Papers by Larisa Gimpelevich
PloS one, 2014
An adverse effect of acid-suppression medications on the occurrence of Clostridium difficile infe... more An adverse effect of acid-suppression medications on the occurrence of Clostridium difficile infection (CDI) has been a common finding of many, but not all studies. We hypothesized that association between acid-suppression medications and CDI is due to the residual confounding in comparison between patients with infection to those without, predominantly from non-tested and less sick subjects. We aimed to evaluate the effect of acid suppression therapy on incidence of CDI by comparing patients with CDI to two control groups: not tested patients and patients suspected of having CDI, but with a negative test. We conducted a case-control study of adult patients hospitalized in internal medicine department of tertiary teaching hospital between 2005-2010 for at least three days. Controls from each of two groups (negative for CDI and non-tested) were individually matched (1:1) to cases by primary diagnosis, Charlson comorbidity index, year of hospitalization and gender. Primary outcomes we...
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Papers by Larisa Gimpelevich