Conference Presentations by WENDY PURCELL
Policy Report for COP28, 2023
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Papers by WENDY PURCELL
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The Plymouth Student Scientist, Jan 29, 2009
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Journal of Chromatography B: Biomedical Sciences and Applications, Sep 1, 1999
This study presents a HPLC method for the separation and purification of p-bromophenylacetylurea ... more This study presents a HPLC method for the separation and purification of p-bromophenylacetylurea (BPAU) and its metabolites. The method effectively separated and purified BPAU and its metabolites. Three metabolites of BPAU, M1, M2 and M3 were characterised by mass spectroscopy and nuclear magnetic resonance. They are named as N′-hydroxy-p-bromophenylacetylurea, 4-(4-bromophenyl)-3-oxapyrrolidine-2,5-dione and N′-methyl-p-bromophenylacetylurea, respectively. The major metabolic pathways of BPAU were
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Toxicology in Vitro, Feb 1, 2004
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COVID-19: Paving the Way for a More Sustainable World, 2021
The chapter reviews the education sector’s COVID-19 policy implementation for managing the impact... more The chapter reviews the education sector’s COVID-19 policy implementation for managing the impact of the coronavirus on school plans in South Africa. Complex and problematic policy issues emanate from the effects of the coronavirus and the quick-fix strategies used to implement policy without consideration of the contextual factors in underprivileged schools. Closure of schools as a short-term measure was not sustainable and had unintended consequences. On paper, the COVID-19 policy looks good, but it is devoid of the contextual realities of the places where it needs to be implemented. Gaps identified in the policy gave rise to protracted resistance by stakeholders due to lack of ownership. These challenges led to shifting of goals regarding the early reopening of schools. Systems thinking offers tools to improve on the implementation challenges faced by policy makers, while a systems dynamics approach seeks to bring understanding of the interconnection among stakeholders and the views they hold. The Soft Systems Methodology (SSM) provides a perspective for modelling the underlying problematic issues in structured manner. It shows the complex relationship that exists starting from the conception of the policy to its implementation. The SSM model addresses the challenges faced by policy makers in communicating the policy and engaging the stakeholders, and conceives the root cause of problematic issues in the implementation of the policy by proposing an ideal conceptual model.
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Neurotoxicology
Neurotrophic factors (NTFs) such as nerve growth factor (NGF), brain-derived neurotrophic factor ... more Neurotrophic factors (NTFs) such as nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF) and ciliary neurotrophic factor (CNTF) are currently being explored as novel therapeutics in a range of neurodegenerative disorders such as amyotrophic lateral sclerosis (ALS) and Alzheimer's disease. To this end, animal studies and clinical trials have been conducted to assess the toxic effects of recombinant NTFs. It is apparent that both NGF and BDNF induce a range of adverse effects, for example inflammation, hyperalgesia, and disturbances in CNS biogenic amine levels which variously manifest as weight loss/gain, changes in feeding behaviour and general malaise. It has been demonstrated that NGF induces release of biologically active mediators, such as histamine, from rat peritoneal mast cells (RPMC). However, whether other NTFs do likewise or indeed are able to induce secretion from other mast cells types had not been explored. We have developed a novel protocol for dispe...
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Neurochemical Research, 1995
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International Archives of Allergy and Immunology, 1989
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Human & Experimental Toxicology, 1994
1 In both the developing and adult nervous systems, nerve growth factor (NGF) influences neuronal... more 1 In both the developing and adult nervous systems, nerve growth factor (NGF) influences neuronal survival, differentiation and recovery following insult, 2 The effect of NGF upon human placental mast cells (HPMC) was investigated, since it is known that rodent mast cells express a functional receptor for NGF and secrete histamine upon challenge with this neurotrophic factor. Furthermore, human placental tissue contains a significant amount of NGF and expresses a NGF receptor. 3 HPMC were shown to secrete histamine in a concentration dependent manner in response to NGF (0.001-10.0 μg ml-1) in the presence of the lipid cofactor phosphatidylserine (10.0 μg ml-1). 4 NGF induced histamine release from isolated HPMC with an EC50 of 0.1 μg ml -1 NGF and maximal secretion of total cellular histamine of 22.3 ± 3.4% at 3.0 μg ml-1. 5 The response was shown to be a secretory process, dependent upon the presence of exogenous calcium ions and to be pH- and temperature-sensitive. 6 HPMC are sugg...
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In the last decade, in particular, empirical research has brought evidence of the measurable payo... more In the last decade, in particular, empirical research has brought evidence of the measurable payoff of CSR initiatives to companies as well as their stakeholders. Companies have a variety of reasons for being attentive to CSR. This section documents some of the potential bottom-line benefits: reducing cost and risk, gaining competitive advantage, developing and maintaining legitimacy and reputational capital, and achieving win-win outcomes through synergistic value creation.
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Huffington Post, 2012
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Huffington Post, 2012
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Horizonti. Serija A. Opštestveni i humanistički nauki, Dec 10, 2021
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The Business & Management Collection, Dec 31, 2019
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PubMed, 1999
Colony stimulating factors (CSFs) are now widely used in cancer treatment and immunological disea... more Colony stimulating factors (CSFs) are now widely used in cancer treatment and immunological disease therapy. Both granulocyte CSF (G-CSF) and granulocyte-macrophage CSF (GM-CSF) are used to increase neutrophil counts in Felty syndrome. In the present study, the effects of macrophage CSF (M-CSF), G-CSF, GM-CSF and interleukin-3 (IL-3) (10 ng/ml) on the production of nitric oxide and prostaglandin E2 (PGE2) by cartilage explants were examined over 24 and 48 h. The effects of these CSFs were also measured in combination with IL-1 beta (10 ng/ml). M-CSF, GM-CSF and IL-3 had no effect on nitrite production. However, both IL-1 beta and G-CSF caused a significant increase (p < 0.05) in nitrite levels at 48 h. NG-L-arginine-methyl-ester was used to inhibit nitrite production induced by G-CSF and this implicated nitric oxide synthase activity. When G-CSF and IL-1 beta were used in a combined treatment, nitrite levels were significantly increased (p < 0.05) at both 24 and 48 h. Both IL-3 alone and in combination with IL-1 beta caused elevated PGE2 production in this model. PGE2 levels were also significantly increased by stimulation with GM-CSF and IL-3 combined with IL-1 beta. These findings demonstrate that GM-CSF, G-CSF and IL-3 may induce changes in the production of inflammatory mediators such nitric oxide and PGE2 in cartilage chondrocytes. Hence, CSFs may play a vital role in influencing cartilage metabolism in rheumatoid and osteoarthritis.
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Conference Presentations by WENDY PURCELL
Papers by WENDY PURCELL