Papers by Maheshwari Sharma
Concepts utilizing polymers as therapeutic agents have been widely investigated for a number of d... more Concepts utilizing polymers as therapeutic agents have been widely investigated for a number of decades. Nanosized drug delivery systems formulated from biocompatible and biodegradable polymers constitute an evolving approach to drug delivery and tumor targeting. The increasing interest in Polyethylene oxide(PEO)-Polypropylene oxide (PPO) block copolymers(known as Pluronics®) arises mainly due to their surface-active and self-associative characteristics leading to micellar formation. Pluronic polymers are approved by FDA for pharmaceutical and medical applications, including parenteral administration and listed in the US and British pharmacopoeia as pharmaceutical excipients and extensively used in drug formulations. The present article will be explained the basics of these polymers, its nanomicelles and applications of such nanomicelles in drug formulations specifically for an anticarcinogenic drug, Curcumin for improved solubility, stability, release, and bioavailability.
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Papers by Maheshwari Sharma