Papers by Humayra Nazneen
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Blood Advances, 2017
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Journal of Dhaka Medical College, 2016
Acute myeloid leukemia (AML) is a clonal, malignant disease of hematopoietic tissue.Main variable... more Acute myeloid leukemia (AML) is a clonal, malignant disease of hematopoietic tissue.Main variables precluding cure are the treatment-related mortality and relapse rates.The most common induction chemotherapy regimens in AML involve the use of cytarabine (Ara-C) and an anthracycline. It was observational study carried out in the inpatient Department of Hematology, Dhaka Medical College Hospital, Dhaka, from July 2009 to June 2014.76 newly diagnosed cases of AML patients between 15 year to 60 yearwere enrolled in this study. All patient received standard induction therapy with Daunorubicin 45mg/m2 I/V for 3 days and Ara-C 100mg/m2 I/V over 24 hours for 7 days. A bone marrow aspirate to assess remission status was carried out at day 28+, after the peripheral recovery.The mean age of the patients were 35.12±12.45 years, ranging from 17 to 55 years. 68% were male and 32% cases were female. Total 34(44.7%) patient achieved complete remission (CR), out of them 17% had t(8:21), 5.8% had inv...
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Orphanet Journal of Rare Diseases
Background Hemophilia is one of the commonest inherited bleeding disorders which may lead to chro... more Background Hemophilia is one of the commonest inherited bleeding disorders which may lead to chronic bleeding tendencies and life-long disabilities if not properly managed. Knowing the pattern of the disease aids in the prevention of disability and improvement of quality of life in hemophilia. However, there is a dearth of literature on the issue in Bangladesh. So, this study was designed to explore the frequency and site of spontaneous bleeding in moderate and severe hemophilia patients visiting in a tertiary level hospital. Methods This descriptive cross-sectional study was conducted at the department of Hematology and Bone Marrow Transplantation (BMT) Center in Dhaka Medical College Hospital, Dhaka between February 2020 and August 2020. A total of 44 diagnosed cases of moderate to severe hemophilia were included in the study according to inclusion criteria. A detailed inquiry of history, thorough physical examination and relevant investigations were done and were recorded in case...
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Bangladesh started the journey of hematopoietic stem cell transplantation (HSCT) in March 2014 wi... more Bangladesh started the journey of hematopoietic stem cell transplantation (HSCT) in March 2014 with the first autologous stem cell transplant (ASCT) performed at Dhaka Medical College Hospital (DMCH), the first and the pioneer HSCT center in Bangladesh with the partnership collaboration program
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Journal of Global Oncology
Purpose Treatment of malignant and nonmalignant hematologic diseases with hematopoietic stem-cell... more Purpose Treatment of malignant and nonmalignant hematologic diseases with hematopoietic stem-cell transplantation (HSCT) was first described almost 60 years ago, and its use has expanded significantly over the last 20 years. Whereas HSCT has become the standard of care for many patients in developed countries, the significant economic investment, infrastructure, and health care provider training that are required to provide such a service have prohibited it from being widely adopted, particularly in developing countries. Methods Over the past two decades, however, efforts to bring HSCT to the developing world have increased, and several institutions have described their efforts to establish such a program. We aim to provide an overview of the current challenges and applications of HSCT in developing countries as well as to describe our experience in developing an HSCT program at Dhaka Medical College and Hospital in Bangladesh via a partnership with health care providers at Massachu...
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Journal of Dhaka Medical College, 2015
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Journal of Global Oncology, Dec 1, 2018
Purpose Treatment of malignant and nonmalignant hematologic diseases with hematopoietic stem-cell... more Purpose Treatment of malignant and nonmalignant hematologic diseases with hematopoietic stem-cell transplantation (HSCT) was first described almost 60 years ago, and its use has expanded significantly over the last 20 years. Whereas HSCT has become the standard of care for many patients in developed countries, the significant economic investment, infrastructure, and health care provider training that are required to provide such a service have prohibited it from being widely adopted, particularly in developing countries. Methods Over the past two decades, however, efforts to bring HSCT to the developing world have increased, and several institutions have described their efforts to establish such a program. We aim to provide an overview of the current challenges and applications of HSCT in developing countries as well as to describe our experience in developing an HSCT program at Dhaka Medical College and Hospital in Bangladesh via a partnership with health care providers at Massachusetts General Hospital. Results and Conclusion We discuss key steps of the program, including the formation of a collaborative partnership, infrastructure development, human resource capacity building, and financial considerations.
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Journal of Dhaka Medical College, 2016
Acute myeloid leukemia (AML) is a clonal, malignant disease of hematopoietic tissue.Main variable... more Acute myeloid leukemia (AML) is a clonal, malignant disease of hematopoietic tissue.Main variables precluding cure are the treatment-related mortality and relapse rates.The most common induction chemotherapy regimens in AML involve the use of cytarabine (Ara-C) and an anthracycline. It was observational study carried out in the inpatient Department of Hematology, Dhaka Medical College Hospital, Dhaka, from July 2009 to June 2014.76 newly diagnosed cases of AML patients between 15 year to 60 yearwere enrolled in this study. All patient received standard induction therapy with Daunorubicin 45mg/m2 I/V for 3 days and Ara-C 100mg/m2 I/V over 24 hours for 7 days. A bone marrow aspirate to assess remission status was carried out at day 28+, after the peripheral recovery.The mean age of the patients were 35.12±12.45 years, ranging from 17 to 55 years. 68% were male and 32% cases were female. Total 34(44.7%) patient achieved complete remission (CR), out of them 17% had t(8:21), 5.8% had inv...
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Papers by Humayra Nazneen