Aims Peripheral arterial disease (PAD) is a major public health burden requiring more intensive population screening. Ankle brachial index (ABI) using arm and ankle cuffs is considered as the reference method for the detection of PAD.... more
Aims Peripheral arterial disease (PAD) is a major public health burden requiring more intensive population screening. Ankle brachial index (ABI) using arm and ankle cuffs is considered as the reference method for the detection of PAD. Although it requires a rigorous methodology by trained operators, it remains time-consuming and more technically difficult in patients with diabetes due to mediacalcosis. Techniques based on the study of hemodynamic, such as the systolic rise time (SRT), appear promising but need to be validated. We retrospectively compared the reliability and accuracy of SRT using a photoplethysmography (PPG) technique to the SRT measured by ultrasound doppler (UD) in PAD patients diagnosed with the ABI (137 patients, 200 lower limbs). Methods and results There was a significant correlation between SRT measured with UD (SRTud) compared with that with PPG (SRTppg, r = 0.25; P = 0.001). Best correlation was found in patients without diabetes (r = 0.40; P = 0.001). Bland...
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Relationship between the aortic valves and an anatomical landmark using chest CT scan
The photoplethysmogram (PPG) signal is widely measured by clinical and consumer devices, and it is emerging as a potential tool for assessing vascular age. The shape and timing of the PPG pulse wave are both influenced by normal vascular... more
The photoplethysmogram (PPG) signal is widely measured by clinical and consumer devices, and it is emerging as a potential tool for assessing vascular age. The shape and timing of the PPG pulse wave are both influenced by normal vascular ageing, changes in arterial stiffness and blood pressure, and atherosclerosis. This review summarises research into assessing vascular age from the PPG. Three categories of approaches are described: (i) those which use a single PPG signal (based on pulse wave analysis); (ii) those which use multiple PPG signals (such as pulse transit time measurement); and (iii) those which use PPG and other signals (such as pulse arrival time measurement). Evidence is then presented on the performance, repeatability and reproducibility, and clinical utility of PPG-derived parameters of vascular age. Finally, the review outlines key directions for future research to realise the full potential of photoplethysmography for assessing vascular age.
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The context of this work concerns the development of a connected smartwatch for the continuous daily monitoring of physiological parameters to prevent cardiovascular diseases, and for the follow-up of the efficiency of treatments, against... more
The context of this work concerns the development of a connected smartwatch for the continuous daily monitoring of physiological parameters to prevent cardiovascular diseases, and for the follow-up of the efficiency of treatments, against hypertension for example. This paper focuses on a particular parameter, the blood pressure (BP), to be automatically measured from the Photoplethysmogram (PPG) signal, to be acquired using a smartwatch. The proposed method is based on the automatic pulse wave detection from the PPG signal. Then, using the Lasso algorithm, a relation has been established between the blood pressure and the spectral representation of the normalized pulse wave, combined with other physiological information (age, body mass index and hear rate). The proposed method has been evaluated on a recent large public database of 219 subjects, covering a large range of ages (20–89), body mass indices and of blood pressures. Experimental results show acceptable performances in term...
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In this paper, a new approach for predicting the blood pressure (BP) from the photoplethysmogram (PPG) signal is proposed related with a new original public dataset. The originality of the dataset is based on the fact that subjects are... more
In this paper, a new approach for predicting the blood pressure (BP) from the photoplethysmogram (PPG) signal is proposed related with a new original public dataset. The originality of the dataset is based on the fact that subjects are periodically monitored over weeks, while public datasets consider short acquisition periods. The proposed BP estimation approach uses key frequencies in the spectrum of the PPG signal isolated using the LASSO algorithm, then a predictive model is constructed as a patient-specific BP estimation model. The efficiency of the proposed methodology is evaluated on experimental data recorded over a long time period. Moreover, an evaluation of the various temporal markers of the PPG signal that have been proposed in the literature is conducted on the same data set. It is showed that only few of these temporal markers are useful for the estimation of the systolic and diastolic blood pressures. The results highlight that better blood pressure estimations are ob...
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s 13 atherosclerotic burden and PWV than (C) and also the clinical score of risk (FRS) and the severity of vascular disease score. DBT2 and MS were almost similar. Conclusion: The progression of vascular disease from the early MS to DBT2... more
s 13 atherosclerotic burden and PWV than (C) and also the clinical score of risk (FRS) and the severity of vascular disease score. DBT2 and MS were almost similar. Conclusion: The progression of vascular disease from the early MS to DBT2 could explain the higher degree of complications in DBT2. These findings suggest the usefulness of vascular evaluation of MS patients to guide and intensify preventive measures to improve the prognosis of DBT2 patients.
Background: Gestational diabetes is an intolerance of glucose with the first appearance during the pregnancy. This hyperglycaemia status, because of the pre-existing insulin-resistance, constitute a favourable land of arterial stiffness.... more
Background: Gestational diabetes is an intolerance of glucose with the first appearance during the pregnancy. This hyperglycaemia status, because of the pre-existing insulin-resistance, constitute a favourable land of arterial stiffness. The aim of this study is to determine the impact of non obese gestational diabetes on arterial stiffness by measuring the pulse wave velocity (PWV).Methods: We recruited 60 pregnant women aged from 20 to 35 years old. They were between twentieth four and thirtieth five weeks of gestational age. Subjects were divided into two groups: the first group (G1), considered as control group, included 25 normoglycemic pregnant subjects without any history of illness or risk factors of gestational diabetes; the second group (G2) included 35 women with Gestational Diabetes Mellitus (GDM). All pregnant women had not history of smoking, were not taking decoction or medicine, which could disturb pregnancy evolution. Anthropo-physiological and biochemical parameter...
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Analysis of the contour of the peripheral pulse to assess arterial properties was first described in the nineteenth century. The reference technique to estimate central blood pressure (CBP), non-invasively, is by analyzing the radial... more
Analysis of the contour of the peripheral pulse to assess arterial properties was first described in the nineteenth century. The reference technique to estimate central blood pressure (CBP), non-invasively, is by analyzing the radial pressure pulse acquired using a tonometer and then to establish a transfer function relating the radial pressure to the CBP. An alternative technique utilizes a volume pulse. This may conveniently be acquired optically from a finger. This technique deserves further consideration because of its simplicity and ease of use. The objective is to establish a transfer function estimating the central blood pressure (CBP), calibrated with a brachial pressure cuff and using the parameters obtained with the contour analysis of the photoplethysmographic pulse measured at the finger with the pOpmetre® system. We positioned the photodiode sensor on the finger, insuring that the sensor's lens is in contact with the finger. Brachial blood pressure measurements was performed with a standard cuff. The central blood pressure values measured with Sphygmocor used as the reference values. Multiple regression analysis was done to establish the transfer functions. Sixty-nine subjects were included: 24 healthy subjects and 45 patients with essential hypertension aged 33 ± 8 years and 59 ± 17 years respectively. The correlation between the estimated central systolic pressure (CSP) and the reference one, was good and significant (r2 = 0.91; P
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Sickle cell trait (SCT) is a benign condition of sickle cell disease. Nevertheless, previous reports showed that SCT carriers have increased blood viscosity and decreased vascular reactivity compared to non-SCT carrier. The benefit of... more
Sickle cell trait (SCT) is a benign condition of sickle cell disease. Nevertheless, previous reports showed that SCT carriers have increased blood viscosity and decreased vascular reactivity compared to non-SCT carrier. The benefit of regular exercise on vascular function has been well documented in the general population but no study focused on the SCT population. The aim of our study was to compare arterial stiffness and blood viscosity between trained and untrained SCT carriers, as well as a group of untrained non-SCT. Arterial stiffness (finger-toe pulse wave velocity) and blood viscosity were evaluated in untrained non-SCT carriers (n = 10), untrained SCT carriers (n = 23) and trained SCT carriers (n = 17) who reported at least 10 hours of physical exercise per week. Untrained SCT carriers had higher pulse wave velocity (p = 0.032) and blood viscosity (p < 0.001) than their trained counterparts. In addition, untrained SCT carriers had higher blood viscosity (p < 0.001) th...
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Background Arterial pulse wave velocity and pulse waveform analysis have become an established component of cardiovascular research. As validation and assessment of devices is not always trivial in an in vivo setting, arterial network... more
Background Arterial pulse wave velocity and pulse waveform analysis have become an established component of cardiovascular research. As validation and assessment of devices is not always trivial in an in vivo setting, arterial network computer models may be useful for that purpose. It is, however, mandatory that the model includes sufficient detail, especially when analysing peripheral waveforms. Purpose To extend the existing 1D arterial network model (103 segments) of Reymond et al. to a more detailed model (143 segments) including the foot and hand circulation (radial and tibial arteries). The goal is to (i) extend the existing 1D arterial network model (103 segments) of Reymond et al. to a more detailed model (143 segments) including the foot and hand circulation (Radial and Tibial arteries); (ii) use the extending model as testing tool for pOpmetre® (finger–toe pulse wave velocity). Method The arterial tree dimensions and properties were taken from the literature and completed with data from patient scans. The model solves the one-dimensional form of the Navier-Stokes equations over each arterial segment. A non-linear viscoelastic constitutive law for the arterial wall was considered. Result Comparison of simulations with & without detailed hand and foot circulation demonstrate important differences in waveform morphology in the distal beds. The completed model predicts pressure and flow waves in the hand and foot arteries which are in good qualitative agreement with the published in-vivo measurements. The agreement is especially good for the shape and wave details of the flow wave, where all features are reproduced in a rather faithful manner. The correlation between ftPWV and aPWV was good and significant (R2 = 0.95). The Bland and Altman analysis, mean difference was 0.4 m/s, classifying the ftPWV as good agreement with reference method. Conclusion The extended model yields realistic pressure and flow waveforms in arteries of the hand and the foot.
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Carotid-femoral pulse wave velocity (PWV) (cf-PWV) is the gold standard for measuring aortic stiffness. Finger-toe PWV (ft-PWV) is a simpler noninvasive method for measuring arterial stiffness. Although the validity of the method has been... more
Carotid-femoral pulse wave velocity (PWV) (cf-PWV) is the gold standard for measuring aortic stiffness. Finger-toe PWV (ft-PWV) is a simpler noninvasive method for measuring arterial stiffness. Although the validity of the method has been previously assessed, its accuracy can be improved. ft-PWV is determined on the basis of a patented height chart for the distance and the pulse transit time (PTT) between the finger and the toe pulpar arteries signals (ft-PTT). The objective of the first study, performed in 66 patients, was to compare different algorithms (intersecting tangents, maximum of the second derivative, 10% threshold and cross-correlation) for determining the foot of the arterial pulse wave, thus the ft-PTT. The objective of the second study, performed in 101 patients, was to investigate different signal processing chains to improve the concordance of ft-PWV with the gold-standard cf-PWV. Finger-toe PWV (ft-PWV) was calculated using the four algorithms. The best correlations relating ft-PWV and cf-PWV, and relating ft-PTT and carotid-femoral PTT were obtained with the maximum of the second derivative algorithm [PWV: r = 0.56, P &lt; 0.0001, root mean square error (RMSE) = 0.9 m/s; PTT: r = 0.61, P &lt; 0.001, RMSE = 12 ms]. The three other algorithms showed lower correlations. The correlation between ft-PTT and carotid-femoral PTT further improved (r = 0.81, P &lt; 0.0001, RMSE = 5.4 ms) when the maximum of the second derivative algorithm was combined with an optimized signal processing chain. Selecting the maximum of the second derivative algorithm for detecting the foot of the pressure waveform, and combining it with an optimized signal processing chain, improved the accuracy of ft-PWV measurement in the current population sample. Thus, it makes ft-PWV very promising for the simple noninvasive determination of aortic stiffness in clinical practice.
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Pulse wave velocity is a marker of arterial stiffness. The aim of this study was to compare pulse wave velocity in patients with type 2 diabetes (T2DM), or obesity and healthy subjects in an outpatient setting. A cross-sectional study was... more
Pulse wave velocity is a marker of arterial stiffness. The aim of this study was to compare pulse wave velocity in patients with type 2 diabetes (T2DM), or obesity and healthy subjects in an outpatient setting. A cross-sectional study was conducted in patients with obesity without T2DM (n = 37), T2DM without obesity (n = 40), T2DM plus obesity (n = 43), and healthy controls (n = 114). Outpatient measurement of the finger-toe pulse wave velocity (ftPWV) was performed using a pOpmètre® device. The ftPWV was higher in men than in women (10.57 ± 5.02 vs 9.14 ± 3.68 m/s, mean ± SD, p = 0.006). It was positively correlated with age (r(2) = 0.31, p &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.0001), body mass index (r(2) = 0.03, p = 0.01), systolic blood pressure (r(2) = 0.06, p &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.0001), and right (r(2) = 0.03, p = 0.01) and left ankle-brachial index (r(2) = 0.03, p = 0.01). In a stepwise regression analysis, age, systolic blood pressure and ankle-brachial index remained significantly correlated with ftPWV. The ftPWV was 8.32 ± 2.68, 9.50 ± 3.38, 11.29 ± 4.34, and 12.36 ± 6.67 m/s in the controls and in the participants with obesity, T2DM, and T2DM plus obesity, respectively (p &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.0001). These differences remained significant after adjustments for sex, age, systolic blood pressure, and ankle-brachial index (p = 0.008). The ftPWV was higher in patients with macrovascular complications compared to others (13.11 ± 6.25 vs 10.40 ± 4.54 m/s, p = 0.006) in the univariate analysis but not in the multi-adjusted model. The outpatient-measured ftPWV was correlated with age, systolic blood pressure and ankle-brachial index. It was higher in patients with T2DM and obesity compared to healthy controls. The highest ftPWV was observed in patients with both T2DM and obesity. This article is protected by copyright. All rights reserved.
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Systemic sclerosis (SSc) is a connective desease affecting connective tissue and vessels of any caliber. The affect of large arteries appears by a stiffness that can be an element of disease monitoring. The aim of this study was to... more
Systemic sclerosis (SSc) is a connective desease affecting connective tissue and vessels of any caliber. The affect of large arteries appears by a stiffness that can be an element of disease monitoring. The aim of this study was to evaluate the contribution of pOpmetre in the arterial stiffness measurement in patients with SSc. It was a descriptive and prospective study carried out with scleroderma patients and control subjects. Anthropometric measurements were collected and associated to a questionnaire about demographic and clinical data. The fingertoe pulse wave velocity (ft-PWV) measured by pOpmetre® allowed to explore arterial stiffness. Twenty patients and 26 controls were included in our study. Patients had higher heart rate (p = 0.038) and ft-PWV (p = 0.001). The ft-PWV was correlated with age in controls (r = 0.69 ; p = 0.0001) and showed a trend with systolic blood pressure (r = 0.37, p = 0.09) in patients’ group. The pOpmetre®, a simple and practical tool, highlighted an increase in arterial stiffness in patients with SSc by measuring the ft-PWV. It could play a role in this disease monitoring and in prediction of cardiovascular complications.
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ABSTRACT Effect of essential hypertension on urinary albumin excretion of non insulin-dependent diabetics.
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We revue the epidemiology of cardiovascular disease in the elderly, their relationship to arterial stiffness. The measurement of arterial stiffness is of considerable increasing interest in this early 21 century. This paper is focusing on... more
We revue the epidemiology of cardiovascular disease in the elderly, their relationship to arterial stiffness. The measurement of arterial stiffness is of considerable increasing interest in this early 21 century. This paper is focusing on modeling, in different measurement methods. Several measurement techniques are presented. A review of the bibliography that explain the link between cardiovascular risk factors and arterial stiffness is summarized, as are the relationships between the various risk factors and arterial stiffness. The current role of these measurement methods seems to be time consuming although the European consensus recommends the measure once a year in the management of vascular patients. New techniques for the assessment of the arterial stiffness, more reproducible and easy to use, could ultimately trivialize this measurement, contributing in medical practice to the assessment and the management of the vascular risk.
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The mechanism of action of angiotensin converting enzyme (ACE) inhibitors on urinary albumin excretion (UAE) in diabetics is controversial. In order to dissociate the hypotensive and intrarenal effects, 16 insulin-dependant diabetics with... more
The mechanism of action of angiotensin converting enzyme (ACE) inhibitors on urinary albumin excretion (UAE) in diabetics is controversial. In order to dissociate the hypotensive and intrarenal effects, 16 insulin-dependant diabetics with permanent microalbuminuria (30-300 mg/24 h) without hypertension were given Ramipril, a long acting ACE inhibitor, at hypotensive (treatment A 5 mg/day; N = 8) and at sub-hypotensive doses (treatment B, 1.25 mg/day; N = 8) over a 6 week period in parallel double-blind study. Blood pressure, UAE, glomerular filtration renal blood flow (continuous 125I-Iodothalamate + 131I-Hippurate infusion) and converting enzyme activity (Liebermann's method), before and after treatment. In treatment group A, the blood pressure fell from 133 +/- 5/79 +/- 4 (mean +/- SE) to 125 +/- 4/77 +/- 2 mmHg (p less than 0.05 for systolic blood pressure) whereas it remained stable in treatment group B (132 +/- 7/79 +/- 4 to 128 +/- 5/80 +/- 4 mmHg). The UAE decreased in bo...
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Patients with insulin dependent diabetes mellitus (IDDM) often suffer from cardiovascular diseases as renal failure occurs. Elevated albumin excretion rate (AER) is a predictive value of this event. Relations between AER, blood pressure,... more
Patients with insulin dependent diabetes mellitus (IDDM) often suffer from cardiovascular diseases as renal failure occurs. Elevated albumin excretion rate (AER) is a predictive value of this event. Relations between AER, blood pressure, serum lipids and apoproteins concentrations in 100 patients with IDDM have been surveyed. Twenty one hypertensive patients (HT group) were compared to 21 patients without hypertension (n HT group), matched for sex, age, diabetes duration, and metabolic control, assessed by glycosylated haemoglobin. Comparison of both groups showed HT group had elevated systolic blood pressure (137 +/- 12 vs 126 +/- 20 mmHg; p less than .05), elevated diastolic blood pressure (80 +/- 7 vs 71 +/- 8 mmHg; p less than .001), increase in AER (27 range 3-4023 vs 6 range 2-51 mg/day; p less than .001), slightly elevated serum creatinine (95 +/- 32 vs 78 +/- 15 mumol/l; p less than .05). In HT group, serum lipid composition showed: raise in total cholesterol (251 +/- 43 vs ...
Research Interests: Medicine, Lipids, Humans, Hypertension, Female, and 7 moreMale, Clinical Sciences, Aged, Middle Aged, Adult, Albuminuria, and Type 2 Diabetes Mellitus
We revue the epidemiology of cardiovascular disease in the elderly, their relationship to arterial stiffness. The measurement of arterial stiffness is of considerable increasing interest in this early 21 century. This paper is focusing on... more
We revue the epidemiology of cardiovascular disease in the elderly, their relationship to arterial stiffness. The measurement of arterial stiffness is of considerable increasing interest in this early 21 century. This paper is focusing on modeling, in different measurement methods. Several measurement techniques are presented. A review of the bibliography that explain the link between cardiovascular risk factors and arterial stiffness is summarized, as are the relationships between the various risk factors and arterial stiffness. The current role of these measurement methods seems to be time consuming although the European consensus recommends the measure once a year in the management of vascular patients. New techniques for the assessment of the arterial stiffness, more reproducible and easy to use, could ultimately trivialize this measurement, contributing in medical practice to the assessment and the management of the vascular risk.
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Research Interests: Diabetes, Pancreatitis, Humans, Blood Glucose, Diabetes mellitus, and 15 moreCholesterol, Diabetic Retinopathy, Chronic Disease, Female, Male, Regression Analysis, Clinical Sciences, Aged, Middle Aged, Adult, Analysis of Variance, Lipoproteins, Reference Values, Glomerular Filtration Rate, and Diabetic nephropathies
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The mechanism of action of angiotensin-converting enzyme (ACE) inhibitors on urinary albumin excretion (UAE) in diabetic patients remains controversial. Sixteen type 1, insulin-dependent diabetics with incipient nephropathy received... more
The mechanism of action of angiotensin-converting enzyme (ACE) inhibitors on urinary albumin excretion (UAE) in diabetic patients remains controversial. Sixteen type 1, insulin-dependent diabetics with incipient nephropathy received ramipril, a long-acting ACE inhibitor, at hypotensive doses (treatment A: 5 mg/day, n = 8) or at nonhypotensive doses (treatment B: 1.25 mg/day, n = 8) during a 6-week, double-blind, parallel study to establish whether its antihypertensive effects could be dissociated from its local renal effects. Blood pressure, UAE, glomerular filtration rate (GFR), effective renal plasma flow (ERPF, constant [125I]iodothalamate + [131I]hippurate infusion), and ACE activity were measured before and after treatment. Blood pressure was lowered with treatment A but not with treatment B. UAE and ACE activity were reduced with both treatments. Baseline GFR and ERPF were not altered by either treatment. In the patient population as a whole, ACE inhibition correlated with a rise in ERPF and with a reduction in filtration fraction (GFR/ERPF), but not with the changes in blood pressure. Changes in UAE correlated with the changes in filtration fraction. It is concluded that renal hemodynamics may be modified by ramipril independently of blood pressure changes.
Research Interests: Humans, Blood Glucose, Blood Pressure, Cardiovascular Pharmacology, Female, and 13 moreMale, Urea, Potassium, Middle Aged, Adult, Sodium, Albuminuria, Type 2 Diabetes Mellitus, Angiotensin Converting Enzyme Inhibitors, Cardiovascular medicine and haematology, Pharmacology and pharmaceutical sciences, Diabetic nephropathies, and ramipril
Research Interests: Diabetes, Pancreatitis, Humans, Blood Glucose, Diabetes mellitus, and 15 moreCholesterol, Diabetic Retinopathy, Chronic Disease, Female, Male, Regression Analysis, Clinical Sciences, Aged, Middle Aged, Adult, Analysis of Variance, Lipoproteins, Reference Values, Glomerular Filtration Rate, and Diabetic nephropathies
Introduction La mesure de la vitesse de l’onde de pouls entre le doigt et l’orteil (VOPdo) pourrait representer une alternative pour evaluer la rigidite arterielle (RA) reflet des lesions macro vasculaires. Le but est d’evaluer un nouvel... more
Introduction La mesure de la vitesse de l’onde de pouls entre le doigt et l’orteil (VOPdo) pourrait representer une alternative pour evaluer la rigidite arterielle (RA) reflet des lesions macro vasculaires. Le but est d’evaluer un nouvel appareil pOpmetre ® (Axelife sas – France). Patients et methodes pOpmetre ® dispose de 2 capteurs photodiodes, positionnes sur le doigt et sur l’orteil, en regard de l’artere pulpaire. Des ondes de pouls sont enregistrees simultanement en continu pendant 20 secondes, et la difference entre les pieds des ondes de pouls determine les temps de transit (TT). La distance de parcours etait basee sur la taille du sujet. Etude 1 a compare la VOPdo a la VOP carotide-femorale (VOPcf) obtenue par la methode avec SphygmoCor ® chez 86 sujets (53 ± 20 ans) dont 69 patients atteints de diverses pathologies et 17 normotendus sains. L’Etude 2 a compare les variations de VOPdo et VOPcf lors d’un stress test chez 10 sujets sains. L’etude 3 a etudie la repetabilite chez 45 patients. Resultats La VOPdo etait significativement correlee avec la VOPcf (r 2 = 0,43 ; p 2 = 0,6 ; p Conclusion pOpmetre ® est un dispositif prometteur pour evaluer et suivre la rigidite arterielle dans la pratique clinique de routine. C’est un integrateur de la rigidite aortique centrale et de celle des membres inferieurs.
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Objectif La rigidite arterielle RA est le meilleur predicteur de risque cardio vasculaire. Elle peut se mesure simplement par un appareil pOpmetre ® (Axelife-sasFrance). Chez des patients a risque, porteurs de syndrome metabolique, nous... more
Objectif La rigidite arterielle RA est le meilleur predicteur de risque cardio vasculaire. Elle peut se mesure simplement par un appareil pOpmetre ® (Axelife-sasFrance). Chez des patients a risque, porteurs de syndrome metabolique, nous avons etudie le lien entre les indices pOpmetre ® et 1- la presence de plaques d'atherome, 2- le lien au vieillissement. Patients et methodes Lors d'un bilan vasculaire, un echo doppler arteriel habituel a defini la presence ou non de de plaques, et calcule l'epaisseur intima media (EIM). La Rigidite Aortique par impedance-metre (Physioflow ® ESAOTE, Italie), et la rigidite par pOpmetre ® ont ete determinees. Celui-ci mesure les temps de transit entre l'ECG et les pieds de l'onde de pouls au doigt et a l'orteil, ensuite il calcule : 1- la Vitesse de l'onde de pouls (VOP), 2- la difference des temps de transit DOD 3- l'indice de velocite ou pOpscore ® = VOP membre inferieur/VOP membre superieur. La pression arterielle et l'indice de pression systolique (IPS) ont ete mesures comme indices habituels de RA. Resultats Les deux groupes etaient comparables pour la pression arterielle et l'indice de pression systolique (1,15±0,04 vs 1,12±0,03 ; ns). Les patients avec plaques, etaient plus âges (59±2 ans vs 49±2, P ® (VOPdo (14,3±1,0 vs 10,7±0,7m/s, p ® (1,51±0,3 vs 1,41±0,2, p 2 =0,11), la rigidite aortique (r 2 =0,15, p=0,002), les indices pOpmetre DOD (r 2 =0,28, p ® (r 2 =0,19, p 2 =0,24, p 2 =0,17, p=0,0003), mais pas avec l'IPS. Conclusion Dans cette population de sujets a risque : 1 - La rigidite arterielle mesuree par pOpmetre ® est liee au risque vasculaire infra clinique comme la presence de plaques carotidiennes contrairement a l'IPS, 2 - L'âge contribue a la rigidite arterielle.