Preterm premature rupture of membranes is responsible for one-third of preterm births. Ehlers-Dan... more Preterm premature rupture of membranes is responsible for one-third of preterm births. Ehlers-Danlos syndrome (EDS) is associated with preterm premature rupture of membranes in humans. In particular, an EDS variant is caused by a genetic mutation resulting in abnormal secretion of biglycan and decorin, two small leucine-rich proteoglycans highly expressed in reproductive tissues. Because biglycan/decorin null mutant (Bgn(-/-)Dcn(-/-)) mice demonstrate phenotypic changes similar to EDS, we used this model to test whether either biglycan or decorin or both play a role in the attainment of successful term gestation. Wild-type biglycan null mutant, decorin null mutant, and biglycan/decorin null mutant pregnancies were assessed for the length of gestation, pup and placenta weight, and litter size. Quantitative real-time PCR was performed to measure biglycan and decorin gene expression, and immunohistochemistry was performed to assess protein expression in placenta and fetal membranes at ...
Objective. Childhood obesity has contributed to an increased incidence of type 2 diabetes mellitu... more Objective. Childhood obesity has contributed to an increased incidence of type 2 diabetes mellitus and metabolic syndrome (MS) among children. Intrauterine exposure to diabetes and size at birth are risk factors for type 2 diabetes mellitus, but their association with MS in childhood has not been demonstrated. We examined the development of MS among large-for-gestational-age (LGA) and appropriate-for-gestational age (AGA) children. Study Design. The major components of MS (obesity, hypertension, dyslipidemia, and glucose intolerance) were evaluated in a longitudinal cohort study of children at age 6, 7, 9, and 11 years who were LGA (n = 84) or AGA (n = 95) offspring of mothers with or without gestational diabetes mellitus (GDM). The cohort consisted of 4 groups, ie, LGA offspring of control mothers, LGA offspring of mothers with GDM, AGA offspring of control mothers, and AGA offspring of mothers with GDM. Biometric and anthropometric measurements were obtained at 6, 7, 9, and 11 yea...
Journal of human lactation : official journal of International Lactation Consultant Association, Jan 26, 2015
Colonization increases risk for invasive candidiasis in neonates. Breast milk host defense protei... more Colonization increases risk for invasive candidiasis in neonates. Breast milk host defense proteins may affect yeast colonization of infants. This study aimed to evaluate breast milk host defense proteins relative to yeast colonization in infants. Infants admitted for longer than 72 hours to the neonatal intensive care unit at Women & Infants Hospital in Providence, Rhode Island, were eligible. After consent, expressed breast milk and swabs from oral, rectal, and inguinal sites from infants were cultured weekly for 12 weeks, or until discharge, transfer, or death. Breast milk was tested for levels of human lactoferrin, lysozyme, apolipoprotein J, mucin-1, dermcidin, and soluble CD14 using commercial ELISA. Concentrations of these components were compared in breast milk received by infants who were colonized or not colonized with yeast. From an original cohort of 130, 61 infants had samples available for this subanalysis. A convenience sample of stored breast milk was analyzed. Media...
Objective The objective of this study was to study the temporal profile of pulmonary hypertension... more Objective The objective of this study was to study the temporal profile of pulmonary hypertension (PH) in preterm infants. Study Design Infants < 28 weeks were screened for early PH at 10 to 14 days of life. Infants with early PH (n = 10) and gestationally matched controls (n = 18) underwent serial echocardiography every 7 to 10 days until 36 weeks postmenstrual age. Results Groups with and without early PH were comparable except for higher Fio 2 by day 10 among infants with early PH. Early PH was moderate in extent and resolved in all infants with recurrence in one infant. Among infants without early PH, five infants developed late PH. In both groups, development of late PH occurred in association with important neonatal morbidities, such as patent ductus arteriosus, bronchopulmonary dysplasia, and infection. Conclusion Early moderate PH among preterm infants resolves over a variable time period but recurrence is possible. Late PH can appear during the course of hospitalization in association with other clinical morbidities.
... Correspondence to: Dr. P. Arun Kumar Nair, Senior Consultant and Neonatologist, Division of C... more ... Correspondence to: Dr. P. Arun Kumar Nair, Senior Consultant and Neonatologist, Division of Child Health, Royal Hospital, PO Box 1331, PC 111 Seeb, Sultanate of Oman. E-mail:srinavin@omantel.net.om Manuscript received: December 9, 2002, Initial review completed ...
Deakin Teaching and Learning Conference 2007, 2007
Copyright notice: This website and its contents are subject to copyright under the laws of Austra... more Copyright notice: This website and its contents are subject to copyright under the laws of Australia and, through international treaties, other countries. The copyright in materials in this website as a whole is owned by Deakin University. Third parties own the copyright in some materials incorporated within this website. You may view this website and its contents using your web browser and save an electronic copy, or print out a copy, of parts of this website solely for your own information, research or study, but only if you: do not modify ...
Proceedings of the 2008 Association For Business Communication Annual Convention Strategic Business Communication a Reflection of Critical Thinking in the Classroom and the Workplace, 2008
... the effects of air pollution; Stern and Cole (1984) used the model to estimate a model of rai... more ... the effects of air pollution; Stern and Cole (1984) used the model to estimate a model of rainfall data. The model extends readily to the case of an ordered or multinomial outcome, and Zeger and Qaqish (1988) extend the model for count data. Page 11. 9 ...
There is considerable evidence of general student scepticism regarding the purpose of team assign... more There is considerable evidence of general student scepticism regarding the purpose of team assignments and high levels of concern for the fairness of assessment procedures when all members of a team receive the same grade. Some educators are similarly anxious about not only the validity of team grades, but also the need to assess ongoing team processes in addition to
To compare the impact of low-grade haemorrhage on neurocognitive function in 16-year-old adolesce... more To compare the impact of low-grade haemorrhage on neurocognitive function in 16-year-old adolescents born preterm, by grade of intraventricular haemorrhage, and term controls. We evaluated 338 preterm adolescents (birth weight 600-1250 g) for intelligence, executive function and memory tasks. Eleven had grade 3-4 haemorrhage, 44 had grade 2, 31 had grade 1, and 251 had no haemorrhage. Group comparisons were made with 102 term age-matched controls, and regression models used to identify the risk that low-grade haemorrhage posed for cognitive, executive function and memory deficits. Preterm adolescents with grade 2 haemorrhage had higher deficit rates of verbal intelligence, receptive vocabulary, phonemic fluency, cognitive flexibility and phonological fluency than preterm adolescents with grade 1 or no haemorrhage, compared with term controls. After excluding preterm adolescents with both grade 2 haemorrhage and cystic periventricular leukomalacia, those with isolated grade 2 haemorr...
There is considerable evidence of student scepticism regarding the purpose of team assignments an... more There is considerable evidence of student scepticism regarding the purpose of team assignments and high levels of concerns for the fairnesss of assessment when all team members receive the same grade. This chapter considers online self-and-peer assessment (SAPA) as a fair, valid and reliable method aof assessing team processes and individualising grades. A pilot studey is detailed that evaluated an online self-and-peer continuous assessment (SAPCA-a particular form of SAPA) tool originally developed for ...
This study tested if measures of central nervous system (CNS) immaturity reflected by amplitude i... more This study tested if measures of central nervous system (CNS) immaturity reflected by amplitude integrated electroencephalogram (aEEG) and associated clinical morbidities are determinants of length of hospitalization among late preterm infants born at 34 wk. This was a prospective cohort study of infants with a gestational age of 34 wk 0-6 d who had a single aEEG recording acquired over 6 h in a neonatal intensive care unit within 72 h of birth (n = 80). Infants were followed for predefined morbidities (classified as CNS or non-CNS) and length of hospitalization (determined by the clinical care team). aEEG variables were correlated with length of hospitalization. Eighty infants were enrolled and 75 aEEG recordings were analyzed. The average length of hospitalization was 10.4 ± 7.2 d (range 3-46 d). The total number of cycles recorded in the first 72 h following birth were inversely correlated with the length of hospitalization (r(2) = 0.44, P < 0.001). Kaplan-Meier curves indicated that morbidities consistent with neurological immaturity were associated with a longer length of hospitalization (P < 0.001). Neurological maturation as indicated by aEEG and specific clinical morbidities is an important determinant of length of hospitalization among late-preterm infants.
To study the efficacy and complications of low dose indomethacin in the reduction of major intrav... more To study the efficacy and complications of low dose indomethacin in the reduction of major intraventricular hemorrhage (IVH) in very low birth weight (VLBW) babies. prospective randomized controlled trial (interim analysis) Level III neonatal intensive care unit of a perinatal tertiary care center. Newborn babies with birth weights between 750-1250 g were randomized into indomethacin or control groups. They were further stratified into two birth weight groups 750-999 g and 1000-1250 g for subgroup analysis. 3 doses of indomethacin were administered to the indomethacin group at the dose of 0.1 mg/kg/dose intravenously. The control group did not receive any specific intervention other than standard neonatal intensive care. The primary outcome measure was the occurrence of IVH and the secondary outcome measures were necrotising enterocolitis, symptomatic patent ductus arteriosus (PDA), bleeding episodes, renal failure, chronic-lung disease and death. Out of 115 eligible newborn babies,...
Preterm premature rupture of membranes is responsible for one-third of preterm births. Ehlers-Dan... more Preterm premature rupture of membranes is responsible for one-third of preterm births. Ehlers-Danlos syndrome (EDS) is associated with preterm premature rupture of membranes in humans. In particular, an EDS variant is caused by a genetic mutation resulting in abnormal secretion of biglycan and decorin, two small leucine-rich proteoglycans highly expressed in reproductive tissues. Because biglycan/decorin null mutant (Bgn(-/-)Dcn(-/-)) mice demonstrate phenotypic changes similar to EDS, we used this model to test whether either biglycan or decorin or both play a role in the attainment of successful term gestation. Wild-type biglycan null mutant, decorin null mutant, and biglycan/decorin null mutant pregnancies were assessed for the length of gestation, pup and placenta weight, and litter size. Quantitative real-time PCR was performed to measure biglycan and decorin gene expression, and immunohistochemistry was performed to assess protein expression in placenta and fetal membranes at ...
Objective. Childhood obesity has contributed to an increased incidence of type 2 diabetes mellitu... more Objective. Childhood obesity has contributed to an increased incidence of type 2 diabetes mellitus and metabolic syndrome (MS) among children. Intrauterine exposure to diabetes and size at birth are risk factors for type 2 diabetes mellitus, but their association with MS in childhood has not been demonstrated. We examined the development of MS among large-for-gestational-age (LGA) and appropriate-for-gestational age (AGA) children. Study Design. The major components of MS (obesity, hypertension, dyslipidemia, and glucose intolerance) were evaluated in a longitudinal cohort study of children at age 6, 7, 9, and 11 years who were LGA (n = 84) or AGA (n = 95) offspring of mothers with or without gestational diabetes mellitus (GDM). The cohort consisted of 4 groups, ie, LGA offspring of control mothers, LGA offspring of mothers with GDM, AGA offspring of control mothers, and AGA offspring of mothers with GDM. Biometric and anthropometric measurements were obtained at 6, 7, 9, and 11 yea...
Journal of human lactation : official journal of International Lactation Consultant Association, Jan 26, 2015
Colonization increases risk for invasive candidiasis in neonates. Breast milk host defense protei... more Colonization increases risk for invasive candidiasis in neonates. Breast milk host defense proteins may affect yeast colonization of infants. This study aimed to evaluate breast milk host defense proteins relative to yeast colonization in infants. Infants admitted for longer than 72 hours to the neonatal intensive care unit at Women & Infants Hospital in Providence, Rhode Island, were eligible. After consent, expressed breast milk and swabs from oral, rectal, and inguinal sites from infants were cultured weekly for 12 weeks, or until discharge, transfer, or death. Breast milk was tested for levels of human lactoferrin, lysozyme, apolipoprotein J, mucin-1, dermcidin, and soluble CD14 using commercial ELISA. Concentrations of these components were compared in breast milk received by infants who were colonized or not colonized with yeast. From an original cohort of 130, 61 infants had samples available for this subanalysis. A convenience sample of stored breast milk was analyzed. Media...
Objective The objective of this study was to study the temporal profile of pulmonary hypertension... more Objective The objective of this study was to study the temporal profile of pulmonary hypertension (PH) in preterm infants. Study Design Infants < 28 weeks were screened for early PH at 10 to 14 days of life. Infants with early PH (n = 10) and gestationally matched controls (n = 18) underwent serial echocardiography every 7 to 10 days until 36 weeks postmenstrual age. Results Groups with and without early PH were comparable except for higher Fio 2 by day 10 among infants with early PH. Early PH was moderate in extent and resolved in all infants with recurrence in one infant. Among infants without early PH, five infants developed late PH. In both groups, development of late PH occurred in association with important neonatal morbidities, such as patent ductus arteriosus, bronchopulmonary dysplasia, and infection. Conclusion Early moderate PH among preterm infants resolves over a variable time period but recurrence is possible. Late PH can appear during the course of hospitalization in association with other clinical morbidities.
... Correspondence to: Dr. P. Arun Kumar Nair, Senior Consultant and Neonatologist, Division of C... more ... Correspondence to: Dr. P. Arun Kumar Nair, Senior Consultant and Neonatologist, Division of Child Health, Royal Hospital, PO Box 1331, PC 111 Seeb, Sultanate of Oman. E-mail:srinavin@omantel.net.om Manuscript received: December 9, 2002, Initial review completed ...
Deakin Teaching and Learning Conference 2007, 2007
Copyright notice: This website and its contents are subject to copyright under the laws of Austra... more Copyright notice: This website and its contents are subject to copyright under the laws of Australia and, through international treaties, other countries. The copyright in materials in this website as a whole is owned by Deakin University. Third parties own the copyright in some materials incorporated within this website. You may view this website and its contents using your web browser and save an electronic copy, or print out a copy, of parts of this website solely for your own information, research or study, but only if you: do not modify ...
Proceedings of the 2008 Association For Business Communication Annual Convention Strategic Business Communication a Reflection of Critical Thinking in the Classroom and the Workplace, 2008
... the effects of air pollution; Stern and Cole (1984) used the model to estimate a model of rai... more ... the effects of air pollution; Stern and Cole (1984) used the model to estimate a model of rainfall data. The model extends readily to the case of an ordered or multinomial outcome, and Zeger and Qaqish (1988) extend the model for count data. Page 11. 9 ...
There is considerable evidence of general student scepticism regarding the purpose of team assign... more There is considerable evidence of general student scepticism regarding the purpose of team assignments and high levels of concern for the fairness of assessment procedures when all members of a team receive the same grade. Some educators are similarly anxious about not only the validity of team grades, but also the need to assess ongoing team processes in addition to
To compare the impact of low-grade haemorrhage on neurocognitive function in 16-year-old adolesce... more To compare the impact of low-grade haemorrhage on neurocognitive function in 16-year-old adolescents born preterm, by grade of intraventricular haemorrhage, and term controls. We evaluated 338 preterm adolescents (birth weight 600-1250 g) for intelligence, executive function and memory tasks. Eleven had grade 3-4 haemorrhage, 44 had grade 2, 31 had grade 1, and 251 had no haemorrhage. Group comparisons were made with 102 term age-matched controls, and regression models used to identify the risk that low-grade haemorrhage posed for cognitive, executive function and memory deficits. Preterm adolescents with grade 2 haemorrhage had higher deficit rates of verbal intelligence, receptive vocabulary, phonemic fluency, cognitive flexibility and phonological fluency than preterm adolescents with grade 1 or no haemorrhage, compared with term controls. After excluding preterm adolescents with both grade 2 haemorrhage and cystic periventricular leukomalacia, those with isolated grade 2 haemorr...
There is considerable evidence of student scepticism regarding the purpose of team assignments an... more There is considerable evidence of student scepticism regarding the purpose of team assignments and high levels of concerns for the fairnesss of assessment when all team members receive the same grade. This chapter considers online self-and-peer assessment (SAPA) as a fair, valid and reliable method aof assessing team processes and individualising grades. A pilot studey is detailed that evaluated an online self-and-peer continuous assessment (SAPCA-a particular form of SAPA) tool originally developed for ...
This study tested if measures of central nervous system (CNS) immaturity reflected by amplitude i... more This study tested if measures of central nervous system (CNS) immaturity reflected by amplitude integrated electroencephalogram (aEEG) and associated clinical morbidities are determinants of length of hospitalization among late preterm infants born at 34 wk. This was a prospective cohort study of infants with a gestational age of 34 wk 0-6 d who had a single aEEG recording acquired over 6 h in a neonatal intensive care unit within 72 h of birth (n = 80). Infants were followed for predefined morbidities (classified as CNS or non-CNS) and length of hospitalization (determined by the clinical care team). aEEG variables were correlated with length of hospitalization. Eighty infants were enrolled and 75 aEEG recordings were analyzed. The average length of hospitalization was 10.4 ± 7.2 d (range 3-46 d). The total number of cycles recorded in the first 72 h following birth were inversely correlated with the length of hospitalization (r(2) = 0.44, P < 0.001). Kaplan-Meier curves indicated that morbidities consistent with neurological immaturity were associated with a longer length of hospitalization (P < 0.001). Neurological maturation as indicated by aEEG and specific clinical morbidities is an important determinant of length of hospitalization among late-preterm infants.
To study the efficacy and complications of low dose indomethacin in the reduction of major intrav... more To study the efficacy and complications of low dose indomethacin in the reduction of major intraventricular hemorrhage (IVH) in very low birth weight (VLBW) babies. prospective randomized controlled trial (interim analysis) Level III neonatal intensive care unit of a perinatal tertiary care center. Newborn babies with birth weights between 750-1250 g were randomized into indomethacin or control groups. They were further stratified into two birth weight groups 750-999 g and 1000-1250 g for subgroup analysis. 3 doses of indomethacin were administered to the indomethacin group at the dose of 0.1 mg/kg/dose intravenously. The control group did not receive any specific intervention other than standard neonatal intensive care. The primary outcome measure was the occurrence of IVH and the secondary outcome measures were necrotising enterocolitis, symptomatic patent ductus arteriosus (PDA), bleeding episodes, renal failure, chronic-lung disease and death. Out of 115 eligible newborn babies,...
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