth citrate (2 x 400 mg) + 2 x 500 mg metronidazole + 2 x 250 mg clarithromycin (group II, 61 cases) on the eradication of Hp infection in duodenal ulcer patients. The diagnosis was stated endoscopically. Hp infection was confirmed from 2 antral + 2 corporeal biopsies by the modified Giemsa stain and rapid urease test. After eradication the patients were given on-demand treatment with 30 mg lansoprazole (group I) or 2 x 150 mg ranitidine (group II). Control 13C-urea breath test was performed 4-6 weeks after eradication. On intention to treat basis, Hp was eradicated in 78.3% (confidence interval, CI: 67.6-89.1%) in group I and 78.7% (CI: 68.1-89.2%) in group II (p > 0.05). Per protocol eradication rates were 92.1% (CI: 84.5-99.7%) in grou...
Introduction and aims: Prostate cancer is the most common malignant tumor in male; its diagnostic... more Introduction and aims: Prostate cancer is the most common malignant tumor in male; its diagnostic algorithm and therapy were investigated. The goal of the study was to compare the data from the first year of clinical use of prostate specific antigen (1994) and the data of 2004. Results: During the first decade, the number of prostate biopsies has increased 4.5-fold times. In 1994, 36.2%, while in 2004, 47.5% of the biopsies demonstrated cancer. The average age of the patients, who underwent biopsy, decreased from 69.7 to 62.3 years; however, the average age of patients who suffered from prostate cancer reamined constant (70.8 vs. 71.3 years old). Conclusion: In 2004, along with the earlier used PSA level, the free-PSA and PSA-density was also involved in the diagnostic algorithm. The prostate biopsy is guided by a transrectal US, in contrast to the earlier used blind or transperineal method. Consequently, the effectiveness of the prostate biopsy has improved, but the earlier diagnos...
Primary melanin pigment containing tumors of the breast are rare. We report a pigmented papillary... more Primary melanin pigment containing tumors of the breast are rare. We report a pigmented papillary carcinoma of a 60-year-old male patient who presented a firm mass 1.7 cm in diameter with an ill defined border on ultrasonography behind the mamilla. To the best of our knowledge this is the third case report of this type of tumor in male breast.
The aim of the present study was to analyze the clo nal relations and virulence profile of clinic... more The aim of the present study was to analyze the clo nal relations and virulence profile of clinically r elevant MRSA strains collected during one year from pat ients admitted to clinical wards with high risk for nosocomial infections in a university hospital. One hundred and twenty two MRSA strains isolated from patients admitted to surgical and intensive care units during 2010 we re analyzed. Molecular characterization was perform ed using PFGE (pulsed-field gel electrophoresis), determinin g spa polymorphism and SCCmec type. The presence of genes encoding for virulence factors was assessed. We have identified 25 distinct pulsotypes clusterin g into 4 major clonal groups. Group A comprised 82% of MRSA strains (n=100), corresponding to spa type t030. Th ese strains harboured SCCmec type III and were positive for enterotoxin A genes. Fifteen percent of the st rains (n=18) belonged to group B representing spa types t 127, t015 and t321, carrying SCCmec type IV and gen es encoding for ...
This is a report of a successfully operated case of a solid liver metastasis developed following ... more This is a report of a successfully operated case of a solid liver metastasis developed following radical total laryngeal extirpation. The biological characteristic of the laryngeal cancer is also discussed from the surgical point of view. We underline the importance of a detailed, regular control of patients with malignancies and encourage of active surgical treatment of solid metachronous liver metastases.
The aim of this study was to compare in an open, controlled and prospective trial the efficacy of... more The aim of this study was to compare in an open, controlled and prospective trial the efficacy of one-week regimen using either lansoprazole (2 x 30 mg) + 2 x 500 mg metronidazole + 2 x 250 mg clarithromycin (group I, 60 cases) or ranitidine bismuth citrate (2 x 400 mg) + 2 x 500 mg metronidazole + 2 x 250 mg clarithromycin (group II, 61 cases) on the eradication of Hp infection in duodenal ulcer patients. The diagnosis was stated endoscopically. Hp infection was confirmed from 2 antral + 2 corporeal biopsies by the modified Giemsa stain and rapid urease test. After eradication the patients were given on-demand treatment with 30 mg lansoprazole (group I) or 2 x 150 mg ranitidine (group II). Control 13C-urea breath test was performed 4-6 weeks after eradication. On intention to treat basis, Hp was eradicated in 78.3% (confidence interval, CI: 67.6-89.1%) in group I and 78.7% (CI: 68.1-89.2%) in group II (p > 0.05). Per protocol eradication rates were 92.1% (CI: 84.5-99.7%) in grou...
Introduction and aims: Prostate cancer is the most common malignant tumor in male; its diagnostic... more Introduction and aims: Prostate cancer is the most common malignant tumor in male; its diagnostic algorithm and therapy were investigated. The goal of the study was to compare the data from the first year of clinical use of prostate specific antigen (1994) and the data of 2004. Results: During the first decade, the number of prostate biopsies has increased 4.5-fold times. In 1994, 36.2%, while in 2004, 47.5% of the biopsies demonstrated cancer. The average age of the patients, who underwent biopsy, decreased from 69.7 to 62.3 years; however, the average age of patients who suffered from prostate cancer reamined constant (70.8 vs. 71.3 years old). Conclusion: In 2004, along with the earlier used PSA level, the free-PSA and PSA-density was also involved in the diagnostic algorithm. The prostate biopsy is guided by a transrectal US, in contrast to the earlier used blind or transperineal method. Consequently, the effectiveness of the prostate biopsy has improved, but the earlier diagnos...
Primary melanin pigment containing tumors of the breast are rare. We report a pigmented papillary... more Primary melanin pigment containing tumors of the breast are rare. We report a pigmented papillary carcinoma of a 60-year-old male patient who presented a firm mass 1.7 cm in diameter with an ill defined border on ultrasonography behind the mamilla. To the best of our knowledge this is the third case report of this type of tumor in male breast.
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