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    M. Cid

    To evaluate the feasibility of using a replication-deficient recombinant adenovirus to transfer human genes to the human endothelium, human umbilical vein endothelial cells were infected in vitro with adenovirus vectors containing the... more
    To evaluate the feasibility of using a replication-deficient recombinant adenovirus to transfer human genes to the human endothelium, human umbilical vein endothelial cells were infected in vitro with adenovirus vectors containing the lacZ gene or a human alpha_1-antitrypsin (alpha_1AT) cDNA. After in vitro infection with the lacZ adenovirus vector, cultured endothelial cells expressed beta-galactosidase. In parallel studies with the alpha_1AT
    ABSTRACT Considering the recent modification of n-type highly doped silicon parameters, this work has been based on one-dimensional models with analytical solutions. In order to obtain a good accuracy, a fifth order approximation has been... more
    ABSTRACT Considering the recent modification of n-type highly doped silicon parameters, this work has been based on one-dimensional models with analytical solutions. In order to obtain a good accuracy, a fifth order approximation has been considered. Passivated emitters with a Gaussian profile of n+pp+ solar cells were optimized. According to our results, emitter solar cells show their best efficiencies (η≅21.60-21.70%) with Ns=1×1019-5×1018 (cm-3 ) and (1.2-2.0) μm emitter thickness range
    ABSTRACT Homogeneous emitter solar cells were optimized based on a one-dimensional theoretical model with analytical solutions. A complete structure n+pp+ was optimized considering the shadowing factor Fm=10%, typical for a large scale... more
    ABSTRACT Homogeneous emitter solar cells were optimized based on a one-dimensional theoretical model with analytical solutions. A complete structure n+pp+ was optimized considering the shadowing factor Fm=10%, typical for a large scale fabrication process. A comparison between the optimum output electrical parameters obtained for Fm=3% and 10% has been made. A small sensitivity of the moderately thick emitters to the surface conditions was found. Therefore, a study of the requirements of this technology for industrial applications is clearly necessary
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    The susceptibility to stress corrosion cracking (SCC) of the Al-Zn-Mg-Cu French 7010 alloy of different temper has been investigated by Slow Strain Rate Testing. The tests have been carried out at strain rate ranged between 10− 5 and 10−... more
    The susceptibility to stress corrosion cracking (SCC) of the Al-Zn-Mg-Cu French 7010 alloy of different temper has been investigated by Slow Strain Rate Testing. The tests have been carried out at strain rate ranged between 10− 5 and 10− 7s− 1, at corrosion potential and ...
    Motions of the temporomandibular joint (TMJ) involve both translation and rotation; however, there may be substantial variations from one human to another, and these variations present significant difficulties when designing TMJ... more
    Motions of the temporomandibular joint (TMJ) involve both translation and rotation; however, there may be substantial variations from one human to another, and these variations present significant difficulties when designing TMJ prostheses. The disc-condyle glides along the temporal bone and the condyle centre describe a curve that depends on the individual morphology. This study analyses disc-condyle rotatory and translatory displacements moving all along the temporal bone facets which are mainly composed of two areas: the articular tubercle slope (ATS) and the preglenoid plane separated by the articular tubercle crest. Displacements were quantified using 3D video analysis, and this technique was computer-assisted. From a population of 32 volunteers, we were able to establish a correlation between the kinematic characteristics of the joint and the disc-condyle trajectories. This study quantifies the geometrical characteristics of the ATS and their inter-individual variations, which are useful in TMJ prosthesis design.
    Different lines of evidence have highlighted the role of IL-17A in the inflammatory process occurring in giant cell arteritis (GCA). The aim of the present study was to assess whether the IL17A locus influences GCA susceptibility and its... more
    Different lines of evidence have highlighted the role of IL-17A in the inflammatory process occurring in giant cell arteritis (GCA). The aim of the present study was to assess whether the IL17A locus influences GCA susceptibility and its clinical subphenotypes. We carried out a large meta-analysis including a total of 1266 biopsy-proven GCA patients and 3779 healthy controls from four European populations (Spain, Italy, Germany and Norway). Five IL17A polymorphisms (rs4711998, rs8193036, rs3819024, rs2275913 and rs7747909) were selected by tagging and genotyped using TaqMan assays. Allelic combination and dependency tests were also performed. In the pooled analysis, two of the five analysed polymorphisms showed evidence of association with GCA (rs2275913: PMH=1.85E-03, OR=1.17 (1.06-1.29); rs7747909: PMH=8.49E-03, OR=1.15 (1.04-1.27)). A clear trend of association was also found for the rs4711998 variant (PMH=0.059, OR=1.11 (1.00-1.23)). An independent effect of rs2275913 and rs4711998 was evident by conditional regression analysis. In addition, the haplotype harbouring the risk alleles better explained the observed association than the polymorphisms independently (likelihood p value <10(-05)). Polymorphisms within the IL17A locus show a novel association with GCA. This finding supports the relevant role of the Th17 cells in this vasculitis pathophysiology.