We have analysed 139 consecutive cases (71 males and 68 females) of nutritional megaloblastic ana... more We have analysed 139 consecutive cases (71 males and 68 females) of nutritional megaloblastic anaemia over a period of four and a half years. The majority of these patients belonged to the low socio-economic class and many of them were strict vegetarians. Sixty one percent were in the second and third decades of life. At the time of presentation, 46% had mild hepatomegaly, 42% fever, 34% mild splenomegaly and 20% bleeding manifestations. Of 102 cases in whom the biochemical parameters were available, vitamin B12 deficiency was detected in 76%, folate deficiency in 6.8%, combined B12 and folate deficiency in 8.8%; the remaining 7.8% had normal vitamin levels at presentation. All 139 patients had severe anaemia, 80.5% had thrombocytopenia and 43.8% had neutropenia as well as thrombocytopenia. It appears that during progression (in terms of duration) of megaloblastosis, anaemia is followed by thrombocytopenia and then neutropenia. Infection and bleeding in these patients may be aggrava...
... through Four Beacons for Wireless Sensor Network Alok Kumar Indian Institute of Information T... more ... through Four Beacons for Wireless Sensor Network Alok Kumar Indian Institute of Information Technology, Allahabad, India Shirshu Varma Indian Institute of Information Technology, Allahabad, India Rajeev Sonkar IBM India, Pune, India ...
Indian Journal of Hematology and Blood Transfusion, 2012
Pseudo-Chediak-Highashi granules are giant cytoplasmic inclusions commonly encountered in myelobl... more Pseudo-Chediak-Highashi granules are giant cytoplasmic inclusions commonly encountered in myeloblasts or other myeloid precursors in acute myeloid leukemia and myelodysplastic syndromes. They derive their name from the inherited Chediak-Higashi syndrome that presents with oculocutaneous albinism, chronic infections and platelet dense granule deficiency. We report possibly the third case in world literature where these granules were seen in the blast cells of acute lymphoblastic leukemia in a 15-year-old male.
Sequestrated meningocoele is an uncommon developmental anomaly in which meningothelial elements a... more Sequestrated meningocoele is an uncommon developmental anomaly in which meningothelial elements are found in the skin or subcutaneous tissue without underlying bony defect. By contrast, naevus sebaceous of Jadassohn (NSJ) is a circumscribed hamartomatous lesion occurring in about 0.3% of newborns. We report a child with a histologically confirmed sequestrated meningocoele within an NSJ on his scalp vertex. Such an occurrence has not been reported previously.
Abstract Microarray and Next-Gen Sequencing technologies have generated a huge amount of genome s... more Abstract Microarray and Next-Gen Sequencing technologies have generated a huge amount of genome scale expression data. Many software tools permit extraction of expression profiles/data for a given gene or a set of genes. It has been established that genes with ...
The current convergence of molecular and pharmacological data provides unprecedented opportunitie... more The current convergence of molecular and pharmacological data provides unprecedented opportunities to gain insights into the relationships between the two types of data. Multiple forms of large-scale molecular data, including but not limited to gene and microRNA transcript expression, DNA somatic and germline variations from next-generation DNA and RNA sequencing, and DNA copy number from array comparative genomic hybridization are all potentially informative when one attempts to recognize the panoply of potentially influential events both for cancer progression and therapeutic outcome. Concurrently, there has also been a substantial expansion of the pharmacological data being accrued in a systematic fashion. For cancer cell lines, the National Cancer Institute cell line panel (NCI-60), the Cancer Cell Line Encyclopedia (CCLE), and the collaborative Genomics of Drug Sensitivity in Cancer (GDSC) databases all provide subsets of these forms of data. For the patient-derived data, The C...
2009 First International Conference on Computational Intelligence, Communication Systems and Networks, 2009
Abstract Wireless sensor network is need of present era or advanced technology. In this paper we ... more Abstract Wireless sensor network is need of present era or advanced technology. In this paper we have presented the details of methodology followed for implementation of a Wireless Sensor Network in a process plant for based solution for data acquisition in a process plant. Due ...
Serum cortisol concentrations fluctuate in a circadian fashion, and glucocorticoids exert strong ... more Serum cortisol concentrations fluctuate in a circadian fashion, and glucocorticoids exert strong effects on adipose tissue and induce obesity through the glucocorticoid receptor. To examine the impact of physiologic levels of circulating cortisol on subcutaneous adipose tissue, 25 overweight and obese subjects were employed, and their serum levels of morning (AM) and evening (PM) cortisol, AM/PM cortisol ratios, and 24-h urinary-free cortisol (UFC) were compared with their clinical parameters, serum cytokine levels, and mRNA expression of 93 receptor action-regulating and 93 glucocorticoid-responsive genes in abdominal subcutaneous fat. AM cortisol levels did not correlate with mRNA expression of the all genes examined, whereas PM cortisol levels, AM/PM cortisol ratios, and 24-h UFC were associated with distinct sets of these genes. Body mass index did not significantly correlate with the four cortisol parameters employed. These results suggest that physiologic levels of AM serum cortisol do not solely represent biological effects of circulating cortisol on the expression of glucocorticoid-related genes in subcutaneous adipose tissue, whereas PM levels, amplitude, and net amounts of the diurnally fluctuating serum cortisol have distinct effects. Through the genes identified in this study, glucocorticoids appear to influence intermediary metabolism, energy balance, inflammation, and local circadian rythmicity in subcutaneous fat. Our results may also explain in part the development of metabolic abnormality and obesity in subjects under stress or patients with melancholic/atypical depression who demonstrate elevated levels of PM serum cortisol.
... Our micro-Raman and X-ray photoelectron studies revealed the existence of these defects which... more ... Our micro-Raman and X-ray photoelectron studies revealed the existence of these defects which are believed to be the origin of the unconventional ferromagnetism (FM) of ZnO bulk ceramic at room temperature. PACS: 70; 71.55.Gs; 75.50.Pp. ...
We have analysed 139 consecutive cases (71 males and 68 females) of nutritional megaloblastic ana... more We have analysed 139 consecutive cases (71 males and 68 females) of nutritional megaloblastic anaemia over a period of four and a half years. The majority of these patients belonged to the low socio-economic class and many of them were strict vegetarians. Sixty one percent were in the second and third decades of life. At the time of presentation, 46% had mild hepatomegaly, 42% fever, 34% mild splenomegaly and 20% bleeding manifestations. Of 102 cases in whom the biochemical parameters were available, vitamin B12 deficiency was detected in 76%, folate deficiency in 6.8%, combined B12 and folate deficiency in 8.8%; the remaining 7.8% had normal vitamin levels at presentation. All 139 patients had severe anaemia, 80.5% had thrombocytopenia and 43.8% had neutropenia as well as thrombocytopenia. It appears that during progression (in terms of duration) of megaloblastosis, anaemia is followed by thrombocytopenia and then neutropenia. Infection and bleeding in these patients may be aggrava...
... through Four Beacons for Wireless Sensor Network Alok Kumar Indian Institute of Information T... more ... through Four Beacons for Wireless Sensor Network Alok Kumar Indian Institute of Information Technology, Allahabad, India Shirshu Varma Indian Institute of Information Technology, Allahabad, India Rajeev Sonkar IBM India, Pune, India ...
Indian Journal of Hematology and Blood Transfusion, 2012
Pseudo-Chediak-Highashi granules are giant cytoplasmic inclusions commonly encountered in myelobl... more Pseudo-Chediak-Highashi granules are giant cytoplasmic inclusions commonly encountered in myeloblasts or other myeloid precursors in acute myeloid leukemia and myelodysplastic syndromes. They derive their name from the inherited Chediak-Higashi syndrome that presents with oculocutaneous albinism, chronic infections and platelet dense granule deficiency. We report possibly the third case in world literature where these granules were seen in the blast cells of acute lymphoblastic leukemia in a 15-year-old male.
Sequestrated meningocoele is an uncommon developmental anomaly in which meningothelial elements a... more Sequestrated meningocoele is an uncommon developmental anomaly in which meningothelial elements are found in the skin or subcutaneous tissue without underlying bony defect. By contrast, naevus sebaceous of Jadassohn (NSJ) is a circumscribed hamartomatous lesion occurring in about 0.3% of newborns. We report a child with a histologically confirmed sequestrated meningocoele within an NSJ on his scalp vertex. Such an occurrence has not been reported previously.
Abstract Microarray and Next-Gen Sequencing technologies have generated a huge amount of genome s... more Abstract Microarray and Next-Gen Sequencing technologies have generated a huge amount of genome scale expression data. Many software tools permit extraction of expression profiles/data for a given gene or a set of genes. It has been established that genes with ...
The current convergence of molecular and pharmacological data provides unprecedented opportunitie... more The current convergence of molecular and pharmacological data provides unprecedented opportunities to gain insights into the relationships between the two types of data. Multiple forms of large-scale molecular data, including but not limited to gene and microRNA transcript expression, DNA somatic and germline variations from next-generation DNA and RNA sequencing, and DNA copy number from array comparative genomic hybridization are all potentially informative when one attempts to recognize the panoply of potentially influential events both for cancer progression and therapeutic outcome. Concurrently, there has also been a substantial expansion of the pharmacological data being accrued in a systematic fashion. For cancer cell lines, the National Cancer Institute cell line panel (NCI-60), the Cancer Cell Line Encyclopedia (CCLE), and the collaborative Genomics of Drug Sensitivity in Cancer (GDSC) databases all provide subsets of these forms of data. For the patient-derived data, The C...
2009 First International Conference on Computational Intelligence, Communication Systems and Networks, 2009
Abstract Wireless sensor network is need of present era or advanced technology. In this paper we ... more Abstract Wireless sensor network is need of present era or advanced technology. In this paper we have presented the details of methodology followed for implementation of a Wireless Sensor Network in a process plant for based solution for data acquisition in a process plant. Due ...
Serum cortisol concentrations fluctuate in a circadian fashion, and glucocorticoids exert strong ... more Serum cortisol concentrations fluctuate in a circadian fashion, and glucocorticoids exert strong effects on adipose tissue and induce obesity through the glucocorticoid receptor. To examine the impact of physiologic levels of circulating cortisol on subcutaneous adipose tissue, 25 overweight and obese subjects were employed, and their serum levels of morning (AM) and evening (PM) cortisol, AM/PM cortisol ratios, and 24-h urinary-free cortisol (UFC) were compared with their clinical parameters, serum cytokine levels, and mRNA expression of 93 receptor action-regulating and 93 glucocorticoid-responsive genes in abdominal subcutaneous fat. AM cortisol levels did not correlate with mRNA expression of the all genes examined, whereas PM cortisol levels, AM/PM cortisol ratios, and 24-h UFC were associated with distinct sets of these genes. Body mass index did not significantly correlate with the four cortisol parameters employed. These results suggest that physiologic levels of AM serum cortisol do not solely represent biological effects of circulating cortisol on the expression of glucocorticoid-related genes in subcutaneous adipose tissue, whereas PM levels, amplitude, and net amounts of the diurnally fluctuating serum cortisol have distinct effects. Through the genes identified in this study, glucocorticoids appear to influence intermediary metabolism, energy balance, inflammation, and local circadian rythmicity in subcutaneous fat. Our results may also explain in part the development of metabolic abnormality and obesity in subjects under stress or patients with melancholic/atypical depression who demonstrate elevated levels of PM serum cortisol.
... Our micro-Raman and X-ray photoelectron studies revealed the existence of these defects which... more ... Our micro-Raman and X-ray photoelectron studies revealed the existence of these defects which are believed to be the origin of the unconventional ferromagnetism (FM) of ZnO bulk ceramic at room temperature. PACS: 70; 71.55.Gs; 75.50.Pp. ...
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