Introduction: Unlike type 1 myocardial infarction (T1MI) which is caused by plaque rupture and er... more Introduction: Unlike type 1 myocardial infarction (T1MI) which is caused by plaque rupture and erosion, type 2 myocardial infarction (T2MI) is due to the mismatch between supply-demand of oxygen. To date, there were limited studies available and consequently, the outcomes of patients with T1MI compared to T2MI remained inconclusive. Hypothesis: We aimed to compare the outcomes of T1MI and T2MI patients in terms of mortality and adverse cardiovascular outcomes. Methods: We performed a systematic literature search of databases for relevant articles from inception until March 20, 2022. Results: 340,802 patients had T1MI while the remaining 52,855 patients had T2MI. Mean age was similar between both groups (T1MI: 69.4 years, T2MI: 71.8 years) while proportion of female was found to be more higher in T2MI (61% vs 38%). Our analysis revealed that patients with T1MI had a significantly lower odds of all-cause mortality (OR 0.44, 95%CI 0.34 to 0.56, p<0.001), in-hospital mortality (OR 0....
BACKGROUND There is limited and conflicting data available regarding the Cardiovascular disease o... more BACKGROUND There is limited and conflicting data available regarding the Cardiovascular disease outcomes associated with Inflammatory Bowel Disease (IBD) OBJECTIVE We aim to perform a systematic review to evaluate the cardiovascular outcomes and mortality associated with IBD patients. METHODS A systematic literature search has been performed on PubMed, Embase, Cochrane, and Scopus from inception till May 2022 without any language restrictions. RESULTS A total of 2,029,941 patients were included into the analysis from 16 studies. The mean age of the patients was 45.6 years. More females were found compared with males (57% vs 43%). The most common risk factors for Cardiovascular disease (CVD) included smoking (24.19%) and alcohol (4.60%). The most common co-morbidities included hypertension (30%), diabetes mellitus (14.41%), dyslipidemia (18.42%), previous CVD (22%), and renal disease (10%). Among outcomes All-cause mortality among IBD patients was 1.66%; Ulcerative Colitis (UC): 15.9...
Congenital Diaphragmatic Eventration (DE) requires a prompt diagnosis to avert the potentially li... more Congenital Diaphragmatic Eventration (DE) requires a prompt diagnosis to avert the potentially life‐threatening complications. Herein, a 5‐month‐old male presented with recurrent respiratory infections due to a right‐sided diaphragmatic eventration. Misdiagnosed from previous medical visits, timely surgical intervention by thoracoscopic plication of the diaphragm was crucial for our patient's survival.
Multilayer piezocomposite transducers are widely used in many applications where broad bandwidth ... more Multilayer piezocomposite transducers are widely used in many applications where broad bandwidth is required for tracking and detection purposes. However, it is difficult to operate these multilayer transducers efficiently under frequencies of 100 kHz. Therefore, this work presents the modeling and optimization of a five-layer piezocomposite transducer with ten variables of nonuniform layer thicknesses and different volume fractions by exploiting the strength of the genetic algorithm (GA) with a one-dimensional model (ODM). The ODM executes matrix manipulation by resolving wave equations and produces mechanical output in the form of pressure and electrical impedance. The product of gain and bandwidth is the required function to be maximized in this multi-objective and multivariate optimization problem, which is a challenging task having ten variables. Converting it into the minimization problem, the reciprocal of the gain-bandwidth product is considered. The total thickness is adjus...
e16183 Background: Molecular-targeted agents such as Lenvatinib and Sorafenib have improved survi... more e16183 Background: Molecular-targeted agents such as Lenvatinib and Sorafenib have improved survival outcomes in patients with hepatocellular carcinoma (HCC). However, using these agents in the primary treatment for advanced HCC is still under debate, with limited literature comparing the therapeutic effects of Lenvatinib versus Sorafenib. Methods: We performed a systematic literature search using the PubMed, Embase, Scopus, and Cochrane libraries for relevant articles from inception until 10th February 2023. Results: A total of 8 studies with 1995 patients (955 Lenvatinib vs. 1040 Sorafenib) were included in our analysis. The mean age of the patients in both groups was comparable (65 vs. 66) years. The overall survival was also comparable between the groups (HR = 0.83; 95%CI: 0.67-1.02; p = 0.08). However, progression-free survival (HR = 0.83; 95%CI: 0.77-0.89; p<0.00001) and time to progression (HR = 0.69; 95%CI: 0.51-0.93; p = 0.02) were significantly improved in the Lenvatini...
To date, there were limited studies available on myocardial infarction (MI), and consequently, th... more To date, there were limited studies available on myocardial infarction (MI), and consequently, the outcomes of patients with type 1 myocardial infarction (T1MI) compared to type 2 myocardial infarction (T2MI) remained inconclusive. We aimed to compare the outcomes of T1MI and T2MI patients in terms of mortality and adverse cardiovascular outcomes. We performed a systematic literature search on PubMed, Embase, and Scopus for relevant articles from inception until March 20, 2022. 341,049 patients had T1MI, while the remaining 67,537 patients had T2MI. Mean age was similar between both groups (T1MI: 67.3 years, T2MI: 71.03 years), while the proportion of females was lower in T1MI (37.81% vs 47.15%). Our analysis revealed that patients with T1MI had significantly lower odds of all-cause mortality (OR 0.45, 95% CI 0.36–0.56, p < 0.001), in-hospital mortality (OR 0.63, 95% CI 0.46–0.86, p < 0.001), 1-year mortality (OR 0.35, 95% CI 0.25–0.47, p < 0.001), and major adverse cardiov...
Funding Acknowledgements Type of funding sources: None. Background Sodium glucose co-transporter ... more Funding Acknowledgements Type of funding sources: None. Background Sodium glucose co-transporter 2 (SGLT2) inhibitors have been recommended in the practice guidelines for the treatment of patients with heart failure with reduced ejection fraction, however their effects among patients with preserved ejection fraction has been debatable. Objective We aim to evaluate the SGLT2 inhibitor effect among patients with HFpEF including DELIVER and EMPEROR-Preserved trials. Methods We performed a systematic literature search using the PubMed, Embase, Scopus, and Cochrane libraries for relevant articles from inception until August 30th, 2022. Statistical analysis was performed by calculating hazard ratio (HR) using the random effect model with 95% confidence interval (CI) and probability value (P). Statistical significance was met if 95% CI doesn’t cross numeric "1" and p <0.05. Results A total of 4 studies with 30418 patients (15390 SGLT2 inhibitor vs 15028 placebo) were included ...
Introduction: Unlike type 1 myocardial infarction (T1MI) which is caused by plaque rupture and er... more Introduction: Unlike type 1 myocardial infarction (T1MI) which is caused by plaque rupture and erosion, type 2 myocardial infarction (T2MI) is due to the mismatch between supply-demand of oxygen. To date, there were limited studies available and consequently, the outcomes of patients with T1MI compared to T2MI remained inconclusive. Hypothesis: We aimed to compare the outcomes of T1MI and T2MI patients in terms of mortality and adverse cardiovascular outcomes. Methods: We performed a systematic literature search of databases for relevant articles from inception until March 20, 2022. Results: 340,802 patients had T1MI while the remaining 52,855 patients had T2MI. Mean age was similar between both groups (T1MI: 69.4 years, T2MI: 71.8 years) while proportion of female was found to be more higher in T2MI (61% vs 38%). Our analysis revealed that patients with T1MI had a significantly lower odds of all-cause mortality (OR 0.44, 95%CI 0.34 to 0.56, p<0.001), in-hospital mortality (OR 0....
BACKGROUND There is limited and conflicting data available regarding the Cardiovascular disease o... more BACKGROUND There is limited and conflicting data available regarding the Cardiovascular disease outcomes associated with Inflammatory Bowel Disease (IBD) OBJECTIVE We aim to perform a systematic review to evaluate the cardiovascular outcomes and mortality associated with IBD patients. METHODS A systematic literature search has been performed on PubMed, Embase, Cochrane, and Scopus from inception till May 2022 without any language restrictions. RESULTS A total of 2,029,941 patients were included into the analysis from 16 studies. The mean age of the patients was 45.6 years. More females were found compared with males (57% vs 43%). The most common risk factors for Cardiovascular disease (CVD) included smoking (24.19%) and alcohol (4.60%). The most common co-morbidities included hypertension (30%), diabetes mellitus (14.41%), dyslipidemia (18.42%), previous CVD (22%), and renal disease (10%). Among outcomes All-cause mortality among IBD patients was 1.66%; Ulcerative Colitis (UC): 15.9...
Congenital Diaphragmatic Eventration (DE) requires a prompt diagnosis to avert the potentially li... more Congenital Diaphragmatic Eventration (DE) requires a prompt diagnosis to avert the potentially life‐threatening complications. Herein, a 5‐month‐old male presented with recurrent respiratory infections due to a right‐sided diaphragmatic eventration. Misdiagnosed from previous medical visits, timely surgical intervention by thoracoscopic plication of the diaphragm was crucial for our patient's survival.
Multilayer piezocomposite transducers are widely used in many applications where broad bandwidth ... more Multilayer piezocomposite transducers are widely used in many applications where broad bandwidth is required for tracking and detection purposes. However, it is difficult to operate these multilayer transducers efficiently under frequencies of 100 kHz. Therefore, this work presents the modeling and optimization of a five-layer piezocomposite transducer with ten variables of nonuniform layer thicknesses and different volume fractions by exploiting the strength of the genetic algorithm (GA) with a one-dimensional model (ODM). The ODM executes matrix manipulation by resolving wave equations and produces mechanical output in the form of pressure and electrical impedance. The product of gain and bandwidth is the required function to be maximized in this multi-objective and multivariate optimization problem, which is a challenging task having ten variables. Converting it into the minimization problem, the reciprocal of the gain-bandwidth product is considered. The total thickness is adjus...
e16183 Background: Molecular-targeted agents such as Lenvatinib and Sorafenib have improved survi... more e16183 Background: Molecular-targeted agents such as Lenvatinib and Sorafenib have improved survival outcomes in patients with hepatocellular carcinoma (HCC). However, using these agents in the primary treatment for advanced HCC is still under debate, with limited literature comparing the therapeutic effects of Lenvatinib versus Sorafenib. Methods: We performed a systematic literature search using the PubMed, Embase, Scopus, and Cochrane libraries for relevant articles from inception until 10th February 2023. Results: A total of 8 studies with 1995 patients (955 Lenvatinib vs. 1040 Sorafenib) were included in our analysis. The mean age of the patients in both groups was comparable (65 vs. 66) years. The overall survival was also comparable between the groups (HR = 0.83; 95%CI: 0.67-1.02; p = 0.08). However, progression-free survival (HR = 0.83; 95%CI: 0.77-0.89; p<0.00001) and time to progression (HR = 0.69; 95%CI: 0.51-0.93; p = 0.02) were significantly improved in the Lenvatini...
To date, there were limited studies available on myocardial infarction (MI), and consequently, th... more To date, there were limited studies available on myocardial infarction (MI), and consequently, the outcomes of patients with type 1 myocardial infarction (T1MI) compared to type 2 myocardial infarction (T2MI) remained inconclusive. We aimed to compare the outcomes of T1MI and T2MI patients in terms of mortality and adverse cardiovascular outcomes. We performed a systematic literature search on PubMed, Embase, and Scopus for relevant articles from inception until March 20, 2022. 341,049 patients had T1MI, while the remaining 67,537 patients had T2MI. Mean age was similar between both groups (T1MI: 67.3 years, T2MI: 71.03 years), while the proportion of females was lower in T1MI (37.81% vs 47.15%). Our analysis revealed that patients with T1MI had significantly lower odds of all-cause mortality (OR 0.45, 95% CI 0.36–0.56, p < 0.001), in-hospital mortality (OR 0.63, 95% CI 0.46–0.86, p < 0.001), 1-year mortality (OR 0.35, 95% CI 0.25–0.47, p < 0.001), and major adverse cardiov...
Funding Acknowledgements Type of funding sources: None. Background Sodium glucose co-transporter ... more Funding Acknowledgements Type of funding sources: None. Background Sodium glucose co-transporter 2 (SGLT2) inhibitors have been recommended in the practice guidelines for the treatment of patients with heart failure with reduced ejection fraction, however their effects among patients with preserved ejection fraction has been debatable. Objective We aim to evaluate the SGLT2 inhibitor effect among patients with HFpEF including DELIVER and EMPEROR-Preserved trials. Methods We performed a systematic literature search using the PubMed, Embase, Scopus, and Cochrane libraries for relevant articles from inception until August 30th, 2022. Statistical analysis was performed by calculating hazard ratio (HR) using the random effect model with 95% confidence interval (CI) and probability value (P). Statistical significance was met if 95% CI doesn’t cross numeric "1" and p <0.05. Results A total of 4 studies with 30418 patients (15390 SGLT2 inhibitor vs 15028 placebo) were included ...
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