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Research Interests: Genetics, Cardiology, Polymorphism, Life Sciences, Treatment Outcome, and 24 moreHR, Humans, Female, Male, Health Science, Cohort Study, Gene, Risk factors, Lipoprotein(a), Heart Disease, Middle Aged, C reactive protein, Acute Coronary Syndrome, Kinesin, Gen, Dose Response Relationship, Coronary heart disease, Risk Reduction, Public health systems and services research, Risk Factors, Lipoprotein a, Confidence Interval, Cohort Studies, and The American
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Research Interests: Genetics, Polymorphism, Vascular biology, Humans, Female, and 14 moreMale, Risk factors, Lipoprotein(a), Clinical Sciences, Aged, Middle Aged, Risk Factor, Single Nucleotide Polymorphism, Risk Factors, Coronary Artery Disease, Case Control Study, Lipoprotein a, Confidence Interval, and Case Control Studies
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Research Interests: Genetics, Cardiovascular disease, Multidisciplinary, Genetics of complex disease, Humans, and 18 moreFemale, Male, Risk factors, PLoS one, Aged, Middle Aged, Potential Function, Genotype, Myocardial Infarction, Adult, Single Nucleotide Polymorphism, Gene Function, False discovery rate, Risk Factors, Amino Acid Substitution Rates, Case Control Study, Case Control Studies, and Iron binding proteins
Research Interests: Engineering, Physics, Chemistry, Biology, Costa Rica, and 19 moreMedicine, Multidisciplinary, Multiple testing, Humans, Female, Male, Risk factors, PLoS one, Aged, Middle Aged, Kinesin, Genotype, Myocardial Infarction, Adult, Risk Factors, Case Control Study, Prospective Study, Confidence Interval, and Case Control Studies
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Research Interests: Genetics, Adolescent, Humans, Deep Vein Thrombosis, Haplotypes, and 15 moreGenetic Association Studies, Young Adult, cerebral Venous sinus thrombosis, Haemostasis and Thrombosis, Risk factors, Clinical Sciences, Aged, Middle Aged, Genotype, Adult, Single Nucleotide Polymorphism, Odds ratio, Risk Factors, Case Control Studies, and Factor XI
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Research Interests:
Research Interests: Genetics, Cardiology, Polymorphism, Life Sciences, Treatment Outcome, and 24 moreHR, Humans, Female, Male, Health Science, Cohort Study, Gene, Risk factors, Lipoprotein(a), Heart Disease, Middle Aged, C reactive protein, Acute Coronary Syndrome, Kinesin, Gen, Dose Response Relationship, Coronary heart disease, Risk Reduction, Public health systems and services research, Risk Factors, Lipoprotein a, Confidence Interval, Cohort Studies, and The American
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Research Interests: Genetics, Medicine, Logistic Regression, Humans, Deep Vein Thrombosis, and 21 moreFemale, Male, cerebral Venous sinus thrombosis, Gene, Risk factors, Genes, Association, Middle Aged, Gen, Adult, Single Nucleotide Polymorphism, Genetic variation, False discovery rate, Risk Factors, Case Control Study, Logistic Models, Variant, Allele Frequency, JAMA, Confidence Interval, and Factor XI
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Research Interests: Immunohistochemistry, Gene expression, Disease susceptibility, Biological Sciences, Association study, and 19 moreHumans, Human Molecular Genetics, Risk factors, Aged, Middle Aged, Single Nucleotide Polymorphism, Odds ratio, Linkage Disequilibrium, Reproducibility of Results, Genetic variation, Risk Factors, Large Scale, Alzheimer Disease, Genetic Markers, Logistic Models, Age of Onset, Parkinson Disease, Case Control Studies, and Statistics as Topic
Genetic ancestry and environmental factors may contribute to the ethnic differences in risk of coronary heart disease (CHD), metabolic syndrome (MS) or its individual components. The population of the Central Valley of Costa Rica offers a... more
Genetic ancestry and environmental factors may contribute to the ethnic differences in risk of coronary heart disease (CHD), metabolic syndrome (MS) or its individual components. The population of the Central Valley of Costa Rica offers a unique opportunity to assess the role of genetic ancestry in these chronic diseases because it derived from the admixture of a relatively small number of founders of Southern European, Amerindian, and West African origin. We aimed to determine whether genetic ancestry is associated with risk of myocardial infarction (MI), MS and its individual components in the Central Valley of Costa Rica. We genotyped 39 ancestral informative markers in cases (n = 1,998) with a first non-fatal acute MI and population-based controls (n = 1,998) matched for age, sex, and area of residence, to estimate individual ancestry proportions. Odds ratios (ORs) and 95% confidence intervals (95% CI) were estimated using conditional (MI) and unconditional (MS and its components) logistic regression adjusting for relevant confounders. Mean individual ancestry proportions in cases and controls were 57.5 versus 57.8% for the Southern European, 38.4 versus 38.3% for the Amerindian and 4.1 versus 3.8% for the West African ancestry. Compared with Southern European ancestry, each 10% increase in West African ancestry was associated with a 29% increase in MI, OR (95% CI) = 1.29 (1.07, 1.56), and with a 30% increase on the risk of hypertension, OR (95% CI) = 1.30 (1.00, 1.70). Each 10% increase in Amerindian ancestry was associated with a 14% increase on the risk of MS, OR (95% CI) = 1.14 (1.00, 1.30), and 20% increase on the risk of impaired fasting glucose, OR (95% CI) = 1.20 (1.01, 1.42). These results show that the high variability of admixture proportions in the Central Valley population offers a unique opportunity to uncover the genetic basis of ethnic differences on the risk of disease.
Research Interests: Genetics, Human Genetics, Complementary and Alternative Medicine, Risk, Costa Rica, and 15 moreLogistic Regression, Metabolic syndrome, Humans, Hypertension, Chronic Disease, Confidence intervals, Risk factors, Genotype, Myocardial Infarction, Coronary heart disease, Odds ratio, Risk Factors, Logistic Models, Ethnic Difference, and Confidence Interval
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Research Interests: Open Access, Adolescent, Humans, Deep Vein Thrombosis, Haplotypes, and 16 moreFemale, Male, Young Adult, cerebral Venous sinus thrombosis, Risk factors, Aged, Middle Aged, Genotype, Adult, Single Nucleotide Polymorphism, Odds ratio, Linkage Disequilibrium, Risk Factors, Case Control Study, Confidence Interval, and Case Control Studies
Statin therapy has been found to substantially and significantly reduce coronary events in carriers of the KIF6 719Arg variant (rs20455) but not in noncarriers. We investigated whether, among the elderly, statin therapy also significantly... more
Statin therapy has been found to substantially and significantly reduce coronary events in carriers of the KIF6 719Arg variant (rs20455) but not in noncarriers. We investigated whether, among the elderly, statin therapy also significantly reduced coronary events in carriers but not in noncarriers. Among 5,752 patients of the PROspective Study of Pravastatin in the Elderly at Risk (PROSPER) study, we assessed the effect of pravastatin, compared with placebo, on coronary events according to 719Arg carrier status using proportional hazards models. Since benefit from statin therapy in elderly patients has been primarily shown among those with prior vascular disease, we performed analyses in PROSPER patients with prior disease and found that pravastatin therapy significantly reduced events in 719Arg carriers [hazards ratio (HR): 0.66, 95% confidence interval (CI): 0.52-0.86] but not in noncarriers (HR: 0.94, 95% CI: 0.69-1.28), P=0.09 for interaction between treatment and carrier status. Among those without prior disease, no significant benefit was observed in either carriers or noncarriers. Among those with prior vascular disease in the placebo arm, Trp719Arg heterozygotes were at significantly greater risk, compared with noncarriers (HR: 1.36, 95% CI: 1.03-1.81, P=0.03); the HR of 719Arg carriers, compared with noncarriers, was 1.28 (95% CI: 0.98-1.69, P=0.07). Elderly carriers of the KIF6 719Arg variant with prior vascular disease received significant benefit from pravastatin therapy; no benefit was observed in noncarriers with prior disease or in those without prior disease (carriers or noncarriers).