Background: Accumulating evidence from single case studies, small case series and randomized controlled trials seems to suggest that inhibitory noninvasive brain stimulation (NIBS) over the contralesional inferior frontal gyrus (IFG) of... more
Background: Accumulating evidence from single case studies, small case series and randomized controlled trials seems to suggest that inhibitory noninvasive brain stimulation (NIBS) over the contralesional inferior frontal gyrus (IFG) of right-handers in conjunction with speech and language therapy (SLT) improves recovery from poststroke aphasia. Application of inhibitory NIBS to improve recovery in left-handed patients has not yet been reported. Methods: A total of 29 right-handed subacute poststroke aphasics were randomized to receive either 10 sessions of SLT following 20 min of inhibitory repetitive transcranial magnetic stimulation (rTMS) over the contralesional IFG or 10 sessions of SLT following sham stimulation; 2 left-handers were treated according to the same protocol with real rTMS. Language activation patterns were assessed with positron emission tomography prior to and after the treatment; 95% confidence intervals for changes in language performance scores and the activa...
Research Interests: Aphasia, Transcranial Magnetic Stimulation, Treatment Outcome, Language, Positron Emission Tomography, and 14 moreMedicine, Stroke, Humans, Cerebrovascular diseases, Clinical Sciences, Aged, Middle Aged, Speech Therapy, Stimulation, Neurosciences, Frontal Lobe, Psychology and Cognitive Sciences, Patient selection, and Medical and Health Sciences
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Abstract Studies examined the neurological involvement of ankylosing spondylitis (AS) are limited. This study aimed to assess the frequency of myelopathy, radiculopathy and myop-athy in AS correlating them to the clinical, radiological... more
Abstract Studies examined the neurological involvement of ankylosing spondylitis (AS) are limited. This study aimed to assess the frequency of myelopathy, radiculopathy and myop-athy in AS correlating them to the clinical, radiological and laboratory parameters. Included ...
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s of Oral Presentations / Clinical Neurophysiology 125, Supplement 1 (2014) S1–S339 S43 Ashworth scale (MAS) and Motor activity log amount of use score (MAL) were assessed before, post and 3 months after the end of HANDS therapy. Paired... more
s of Oral Presentations / Clinical Neurophysiology 125, Supplement 1 (2014) S1–S339 S43 Ashworth scale (MAS) and Motor activity log amount of use score (MAL) were assessed before, post and 3 months after the end of HANDS therapy. Paired pulse TMS paradigm was applied to assess the short intracortical inhibition (SICI). Reciprocal inhibition (RI) was assessed with a flexor carpi radialis H reflex conditioning-test paradigm. The conditioning-test stimulus interval was set at 0, 20, 100ms (RI at 0ms, RI at 20ms, RI at 100ms). Results: FM, MAL and MAS improved with HANDS therapy (P<0.01) and these improvements lasted for 3months (p<0.01). We found significant disinhibition of affected SICI, and strengthened RI at 20ms and100ms with HANDS therapy. The change of FM from before to 3 months after HANDS therapy was correlated with the change of the affected SICI from before to post HANDS therapy (P<0.01). The change of wrist MAS from before to post HANDS therapy was correlated with the change of RI at 100ms (P<0.05). Conclusions: In chronic stroke patients with moderate or severe hemiparesis, functional improvement of upper extremity motor function and spasticity was based on the disinhibition of affected hemisphere and modulation of reciprocal inhibition. O48 The use of repetitive transcranial magnetic stimulation to enhance stroke recovery
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Research Interests: Transcranial Magnetic Stimulation, Adolescent, Medicine, Anatomy, Humans, and 14 moreMale, Reaction Time, Motor Cortex, Motor Evoked Potentials, Middle Aged, Magnetics, Adult, Hemispheric Specialization, Stimulation, Human Subjects, Phrenic Nerve, Motor evoked potential, Electric stimulation, and diaphragm
Research Interests: Cognitive Science, Medicine, Physical Medicine and Rehabilitation, Humans, Female, and 15 moreMale, Reaction Time, Electromagnetic Fields, Motor Cortex, Clinical Sciences, Rating Scale, European, Aged, Middle Aged, Adult, Analysis of Variance, Motor Function, Neurosciences, Parkinson Disease, and Motor Skills
Background: Parkinson’s disease (PD) is the most common movement disorder and represents the second most common degenerative disease of the central nervous system. Objective: To measure the effect of repetitive transcranial magnetic... more
Background: Parkinson’s disease (PD) is the most common movement disorder and represents the second most common degenerative disease of the central nervous system. Objective: To measure the effect of repetitive transcranial magnetic stimulation (rTMS) as therapeutic treatment on sleep disorders in patients with Parkinson’s disease (PD). Patients and methods: This double-blinded study included 20 PD patients (10 received real rTMs and 10 received sham rTMs) patients recruited from Inpatient and Outpatient Clinic of Neuropsychiatric Department of Aswan University Hospital. Our patients were divided into 2 groups (10 patients each). Results: As regards the effect of rTMs on PDSS and sleep latency, our study results found no significant change in Parkinson disease sleep scale between both groups but there was significant change in sleep latency that it decreased in the group received real rTMS in comparison with the SHAM group. In addition, there were significant changes in wake stage a...
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Research Interests: Medicine, Physical Medicine and Rehabilitation, Humans, Cerebral Cortex, Female, and 15 moreMale, Motor Cortex, Electromyography, Brain Ischemia, Clinical Sciences, Middle Aged, Questionnaires, Motor Function, Long Term Effect, Acute Ischemic Stroke, Neurosciences, Motor Skills, Functional Laterality, Acute Disease, and Disability Evaluation
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Research Interests: Medicine and Peripheral
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Research Interests: Cognitive Science, Neurology, Medicine, Humans, Female, and 15 moreMale, Hemiplegia, Motor Cortex, Electromyography, Brain Ischemia, Clinical Sciences, Motor Evoked Potentials, Middle Aged, Muscle contraction, Acute Ischemic Stroke, Neurosciences, Repetitive transcranial magnetic stimulation, Neurologic Examination, Recovery of Function, and Disability Evaluation
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Research Interests: Cognitive Science, Facial Paralysis, Treatment Outcome, STEROIDS, Medicine, and 14 moreHumans, Female, Male, Young Adult, Follow-up studies, Electromyography, Facial Nerve, Motor Evoked Potentials, Adult, Randomized Controlled Trial, Neurosciences, Antiviral Agents, Acyclovir, and Severity of Illness Index
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Research Interests: Egypt, Medicine, Humans, Female, Male, and 15 moreIncidence, Clinical Sciences, Neurological, Aged, Prevalence, Middle Aged, Urban Population, Cross sectional Study, Cross Sectional Studies, Parkinson´s Disease, Neurosciences, Parkinsonism, Severity of Illness Index, Surveys and Questionnaires, and parkinsonian disorders
Research Interests: Epidemiology, Neuroepidemiology, Egypt, Intellectual Disability, Medicine, and 15 moreBiopsy, Humans, Muscular Dystrophy, Muscular Dystrophies, Electromyography, Creatine Kinase, Myasthenia Gravis, Myositis, Myopathy, Health surveys, Intelligence tests, Cross sectional Study, Cross Sectional Studies, Epidemiologic Studies, and Neurosciences
Research Interests: Engineering, Neuroscience, Adolescent, Medicine, Low Frequency, and 15 moreHumans, Female, Male, Motor Cortex, Electromyography, Clinical Neurophysiology, Motor Evoked Potentials, Magnetics, Adult, Primary Motor Cortex, Healthy Subjects, Intracortical Inhibition, Cortical Excitability, Medical and Health Sciences, and Electric stimulation
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Research Interests: Psychology, Cognitive Science, Neurology, Audiology, Transcranial Magnetic Stimulation, and 15 moreMedicine, Temporal Lobe, Tinnitus, Humans, Female, Male, Clinical Sciences, Middle Aged, Adult, Parietal Lobe, Auditory Cortex, Repetitive transcranial magnetic stimulation, Occipital Lobe, Psychology and Cognitive Sciences, and Medical and Health Sciences
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Research Interests: Neuroscience, Psychology, Chronic Pain, Transcranial Magnetic Stimulation, Medicine, and 12 morePain Management, Brain, Humans, Neuropathic pain, Fibromyalgia, Chronic Disease, Analgesia, Transcranial Direct Current Stimulation, Brain Stimulation, Stimulation, Neuralgia, and Medical and Health Sciences
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It has been proposed that tinnitus may be caused by maladaptive plasticity of processing in the central auditory pathways, and that this may be due in part to a generalised deficit in NMDA-dependent glutamatergic synapses. To test this... more
It has been proposed that tinnitus may be caused by maladaptive plasticity of processing in the central auditory pathways, and that this may be due in part to a generalised deficit in NMDA-dependent glutamatergic synapses. To test this hypothesis, we used transcranial magnetic stimulation to assess the excitability of a number of well-defined synaptic connections in the motor cortex of patients with tinnitus. Thirty-seven patients with chronic tinnitus and 12 normal age- and sex-matched volunteers were used as a control group. We measured resting and active motor thresholds (rMT/aMT) and the duration of the contralateral and ipsilateral cortical silent periods (CSP and ISP). Short interval intracortical inhibition (SICI) and intracortical facilitation (ICF) were evaluated using a paired pulse stimulation paradigm in the left (dominant) hemisphere. There was no difference between patients and healthy subjects in rMT or aMT or the onset latency of the ISP. The CSP was shorter in patients (P=0.046) whereas the ISP was longer than in healthy subjects (P=0.048) but there was no difference between the hemispheres nor any relation to tinnitus side in patients with predominantly unilateral symptoms. There was no difference in the time course of SICI/ICF between patients and control groups and no significant correlation between tinnitus handicap inventory (THI) score and any of the measures of cortical excitability. There are small changes incortical excitability in patients with chronic tinnitus. However, given the number of factors we examined in each individual, such minor changes seem unlikely to be an important factor in development of clinical symptoms.