Ring flips of cyclic C 9 H 7 X allenes over triplet carbenes are compared and contrasted for X = ... more Ring flips of cyclic C 9 H 7 X allenes over triplet carbenes are compared and contrasted for X = H, F, Cl and Br. Three series of conjugated non-planar allenes including 4-, 5-, and 6-X-1,2, 4,6,8-cyclononapentaenes, turn into their mirror images; through their corresponding ...
Morphine withdrawal usually results in unsuccessful outcomes. Despite partial benefits from alter... more Morphine withdrawal usually results in unsuccessful outcomes. Despite partial benefits from alternative substances such as methadone, its use may not lead to the desired result due to the lack of mental tranquility during the withdrawal period. In this study, by means of an animal model, morphine itself was used to manage morphine dependence. Forty mice were divided into 5 groups, in which 4 groups became dependent by increasing daily doses of morphine for 7 days (15-45 mg/kg). Afterwards, the animals received morphine for 14 days by either of the following regimens: Once daily 45 mg/kg (positive controls)Increasing the interval (each time 6 hours longer than the previous interval)Irregular interval in every 36, 12 and 24 hours until the 21(th) day12, 24, 36 hours decreasing doses (each time 2.5 mg/kg less than the former dosage). Negative controls received saline solution only. On day 22, total withdrawal index (TWI) was determined by injecting 3 mg/kg of naloxone. Thereafter, bloo...
Ab initio studies show the possibility of involvement of cyclic, planar, singlet and/or triplet 2... more Ab initio studies show the possibility of involvement of cyclic, planar, singlet and/or triplet 2-X-2,4,6,8-cyclononatetraenylidenes, carbenic transition states (1X-S* and/or 1X-T*), in the conversion of cyclic conjugated non-planar allenes, 1-X-1,2,4,6,8-cyclonona-pentaenes (1X), to their corresponding mirror images, 1X′ (where X=H, F, Cl and Br).
Barriers of umbrella inversions for non-planar triplet 2-, 3-, 4-, or 5-X-2,4,6,8-cyclononatetrae... more Barriers of umbrella inversions for non-planar triplet 2-, 3-, 4-, or 5-X-2,4,6,8-cyclononatetraenylidenes , inverting through planar transition states, appear roughly four times lower in energy than their corresponding singlet states, at ab initio and DFT levels (X = H, F, Cl, Br). Relative ...
Molecular and cellular endocrinology, Jan 30, 2007
A phenotypic definition of the term estrogen has become increasingly problematic due to the multi... more A phenotypic definition of the term estrogen has become increasingly problematic due to the multiple modes of estrogen action which can now be defined by differing nuclear and membrane receptors for the classic ligand, 17beta-estradiol, and by the multiple signalling pathways that are consequently addressed. This has led to the term xenoestrogen being largely determined by whatever assay system is used for its definition. Here we describe a novel and simple matrix for a transfection system using MBA-MD231 and MCF-7 breast cancer cells as hosts. This matrix is able to vary the type of nuclear estrogen receptor used, and by varying the promoter-reporter construct between one using a classic estrogen response element (ERE) enhancer, and one using an enhancer element derived from the bovine oxytocin gene promoter binding an orphan nuclear receptor, direct classical effects can be neatly discriminated from non-classical and non-genomic actions of test substances. This assay matrix has be...
... A. Solati (*) Islamic Azad University Saveh Branch, Saveh, Iran e-mail: drsolati@iau-saveh.ac... more ... A. Solati (*) Islamic Azad University Saveh Branch, Saveh, Iran e-mail: drsolati@iau-saveh.ac. ir ... Toxicol Appl Pharmacol 177:6876 Kazmi F, Shakoori AR, Hafeez MA, Ali SS (2003) Short-term effecchlorpyrifos on hematology and biochemical components of blood of the ...
Ring flips of cyclic C 9 H 7 X allenes over triplet carbenes are compared and contrasted for X = ... more Ring flips of cyclic C 9 H 7 X allenes over triplet carbenes are compared and contrasted for X = H, F, Cl and Br. Three series of conjugated non-planar allenes including 4-, 5-, and 6-X-1,2, 4,6,8-cyclononapentaenes, turn into their mirror images; through their corresponding ...
Ring flips of cyclic C 9 H 7 X allenes over triplet carbenes are compared and contrasted for X = ... more Ring flips of cyclic C 9 H 7 X allenes over triplet carbenes are compared and contrasted for X = H, F, Cl and Br. Three series of conjugated non-planar allenes including 4-, 5-, and 6-X-1,2, 4,6,8-cyclononapentaenes, turn into their mirror images; through their corresponding ...
Morphine withdrawal usually results in unsuccessful outcomes. Despite partial benefits from alter... more Morphine withdrawal usually results in unsuccessful outcomes. Despite partial benefits from alternative substances such as methadone, its use may not lead to the desired result due to the lack of mental tranquility during the withdrawal period. In this study, by means of an animal model, morphine itself was used to manage morphine dependence. Forty mice were divided into 5 groups, in which 4 groups became dependent by increasing daily doses of morphine for 7 days (15-45 mg/kg). Afterwards, the animals received morphine for 14 days by either of the following regimens: Once daily 45 mg/kg (positive controls)Increasing the interval (each time 6 hours longer than the previous interval)Irregular interval in every 36, 12 and 24 hours until the 21(th) day12, 24, 36 hours decreasing doses (each time 2.5 mg/kg less than the former dosage). Negative controls received saline solution only. On day 22, total withdrawal index (TWI) was determined by injecting 3 mg/kg of naloxone. Thereafter, bloo...
Ab initio studies show the possibility of involvement of cyclic, planar, singlet and/or triplet 2... more Ab initio studies show the possibility of involvement of cyclic, planar, singlet and/or triplet 2-X-2,4,6,8-cyclononatetraenylidenes, carbenic transition states (1X-S* and/or 1X-T*), in the conversion of cyclic conjugated non-planar allenes, 1-X-1,2,4,6,8-cyclonona-pentaenes (1X), to their corresponding mirror images, 1X′ (where X=H, F, Cl and Br).
Barriers of umbrella inversions for non-planar triplet 2-, 3-, 4-, or 5-X-2,4,6,8-cyclononatetrae... more Barriers of umbrella inversions for non-planar triplet 2-, 3-, 4-, or 5-X-2,4,6,8-cyclononatetraenylidenes , inverting through planar transition states, appear roughly four times lower in energy than their corresponding singlet states, at ab initio and DFT levels (X = H, F, Cl, Br). Relative ...
Molecular and cellular endocrinology, Jan 30, 2007
A phenotypic definition of the term estrogen has become increasingly problematic due to the multi... more A phenotypic definition of the term estrogen has become increasingly problematic due to the multiple modes of estrogen action which can now be defined by differing nuclear and membrane receptors for the classic ligand, 17beta-estradiol, and by the multiple signalling pathways that are consequently addressed. This has led to the term xenoestrogen being largely determined by whatever assay system is used for its definition. Here we describe a novel and simple matrix for a transfection system using MBA-MD231 and MCF-7 breast cancer cells as hosts. This matrix is able to vary the type of nuclear estrogen receptor used, and by varying the promoter-reporter construct between one using a classic estrogen response element (ERE) enhancer, and one using an enhancer element derived from the bovine oxytocin gene promoter binding an orphan nuclear receptor, direct classical effects can be neatly discriminated from non-classical and non-genomic actions of test substances. This assay matrix has be...
... A. Solati (*) Islamic Azad University Saveh Branch, Saveh, Iran e-mail: drsolati@iau-saveh.ac... more ... A. Solati (*) Islamic Azad University Saveh Branch, Saveh, Iran e-mail: drsolati@iau-saveh.ac. ir ... Toxicol Appl Pharmacol 177:6876 Kazmi F, Shakoori AR, Hafeez MA, Ali SS (2003) Short-term effecchlorpyrifos on hematology and biochemical components of blood of the ...
Ring flips of cyclic C 9 H 7 X allenes over triplet carbenes are compared and contrasted for X = ... more Ring flips of cyclic C 9 H 7 X allenes over triplet carbenes are compared and contrasted for X = H, F, Cl and Br. Three series of conjugated non-planar allenes including 4-, 5-, and 6-X-1,2, 4,6,8-cyclononapentaenes, turn into their mirror images; through their corresponding ...
Uploads
Papers by Mohammad Koohi