Papers by Rossella Gaudino
Journal of medical screening, 2004
To evaluate the effectiveness of thyroid-stimulating hormone (TSH) and thyroxine (T4) measurement... more To evaluate the effectiveness of thyroid-stimulating hormone (TSH) and thyroxine (T4) measurements at neonatal screening for congenital hypothyroidism, we compared our false-negative results with those we would have obtained if we had used TSH screening alone. Between January 1989 and December 2001 745,258 newborns were screened (98.3% of total born) for congenital hypothyroidism in northeast Italy. T4 and TSH were measured simultaneously on blood spots collected after birth. Between 1989 and 1998, semi-quantitative total T4 (tT4) and TSH concentrations were measured by radiolabelled immunological assay and, from 1999 to 2001, using time-resolved fluorometer Delfia instruments (EG&G Wallac Oy, Finland) and fluoroimmunometric assay (Delfia neonatal hTSH and T4 kits). Ten neonates were missed by our screening programme (normal tT4 and TSH) and classified as false negatives; these infants were diagnosed later in life with central hypothyroidism. If we had measured TSH alone in our scre...
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Journal of Endocrinological Investigation, 2014
The diagnosis of congenital hypopituitarism is difficult and often delayed because its symptoms a... more The diagnosis of congenital hypopituitarism is difficult and often delayed because its symptoms are nonspecific. To describe the different clinical presentations of children with congenital hypopituitarism to reduce the time for diagnosis and to begin a precocious and appropriate treatment. We analyzed a cohort of five children with congenital hypopituitarism, describing their clinical, biochemical and radiological characteristics from the birth to diagnosis. As first sign of the disease, all of five patients presented a neonatal hypoglycemia, associated in four cases with jaundice. In all these four cases, the clinicians hypothesized a metabolic disease delaying the diagnosis, which was performed in only two cases within the neonatal period. In the other three cases, the diagnosis was formulated at 2, 5 and 8 years of life because there was severe and precocious growth impairment. It is important to suspect congenital hypopituitarism in the presence of persistent neonatal hypoglycemia associated with jaundice and of a precocious and severe reduction of the growth velocity in childhood. In all these cases, it is necessary to undertake a hypothalamic-pituitary magnetic resonance imaging scan as soon as possible, and to start appropriate treatment.
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Expert Review of Endocrinology & Metabolism, 2010
Page 1. 273 Review www.expert-reviews.com ISSN 1744-6651 © 2010 Expert Reviews Ltd 10.1586/EEM.09... more Page 1. 273 Review www.expert-reviews.com ISSN 1744-6651 © 2010 Expert Reviews Ltd 10.1586/EEM.09.69 Human height depends on interactions between different factors, such as genetic predisposition, nutritional status, hormonal secretion and envi-ronmental factors. ...
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The Journal of Clinical Endocrinology & Metabolism, 2002
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Fertility and Sterility, 2008
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Fertility and Sterility, 2010
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Fertility and Sterility, 2010
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European Journal of Epidemiology, 2000
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Acta Paediatrica, 2007
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Journal of Pediatric Endocrinology and Metabolism, 2014
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Papers by Rossella Gaudino