- PERSONAL BIOGRAPHYNAME: Saeid Abbasi-MalekiDATE OF BIRTH: Friday, September 21, 1979PLACE OF BIRTH: East Azarbaijan,... morePERSONAL BIOGRAPHYNAME: Saeid Abbasi-MalekiDATE OF BIRTH: Friday, September 21, 1979PLACE OF BIRTH: East Azarbaijan,MalekanFATHER: MasoudMOTHER: Shamsol-MollokMARRIED TO: 2009CHILDREN: 1 sun.OCCUPATION: University ProfessorOFFICE ADDRESS: Postal Code: 57169-63896, P.O Box: 969Dr. Saeid Abbasi-Maleki Room (No) 146, Department of Pharmacologyedit
Background: Studies have reported certain side effects that occur with the use of conventional antidepressants limit their clinical use. Plant derivatives such as Rhus coriaria L. extract can be used as alternatives for depression.... more
Background: Studies have reported certain side effects that occur with the use of conventional antidepressants limit their clinical use. Plant derivatives such as Rhus coriaria L. extract can be used as alternatives for depression. Objectives: This study was designed to investigate the antidepressant-like effects of R. coriaria in a mouse model and the role of the monoaminergic system in its mechanism of action. Methods: A total of 174 male NMRI mice were used. Thirty minutes after treating animals with common antidepressants and R. coriaria extract (25 - 200 mg/kg), the tail suspension test (TST) was performed. One hour after treating mice with serotonergic, adrenergic, and dopaminergic antagonists, 100 mg/kg of the extract was administered, and TST was performed after 30 minutes. Potential synergistic interactions between the extract and the sub-doses of fluoxetine (Flx) and imipramine (Imp) were also investigated. Injections were all administered intraperitoneally. Results: Rhus ...
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ABSTRACT
Dementia involves several factors, and it is required to administer an agent with several efficiencies for its treatment. Sake is known to have antioxidant and anti-inflammatory properties and improves the serum concentration of BDNF.... more
Dementia involves several factors, and it is required to administer an agent with several efficiencies for its treatment. Sake is known to have antioxidant and anti-inflammatory properties and improves the serum concentration of BDNF. This study aimed to evaluate the neuroprotective action of Japanese sake yeast on dementia of the Alzheimer disease type in rats by behavioral evaluation and neurobiochemical assessment. The rats were grouped as non-Alzheimer rats (control rats) and Alzheimer rats administrated with 0 (AD), 10 (10-AD), 20 (20-AD), 30 (30-AD), and 40 mg/kg (40-AD) of sake. Anxiety-like and depression-like behaviors, the concentrations of brain-derived neurotrophic factor (BDNF), malondialdehyde (MDA), and ferric reducing ability of plasma (FRAP) were evaluated. The expressions of IL-1β, TNF-α, and IL-6 were assessed. The results showed that Alzheimer disease caused anxiety-like and depression-like behaviors (p = 0.000), decreased the concentrations of BDNF (p = 0.000) a...
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Introduction: Ziziphora tenuior L. (Z. tenuior) has multiple biological activities such as spasmolytic, antidiarrheal, analgesic, antidepressant and sedative effects. In the present study, the effect of ethanolic extract of Z. tenuior on... more
Introduction: Ziziphora tenuior L. (Z. tenuior) has multiple biological activities such as spasmolytic, antidiarrheal, analgesic, antidepressant and sedative effects. In the present study, the effect of ethanolic extract of Z. tenuior on morphine withdrawal symptoms was investigated in the male mice. Materials and Methods: In this study, 40 male mice weighing 20-30 g were used. The animals were divided into five groups of eight. The study groups included negative control or normal saline (10 ml/kg), positive control or clonidine (3.5 mg/kg), and different doses of Z. tenuior (50, 75, and 100 mg/kg). Dependency on morphine was induced by administration of different doses of morphine (50, 50, 75, and 50 mg/kg) in four days. On last day, after administration of single dose of morphine, naloxone (5 mg /kg) was injected and morphine withdrawal signs were observed and recorded within 30 min. All drugs and extracts were injected intraperitoneally with a single volume of 10 ml/kg. Results: ...
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ABSTRACT The new mild chromium(VI) oxidizing agent, propyltriphenylphos-phonium chlorochromate(VI), (PTriPPCC), was prepared and characterized. This new compound is effective in the oxidation of organic substrates specially alcohols to... more
ABSTRACT The new mild chromium(VI) oxidizing agent, propyltriphenylphos-phonium chlorochromate(VI), (PTriPPCC), was prepared and characterized. This new compound is effective in the oxidation of organic substrates specially alcohols to corresponding carbonyl compounds. The facile oxidation of triphenylphosphine to triphenylphosphine oxide by this reagent in CH3CN provides a clear cut indicating for oxygen atom transfer mechanism.
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Trans-anethole (ANE) is a monoterpene present in many aromatic plants, especially Pimpinella anisum (PA). In this regard, we previously reported the anti-depressant potential of PA. Here, we examined the anti-depressant activity of ANE... more
Trans-anethole (ANE) is a monoterpene present in many aromatic plants, especially Pimpinella anisum
(PA). In this regard, we previously reported the anti-depressant potential of PA. Here, we examined the
anti-depressant activity of ANE and its possible mechanism in mice. In experiment 1, the animals
received ANE (12.5–50 mg.kg -1) 60 min prior to forced swimming and open-field tests. In experiment
2, the animals received several receptor antagonists to assess the possible mechanism of ANE. The administration
of ANE (25 and 50 mg.kg -1; p < 0.01 and p < 0.001, respectively) exhibited an anti-depressivelike
effect in FST without any significant effect on animal locomotion(p > 0.05). Moreover, haloperidol(
p < 0.001), SCH23390(p < 0.001), sulpiride(p < 0.001), ketanserin(p < 0.001), p-chlorophenylalanine(p <
0.001), WAY100135(p < 0.001), reserpine, (p < 0.001) prazosin(p < 0.001), and yohimbine(p < 0.001)
inhibited the anti-depressive-like effect of ANE. Furthermore, co-treatment of a subeffective dose of
ANE with imipramine or fluoxetine induced synergistic anti-depressant-like effects(p < 0.001). Our data
mainly showed that the anti-depressive-like effect of ANE, which can be attributed to the contribution of
the monoaminergic system.
(PA). In this regard, we previously reported the anti-depressant potential of PA. Here, we examined the
anti-depressant activity of ANE and its possible mechanism in mice. In experiment 1, the animals
received ANE (12.5–50 mg.kg -1) 60 min prior to forced swimming and open-field tests. In experiment
2, the animals received several receptor antagonists to assess the possible mechanism of ANE. The administration
of ANE (25 and 50 mg.kg -1; p < 0.01 and p < 0.001, respectively) exhibited an anti-depressivelike
effect in FST without any significant effect on animal locomotion(p > 0.05). Moreover, haloperidol(
p < 0.001), SCH23390(p < 0.001), sulpiride(p < 0.001), ketanserin(p < 0.001), p-chlorophenylalanine(p <
0.001), WAY100135(p < 0.001), reserpine, (p < 0.001) prazosin(p < 0.001), and yohimbine(p < 0.001)
inhibited the anti-depressive-like effect of ANE. Furthermore, co-treatment of a subeffective dose of
ANE with imipramine or fluoxetine induced synergistic anti-depressant-like effects(p < 0.001). Our data
mainly showed that the anti-depressive-like effect of ANE, which can be attributed to the contribution of
the monoaminergic system.
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Introduction: Previous studies revealed that anise (Pimpinella anisum L.) has several pharmacological effects including analgesic, antidepressant, anxiolytic, anti-inflammatory and antispasmodic activities. This study aimed to evaluate... more
Introduction: Previous studies revealed that anise (Pimpinella anisum L.) has several pharmacological effects including analgesic, antidepressant, anxiolytic, anti-inflammatory and antispasmodic activities. This study aimed to evaluate its effect on morphine physical dependence in mice.Methods: In this experimental study, 40 male NMRI mice (25-30 g) were randomly divided into 5 groups of 8. Control group received morphine and normal saline (10 mL/kg, i.p.) and other groups received diazepam (5 mg/kg) plus one of three doses of P. anisum (50,100 or 200 mg/kg, i.p.). Dependence was induced by administration of increasing doses (50-75 mg/kg, i.p.) of morphine. A time of 30 minutes after naloxone injection was considered for the critical period of the withdrawal syndrome. The number of jumps and scores of 0 to 3 were given for incidences of wet dog shakes, teeth chattering, climbing, writing, diarrhea, grooming, and rearing during a 30-minute period.Results: All doses of P. anisum (P 0....
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Background and aims: Several pharmacological and biological activities have been attributed to Cuminum cyminum L. (CC), including analgesic, antioxidant, anti-inflammatory, and anti-epileptic effects. In this regard, the present study... more
Background and aims: Several pharmacological and biological activities have been attributed to Cuminum cyminum L. (CC), including analgesic, antioxidant, anti-inflammatory, and anti-epileptic effects. In this regard, the present study evaluated the antidepressant-like effects of the CC essential oil (EO) on the forced swim test (FST) and tail suspension test (TST) in male mice. Materials and Methods: The gas chromatography-mass spectrometry (GC-MS) apparatus was used for detecting the chemical compounds of CC EO. In the present study, 72 male NMRI mice were randomly allocated to 12 groups (each containing 6 animals) including control or vehicle (10 mL/kg, i.p.), fluoxetine (20 mg/kg, i.p.), imipramine (30 mg/kg, i.p), and the CC EO (100, 200, and 300 mg/kg, i.p.). Then, several parameters were measured and recorded, including immobility time, swimming time, and climbing time in FST, along with immobility time in TST, respectively. Results: Cuminaldehyde followed by cymene, γ-terpine...
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Background and Aim: Previous studies have reported many pharmacological properties for Origanum majorana, including anticonvulsant, analgesic, sedative, and antidepressant-like effects. Given this, the aim of this study was to compare the... more
Background and Aim: Previous studies have reported many pharmacological properties for Origanum majorana, including anticonvulsant, analgesic, sedative, and antidepressant-like effects. Given this, the aim of this study was to compare the anxiolytic and hypnotic effects of Origanum majorana essential oil (OMEO) and alprazolam in male mice. Material and Methods: In this experimental study, 60 male NMRI mice were divided into 10 groups of six each. In both of the experiments, negative control groups received vehicle (10 ml/kg) and positive control groups received alprazolam (0.5 mg/kg) and treatment groups received OMEO (10, 20 and 40 mg/kg). For assessing anxiolytic effects, the number of entries and the time spent in the open and closed arms were recorded by using elevated plus maze (EPM). For evaluating hypnotic effects, the onset and duration of the sleep were recorded by using ketamine-induced sleeping time test. One-way ANOVA followed by post hoc Tukey's test were used for s...
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Background and aims: Antidepressant agents such as imipramine are clinically used to control and treat different types of pain, especially neuropathic pain. Studies have shown the antidepressant-like activity of folic acid (FA). This... more
Background and aims: Antidepressant agents such as imipramine are clinically used to control and treat different types of pain, especially neuropathic pain. Studies have shown the antidepressant-like activity of folic acid (FA). This study aimed to investigate the potential antinociceptive effects of FA using formalin and acetic acid tests in male mice. Methods: Sixty male albino mice (20-30 g) were randomly divided into 10 groups (n=6 in each group) of negative control, positive control (morphine or indomethacin), and FA (10, 15, and 30 mg/kg) groups. In the formalin test, duration of paw licking and biting the right hind paw during acute (0-5 minutes) and chronic (15-60 minutes) pain after intraplantar injection of formalin 2.5% (25 µL) was recorded. In the writhing test, the abdominal constrictions were recorded after the intraperitoneal injection of acetic acid 1%. Results: Only a high dose (30 mg/kg) of FA significantly reduced acute pain (P=0.001) compared with the control gro...
Background and aims: Giardiasis is known as intestinal infection and created by the flagellate protozoan Giardia lamblia. Some studies showed that phenolic components, present in plant extracts and essential oils, have anti-Giardia... more
Background and aims: Giardiasis is known as intestinal infection and created by the flagellate protozoan Giardia lamblia. Some studies showed that phenolic components, present in plant extracts and essential oils, have anti-Giardia activity. The current study was performed to compare anti-Giardia activity of Satureja hortensis (SH) alcoholic extract and metronidazole in vitro. Methods: In this Laboratory-experimental study, it was separated cysts from the feces by Bingham procedure with minor modification. The numbers of cysts were calculated with Hemusytumetr and the purified cysts of Giardia lamblia (500 µl) were exposed with 500 µl of extract at concentrations of 10, 100 and 200 mg/ml and 125 mg/kg of metronidazole for 30, 60 and 120 min. The numbers of dead and live cysts was enumerated with a microscope. Results: Findings in the currnt studyshowed an increase in anti-Giardia activity of extract at high concentrations with increasing time. SH, at 100 mg/ml killed 53% in 30 min, ...
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Materials and Methods: In this experimental study, one hundred-fourteen male albino mice were randomly divided into normal saline or control (10ml/kg, i.p), fluoxetine (20mg/kg, i.p), imipramine (30mg/kg, i.p) and, VO extract (50, 100,... more
Materials and Methods: In this experimental study, one hundred-fourteen male albino mice were randomly divided into normal saline or control (10ml/kg, i.p), fluoxetine (20mg/kg, i.p), imipramine (30mg/kg, i.p) and, VO extract (50, 100, 200, 400 mg/kg, i.p), respectively. The antidepressant-like activity was performed by behavioral tests as forced swimming test (FST), tail suspension test (TST), and open field test.
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It is shown that diabetes can change hematological parameters and some microalgae, i.e. Spirulina platensis, could improve hematological parameters in non-diabetic rats. The purpose of this study was to investigate the effects of... more
It is shown that diabetes can change hematological parameters and some microalgae, i.e. Spirulina platensis, could improve hematological parameters in non-diabetic rats. The purpose of this study was to investigate the effects of Spirulina platensis (SPM) microalgae on hematological parameters in diabetic rats induced by Streptozotocin. Rats, 2.5 males old, were grouped into two sections including healthy and diabetic and received orally 15 and 30 mg/kg body weight SPM for 5 weeks. Control rats received 0.3 ml of distilled water. The experimental groups were as follows; (SH15), healthy rats fed SPM (SH30) 30 mg/kg, diabetic rats fed 15 mg/kg SPM (SD15), diabetic rats fed SPM (SD30) 15 mg/kg, and diabetic control (DC). At the end of the test, blood samples were collected to measure red blood cells, white blood cells, mean corpuscular hemoglobin concentration (MCHC), mean cell volume (MCV) and packed cell volume (PCV). The induction of diabetes decreased RBC, MCHC, PCV, MCV and WBC (P...
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Background and aims: Several pharmacological and biological activities have been attributed to Cuminum cyminum L. (CC), including analgesic, antioxidant, anti-inflammatory, and anti-epileptic effects. In this regard, the present study... more
Background and aims: Several pharmacological and biological activities have been attributed to Cuminum cyminum L. (CC), including analgesic, antioxidant, anti-inflammatory, and anti-epileptic effects. In this regard, the present study evaluated the antidepressant-like effects of the CC essential oil (EO) on the forced swim test (FST) and tail suspension test (TST) in male mice. Materials and Methods: The gas chromatography-mass spectrometry (GC-MS) apparatus was used for detecting the chemical compounds of CC EO. In the present study, 72 male NMRI mice were randomly allocated to 12 groups (each containing 6 animals) including control or vehicle (10 mL/kg, i.p.), fluoxetine (20 mg/kg, i.p.), imipramine (30 mg/kg, i.p), and the CC EO (100, 200, and 300 mg/kg, i.p.). Then, several parameters were measured and recorded, including immobility time, swimming time, and climbing time in FST, along with immobility time in TST, respectively. Results: Cuminaldehyde followed by cymene, γ-terpine...
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Objective: Pimpinella anisum (P. anisum) has different pharmacological properties such as anticonvulsant, analgesic, tranquilizer, antidepressant and anti-anxiety effects. In this study the antidepressant-like effect of aqueous and... more
Objective: Pimpinella anisum (P. anisum) has different pharmacological properties such as anticonvulsant, analgesic, tranquilizer, antidepressant and anti-anxiety effects. In this study the antidepressant-like effect of aqueous and ethanolic extracts of P. anisum fruit in mice was investigated. Materials and Methods: Forced swimming test (FST) and tail suspension test (TST) were used to determine the antidepressant effects of P. anisum (50, 100 and 200 mg/kg, i.p.) fruit extracts. Fluoxetine (20 mg/kg, i.p.) and imipramine (30 mg/kg, i.p.) were used as standard drugs. Results: All the three doses of aqueous and ethanolic extracts (except 50 mg/kg of aqueous extract in FST) significantly and dose-dependently reduced the immobility times in both FST and TST. All doses of extracts increased the swimming time dose-dependently, without any significant change in climbing time. In addition, all doses of ethanolic extract reduced immobility times and increased swimming time insignificantly ...
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Background Giardiasis, an intestinal infection, is made by the flagellate protozoan and on the other hand, positive effects of plants derivatives, especially phenolic derivatives, against giardiasis. The effect of Origanum vulgare (OV)... more
Background Giardiasis, an intestinal infection, is made by the flagellate protozoan and on the other hand, positive effects of plants derivatives, especially phenolic derivatives, against giardiasis. The effect of Origanum vulgare (OV) hydroalcoholic extract is still uninvestigated. Thus, this study was conducted to evaluate the effect of OV hydroalcoholic extract on Giardia lamblia cysts compared with metronidazole in vitro. Methods The present experimental study was conducted in 2015-2016 in the Laboratory of Department of Parasitology of Islamic Azad University (Abhar Branch, Abhar, Iran). Cysts separated from feces by Bingham procedure were calculated by using the Hemusytumetr method. Five hundred μl of concentrations of 10, 100 and 200 mg/ml of OV hydroalcoholic extract and also125 mg/kg of metronidazole were added to the purified cysts of giardia. Control group was treated with normal saline. Anti-Giardia activity was calculated by using the light microscope for 30, 60 and 120...
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Background and aims: Safflower (Carthamus tinctorius L.)from Asteraceae family has different biological activities including analgesic, antidepressant, anti-inflammatory, antispasmodic and neuroprotective effects. This study designed to... more
Background and aims: Safflower (Carthamus tinctorius L.)from Asteraceae family has different biological activities including analgesic, antidepressant, anti-inflammatory, antispasmodic and neuroprotective effects. This study designed to evaluate its effect on naloxone -induced morphine withdrawal signs. Methods: In this experimental study, male NMRI mice (25-30 g) were randomly divided into 5 groups of 8: control groups received morphine and normal saline (10ml/kg) and other groups received fluoxetine (20mg/kg) and different doses of ethanolic extract of Safflower (100,200 and 400mg/kg).Morphine dependency was induced by intraperitoneal (i.p.) injection of increasing doses (50-75 mg/kg) of morphine. Withdrawal signs were elicited by naloxone (5mg/kg, i.p.) and number of jumpings and also presence of climbing, writing, wet dog shakes, teeth chattering, diarrhea, grooming and rearing during a 30 min period. Results: The ethanolic extract at all doses (100, 200 and 400 mg/kg, i.p., p 0...
Background and Aim: The antispasmodic, analgesic, antioxidant, anti-inflammatory and sedative effects of Cymbopogon citratus ( C. citratus ) have been already examined in various studies . Hence, the present study was conducted to... more
Background and Aim: The antispasmodic, analgesic, antioxidant, anti-inflammatory and sedative effects of Cymbopogon citratus ( C. citratus ) have been already examined in various studies . Hence, the present study was conducted to investigate the effect of C. citratus hydroalcoholic extract on morphine withdrawal signs in male mice. Materials and Methods: Male NMRI mice (20-30g) were rendered dependent by intraperitoneal (i.p.) injections of morphine three times daily at doses of 50, 50 and 75 mg/kg, respectively, for 3 days. After the last administration of morphine on the fourth day, different doses of C. citratus extract (140,280 and 560 mg/kg, i.p.) and clonidine (0.3mg/kg, i.p.) were administered 30 min before the administration of naloxone (5 mg/kg, i.p.). The mice were observed for 30 minutes for the withdrawal signs, i.e., the characteristic jumping, grooming, teeth chattering, climbing, rearing, wet dog shakes, writing and diarrhea. Results: The findings revealed that all d...
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Background and aims: Antidepressant agents such as imipramine are clinically used to control and treat different types of pain, especially neuropathic pain. Studies have shown the antidepressant-like activity of folic acid (FA). This... more
Background and aims: Antidepressant agents such as imipramine are clinically used to control and treat different types of pain, especially neuropathic pain. Studies have shown the antidepressant-like activity of folic acid (FA). This study aimed to investigate the potential antinociceptive effects of FA using formalin and acetic acid tests in male mice. Methods: Sixty male albino mice (20-30 g) were randomly divided into 10 groups (n=6 in each group) of negative control, positive control (morphine or indomethacin), and FA (10, 15, and 30 mg/kg) groups. In the formalin test, duration of paw licking and biting the right hind paw during acute (0-5 minutes) and chronic (15-60 minutes) pain after intraplantar injection of formalin 2.5% (25 μL) was recorded. In the writhing test, the abdominal constrictions were recorded after the intraperitoneal injection of acetic acid 1%. Results: Only a high dose (30 mg/kg) of FA significantly reduced acute pain (P = 0.001) compared with the control g...
The amount of data in electronic and real world is constantly on the rise. Therefore, extracting useful knowledge from the total available data is very important and time consuming task. Data mining has various techniques for extracting... more
The amount of data in electronic and real world is constantly on the rise. Therefore, extracting useful knowledge from the total available data is very important and time consuming task. Data mining has various techniques for extracting valuable information or knowledge from data. These techniques are applicable for all data that are collected inall fields of science. Several research investigations are published about applications of data mining in various fields of sciences such as defense, banking, insurances, education, telecommunications, medicine and etc. This investigation attempts to provide a comprehensive survey about applications of data mining techniques in breast cancer diagnosis, treatment & prognosis till now. Further, the main challenges in these area is presented in this investigation. Since several research studies currently are going on in this issues, therefore, it is necessary to have a complete survey about all researches which are completed up to now, along wi...
Background and aims: Myrtus communis has certain effects including anti-anxiety, analgesic, anti-inflammatory and hypnotic. The aim of this study was to investigate the phythochemical and anesthesia effects of M. communis essential oil... more
Background and aims: Myrtus communis has certain effects including anti-anxiety, analgesic, anti-inflammatory and hypnotic. The aim of this study was to investigate the phythochemical and anesthesia effects of M. communis essential oil co-administration with thiopental in male rat were investigated. Methods: In this experimental study, 24 male rats were randomly divided to three groups of 8 each, consisting of M. communis (MC) (500 mg/kg), thiopental (T) (40 mg/kg), and M. communis + thiopental (MCT) (500 and 40 mg/kg, respectively). Duration of induction and Surgical Anesthesia (SA), walking time, heart rate, respiratory rate, temperature and depth of anesthesia (by withdrawal reflexes) were measured from 0 to 55 minutes. Results: MC could not induce SA. T induced anesthesia had group insignificantly faster than MCT (P>0.05). Duration of anesthesia in T group was shorter and recovery was faster compared to MCT group (P 0.05). The respiratory rate and temperature (between 30 to 5...
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The antidepressant-like effects of zinc (Zn) have been documented in some animal models of depression. In addition, antidepressants may reduce the abuse potential of opioids by affecting their rewarding effect. Hence, this study was... more
The antidepressant-like effects of zinc (Zn) have been documented in some animal models of depression. In addition, antidepressants may reduce the abuse potential of opioids by affecting their rewarding effect. Hence, this study was performed to investigate the effect of Zn on the expression of morphine-induced conditioned place preference (CPP) in male rats. We used an unbiased CPP paradigm for investigating the effect of Zn. The intraperitoneal (i.p.) and intracerebroventricular (i.c.v.) administrations of Zn (5-20 mg/kg, i.p., and 10 nmol/rat, respectively) with or without morphine did not induce conditioned place aversion (CPA) or CPP during acquisition phase. However, the same i.p. and i.c.v. administrations of Zn induced morphine-like CPP in the expression phase. Pre-treatment with dopamine receptor antagonists (SCH23390, sulpiride, and haloperidol) and serotonin receptor antagonists (WAY100135, ketanserin, and ondansetron) reversed the enhancement effect of Zn on the expressi...
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Origanum majorana (L.) is an herb used in the treatment of diseases related to the nervous system in traditional medicine (e.g. as an anticonvulsant and sedative). The present study was conducted to investigate the antidepressant-like... more
Origanum majorana (L.) is an herb used in the treatment of diseases related to the nervous system in traditional medicine (e.g. as an anticonvulsant and sedative). The present study was conducted to investigate the antidepressant-like effects of Origanum majorana essential oil (OMEO) on mice in the forced swimming test (FST). The animals were intraperitoneally (i.p.) injected with OMEO (10–80 mg/kg) 1 h before the FST. To assess the involvement of the monoaminergic system in the antidepressant activity of OMEO, different pharmacological antagonists were administered 15 min before OMEO administration (80 mg/kg). The administration of OMEO (40 and 80 mg/kg, i.p.) decreased immobility time and increased swimming and climbing times significantly. OMEO did not cause any changes in spontaneous locomotor function in the open-field test (OFT). The pre-treatment of the animals with SCH23390, sulpiride, haloperidol, WAY100135, p-chlorophenylalanine (pCPA), ketanserin, prazosin, yohimbine, reserpine, but not propranolol, inhibited the anti-immobility effect of OMEO in the FST. A combination of sub-effective doses of fluoxetine (5 mg/kg, i.p.) or imipramine (5 mg/kg, i.p.) with OMEO (10 mg/kg, i.p.) increased the antidepressant-like effects. OMEO showed antidepressant-like effects through involvement with the dopaminergic (D1 and D2), serotonergic (5HT1A, 5-HT2A receptors) and noradrenergic (α1 and α2 adrenoceptors) systems.
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Studies indicate that major deficiency in the levels of monoaminergic transmitters is a reason for severe depression. On the other hand, it is shown that Carthamus tinctorius L. (CT) may improve neuropsychological injuries by regulation... more
Studies indicate that major deficiency in the levels of monoaminergic transmitters is a reason for severe depression. On the other hand, it is shown that Carthamus tinctorius L. (CT) may improve neuropsychological injuries by regulation of the monoamine transporter action. Hence, the present study was undertaken to evaluate the involvement of monoaminergic systems in antidepressant-like effect of CT extract in the tail suspension test (TST) in mice. The mice were intraperitoneally (IP) treated with CT extract (100-400 mg/kg) 1 hr before the TST. To investigate the involvement of monoaminergic systems in antidepressant-like effect, the mice were treated with receptor antagonists 15 min before CT extract treatment (400 mg/kg, IP) and 1 hr before the TST. Findings showed that CT extract (100-400 mg/kg, IP), dose-dependently induced antidepressant-like effect (P<0.001), but it was not accompanied by alterations in spontaneous locomotor activity in the open-field test. Pretreatment of...
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Introduction: It is reported that the dopaminergic pathway is involved in antidepressant-like effects of creatine in mice. In the other hand, numerous studies have shown that morphine causes a reinforcing effect, which may be attributed... more
Introduction: It is reported that the dopaminergic pathway is involved in antidepressant-like effects of creatine in mice. In the other hand, numerous studies have shown that morphine causes a reinforcing effect, which may be attributed to its facilitating dopaminergic transmission through the release of dopamine. Therefore, the aim of the present study was to investigate the effect of co-administration of creatine and sertraline on expression of morphine-induced conditioned place preference (CPP) in male mice. Methods: In this study, male NMRI mice (weighting 20-30 g) were used. The study carried out in six consecutive days, consisting of three phases: preconditioning, conditioning, and postconditioning. In the first section of study, creatine (1, 10 and 20 mg/kg) and sertraline (2.5, 5 and 10 mg/kg) alone were administered in conditioning and postconditioning phases to assay if they induce CPP or conditioned place aversion (CPA). In the second section, the mice received creatine a...
Introduction: Antidepressants especially those have ability to increase the serotonin and noradrenaline levels, possess several uses in pain management (particularly neuropathic pain). Based on antidepressant-like activity of folic acid... more
Introduction: Antidepressants especially those have ability to increase the serotonin and noradrenaline levels, possess several uses in pain management (particularly neuropathic pain). Based on antidepressant-like activity of folic acid in animal models of depression, the aim of the present study was to investigate the effect of folic acid on acute and chronic pain in male mice. Methods: Forty male NMRI mice (20-30 g) were divided into five groups of eight animals: normal saline, morphine (5 mg/kg) and folic acid groups (5, 10, and 30 mg/kg, intraperitoneally). Assessment of the pain was done using the formalin test. The duration of paw licking and biting during the early phase (0-5 min) and late phase (15-60 min) after formalin injection (25 µl formalin, 2.5 %) in the right hind paw of the animal, subcutaneously Results: Results showed that only high dose of folic acid significantly reduced the early phase of pain compared to the control group (p<0.05), while, all doses of folic...