The aim of this study was to determine the relationship between preterm risk factors and neonatal... more The aim of this study was to determine the relationship between preterm risk factors and neonatal death, cerebral hemorrhage and psychomotor development in very low birth weight infants. A retrospective analysis based on a multivariate logistic regression model was conducted on 253 VLBW infants. Cerebral hemorrhage was assessed by cerebral ultrasound screening within 24 hours of life, psychomotor development by Bailey Psychomotor and Development Index test. Pre-eclampsia and elective cesarean section (CS) are statistically protective factors in the prevention of cerebral hemorrhage; gestational age is a protective factor for neonatal death; whereas, multiple pregnancy, symmetrically small for gestational-age infants, asphyxia at birth, altered cardiotocography, and cerebral hemorrhage are risk factors for neonatal death; emergency CS and gestational age are protective factors for problems in psychomotor development. The number of fetuses and cerebral hemorrhage are risk factors for ...
This prospective study was performed to evaluate perinatal outcome and maternal risk factors in p... more This prospective study was performed to evaluate perinatal outcome and maternal risk factors in pregnancies complicated by fetal intrauterine growth restriction (IUGR). A total of 3 537 women pregnant with a singleton gestation were enrolled in the study: 219 of these pregnancies were complicated by fetal growth restriction (6.2%). Statistical analysis was performed using Wilcoxon test, Kruskall-Wallis test, c2 analysis of variance and ANOVA test. Statistical significance was set at P-value <0.05. Correlations were calculated by Spearman's coefficient. Ethnic group, physical demanding work, maternal smoking, alcohol abuse do not seem to be associated with lower birth weight and worse Apgar score. Sonographic assessment of fetal weight obtained by Hadlock's formula underestimate real newborn's weight. The difference between estimate weight and real weight is statistically significant. Women with intrauterine growth restriction underwent caesarean sections more often th...
Pre-eclampsia and intrauterine growth restriction (IUGR) are among the most common causes of feta... more Pre-eclampsia and intrauterine growth restriction (IUGR) are among the most common causes of fetal and maternal morbidity and mortality. The aim of this study was to examine the value of uterine artery Doppler in the second subsequent pregnancy in a low risk population for the prediction of pre-eclampsia and IUGR at any gestational age. Patients were randomized into two different groups: group A (nine patients) with positive notching both at week 20 and 24 in both pregnancies; group B (five patients) with bilateral positive notching at week 20 and 24 only in the second pregnancy. During the second pregnancy IUGR rate was 11.1% in patients of group A and 60% in patients of group B (P=0.0949). During the first pregnancy IUGR reached 44.4% in group A and 0% in group B (P=0.2208). In conclusion no significant increase of IUGR has been detected if the abnormal maternal Doppler ultrasound recurs in subsequent pregnancies.
Chromosomal abnormalities are leading causes of perinatal death and childhood handicap. Fetal nuc... more Chromosomal abnormalities are leading causes of perinatal death and childhood handicap. Fetal nuchal translucency (NT) measurement has been largely considered an ultrasound marker and screening test to early detect chromosomal defects. The aim of this study was to evaluate increased fetal NT in terms of sensibility and specificity and to determine whether its use in association with mater- nal serum free Beta-HCG and PAPP-A improves screening test accuracy. After informed questionnaire was provided to all patients, we tried to verify if all information about screening procedures had been well understood. Considering detection of trisomy 21 and 18 pregnancies, fetal NT measurement has been associated with a detection rate of 90.9 % for a false positive rate of 4.7%. We also found, similarly to other studies, that the optimal risk cut-off of 1:300 is associated with the best rates of sensibility and the lowest reduction of specificity. Analyzing the answers given from all patients to ...
The aim of this study was to determine the relationship between preterm risk factors and neonatal... more The aim of this study was to determine the relationship between preterm risk factors and neonatal death, cerebral hemorrhage and psychomotor development in very low birth weight infants. A retrospective analysis based on a multivariate logistic regression model was conducted on 253 VLBW infants. Cerebral hemorrhage was assessed by cerebral ultrasound screening within 24 hours of life, psychomotor development by Bailey Psychomotor and Development Index test. Pre-eclampsia and elective cesarean section (CS) are statistically protective factors in the prevention of cerebral hemorrhage; gestational age is a protective factor for neonatal death; whereas, multiple pregnancy, symmetrically small for gestational-age infants, asphyxia at birth, altered cardiotocography, and cerebral hemorrhage are risk factors for neonatal death; emergency CS and gestational age are protective factors for problems in psychomotor development. The number of fetuses and cerebral hemorrhage are risk factors for ...
This prospective study was performed to evaluate perinatal outcome and maternal risk factors in p... more This prospective study was performed to evaluate perinatal outcome and maternal risk factors in pregnancies complicated by fetal intrauterine growth restriction (IUGR). A total of 3 537 women pregnant with a singleton gestation were enrolled in the study: 219 of these pregnancies were complicated by fetal growth restriction (6.2%). Statistical analysis was performed using Wilcoxon test, Kruskall-Wallis test, c2 analysis of variance and ANOVA test. Statistical significance was set at P-value <0.05. Correlations were calculated by Spearman's coefficient. Ethnic group, physical demanding work, maternal smoking, alcohol abuse do not seem to be associated with lower birth weight and worse Apgar score. Sonographic assessment of fetal weight obtained by Hadlock's formula underestimate real newborn's weight. The difference between estimate weight and real weight is statistically significant. Women with intrauterine growth restriction underwent caesarean sections more often th...
Pre-eclampsia and intrauterine growth restriction (IUGR) are among the most common causes of feta... more Pre-eclampsia and intrauterine growth restriction (IUGR) are among the most common causes of fetal and maternal morbidity and mortality. The aim of this study was to examine the value of uterine artery Doppler in the second subsequent pregnancy in a low risk population for the prediction of pre-eclampsia and IUGR at any gestational age. Patients were randomized into two different groups: group A (nine patients) with positive notching both at week 20 and 24 in both pregnancies; group B (five patients) with bilateral positive notching at week 20 and 24 only in the second pregnancy. During the second pregnancy IUGR rate was 11.1% in patients of group A and 60% in patients of group B (P=0.0949). During the first pregnancy IUGR reached 44.4% in group A and 0% in group B (P=0.2208). In conclusion no significant increase of IUGR has been detected if the abnormal maternal Doppler ultrasound recurs in subsequent pregnancies.
Chromosomal abnormalities are leading causes of perinatal death and childhood handicap. Fetal nuc... more Chromosomal abnormalities are leading causes of perinatal death and childhood handicap. Fetal nuchal translucency (NT) measurement has been largely considered an ultrasound marker and screening test to early detect chromosomal defects. The aim of this study was to evaluate increased fetal NT in terms of sensibility and specificity and to determine whether its use in association with mater- nal serum free Beta-HCG and PAPP-A improves screening test accuracy. After informed questionnaire was provided to all patients, we tried to verify if all information about screening procedures had been well understood. Considering detection of trisomy 21 and 18 pregnancies, fetal NT measurement has been associated with a detection rate of 90.9 % for a false positive rate of 4.7%. We also found, similarly to other studies, that the optimal risk cut-off of 1:300 is associated with the best rates of sensibility and the lowest reduction of specificity. Analyzing the answers given from all patients to ...
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Papers by Monica Martina