Papers by Jacques Streith
Bioorg Medicinal Chem Letter, 1993
Cheminform, 2010
ABSTRACT Convenient access to the enantiomerically pure rigid bidentate ligand (-)-[5-(diphenylar... more ABSTRACT Convenient access to the enantiomerically pure rigid bidentate ligand (-)-[5-(diphenylarsino)-2,3 -dimethyl-7-phenyl-7(S)-phosphabicyclo[2.2.1]hept-2-ene is established via an asymmetric [4 + 2] cycloaddition between diphenylvinylarsine and 1-phenyl-3,4-dimethylphosphole using the chiral organopalladium(II) complex containing ortho-metalated dimethyl[1-(2-naphthyl)ethyl]amine as the reaction promoter. The absolute configurations of the four newly generated stereocenters have been assigned by single-crystal X-ray analysis.
Helvetica Chimica Acta, Nov 1, 1995
ABSTRACT An eight-step synthetic sequence led from the known D-xylo-pentodialdose 8 to imidazo-L-... more ABSTRACT An eight-step synthetic sequence led from the known D-xylo-pentodialdose 8 to imidazo-L-xylo-piperidinose 15, the key steps being the build-up of imidazole compound 12 by a van Leusen methodology and the intramolecular SN2 ring closure of the O-triflated benzylidene derivative 13. xylo-Piperidinose 15 appears in a half-chair conformation like the oxocarbonium ions which are the postulated intermediates in the glycoprocessing of the pyranose polysaccharides. This bicyclic azasugar should be a glycosidase inhibitor.
Tetrahedron, Jul 1, 1998
ABSTRACT Imidazolo-L-lyxo-piperidinose 4 was synthesised from the D-galactose derivative 8 by two... more ABSTRACT Imidazolo-L-lyxo-piperidinose 4 was synthesised from the D-galactose derivative 8 by two reaction sequences, via removal of a terminal carbon atom, stepwise incorporation of an imidazole moiety, and eventually intramolecular SN2 reaction to the corresponding piperidine ring. Piperidinose 4 proved to be a poor glycosidase inhibitor.
Nouveau Journal De Chimie, 1985
ChemInform, 1996
On the Way to Glycoprocessing Inhibitors. Synthesis of an Imidazo-L-xylo-piperidinose Derivative.... more On the Way to Glycoprocessing Inhibitors. Synthesis of an Imidazo-L-xylo-piperidinose Derivative. -The title compound (X), a potential glycosidase inhibitor, is synthesized, the formation of the imidazole (VI) by a van Leusen method and the ring closure of (VIII) being the key steps. (X) exists in a half-chair conformation like the oxocarbonium ions, which are intermediates in the glycoprocessing of the pyranose polysaccharides.
Organic Chemistry: A Series of Monographs, 1980
Tetrahedron Letters, 1977
Journal of the Chemical Society, Chemical Communications, 1995
ABSTRACT Photochemical transformations of pyrazolopyridazine 1 give isopropenylpyridazine 2 in ad... more ABSTRACT Photochemical transformations of pyrazolopyridazine 1 give isopropenylpyridazine 2 in addition to cyclopropapyridazine 3 in solution and to the ring-opened diazo isomer 4 observed in frozen gas matrices.
6-Deoxy-allo-nojirimycin in the Racemic and D-Series, 6-Deoxy-D,L-talo-Nojirimycin, Their 1-Deoxy... more 6-Deoxy-allo-nojirimycin in the Racemic and D-Series, 6-Deoxy-D,L-talo-Nojirimycin, Their 1-Deoxyderivatives and 6-Deoxy-2-D,Lallosamine via Hetero-Diels-Alder Cycloadditions.
Journal of the Chemical Society, Chemical Communications, 1982
ChemInform, 2000
ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was e... more ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Tetrahedron Letters, 1971
Tetrahedron Letters, 1980
ABSTRACT Ionic and radical mechanistic steps are postulated in order to explain the formation of ... more ABSTRACT Ionic and radical mechanistic steps are postulated in order to explain the formation of the rearrangement-, the isomerization- and the fragmentation-products isolated during the thermal treatment of pyrazolo-diazepines.
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Papers by Jacques Streith